March 2009 Volume 23 Number 3, pp 433 - 630
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EDITORIAL
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Is angiogenesis essential for the progression of hematological
malignancies or is it an epiphenomenon?
D Ribatti
http://links.ealert.nature.com/ctt?kn=32&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
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SPOTLIGHT REVIEWS
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Pathogenesis of myeloma bone disease
G D Roodman
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Role of autologous and allogeneic stem cell transplantation in myeloma
W I Bensinger
Abstract: http://links.ealert.nature.com/ctt?kn=116&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Treatment of newly diagnosed myeloma
A Palumbo and S V Rajkumar
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=130&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
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REVIEWS
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Treatment of B-cell chronic lymphocytic leukemia with nonchemotherapeutic
agents: experience with single-agent and combination therapy
S Faderl, A Ferrajoli, O Frankfurt and A Pettitt
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Inhibitor of apoptosis proteins in hematological malignancies
S Fulda
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Global target profile of the kinase inhibitor bosutinib in primary
chronic myeloid leukemia cells
L L Remsing Rix, U Rix, J Colinge, O Hantschel, K L Bennett, T Stranzl,
A Muller, C Baumgartner, P Valent, M Augustin, J H Till and
G Superti-Furga
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
CTLA-4 genotype and relapse incidence in patients with acute myeloid
leukemia in first complete remission after induction chemotherapy
A Perez-Garcia, S Brunet, J J Berlanga, M Tormo, J Nomdedeu, R Guardia,
J M Ribera, I Heras, A Llorente, M Hoyos, J Esteve, J Besalduch,
J Bueno, J Sierra and D Gallardo
Abstract: http://links.ealert.nature.com/ctt?kn=122&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
KIR-ligand incompatibility in the graft-versus-host direction improves
outcomes after umbilical cord blood transplantation for acute leukemia
R Willemze, C A Rodrigues, M Labopin, G Sanz, G Michel, G Socie, B Rio,
A Sirvent, M Renaud, L Madero, M Mohty, C Ferra, F Garnier, P Loiseau,
J Garcia, L Lecchi, G Kogler, Y Beguin, C Navarrete, T Devos,
I Ionescu, K Boudjedir, A-L Herr, E Gluckman and V Rocha
Abstract: http://links.ealert.nature.com/ctt?kn=115&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
A dose-dependent tug of war involving the NPM1 leukaemic mutant,
nucleophosmin, and ARF
N Bolli, M F De Marco, M P Martelli, B Bigerna, A Pucciarini, R Rossi,
R Mannucci, N Manes, V Pettirossi, S A Pileri, I Nicoletti and
B Falini
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=134&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+
regulatory T cells in myelodysplastic syndromes (MDS)
I Kotsianidis, I Bouchliou, E Nakou, E Spanoudakis, D Margaritis,
A V Christophoridou, A Anastasiades, C Tsigalou, G Bourikas,
A Karadimitris and C Tsatalas
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
The candidate immunotherapeutical target, the receptor for hyaluronic
acid-mediated motility, is associated with proliferation and
shows prognostic value in B-cell chronic lymphocytic leukemia
K Giannopoulos, D Mertens, A Buhler, T F E Barth, I Idler,
P Moller, A Krober, J Greiner, S Chocholska, A Dmoszynska,
J Rolinski, H Dohner, S Stilgenbauer and M Schmitt
Abstract: http://links.ealert.nature.com/ctt?kn=148&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=137&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Monitoring treatment response of childhood precursor B-cell acute
lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with
multiparameter flow cytometry: predictive impact of early blast
reduction on the remission status after induction
R Ratei, G Basso, M Dworzak, G Gaipa, M Veltroni, P Rhein,
