12 March 2009 Volume 458 Number 7235, pp 125 - 250
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EDITORIALS
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By common consent p125
Engaging with the public helped US scientists build the consensus
that finally overturned federal restrictions on human embryonic
stem-cell research. That public outreach should not stop now.
doi:10.1038/458125a
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Smart thinking pp125-126
The US electricity grid needs to evolve and requires fresh standards
of communication.
doi:10.1038/458125b
http://links.ealert.nature.com/ctt?kn=188&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Delicate balance p126
China's autocratic approach to environmental issues may not always
reap the desired rewards.
doi:10.1038/458126a
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RESEARCH HIGHLIGHTS
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Palaeontology: Brain box p128
doi:10.1038/458128a
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Chemical biology: Sweet disguise p128
doi:10.1038/458128b
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Proteomics: Worm versus fly p128
doi:10.1038/458128c
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Chemistry: Sprouting tubes p128
doi:10.1038/458128d
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Marine ecology: Deadly dusting p128
doi:10.1038/458128e
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Optics: Beyond the invisibility cloak pp128-129
doi:10.1038/458128f
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Palaeontology: Bird in the hand p129
doi:10.1038/458129a
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Neurobiology: Second fiddle p129
doi:10.1038/458129b
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Ecology: Open goal p129
doi:10.1038/458129c
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Materials science: Diaphite domains p129
doi:10.1038/458129d
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JOURNAL CLUB
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Journal club p129
Frank Wilczek
doi:10.1038/458129e
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NEWS
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Obama overturns stem-cell ban pp130-131
President's executive order will allow US human embryonic stem-cell
research to thrive at last.
Erika Check Hayden
doi:10.1038/458130a
http://links.ealert.nature.com/ctt?kn=14&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Obama order deals with scientific integrity p130
Memo puts emphasis on transparency and the best advice.
Eric Hand
doi:10.1038/458130b
http://links.ealert.nature.com/ctt?kn=75&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Personalized cancer therapy gets closer pp131-132
Genetic testing allows doctors to select best treatment.
Erika Check Hayden
doi:10.1038/458131a
http://links.ealert.nature.com/ctt?kn=85&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Gravity mission to launch p133
GOCE satellite will map variations in Earth's gravity field.
Quirin Schiermeier
doi:10.1038/458133a
http://links.ealert.nature.com/ctt?kn=136&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Putting China's wetlands on the map p134
Initiative may shed light on bird flu.
David Cyranoski
doi:10.1038/458134a
http://links.ealert.nature.com/ctt?kn=70&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Web usage data outline map of knowledge p135
Analysis offers fresh perspective on role of humanities and
social sciences.
Declan Butler
doi:10.1038/458135a
http://links.ealert.nature.com/ctt?kn=97&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Obama appoints first federal IT chief p136
Vivek Kundra promises greater transparency and more data.
M. Mitchell Waldrop
doi:10.1038/458136a
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Merck strengthens drug pipeline in rival takeover p137
doi:10.1038/458137a
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Indonesia to sell carbon credits to conserve forests p137
doi:10.1038/458137b
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Drug maker found liable despite FDA warning label p137
doi:10.1038/458137c
http://links.ealert.nature.com/ctt?kn=91&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
NIH-funded primate centre accused of mistreatment p137
doi:10.1038/458137d
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Mars orbiter plans to map out methane plumes p137
doi:10.1038/458137e
http://links.ealert.nature.com/ctt?kn=17&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Hawaiian waters yield corals with thirst for originality p137
doi:10.1038/458137f
http://links.ealert.nature.com/ctt?kn=237&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
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NEWS FEATURES
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Energy efficiency: The energy should always work twice pp138-141
Waste heat from industrial plants and electricity-generating stations
represents a huge amount of lost energy. David Lindley finds out what
engineers and regulators need to do to get it back.
David Lindley
doi:10.1038/458138a
http://links.ealert.nature.com/ctt?kn=164&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Circadian rhythms: Of owls, larks and alarm clocks pp142-144
Could out-of-sync body clocks be contributing to human disease?
