February 12 2009
Visit Nature Reports Stem Cells online.
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OUR TOP STORIES
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Stem cells, systems biology and human feedback
Mathematics can turn experimental data into information, if the personality fits
http://links.ealert.nature.com/ctt?kn=29&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Q&A with Yale's Haifan Lin: peeling back layers of stem cell control
Self-renewing enthusiasm spans from the fly ovary to new RNA-protein guides for gene expression
http://links.ealert.nature.com/ctt?kn=14&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Stem cells ready for prime time
A US regulatory agency gives the go-ahead for first clinical trials of a human embryonic stem-cell treatment
http://links.ealert.nature.com/ctt?kn=1&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
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RESEARCH HIGHLIGHTS AND NEWS STORIES ABOUT RECENT PUBLICATIONS
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How breast cancer resists treatment
Healthy and cancerous stem cells protect their DNA
Diehn, M. et al. Nature advance online publication, doi:10.1038/nature07733 (4 February 2009).
http://links.ealert.nature.com/ctt?kn=8&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Self-renewing blood and leukaemia cells need hedgehog
Attacking an alternative pathway might help defeat disease
Zhao, C. et al. Nature advance online publication, doi:10.1038/nature07737 (25 January 2009).
http://links.ealert.nature.com/ctt?kn=31&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
How different progenitor cells are called from the bone marrow
VEGF prompts cells to get out and help
Pitchford, S. C. et al. Cell Stem Cell 4, 62-72 (2009).
http://links.ealert.nature.com/ctt?kn=18&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Blood stem cells, regulation and visualization
The protein p53 regulates haematopoietic stem cell quiescence; a new labelling technique lets researchers watch cells divide
Liu, Y. et al. Cell Stem Cell 4, 37-48 (2009).
Foudi, A. et al. Nature Biotechnol. 27, 84-90 (2008).
http://links.ealert.nature.com/ctt?kn=12&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
How the four factors reprogram
An analysis of when and where pluripotency factors bind indicate that c-Myc shuts down specialization and the remaining three turn on pluripotency
Sridharan, R. et al. Cell 136, 364-377 (2009).
http://links.ealert.nature.com/ctt?kn=17&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Combinatorial pluripotency
Mouse iPS cells containing subsets of reprogramming genes allow researchers to dissect reprogramming mechanisms
Markoulaki, S. et al. Nature Biotechnol. advance online publication, doi:10.1038/nbt.1520 (18 January 2009).
http://links.ealert.nature.com/ctt?kn=26&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Diet and insulin in a stem cell niche
Hormonal signaling in the fruit fly ovary keeps the niche young
Hsu, H-J. & Drummond-Barbosa, D. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.0809144106 (published online 9 January 2009).
http://links.ealert.nature.com/ctt?kn=4&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Nanotubes guide mesenchymal stem cells toward becoming bone
The surface a cell grows on can control its fate
Seunghan, O. et al. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.0813200106 (published online 26 January 2009).
http://links.ealert.nature.com/ctt?kn=6&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Hybrid embryos fail to live up to stem-cell hopes
Strategy for creating pluripotent cells called into question
Chung, Y. et al. Cloning Stem Cells doi:10.1089/clo.2009.0004 (published online 2 February 2009).
http://links.ealert.nature.com/ctt?kn=32&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
MS stem-cell trial shows promise
Multiple sclerosis treatment seems to reverse symptoms
Burt, R. K. et al. Lancet Neurol. doi:10.1016/S1474-4422(09)70017-1 (published online 29 January 2009).
http://links.ealert.nature.com/ctt?kn=19&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
When is a stem cell specified?
Using time-lapse imaging, researchers study the potency and fate specification of live neural stem cells in culture
Ravin, R. et al. Cell Stem Cell 3, 670-680 (2008).
http://links.ealert.nature.com/ctt?kn=27&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
MicroRNAs: key regulators of stem cells
Epigenetics and the art of self-renewal
Gangaraju, V. K. & Lin, H. Nat. Rev. Mol. Cell Biol. 10, 116-125 (01 February 2009).
http://links.ealert.nature.com/ctt?kn=21&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Cells reprogrammed using only one gene
Taking neural stem cells to pluripotency with Oct4 alone
Kim, J. B. et al. Cell 136, 411-419 (2009).
http://links.ealert.nature.com/ctt?kn=30&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
Characterizing the human embryonic stem cell phosphoproteome
Oct4 and Sox2 have previously unreported phosphorylation sites
Swaney, D. L., Wenger, C. D., Thomson, J. A. & Coon, J.J. (2009). Proc. Natl Acad. Sci. USA 106, 995-1000 (2009).
http://links.ealert.nature.com/ctt?kn=22&m=31396851&r=MTc2NjM3NTc5MQS2&b=2&j=NDU3MzU4MDES1&mt=1&rt=0
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Nature Reports Stem Cells is an interactive forum for stem cell scientists and other stakeholders to communicate about the research, policy, ethics, business and medicine of stem cell science. And it's all free!
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