Signaling Gateway - 27 February 2009
http://links.ealert.nature.com/ctt?kn=33&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CDK5 AND ATM: A ONE-TWO PUNCH IN NEURONAL STRESS SIGNALING
Genotoxic stress stimulates Cdk5-mediated phosphorylation and
activation of ATM to regulate neuronal cell death
Original research paper: Nature Cell Biology 11, 211-218 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
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Molecule Pages
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Dbf4
http://links.ealert.nature.com/ctt?kn=3&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
Dumbbell former 4 (Dbf 4) is an enzyme activator that mimicks cyclins
in function. Its prevailing role is to regulate the activity of Cdc7
serine/threonine kinase via Cdc7-Dbf4 heterodimer formation, thereby
activating Cdc7 kinase during cell-cycle progression. Dbf4 is also
essential for chromosomal replication and, consequently, for cell
viability, both in yeast and in mouse embryonic stem cells.
In addition, it has been postulated that Dbf4 has a role in both DNA
replication and damage checkpoints.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=24&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
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Selected Updates
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T-CELL DEVELOPMENT: CD40-CD40L CROSSTALK IN TH17-CELL DIFFERENTIATION
CD40-CD40L crosstalk is required for the differentiation of TH17
cells in vitro and in vivo in response to antigenic and pathogenic
stimuli.
Original research paper: Proc. Natl Acad. Sci. USA 106, 876-881 (2009)
http://links.ealert.nature.com/ctt?kn=34&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
INFLAMMATION: ORCHESTRATING METASTASIS
The extracellular matrix peptide versican V1 is secreted from
metastatic Lewis lung carcinoma (LLC) cells and stimulates
TLR2-TNFalpha signaling in bone-marrow-derived cells to enhance LLC
metastasis.
Original research paper: Nature 457, 102–106 (2009)
http://links.ealert.nature.com/ctt?kn=23&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
KINASE INHIBITORS: THINKING OUTSIDE THE BOX
In cancer cells, irreversible induction of the pro-apoptotic protein
BIM and subsequent cell death can be triggered to the same extent by
either transient or prolonged tyrosine kinase inhibitor treatment.
Original research paper: Cancer Cell 14, 485–493 (2008)
http://links.ealert.nature.com/ctt?kn=29&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=15&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
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Research Library
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A MECHANOSENSITIVE TRANSCRIPTIONAL MECHANISM THAT CONTROLS
ANGIOGENESIS
Nature 457, 1103-1108 (2009)
http://links.ealert.nature.com/ctt?kn=30&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
CHD8 SUPPRESSES p53-MEDIATED APOPTOSIS THROUGH HISTONE H1 RECRUITMENT
DURING EARLY EMBRYOGENESIS
Nature Cell Biology 11, 172-182 (2009)
http://links.ealert.nature.com/ctt?kn=19&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
THE TUMOR SUPPRESSOR PML REGULATES CELL FATE IN THE DEVELOPING
NEOCORTEX
Nature Neuroscience 12, 132-140 (2009)
http://links.ealert.nature.com/ctt?kn=10&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
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Signaling News
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'HARMLESS' PRION PROTEIN LINKED TO ALZHEIMER'S DISEASE
http://links.ealert.nature.com/ctt?kn=27&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
The non-infectious form of the prion protein (PrPc) interacts with
the amyloid-beta peptides that are hallmarks of Alzheimer's disease.
New research has found that blocking this interaction in mice halted
some neurological defects caused by the accumulation of amyloid-beta
peptide, suggesting that targeting PrPc might be an effective therapy
for Alzheimer's disease patients.
More news
http://links.ealert.nature.com/ctt?kn=22&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - FEBRUARY UPDATE
http://links.ealert.nature.com/ctt?kn=18&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Protein folding: Sweet signals for degradation
http://links.ealert.nature.com/ctt?kn=17&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
N-glycan biosynthesis: Flipping for precursors
http://links.ealert.nature.com/ctt?kn=31&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://links.ealert.nature.com/ctt?kn=28&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
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Job of the Week
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Postdoctoral Positions in Cancer Biology
Employer: Karolinska Institutet
Location: Stockholm, Sweden
http://links.ealert.nature.com/ctt?kn=8&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
Postdoctoral positions are available in the laboratory of Rune
Toftgard in the Department of Biosciences and Nutrition at the
Karolinska Institutet. The successful applicants will use mouse
models and in vitro techniques to study the molecular mechanisms of
Hedgehog signaling in cancer development and stem cell proliferation
and maintenance.
More Jobs:
http://links.ealert.nature.com/ctt?kn=9&m=31759529&r=MTc2ODc4NDI0MAS2&b=2&j=NDYxNjc3NzAS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
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