March 12 2009
Visit Nature Reports Stem Cells online.
Now available at http://links.ealert.nature.com/ctt?kn=9&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
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OUR TOP STORIES
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Obama overturns stem-cell ban
President's executive order will allow US human embryonic stem-cell research to thrive at last.
http://links.ealert.nature.com/ctt?kn=26&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Obituary: Xiangzhong (Jerry) Yang (1959-2009)
Alan Trounson of the California Institute of Regenerative Medicine pays tribute to a leading light in animal cloning
http://links.ealert.nature.com/ctt?kn=22&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Meeting report: Stem cell enthusiasm at industry conference
Companies say clinical trials, product launches, coming up, seek investors
http://links.ealert.nature.com/ctt?kn=14&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Commentary: Stem cell clinical trials must be closely monitored
Clive Svendsen of the University of Wisconsin argues that the results of an unregulated stem cell transplant were predictable and avoidable
Amariglio, N. et al. PLoS Med. 6, e1000029 (2009); doi:10.1371/journal.pmed.1000029.
http://links.ealert.nature.com/ctt?kn=13&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Feature story: Blood feuds
In a field rife with dissension, four recent papers may resolve one of the haematopoietic community's greatest disputes
Zovein, A. C. et al. Cell Stem Cell 3, 625 - 636 (2008).
Chen, M. J. et al. Nature 457, 887 - 891 (2009).
Eilken, H. M. et al. Nature 457, 896 - 900 (2009).
Lancrin, C. et al. Nature 457, 892 - 895 (2009).
http://links.ealert.nature.com/ctt?kn=12&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS AND NEWS STORIES ABOUT RECENT PUBLICATIONS
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Why hES cells make teratomas
Inhibitors of the protein survivin might lower tumour risk
Blum, B. et al. Nature Biotechnol. advance online publication, doi:10.1038/nbt.1527 (1 March 2009).
http://links.ealert.nature.com/ctt?kn=4&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Human embryonic stem cells hit a nerve
A new technique can differentiate more neurons from hES cells in less time
Chambers, S. M. et al. Nature Biotechnol. advance online publication, doi:10.1038/nbt.1529 (1 March 2009).
http://links.ealert.nature.com/ctt?kn=11&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Unregulated stem cell transplant causes tumours
Researchers say cells were poorly characterized prior to transplantation
Amariglio, N. et al. PLoS Med. 6, e1000029 (2009); doi:10.1371/journal.pmed.1000029.
http://links.ealert.nature.com/ctt?kn=25&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Virus-free pluripotency for human cells
Stem-cell advance could bring tailored treatments closer.
Kaji, K. et al. Nature advance online publication, doi:10.1038/nature07864 (1 March 2009).
Woltjen, K. et al. Nature advance online publication, doi:10.1038/nature07863 (1 March 2009).
http://links.ealert.nature.com/ctt?kn=17&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Test tube disease models one step closer
Skin cells from Parkinson's patients transformed into tailor-made neurons, minus reprogramming genes
Soldner, F. et al. Cell 136, 964 - 977 (2009).
http://links.ealert.nature.com/ctt?kn=3&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Why old heart cells don't multiply
Adult cardiac fibroblasts tell neighbouring myocytes to expand; embryonic fibroblasts say proliferate
Ieda, M. et al. Dev. Cell 16, 233 - 244 (2009).
http://links.ealert.nature.com/ctt?kn=8&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Chromatin remodelling is required for postnatal neurogenesis
MLL1 epigenetically regulates postnatal neural specification
Lim, D. et al. Nature advance online publication, doi:10.1038/nature07726 (12 February 2009).
http://links.ealert.nature.com/ctt?kn=16&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Plant stem cells, not so different
New technique allows gene-expression analysis in the shoot meristem
Yadav, R. K. et al. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.0900843106 (published online 27 February 2009).
http://links.ealert.nature.com/ctt?kn=6&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Treatment encourages more and more aggressive brain cancer stem cells
Regulation is controlled by PTEN, PI3K/Akt and drug-effluxing ABCG2
Bleau, A-M. et al. Cell Stem Cell 4, 226 - 235 (2009).
http://links.ealert.nature.com/ctt?kn=24&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Intestinal stem cells: one gene to rule them all
Ascl2, a transcription factor and Wnt target, switches on a stem cell program in the gut
van der Flier, L. G. et al. Cell 136, 903 - 912 (2009).
http://links.ealert.nature.com/ctt?kn=23&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
Is REST a regulator of pluripotency?
Identification of transcription factors that regulate ESC pluripotency is an important goal
Singh, M. N. et al. Nature 453, 223 - 227 (2008).
http://links.ealert.nature.com/ctt?kn=7&m=31954051&r=MTc2NjM3NTc5MQS2&b=2&j=NDY0ODk0MjcS1&mt=1&rt=0
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