19 February 2009 Volume 457 Number 7232, pp 935-1046
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EDITORIALS
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Collective responsibilities p935
China should stop discouraging scientists from setting up
learned societies.
doi:10.1038/457935a
http://links.ealert.nature.com/ctt?kn=130&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Identity crisis pp935-936
It is time for all involved to tackle the chronic scandal of
cell-line contamination. Funders first.
doi:10.1038/457935b
http://links.ealert.nature.com/ctt?kn=162&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Overhead hazards p936
How to keep Earth orbits usable.
doi:10.1038/457936a
http://links.ealert.nature.com/ctt?kn=112&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Geomorphology: On the cusp p938
doi:10.1038/457938a
http://links.ealert.nature.com/ctt?kn=274&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Assisted colonization: Flitter further north p938
doi:10.1038/457938b
http://links.ealert.nature.com/ctt?kn=210&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Ecology: Perils of monoculture p938
doi:10.1038/457938c
http://links.ealert.nature.com/ctt?kn=183&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Micromechanics: Bacterial spin doctors p938
doi:10.1038/457938d
http://links.ealert.nature.com/ctt?kn=200&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Evolution: All for self p938
doi:10.1038/457938e
http://links.ealert.nature.com/ctt?kn=275&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Genetics: Rodent resistance pp938-939
doi:10.1038/457938f
http://links.ealert.nature.com/ctt?kn=35&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Zoology: Restless rodents p939
doi:10.1038/457939a
http://links.ealert.nature.com/ctt?kn=158&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Atmospheric science: Ozone in a warming world p939
doi:10.1038/457939b
http://links.ealert.nature.com/ctt?kn=83&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Networks: Know a good dentist? p939
doi:10.1038/457939c
http://links.ealert.nature.com/ctt?kn=209&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Cancer biology: Room to breathe p939
doi:10.1038/457939d
http://links.ealert.nature.com/ctt?kn=114&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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JOURNAL CLUB
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Journal club p939
Nora Noffke
doi:10.1038/457939e
http://links.ealert.nature.com/ctt?kn=146&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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NEWS
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Kaputnik chaos could kill Hubble pp940-941
Worst-ever orbital collision leads to calls for tighter regulation.
Geoff Brumfiel and Roberta Kwok
doi:10.1038/457940a
http://links.ealert.nature.com/ctt?kn=12&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Tumours spark stem-cell review p941
Russian treatment linked to cancerous growths.
Monya Baker
doi:10.1038/457941a
http://links.ealert.nature.com/ctt?kn=66&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Medical research scores big in US stimulus bill pp942-945
Congress votes to give generous boosts to other agencies too.
Eric Hand and Meredith Wadman
doi:10.1038/457942a
http://links.ealert.nature.com/ctt?kn=74&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
John Holdren: adviser on science, fish and wine pp942-943
Confirmation for Obama's candidate.
Jeff Tollefson
doi:10.1038/457942b
http://links.ealert.nature.com/ctt?kn=119&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Rethinking silk's origins p945
Did the Indian subcontinent start spinning without Chinese know-how?
Philip Ball
doi:10.1038/457945a
http://links.ealert.nature.com/ctt?kn=62&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
European disarray on transgenic crops pp946-947
Forthcoming decisions set to bring disagreements to a head.
Alison Abbott
doi:10.1038/457946a
http://links.ealert.nature.com/ctt?kn=86&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
MRI modified for better images p947
Action-at-a-distance offers more spacious machines.
Katharine Sanderson
doi:10.1038/457947a
http://links.ealert.nature.com/ctt?kn=113&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Developing countries boost spread of GM crops p949
doi:10.1038/457949a
http://links.ealert.nature.com/ctt?kn=37&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
University reforms stall as French protests surge p949
doi:10.1038/457949b
http://links.ealert.nature.com/ctt?kn=251&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Budget crisis drives Harvard to redundancies p949
doi:10.1038/457949c
http://links.ealert.nature.com/ctt?kn=80&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Safety precautions delay start-up of hadron collider p949
doi:10.1038/457949d
http://links.ealert.nature.com/ctt?kn=53&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
GSK backs patent pool for neglected diseases p949
doi:10.1038/457949e
http://links.ealert.nature.com/ctt?kn=15&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Soundbites from Chicago p949
doi:10.1038/457949f
http://links.ealert.nature.com/ctt?kn=205&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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NEWS FEATURES
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Conservation: The genome of the American West pp950-952
What does it mean to save a species? For some, preserving the American
bison means keeping its genome pure, finds Emma Marris.
Emma Marris
doi:10.1038/457950a
http://links.ealert.nature.com/ctt?kn=142&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Materials science: China's crystal cache pp953-955
A Chinese laboratory is the only source of a valuable crystal. David
Cyranoski investigates why it won't share its supplies.
