April 2009 Volume 9 Number 4
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Nature Immunology
FOCUS ON IMMUNE SIGNALING CROSS-TALK
Nature Immunology presents a series of specially commissioned
articles that focus on the molecular basis for and biological
consequences of the interplay among signaling pathways. The web focus
also includes highlights of recent research findings and several
short comments-written by experts-providing in-depth insight into
specific signaling cross-talk points.
For more information, visit http://links.ealert.nature.com/ctt?kn=12&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
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This month's FEATURED article:
B cells in HIV infection and disease
Susan Moir and Anthony S. Fauci
p235 | doi:10.1038/nri2524
http://links.ealert.nature.com/ctt?kn=7&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
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From the editors
p221 | doi:10.1038/nri2544
http://links.ealert.nature.com/ctt?kn=34&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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T-cell responses: Directing responses in death
p222 | doi:10.1038/nri2538
http://links.ealert.nature.com/ctt?kn=78&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Cell death and immunity: CLEC9A: linking necrosis and immunity
p223 | doi:10.1038/nri2531
http://links.ealert.nature.com/ctt?kn=71&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
B-cell development: Fringe benefits
p223 | doi:10.1038/nri2534
http://links.ealert.nature.com/ctt?kn=2&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Innate immunity: Not-so-lucky 7 for West Nile virus
p224 | doi:10.1038/nri2535
http://links.ealert.nature.com/ctt?kn=17&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
IN THE NEWS
Viral trigger for diabetes?
p224 | doi:10.1038/nri2539
http://links.ealert.nature.com/ctt?kn=92&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Tolerance: Key role for DCs in preventing autoimmunity
p224 | doi:10.1038/nri2541
http://links.ealert.nature.com/ctt?kn=32&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
VACCINE WATCH
Programming instant immunity | Autophagy enhances vaccine efficacy
p225 | doi:10.1038/nri2542
http://links.ealert.nature.com/ctt?kn=8&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Regulatory T cells: Fine-tuning TReg cells
p226 | doi:10.1038/nri2537
http://links.ealert.nature.com/ctt?kn=44&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Immune regulation: DAMPening inflammation
p226 | doi:10.1038/nri2540
http://links.ealert.nature.com/ctt?kn=40&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
IN BRIEF
HIV | Innate immunity | Tolerance
p227 | doi:10.1038/nri2543
http://links.ealert.nature.com/ctt?kn=39&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Follicular helper T cells: More pieces of the puzzle
p228 | doi:10.1038/nri2533
http://links.ealert.nature.com/ctt?kn=10&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
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PROGRESS
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Interleukin-22-producing innate immune cells: new players in mucosal
immunity and tissue repair?
Eric Vivier, Hergen Spits and Tom Cupedo
p229 | doi:10.1038/nri2522
Recent studies have identified a new population of
interleukin-22-producing cells in mucosal tissues that share features
with both lymphoid-tissue inducer cells and natural killer cells. How
are these three cell populations related and what might be the
function of the new cell population?
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
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REVIEWS
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B cells in HIV infection and disease
Susan Moir and Anthony S. Fauci
p235 | doi:10.1038/nri2524
This article looks at the dysregulation of specific B-cell
subpopulations that is associated with chronic HIV infection, with a
view to understanding the mechanisms of B-cell pathogenesis in
HIV-associated disease and other diseases that are characterized by
immune dysfunction.
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Antiviral immune responses: triggers of or triggered by autoimmunity?
Christian Munz, Jan D. Lunemann, Meghann Teague Getts and Stephen
D. Miller
p246 | doi:10.1038/nri2527
Viruses have long been suspected to act as triggers of autoimmune
disease. This Review describes the various mechanisms that link
viruses to autoimmune responses and highlights how viral infection
and immune control can be dysregulated during autoimmune disease.
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Trophic macrophages in development and disease
Jeffrey W. Pollard
p259 | doi:10.1038/nri2528
The homeostatic roles of macrophages in tissue development and
maintenance are discussed, and insights are provided into how
dysregulation of these primitive functions can be subverted in
chronic diseases such as cancer and obesity to contribute to
pathology.
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=95&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
The role of TNF superfamily members in T-cell function and diseases
Michael Croft
p271 | doi:10.1038/nri2526
Tumour necrosis factor (TNF)-TNF receptor pairs that regulate the
function of effector T cells have gained prominence as therapeutic
targets. Here, Michael Croft describes the biology of four such
TNF-TNFR pairs and discusses the implications of targeting them
during conditions of inflammation, autoimmunity and cancer.
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
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PERSPECTIVES
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TIMELINE
Towards an understanding of the adjuvant action of aluminium
Philippa Marrack, Amy S. McKee and Michael W. Munks
p287 | doi:10.1038/nri2510
This Timeline article provides an overview of the discovery and
proposed mechanisms of action of aluminium salts, the most widely
used vaccine adjuvants. The recent progresses and outstanding
controversies on how aluminium salts function as adjuvants are also
discussed.
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
OPINION
Models of haematopoiesis: seeing the wood for the trees
Rhodri Ceredig, Antonius G. Rolink and Geoffrey Brown
p293 | doi:10.1038/nri2525
Recent studies indicate that haematopoietic progenitor cells have
more plasticity with regard to lineage choice than previously
appreciated. To account for this developmental plasticity, Rhodri
Ceredig and colleagues propose a new model of haematopoiesis.
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=79&m=32186857&r=MTc2NzU2Mjg3MwS2&b=2&j=NDY4NjM1OTgS1&mt=1&rt=0
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