Melissa Lee Phillips
doi:10.1038/458142a
http://links.ealert.nature.com/ctt?kn=290&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
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CORRESPONDENCE
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OPINION
The belief that genes cannot be changed is now outdated p145
Gerhard Meisenberg
doi:10.1038/458145a
http://links.ealert.nature.com/ctt?kn=254&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Identifying adaptive differences could provide insight p145
Kathryn Holt
doi:10.1038/458145b
http://links.ealert.nature.com/ctt?kn=264&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
The arrogance of trying to sum up abilities in a number p145
David Colquhoun
doi:10.1038/458145c
http://links.ealert.nature.com/ctt?kn=118&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Is poverty better explained by history of colonialism? pp145-146
Jonathan Marks
doi:10.1038/458145d
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Would you wish the research undone? p146
Jim Flynn
doi:10.1038/458146a
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Measured intelligence is a product of social processes p146
David Gillborn
doi:10.1038/458146b
http://links.ealert.nature.com/ctt?kn=95&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Don't fan the flames of a dead debate pp146-147
Steven Rose
doi:10.1038/458146c
http://links.ealert.nature.com/ctt?kn=273&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
A useful way to glean social information p147
Wendy M. Williams and Stephen J. Ceci
doi:10.1038/458147a
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Human rights cannot cover cells that were never in the womb p147
Patricia Pranke and Joao Carlos Silveiro
doi:10.1038/458147b
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COMMENTARY
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OPINION
A smarter way to combat hunger p148
Traditional approaches to supplying food are an inefficient 'band aid',
says Pedro A. Sanchez. New evidence shows that helping farmers to help
themselves is more effective and would be six times cheaper.
Pedro A. Sanchez
doi:10.1038/458148a
http://links.ealert.nature.com/ctt?kn=228&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
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BOOKS AND ARTS
----------------------
OPINION
Shining light upon light pp149-150
Two science histories dissect the transfer of knowledge between the
Greco-Islamic and European civilizations, and put right the impression
that the flow was one way, explains Yasmin Khan.
Yasmin Khan reviews Aladdin's Lamp: How Greek Science Came to Europe
Through the Islamic World by John Freely
doi:10.1038/458149a
http://links.ealert.nature.com/ctt?kn=206&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Myth of the missing mothers pp150-151
Meg Urry reviews Motherhood, the Elephant in the Laboratory by
doi:10.1038/458150a
http://links.ealert.nature.com/ctt?kn=51&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Storing carbon in forests p151
Michael Obersteiner reviews Climate Change and Forests: Emerging
Policy and Market Opportunities by
doi:10.1038/458151a
http://links.ealert.nature.com/ctt?kn=55&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Between life and death p152
Marta Paterlini reviews Mummies: The Dream of Everlasting Life by
doi:10.1038/458152a
http://links.ealert.nature.com/ctt?kn=98&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
A gallery of chimaeric curiosities p152
Giovanni Frazzetto reviews Corpus Extremus (LIFE+) by
doi:10.1038/458152b
http://links.ealert.nature.com/ctt?kn=137&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
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NEWS AND VIEWS
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Palaeoanthropology: Asian Homo erectus converges in time pp153-154
Re-evaluation of the age of Zhoukoudian, a prominent site of
Homo erectus occupation in China, prompts a rethink of the species'
distribution in both the temperate north and the equatorial south of
east Asia.
Russell L. Ciochon and E. Arthur Bettis III
doi:10.1038/458153a
http://links.ealert.nature.com/ctt?kn=213&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Carbon cycle: Fickle trends in the ocean pp155-156
A model analysis of the uptake of carbon dioxide in the North Atlantic
carries with it a cautionary reminder about interpreting what may be
short-term trends as signals of long-term climate change.
Nicolas Gruber
doi:10.1038/458155a
http://links.ealert.nature.com/ctt?kn=30&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Neuroscience: Up, down, flying around pp156-157
The Johnston's hearing organ of the fruitfly has newly discovered
sensitivities to gravity and wind. As in our inner ear, different
sensory signals from this organ travel in parallel to separate zones
in the brain.
Ruth Anne Eatock
doi:10.1038/458156a
http://links.ealert.nature.com/ctt?kn=270&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Quantum optoelectronics: Swift switch of the strong pp157-158
How fast can light and matter be made to interact? 'Almost instantaneously'
is the answer provided in the latest study of semiconductor structures
embedded in an optical microcavity.
Claire Gmachl
doi:10.1038/458157a
http://links.ealert.nature.com/ctt?kn=81&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Condensed-matter physics: Pressure for change in metals pp158-159
When is a metal not a metal? When it is under high pressure, if it's
lithium or sodium. The strange behaviour of dense forms of these
elements exposes difficulties with commonly used models of electronic
structure.
N. W. Ashcroft
doi:10.1038/458158a
http://links.ealert.nature.com/ctt?kn=56&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Cell biology: Detached membrane bending pp159-160
Cells use various protein complexes to remodel membrane-bound organelles.
