Signaling Gateway - 6 February 2009
http://links.ealert.nature.com/ctt?kn=35&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
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In Signaling Update this week:
------------------------
Featured Article
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CELL MIGRATION: CALCIUM FLICKERS AT THE FRONT
High-calcium microdomains (calcium flickers) that play a crucial role
in the guidance of directional movement occur at the front of
migrating fibroblasts.
Original research paper: Nature advance online publication,
31 December 2008 (DOI 10.1038/nature07577)
http://links.ealert.nature.com/ctt?kn=29&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
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Molecule Pages
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S100A6
http://links.ealert.nature.com/ctt?kn=4&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
S100A6, also known as calcyclin, is a member of the S100 family of
Ca2+-binding proteins. Ca2+-binding induces a conformational change
in S100A6, which permits its interaction with several target
proteins. The precise biological function of S100A6 has not yet been
described; however, it has been suggested that S100A6 might have a
role in cell proliferation and ubiquitination, and in the regulation
of heat shock proteins and cytoskeletal dynamics.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=27&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
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Selected Updates
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MOUSE MODELS: ROLE REVERSAL
A mouse model of lung cancer that is induced by the EML4–ALK fusion
protein can be treated with an ALK inhibitor.
Original research paper: Proc. Natl. Acad. Sci. USA 105,
19893-19897 (2008)
http://links.ealert.nature.com/ctt?kn=36&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
THERAPEUTICS: AKT: A DOUBLE-EDGED SWORD
Tumor cells activate Akt in order to proliferate and escape
apoptosis; however, in doing so they render themselves vulnerable
to oxidative stress-induced senescence and apoptosis.
Original research paper: Cancer Cell 14, 458-470 (2008)
http://links.ealert.nature.com/ctt?kn=26&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
CARDIOVASCULAR DISEASE: SILENCING MICRORNA RESCUES THE HEART
Antagonism of microRNA-21 has been shown to improve heart failure
prognosis in mice by derepressing sprouty homolog 1 (SPRY1)
expression and inhibiting ERK activation.
Original research paper: Nature 456, 980-984 (2008)
http://links.ealert.nature.com/ctt?kn=30&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=14&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
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Research Library
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SIGNALLING THROUGH RHEB-1 MEDIATES INTERMITTENT FASTING-INDUCED
LONGEVITY IN C. ELEGANS
Nature 457, 726-730 (2009)
http://links.ealert.nature.com/ctt?kn=32&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
INVOLVEMENT OF LINEAR POLYUBIQUITYLATION OF NEMO IN NF-[kappa]B
ACTIVATION
Nature Cell Biology 11, 123-132 (2009)
http://links.ealert.nature.com/ctt?kn=21&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
DESIGN OF ISOFORM-SELECTIVE PHOSPHOLIPASE D INHIBITORS THAT MODULATE
CANCER CELL INVASIVENESS
Nature Chemical Biology 5, 108-117 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
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Signaling News
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NATUREEVENTS DIRECTORY 2009
http://links.ealert.nature.com/ctt?kn=37&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
The 2009 Natureevents directory is now available online or as a PDF
download. The directory contains a comprehensive list of scientific
events and conferences held around the world in 2009.
Online directory:
http://links.ealert.nature.com/ctt?kn=20&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
PDF download:
http://links.ealert.nature.com/ctt?kn=2&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
More news
http://links.ealert.nature.com/ctt?kn=25&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
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Gateway Updates
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THE CELL MIGRATION GATEWAY - FEBRUARY UPDATE
http://links.ealert.nature.com/ctt?kn=24&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured article is Migration and development: Lipids at
heart http://links.ealert.nature.com/ctt?kn=19&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://links.ealert.nature.com/ctt?kn=31&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
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Job of the Week
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Postdoctoral position
Employer: Ulm University Hospital
Location: Ulm, Germany
http://links.ealert.nature.com/ctt?kn=9&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
A post-doc position is available in the field of apoptosis and cancer
stem cells at Ulm University. The project will focus on apoptotic
pathways in cancer stem cells that are derived from malignant brain
tumors, with the goal of identifying key molecules for the
development of new therapeutics and novel prognostic biomarkers.
Applicants with a strong background in molecular biology,
cancer biology and stem cell biology are encouraged to apply.
More Jobs:
http://links.ealert.nature.com/ctt?kn=10&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=22&m=31296632&r=MTc2ODc4NDI0MAS2&b=2&j=NDU2NTczODAS1&mt=1&rt=0
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