Signaling Gateway - 13 February 2009
http://links.ealert.nature.com/ctt?kn=38&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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ADAPTIVE IMMUNITY: REL-ATIVE CONTRIBUTIONS OF RAF AND SYK
Dectin-1 signals through Syk and Raf-1 to regulate activation of the
noncanonical NF-kappaB pathway and TH cell differentiation in response to
fungal infection.
Original research paper: Nature Immunology 10, 203-213 (2009)
http://links.ealert.nature.com/ctt?kn=32&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
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Molecule Pages
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Nitric oxide synthase 3
http://links.ealert.nature.com/ctt?kn=4&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
The endothelial isoform of nitric oxide synthase (eNOS) is a
calcium/calmodulin-dependent enzyme that was originally identified
as the protein responsible for the synthesis of NO (nitric oxide)
in vascular endothelial cells. NO synthesized by eNOS has been shown
to promote the endothelium-dependent relaxation of vascular smooth
muscle cells, inhibit platelet aggregation, regulate exocytosis by
S-nitrosylation of N-ethylmaleimide-sensitive factor (NSF), and
regulate apoptosis by modifying caspases.
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=30&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
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Selected Updates
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TECHNOLOGY: INDIRECT ACTIVATION
A technique that couples tyrosine kinase-specific antibodies to
polystyrene beads represents a high-throughput, cost-effective
approach that can systematically identify activated tyrosine kinases
in cancer cells irrespectively of the mechanism of kinase activation.
Original research paper: Nature Biotechnology 27, 77-83 (2009)
http://links.ealert.nature.com/ctt?kn=39&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
TUMORIGENESIS: MYCN AND AURORA A: A STABLE RELATIONSHIP
The aurora A kinase blocks PI3K-dependent degradation of N-Myc in
neuroblastomas that contain amplification of the MYCN gene.
Original research paper: Cancer Cell 15, 67–78 (2009)
http://links.ealert.nature.com/ctt?kn=29&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
LUNG DISEASE: ANTIOXIDANT PROTECTION AGAINST CIGARETTE SMOKE
Pharmacological activation of NRF2, a redox-sensitive transcription
factor that controls multiple antioxidative genes, helps protect mice
from the damaging effects of cigarette smoke.
Original research paper: Proc. Natl Acad. Sci. USA 106,
250–255 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=21&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
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Research Library
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A STRESS-RESPONSIVE RNA SWITCH REGULATES VEGFA EXPRESSION
Nature 457, 915-919 (2009)
http://links.ealert.nature.com/ctt?kn=35&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
POLYUBIQUITIN SUBSTRATES ALLOSTERICALLY ACTIVATE THEIR OWN
DEGRADATION BY THE 26S PROTEASOME
Nature Structural & Molecular Biology 16, 219-225 (2009)
http://links.ealert.nature.com/ctt?kn=24&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
SMALL MOLECULE-MEDIATED DISRUPTION OF WNT-DEPENDENT SIGNALING IN
TISSUE REGENERATION AND CANCER
Nature Chemical Biology 5, 100-107 (2009)
http://links.ealert.nature.com/ctt?kn=36&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
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Signaling News
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NATURE: EVERYBODY'S DARWIN
http://links.ealert.nature.com/ctt?kn=20&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
The second of Nature's three Darwin 200 special issues celebrates
'everybody's Darwin' - the great man's legacy in the context of the
human condition. This issue features an editorial on how slavery
affected Darwin's thinking about the natural world, as well as two
opposing commentaries on whether scientists should search for links
between race and IQ.
http://links.ealert.nature.com/ctt?kn=20&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
More news
http://links.ealert.nature.com/ctt?kn=28&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
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Gateway Updates
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NATURE PRECEDINGS: PRE-PUBLICATION RESEARCH AND PRELIMINARY FINDINGS
http://links.ealert.nature.com/ctt?kn=40&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
Nature Precedings is a place for researchers to share pre-publication
research and other scientific documents.
Recent pre-print manuscripts posted to Nature Precedings include:
Effect of Stimulators upon Human Hepatic Adenylate Cyclase
Activity: A Tool of Nitroimidazole Cytotoxicity Assessment
http://links.ealert.nature.com/ctt?kn=14&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
Activation of an Estrogen-Estrogen Receptor Signaling by BIG3
through its Inhibitory Effect on Nuclear Transport of PHB2/REA in
Breast Cancer
http://links.ealert.nature.com/ctt?kn=42&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
Genome-wide association study identifies FUT8 and ESR2 as
co-regulators of a bi-antennary N-linked glycan A2
(GlcNAc2Man3GlcNAc2) in human plasma proteins.
http://links.ealert.nature.com/ctt?kn=18&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
Search for documents or browse recently posted manuscripts to stay
informed of the latest research in your field.
http://links.ealert.nature.com/ctt?kn=13&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
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Job of the Week
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Tenure-track Positions in Gene Expression and Metabolic Biochemistry
Employer: Memorial University of Newfoundland
Location: St. John's, Newfoundland, Canada
http://links.ealert.nature.com/ctt?kn=9&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
The Department of Biochemistry at Memorial University invites
applications for two tenure-track positions at the Assistant
Professor level. The successful applicants will develop a research
program focused on gene regulation or metabolomics and are expected
to show a commitment to effective teaching at the undergraduate and
graduate levels.
More Jobs:
http://links.ealert.nature.com/ctt?kn=12&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=25&m=31418829&r=MTc2ODc4NDI0MAS2&b=2&j=NDU3NTE3ODES1&mt=1&rt=0
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