In vitro reconstitution of the activity of one such complex, ESCRT-III,
shows that it promotes membrane bending in an unconventional way.
Helene Barelli and Bruno Antonny
doi:10.1038/458159a
http://links.ealert.nature.com/ctt?kn=221&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
50 & 100 years ago p159
doi:10.1038/458159b
http://links.ealert.nature.com/ctt?kn=295&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Obituary: Xiangzhong (Jerry) Yang (1959-2009) p161
Leading light in animal cloning.
Alan Trounson
doi:10.1038/458161a
http://links.ealert.nature.com/ctt?kn=78&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
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NEWS AND VIEWS Q&A
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Evolutionary biology: Speciation pp162-164
On the Origin of Species ... the title of Charles Darwin's great work
of 1859 seemed to promise a solution to this "mystery of mysteries".
Although we now know vastly more about speciation than we did 150
years ago, the one mystery has become many -- and the possible
solutions have multiplied.
Andrew P. Hendry
doi:10.1038/458162a
http://links.ealert.nature.com/ctt?kn=23&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
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ARTICLES
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The neural basis of Drosophila gravity-sensing and hearing pp165-171
One of two papers identifying distinct clusters of neurons in the
Johnston's organ, a structure from the fruitfly antenna previously
associated with courtship song detection, that specifically respond
either to continuous deflections of the antenna, as provoked by wind
or gravity, or to vibrating stimuli such as sounds. The segregation
of different mechanosensation modalities through separate neuronal
pathways in one organ is reminiscent of the hearing and vestibular
system division of mammals.
Azusa Kamikouchi et al.
doi:10.1038/nature07810
Abstract: http://links.ealert.nature.com/ctt?kn=304&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Membrane scission by the ESCRT-III complex pp172-177
This study has reconstituted membrane invagination and scission in
vitro using purified endosomal sorting complex required for transport
(ESCRT)-III subunits and giant unilamellar vesicles. Snf7 is important
for membrane scission whereas the ATPase Vps4 is required for recycling
ESCRT-III proteins for further rounds of membrane budding.
Thomas Wollert, Christian Wunder, Jennifer Lippincott-Schwartz and
James H. Hurley
doi:10.1038/nature07836
Abstract: http://links.ealert.nature.com/ctt?kn=144&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=258&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
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LETTERS
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Sub-cycle switch-on of ultrastrong light-matter interaction pp178-181
This study has developed a time-resolved measurement set-up in which
strong light-matter coupling can be switched on in a semiconductor
quantum-well structure as fast as within one cycle of light. This
makes it possible to monitor directly how a population of bare photons
is converted to polaritons, mixed light-matter modes.
G. Gunter et al.
doi:10.1038/nature07838
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=284&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Transparent dense sodium pp182-185
This paper shows that under about 5-fold compression, sodium transforms
into an optically transparent phase. Thus, about ten years after the
basic effect was first predicted it is now shown that high pressure can
turn an archetypal simple metal such as sodium into a dense insulating
material with a rather complex structure and lacking a metallic sheen.
Yanming Ma et al.
doi:10.1038/nature07786
Abstract: http://links.ealert.nature.com/ctt?kn=132&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Direct observation of a pressure-induced metal-to-semiconductor
transition in lithium pp186-189
This study has succeeded in measuring the electrical transport
properties of lithium as a function of pressure. The data clearly
and unambiguously show that at a pressure near 80 GPa, this element
transforms from a metal to a semiconductor.
Takahiro Matsuoka and Katsuya Shimizu
doi:10.1038/nature07827
Abstract: http://links.ealert.nature.com/ctt?kn=99&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Battery materials for ultrafast charging and discharging pp190-193
This paper demonstrates a lithium-ion battery that discharges extremely
fast and maintains a power density similar to a supercapacitor, two
orders of magnitude higher than a normal lithium-ion battery.
Byoungwoo Kang and Gerbrand Ceder
doi:10.1038/nature07853
Abstract: http://links.ealert.nature.com/ctt?kn=105&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=250&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Uplift of the Longmen Shan and Tibetan plateau, and the 2008 Wenchuan
(M = 7.9) earthquake pp194-197
This paper presents balanced geologic cross-sections showing that crustal
shortening, structural relief and topography are strongly correlated in
the Longmen Shan mountain range front, suggesting that crustal shortening
is a primary driver for uplift and topography of the Longmen Shan on the
flanks of the Tibetan plateau. The authors conclude that the 2008
Wenchuan earthquake is an active manifestation of this shortening process.