A Biondi, M Schrappe, W-D Ludwig and L Karawajew
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Post-transcriptional regulation of adapter molecules by IL-10
inhibits TLR-mediated activation of antigen-presenting cells
A Knodler, S M Schmidt, A Bringmann, M M Weck, K M Brauer,
T A W Holderried, A-K Heine, F Grunebach and P Brossart
Abstract: http://links.ealert.nature.com/ctt?kn=133&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=114&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Association of drug metabolism gene polymorphisms with toxicities,
graft-versus-host disease and survival after HLA-identical
sibling hematopoietic stem cell transplantation for patients
with leukemia
V Rocha, R Porcher, J F Fernandes, A Filion, H Bittencourt,
W Silva, G Vilela, D L Zanette, C Ferry, J Larghero, A Devergie,
P Ribaud, Y Skvortsova, R Tamouza, E Gluckman, G Socie and M A Zago
Abstract: http://links.ealert.nature.com/ctt?kn=123&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=108&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Thiopurine methyltransferase activity is related to the risk of
relapse of childhood acute lymphoblastic leukemia: results
from the NOPHO ALL-92 study
K Schmiegelow, E Forestier, J Kristinsson, S Soderhall,
K Vettenranta, R Weinshilboum and F Wesenberg
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
The 3D nuclear organization of telomeres marks the transition
from Hodgkin to Reed-Sternberg cells
H Knecht, B Sawan, D Lichtensztejn, B Lemieux,
R J Wellinger and S Mai
Abstract: http://links.ealert.nature.com/ctt?kn=132&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=146&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Recurrent translocations involving the IRF4 oncogene locus in
peripheral T-cell lymphomas
A L Feldman, M Law, E D Remstein, W R Macon, L A Erickson,
K L Grogg, P J Kurtin and A Dogan
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=125&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
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LETTERS TO THE EDITOR
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Expression profiling of persistent polyclonal B-cell lymphocytosis
suggests constitutive expression of the AP-1 transcription
complex and downregulation of Fas-apoptotic and TGF[beta]
signalling pathways
C H Lawrie, R Shilling, X Troussard, H Cattan, H Mossafa,
F Pezzella, J Boultwood, J S Wainscoat and C S R Hatton
http://links.ealert.nature.com/ctt?kn=93&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Alterations of NFIA in chronic malignant myeloid diseases
F Bernard, V Gelsi-Boyer, A Murati, S Giraudier, V Trouplin,
J Adelaide, J Rey, S Olschwang, W Vainchenker, M Chaffanet,
N Vey, M J Mozziconacci and D Birnbaum
http://links.ealert.nature.com/ctt?kn=58&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Clioquinol inhibits the proteasome and displays preclinical
activity in leukemia and myeloma
X Mao, X Li, R Sprangers, X Wang, A Venugopal, T Wood,
Y Zhang, D A Kuntz, E Coe, S Trudel, D Rose, R A Batey,
L E Kay and A D Schimmer
http://links.ealert.nature.com/ctt?kn=154&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Dasatinib is a potent inhibitor of tumour-associated macrophages,
osteoclasts and the FMS receptor
N Brownlow, C Mol, C Hayford, S Ghaem-Maghami and N J Dibb
http://links.ealert.nature.com/ctt?kn=152&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Noxa upregulation is associated with apoptosis of chronic
lymphocytic leukemia cells induced by hyperforin but
not flavopiridol
M Zaher, I Akrout, M Mirshahi, J-P Kolb and C Billard
http://links.ealert.nature.com/ctt?kn=76&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Polymorphisms in DNA repair and one-carbon metabolism genes
and overall survival in diffuse large B-cell lymphoma and
follicular lymphoma
S S Wang, M J Maurer, L M Morton, T M Habermann, S Davis,
W Cozen, C F Lynch, R K Severson, N Rothman, S J Chanock,
P Hartge and J R Cerhan
