March 2009 Volume 7 Number 3
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Genetics and Genomics of Infectious Diseases 2009
March 21-24, 2009
Ritz Carlton Millenia, Singapore
This conference will engage basic and clinical scientists, including
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This month's FEATURED article:
Under pressure: investigating the biology of plant infection by Magnaporthe oryzae
Richard A. Wilson and Nicholas J. Talbot
p185 | doi:10.1038/nrmicro2032
http://links.ealert.nature.com/ctt?kn=62&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
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In this issue
p173 | doi:10.1038/nrmicro2104
http://links.ealert.nature.com/ctt?kn=43&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Editorial: Microbiology: past, present and future
p174 | doi:10.1038/nrmicro2106
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Bacterial secretion: Turning the cogs in type VI secretion
p175 | doi:10.1038/nrmicro2093
http://links.ealert.nature.com/ctt?kn=33&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
IN BRIEF
Symbiosis | Fungal physiology | Horizontal gene transfer
p176 | doi:10.1038/nrmicro2099
http://links.ealert.nature.com/ctt?kn=76&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Structural biology: Toxoplasma's ROP-a-dope strategy
p176 | doi:10.1038/nrmicro2100
http://links.ealert.nature.com/ctt?kn=3&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Innate immunity: Unfolding antiviral defences
p177 | doi:10.1038/nrmicro2098
http://links.ealert.nature.com/ctt?kn=86&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Microbial ecology: Type III secretion systems: jumping into the reservoir
p177 | doi:10.1038/nrmicro2101
http://links.ealert.nature.com/ctt?kn=42&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Host response: Stalemate
p178 | doi:10.1038/nrmicro2094
http://links.ealert.nature.com/ctt?kn=57&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Antigen presentation: Parasite hijacking
p178 | doi:10.1038/nrmicro2103
http://links.ealert.nature.com/ctt?kn=77&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Virology: E7 takes the foot off the brake
p179 | doi:10.1038/nrmicro2102
http://links.ealert.nature.com/ctt?kn=11&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
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NEWS AND ANALYSIS
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GENOME WATCH
Plasmodium genomics: latest milestone
Arnab Pain and Christiane Hertz-Fowler
p180 | doi:10.1038/nrmicro2096
http://links.ealert.nature.com/ctt?kn=63&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
DISEASE WATCH
In the News
p182 | doi:10.1038/nrmicro2105
http://links.ealert.nature.com/ctt?kn=44&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
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REVIEWS
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Under pressure: investigating the biology of plant infection by Magnaporthe oryzae
Richard A. Wilson and Nicholas J. Talbot
p185 | doi:10.1038/nrmicro2032
Almost one-quarter of the calories consumed by the global human population
is derived from rice. Epidemics of rice blast disease, which are caused by
the filamentous fungus Magnaporthe oryzae, therefore represent a major threat
to global food stocks. This Review discusses how functional genomic approaches
are shedding light on the mechanisms used by M. oryzae during plant infection.
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Systems Biology: Functional analysis of natural microbial consortia using
community proteomics
Nathan C. VerBerkmoes, Vincent J. Denef, Robert L. Hettich and
Jillian F. Banfield
p196 | doi:10.1038/nrmicro2080
It is not easy to study how microbial communities function. Microbial
community proteogenomics, which integrates genomics, ecology, biological
mass spectrometry and informatics, could help us to unravel the physiology,
ecology and evolution of microbial populations and communities.
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Membrane protein architects: the role of the BAM complex in outer
membrane protein assembly
Timothy J. Knowles, Anthony Scott-Tucker, Michael Overduin and
Ian R. Henderson
p206 | doi:10.1038/nrmicro2069
Considerable advances have been made in the field of outer membrane
protein biogenesis during the past year. The [beta]-barrel assembly
machinery (BAM) mediates efficient insertion of folded [beta]-barrels
into the outer membrane of Gram-negative bacteria. The role of the
BAM in the folding of membrane proteins is discussed in this Review.
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
DSB proteins and bacterial pathogenicity
Begona Heras, Stephen R. Shouldice, Makrina Totsika, Martin J. Scanlon,
Mark A. Schembri and Jennifer L. Martin
p215 | doi:10.1038/nrmicro2087
Formation of disulphide bonds between cysteine residues is key for the
stability and activity of a range of exported bacterial proteins.
Disulphide bond formation occurs during the oxidative protein folding
processes that are catalysed by the DSB protein family. In this article,
Heras and colleagues review oxidative folding pathways in Escherichia coli
K12 and other bacteria and their impact on pathogenesis.
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=55&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
The spike protein of SARS-CoV - a target for vaccine and therapeutic development
Lanying Du, Yuxian He, Yusen Zhou, Shuwen Liu, Bo-Jian Zheng and Shibo Jiang
p226 | doi:10.1038/nrmicro2090
The outbreaks of severe acute respiratory syndrome (SARS) between 2002
and 2004 killed hundreds of people. Vaccines against the SARS coronavirus
(SARS-CoV) could protect the population during future outbreaks. In this Review,
Shibo Jiang and colleagues describe such vaccines, as well as other therapeutics,
based on the SARS-CoV spike protein.
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=98&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
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PERSPECTIVES
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OPINION
A new perspective on radiation resistance based on Deinococcus radiodurans
Michael J. Daly
p237 | doi:10.1038/nrmicro2073
How some organisms can withstand extreme levels of radiation has been a
long-standing question. In this Opinion article, Michael Daly makes the
case that high levels of intracellular manganese complexes allow the cell
to repair itself by preventing protein oxidation caused by iron-dependent
reactive oxygen species during irradiation.
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
OPINION
Antimicrobial peptides: linking partition, activity and high membrane-bound
concentrations
Manuel N. Melo, Rafael Ferre and Miguel A. R. B. Castanho
p245 | doi:10.1038/nrmicro2095
Our understanding of the relationship between molecular properties of
antimicrobial peptides and macroscopic effects on bacterial membranes
remains limited. In this Opinion, Castanho and colleagues propose that
even under physiological conditions, millimolar local peptide concentrations
can be reached at the membrane, which enables the minimum inhibitory
concentration to be related to peptide concentration thresholds for
bacterial membrane disruption.
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
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CORRESPONDENCE
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Correspondence: Is Brucella an enteric pathogen?
Jean Pierre Gorvel, Edgardo Moreno and Ignacio Moriyon
p250 | doi:10.1038/nrmicro2012-c1
http://links.ealert.nature.com/ctt?kn=29&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Correspondence: Is Brucella an enteric pathogen? Reply from Tsolis,
Solnick and Baumler
Renee M. Tsolis, Jay V. Solnick and Andreas J. Baumler
p250 | doi:10.1038/nrmicro2012-c2
http://links.ealert.nature.com/ctt?kn=14&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Correspondence: Does the evolution of viral polymerases reflect the
origin and evolution of viruses?
Mart Krupovic and Dennis H. Bamford
p250 | doi:10.1038/nrmicro2030-c1
http://links.ealert.nature.com/ctt?kn=19&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
Correspondence: The complexity of the virus world
Eugene V. Koonin, Yuri I. Wolf, Keizo Nagasaki and Valerian V. Dolja
p250 | doi:10.1038/nrmicro2030-c2
http://links.ealert.nature.com/ctt?kn=30&m=31473771&r=MTc2NzM1ODUwNgS2&b=2&j=NDU4NDI1NTIS1&mt=1&rt=0
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