Judith Hubbard and John H. Shaw
doi:10.1038/nature07837
Abstract: http://links.ealert.nature.com/ctt?kn=232&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Age of Zhoukoudian Homo erectus determined with 26Al/10Be burial
dating pp198-200
This study uses the relatively new aluminium/beryllium method to date
the fossiliferous sediments of Zhoukoudian ('dragon-bone cave', which
yielded specimens of Homo erectus) to around 750,000 years old, some
200,000 years older than usually thought. This implies that hominins
lived at the site during some rather chilly periods, causing us to
revise our ideas about the migration of early hominins northwards only
in clement, interglacial times.
Guanjun Shen, Xing Gao, Bin Gao and Darryl E. Granger
doi:10.1038/nature07741
Abstract: http://links.ealert.nature.com/ctt?kn=247&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=148&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Distinct sensory representations of wind and near-field sound in the
Drosophila brain pp201-205
One of two papers identifying distinct clusters of neurons in the
Johnston's organ, a structure from the fruitfly antenna previously
associated with courtship song detection, that specifically respond
either to continuous deflections of the antenna, as provoked by
wind or gravity, or to vibrating stimuli such as sounds. The
segregation of different mechanosensation modalities through
separate neuronal pathways in one organ is reminiscent of the
hearing and vestibular system division of mammals.
Suzuko Yorozu et al.
doi:10.1038/nature07843
Abstract: http://links.ealert.nature.com/ctt?kn=217&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Enhancing SIV-specific immunity in vivo by PD-1 blockade pp206-210
This study shows that blockade of PD-1 in SIV-infected macaques
transiently increases the frequency, activation and functionality
markers of virus-specific CD8 T cells without adverse side effects.
Vijayakumar Velu et al.
doi:10.1038/nature07662
Abstract: http://links.ealert.nature.com/ctt?kn=234&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=244&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Complete but curtailed T-cell response to very low-affinity antigen
pp211-214
This paper reports the observation that T-cell expansion after initial
activation occurs irrespective of TCR affinity. Low-affinity cells
generate functional effector and memory responses; however, their
expansion ceases earlier, resulting in an overall decreased total
number of low-affinity cells compared to their high-affinity
counterparts.
Dietmar Zehn, Sarah Y. Lee and Michael J. Bevan
doi:10.1038/nature07657
Abstract: http://links.ealert.nature.com/ctt?kn=177&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
A single regulatory gene is sufficient to alter bacterial host range
pp215-218
Here it is shown that the absence or presence of a regulatory gene
determines whether the bioluminescent bacterium Vibrio fischeri
colonizes squid or fishes.
Mark J. Mandel et al.
doi:10.1038/nature07660
Abstract: http://links.ealert.nature.com/ctt?kn=191&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=121&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Cdc14 inhibits transcription by RNA polymerase I during anaphase
pp219-222
The mitotic regulator Cdc14 is shown to mediate transcriptional
silencing of yeast ribosomal genes by preventing the nucleolar
localization of a subunit of RNA polymerase I. If ribosomal
transcription is not shut down, the presence of transcripts
prevents the loading of condensin and blocks chromosome
condensation and segregation.
Andres Clemente-Blanco et al.
doi:10.1038/nature07652
Abstract: http://links.ealert.nature.com/ctt?kn=256&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Chromatin signature reveals over a thousand highly conserved large
non-coding RNAs in mammals pp223-227
This study uses chromatin marks in four mouse cell types to identify
~1,600 large multi-exonic transcriptional units that do not overlap
known protein-coding loci and are highly conserved. Putative
functions are assigned to each of these large intervening non-coding
RNAs, which range from ES pluripotency to cell proliferation.
Mitchell Guttman et al.
doi:10.1038/nature07672
Abstract: http://links.ealert.nature.com/ctt?kn=163&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=211&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation
of eukaryotic transfer RNA pp228-232
This paper shows that the yeast ubiquitin-like protein Urm1p is a
sulphur carrier that modifies tRNA. It identifies a pathway whereby
Urm1p is first adenylated by Uba4p, then is subsequently thiolated by
Uba4p, after which the sulphur moiety is transferred from the thiolated
Urm1p onto U34 of a cytoplasmic adenylated tRNA.