http://links.ealert.nature.com/ctt?kn=24&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Clinical trials underestimate the age of chronic myeloid
leukemia (CML) patients. Incidence and median age of
Ph/BCR-ABL-positive CML and other chronic myeloproliferative
disorders in a representative area in Germany
M Rohrbacher, U Berger, A Hochhaus, G Metzgeroth, K Adam,
T Lahaye, S Saussele, M C Muller, J Hasford, H Heimpel
and R Hehlmann
http://links.ealert.nature.com/ctt?kn=13&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Lenalidomide alone or in combination with dexamethasone is
highly effective in patients with relapsed multiple myeloma
following allogeneic stem cell transplantation and increases
the frequency of CD4+Foxp3+ T cells
M C Minnema, M S van der Veer, T Aarts, M Emmelot, T Mutis
and H M Lokhorst
http://links.ealert.nature.com/ctt?kn=102&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Non-myeloablative transplantation with CD8-depleted or
unmanipulated peripheral blood stem cells: a phase II
randomized trial
E Willems, F Baron, E Baudoux, N Wanten, L Seidel,
J-F Vanbellinghen, C Herens, A Gothot, P Frere, C Bonnet,
K Hafraoui, G Vanstraelen, G Fillet and Y Beguin
http://links.ealert.nature.com/ctt?kn=71&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
UPD1p indicates the presence of MPL W515L mutation in
RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation
H Szpurka, L P Gondek, S R Mohan, E D Hsi, K S Theil and
J P Maciejewski
http://links.ealert.nature.com/ctt?kn=50&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
A novel translocation, t(14;19)(q32;p13), involving IGH@
and the cytokine receptor for erythropoietin
L J Russell, D G De Castro, M Griffiths, N Telford,
O Bernard, R Panzer-Grumayer, O Heidenreich, A V Moorman
and C J Harrison
http://links.ealert.nature.com/ctt?kn=60&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Stimulation of B-cell lymphoproliferations with
CpG-oligonucleotide DSP30 plus IL-2 is more effective
than with TPA to detect clonal abnormalities
S Struski, C Gervais, C Helias, R Herbrecht, B Audhuy
and L Mauvieux
http://links.ealert.nature.com/ctt?kn=113&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
PET imaging of T cells derived from umbilical cord blood
H Singh, A M Najjar, S Olivares, R Nishii, U Mukhopadhyay,
M Alauddin, P R Manuri, H Huls, D A Lee, G Dotti,
C Bollard, P J Simmons, E J Shpall, R E Champlin, J G Gelovani
and L J N Cooper
http://links.ealert.nature.com/ctt?kn=149&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Survivin expression in the bone marrow of patients with
severe congenital neutropenia
G Carlsson, S Boxhammer, D Garwicz, J I Henter, J Palmblad,
M Nordenskjold, A Porwit and B Fadeel
http://links.ealert.nature.com/ctt?kn=5&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
17p13/TP53 deletion in B-CLL patients is associated with
microRNA-34a downregulation
M K Dijkstra, K van Lom, D Tielemans, F Elstrodt, A W Langerak,
M B van /`t Veer and M Jongen-Lavrencic
http://links.ealert.nature.com/ctt?kn=135&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
Rapid complete cytogenetic remission after upfront dasatinib
monotherapy in a patient with a NUP214-ABL1-positive T-cell
acute lymphoblastic leukemia
W Deenik, H B Beverloo, S C P A M van der Poel-van de Luytgaarde,
M M Wattel, J W J van Esser, P J M Valk and J J Cornelissen
http://links.ealert.nature.com/ctt?kn=95&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
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CORRIGENDUM
----------------------
KIR-ligand incompatibility in the graft-versus-host direction
improves outcomes after umbilical cord blood transplantation
for acute leukemia
R Willemze, C A Rodrigues, M Labopin, G Sanz, G Michel, G Socie,
B Rio, A Sirvent, M Renaud, L Madero, M Mohty, C Ferra, F Garnier,
P Loiseau, J Garcia, L Lecchi, G Kogler, Y Beguin, C Navarrete,
T Devos, I Ionescu, K Boudjedir, A-L Herr, E Gluckman and V Rocha
http://links.ealert.nature.com/ctt?kn=28&m=31890138&r=MTc2MzIyNTA1NQS2&b=2&j=NDY0MzAzNzcS1&mt=1&rt=0
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