Gut Bacteria and GVHD

View this message online Hello manoj kumar valluru, Last week we came across a paper demonstrating in a pretty convincing manner that radiation seems to induce a lymphopenia-independent augmentation of T cell responses through induction of bacterial translocation from the gut.  A very interesting immunology piece.  Click here for the Video and discussion. Three patents of interest were issued last week.  #7,498,171 covers the use of various thalidomide analogues for skewing hematopoietic stem cell differentiation away from the erythroid lineage and more towards the myelocytic lineage.  This patent could be very useful since these compounds are also known to be immune modulatory.  #7,498,342 covers novel compositions of matter capable of manipulating activity of c-kit.  These could be useful not only in targeting tumor stem cells, but also manipulation of other types of tissue specific stem cells that express c-kit.  Finally, #7,498,168 will be the favorite of "regenerative dentists" covering methods of generating tooth progenitor cells from neural or embryonic stem cells.   Modulation of stem and progenitor cell differentiation, assays, and uses thereof     Patent Number: 7,498,171 Assignee | Inventor One of the areas in which regenerative medicine is heading is the use of "drugs" to modulate the stem cell compartment.  For example, we have previously seen companies like Stem Cell Therapeutics performing clinical trials with EPO and hCG for stroke.  Drugs already in the clinic such...[Read More] Ask a question OR leave your comments.     Radiation Induced Bacterial Translocation Causes GVHD Tuesday March 10th, 2009 @ 02:44:56 EST [Watch the Video] When cord blood stem cells are used in the context of treatment of leukemia, graft versus host has been reported to occur in some patients.  Although incidence is reduced in patients who receive hematopoietic stem cells in the form of cord blood as compared to bone marrow, GVHD is still a concern.  An important...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News   Media Partnerships (NEW)   NEWS - WHAT'S GETTING ATTENTION?     Bone Marrow Stem Cells for Renal Failure | 2 Comment(s)     RECENTLY ADDED PATENTS     Tooth progenitor cell and method for its production (7,498,168) Assignee | Inventor | Ask a question OR leave your comments     Modulation of stem and progenitor cell differentiation, assays, and uses thereof (7,498,171) Assignee | Inventor | Ask a question OR leave your comments     Compounds modulating c-kit activity (7,498,342) Assignee | Inventor | Ask a question OR leave your comments     Mammalian megakaryocyte progenitor cell (7,494,807) Assignee | Inventor | Ask a question OR leave your comments     Methods and compositions for correction of cardiac conduction disturbances (7,494,644) Assignee | Inventor | Ask a question OR leave your comments     Methods for altering cell fate to generate T-cells specific for an antigen of interest (7,491,534) Assignee | Inventor | 1 Comment     Uses of fibroblasts or supernatants from fibroblasts for the suppression of immune responses in transplantation (7,491,388) Assignee | Inventor | Ask a question OR leave your comments     Use of glycosylceramides as adjuvants for vaccines against infections and cancer (7,488,491) Assignee | Inventor | Ask a question OR leave your comments     Wound and cutaneous injury healing with a nucleic acid encoding perlecan (7,488,719) Assignee | Inventor | Ask a question OR leave your comments     PSCA: prostate stem cell antigen and uses thereof in pancreatic cancer (7,485,296) Assignee | Inventor | Ask a question OR leave your comments     View all 1395 Stem Cell Patents on StemCellPatents.com     LATEST NEWS     Radiation Induced Bacterial Translocation Causes GVHD 11 hours ago     Stem Cell Therapy for Multiple Sclerosis March 2nd     TNF alpha inhibits SDF-1 increases osteoclast precursors March 2nd     EPO Protects from Mouse Multiple Sclerosis February 26th : 1 Comment     Stem Cell Inhibition of Multiple Sclerosis by IDO Induction February 22nd     Read more news on StemCellPatents.com     LATEST JOBS POSTS     View the StemCellPatents.com Job Board   Thanks again for your help in supporting StemCellPatents.com. Media Partnerships (NEW) (BETA) ------------------------------------------------------------ To unsubscribe, click here. Delivered: Tuesday March 10th, 2009 @ 14:40:04 EST