Sebastian Leidel et al.
doi:10.1038/nature07643
Abstract: http://links.ealert.nature.com/ctt?kn=262&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=153&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Coenzyme recognition and gene regulation by a flavin mononucleotide
riboswitch pp233-237
This paper reports the unusual structure of the metabolite-sensing
domain of a flavin mononucleotide (FMN)-specific riboswitch bound to
FMN, riboflavin and an antibiotic. The relatively open ligand-binding
pocket suggests that antimicrobials based on FMN could be devised.
Alexander Serganov, Lili Huang and Dinshaw J. Patel
doi:10.1038/nature07642
Abstract: http://links.ealert.nature.com/ctt?kn=169&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=216&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
----------------------
CORRIGENDUM
----------------------
Global distribution and conservation of rare and threatened
vertebrates p238
Richard Grenyer et al.
doi:10.1038/nature07834
http://links.ealert.nature.com/ctt?kn=35&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
----------------------
ADDENDUM
----------------------
Understanding individual human mobility patterns p238
Marta C. Gonzalez, Cesar A. Hidalgo and Albert-Laszlo Barabasi
doi:10.1038/nature07850
http://links.ealert.nature.com/ctt?kn=6&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
----------------------
CORRIGENDUM
----------------------
A burst of segmental duplications in the genome of the African
great ape ancestor p238
Tomas Marques-Bonet et al.
doi:10.1038/nature07881
http://links.ealert.nature.com/ctt?kn=299&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
----------------------
TECHNOLOGY FEATURES
----------------------
Transcriptomics: The digital generation pp239-242
Next-generation sequencing is pushing gene-expression profiling
further into the digital age. But analog methods still have plenty
of wind left. Nathan Blow looks at the looming battle over the
cell's transcriptome.
Nathan Blow
doi:10.1038/458239a
http://links.ealert.nature.com/ctt?kn=119&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Transcriptomics: Rethinking junk DNA pp240-241
doi:10.1038/458240a
http://links.ealert.nature.com/ctt?kn=239&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Transcriptomics: Table of suppliers pp243-244
doi:10.1038/458243a
http://links.ealert.nature.com/ctt?kn=9&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Prospects
Adjuncts get organized p245
Coalition could become an important voice for contingent and adjunct
faculty members.
Gene Russo
doi:10.1038/nj7235-245a
http://links.ealert.nature.com/ctt?kn=260&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Postdocs and Students
Biotech, the community way p246
Community-college programmes in the United States can be a quick,
cheap route into the pharmaceutical industry. Ted Agres talks to
scientists making the grade.
Ted Agres
doi:10.1038/nj7235-246a
http://links.ealert.nature.com/ctt?kn=57&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
----------------------
FUTURES
----------------------
LADeDeDa p250
Ursula K. Le Guin and Vonda N. McIntyre
doi:10.1038/458250a
http://links.ealert.nature.com/ctt?kn=145&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
11 March 2009
Tumours with PI3K activation are resistant to dietary restriction
Nada Y. Kalaany and David M. Sabatini
doi:10.1038/nature07782
Abstract: http://links.ealert.nature.com/ctt?kn=143&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=292&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Compound vesicle fusion increases quantal size and potentiates
synaptic transmission
Liming He et al.
doi:10.1038/nature07860
Abstract: http://links.ealert.nature.com/ctt?kn=280&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
08 March 2009
Decision-related activity in sensory neurons reflects more than
a neuron's causal effect
Hendrikje Nienborg and Bruce G. Cumming
doi:10.1038/nature07821
Abstract: http://links.ealert.nature.com/ctt?kn=184&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=130&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Initial community evenness favours functionality under selective
stress
Lieven Wittebolle et al.
doi:10.1038/nature07840
Abstract: http://links.ealert.nature.com/ctt?kn=248&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=127&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Embryonic stem cells use ZFP809 to silence retroviral DNAs
Daniel Wolf and Stephen P. Goff
doi:10.1038/nature07844
Abstract: http://links.ealert.nature.com/ctt?kn=186&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=253&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
CBP/p300-mediated acetylation of histone H3 on lysine 56
Chandrima Das, M. Scott Lucia, Kirk C. Hansen and
Jessica K. Tyler
doi:10.1038/nature07861
Abstract: http://links.ealert.nature.com/ctt?kn=223&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=300&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Electromotive force and huge magnetoresistance in magnetic tunnel
junctions
Pham Nam Hai et al.
doi:10.1038/nature07879
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=31911028&r=MjA1NTkxMDA2MAS2&b=2&j=NDY0NDkxMDES1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Genetics and Genomics of Infectious Diseases 2009
March 21-24, 2009
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This conference will engage basic and clinical
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