David Cyranoski
doi:10.1038/457953a
http://links.ealert.nature.com/ctt?kn=255&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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CORRESPONDENCE
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OPINION
Scientists on Turkey's banknotes should inspire young minds p956
Renad Zhdanov
doi:10.1038/457956a
http://links.ealert.nature.com/ctt?kn=219&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Protecting the Hawaiian akepa population p956
J. Michael Scott, Jon S. Horne and Edward O. Garton
doi:10.1038/457956b
http://links.ealert.nature.com/ctt?kn=230&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Evolutionary gems of the plant world shine just as brightly p956
Alexandru M. F. Tomescu
doi:10.1038/457956c
http://links.ealert.nature.com/ctt?kn=104&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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COMMENTARIES
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OPINION
Recession Watch: How to survive the recession: p957
The global economic downturn brings both predicament and promise.
How will science fare and what role should scientists play on the
long road back to recovery and growth? Ten of the world's leading
thinkers and practitioners provide analysis, experience and advice.
doi:10.1038/457957a
http://links.ealert.nature.com/ctt?kn=242&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Recession Watch: Boost the developing world p958
Jeffrey Sachs
doi:10.1038/457958a
http://links.ealert.nature.com/ctt?kn=31&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Recession Watch: Learn to convince politicians pp958-959
Ian Taylor
doi:10.1038/457958b
http://links.ealert.nature.com/ctt?kn=95&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Recession Watch: Work for the greater good pp959-960
Eric Rauchway
doi:10.1038/457959a
http://links.ealert.nature.com/ctt?kn=190&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Recession Watch: No time for nationalism pp960-961
Atsushi Sunami and Kiyoshi Kurokawa
doi:10.1038/457960a
http://links.ealert.nature.com/ctt?kn=102&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Recession Watch: Cut costs and sell what you can pp961-962
John Browning
doi:10.1038/457961a
http://links.ealert.nature.com/ctt?kn=61&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Recession Watch: Cooperation must rule pp962-963
Noreena Hertz
doi:10.1038/457962a
http://links.ealert.nature.com/ctt?kn=227&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Recession Watch: End the obsession with interest p963
John Geanakoplos
doi:10.1038/457963a
http://links.ealert.nature.com/ctt?kn=256&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
----------------------
BOOKS AND ARTS
----------------------
OPINION
Recession Watch: Old lessons for a new economics pp964-965
Nobel prizewinner Paul Krugman's updated analysis of past economic
crises teaches us that recovery now will require more than a new set
of rules, explains Bill Emmott.
Bill Emmott reviews The Return of Depression Economics and the Crisis
of 2008 by Paul Krugman
doi:10.1038/457964a
http://links.ealert.nature.com/ctt?kn=232&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Recession Watch: Investing in the environment pp965-966
Gail Whiteman reviews Sustainable Investing: The Art of Long-Term
Performance
doi:10.1038/457965a
http://links.ealert.nature.com/ctt?kn=145&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
In search of adventure p966
Neil Shubin reviews Remarkable Creatures: Epic Adventures in the
Search for the Origin of Species by Sean B. Carroll
doi:10.1038/457966a
http://links.ealert.nature.com/ctt?kn=57&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Q&A: Building on paradise p967
Communicating the ideas of evolution is as much a challenge now as it
was 150 years ago. In the wake of his recent BBC television programme,
Charles Darwin and the Tree of Life, naturalist and broadcaster
David Attenborough tackles those who challenge evolution head on.
Adam Rutherford
doi:10.1038/457967a
http://links.ealert.nature.com/ctt?kn=238&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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NEWS AND VIEWS
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Carbon cycle: Sink in the African jungle pp969-970
Apparently pristine African tropical forests are increasing in tree
biomass, making them net absorbers of carbon dioxide. Is this a sign
of atmospheric change, or of recovery from past trauma?
Helene C. Muller-Landau
doi:10.1038/457969a
http://links.ealert.nature.com/ctt?kn=247&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Neuroscience: Good and bad cell death pp970-971
Neurodegeneration often has disease connotations. However, it is
also a developmental process for fine sculpting of the nervous
system. One signalling cascade might mediate the process in both
circumstances.
Donald W. Nicholson
doi:10.1038/457970a
http://links.ealert.nature.com/ctt?kn=133&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Medical imaging: MRI rides the wave pp971-972
An innovative approach for exciting and detecting signals in
magnetic resonance imaging not only improves image quality but
also enables radical changes in scanner design by freeing up
space around the patient.
Paul Glover and Richard Bowtell
doi:10.1038/457971a
http://links.ealert.nature.com/ctt?kn=11&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
50 & 100 years ago p972
doi:10.1038/457972a
http://links.ealert.nature.com/ctt?kn=140&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Taxonomy: Three into one will go p973
Striking instances of larval metamorphosis, and of adult sexual
dimorphism, are not uncommon in the animal world. But especially
dramatic examples of these phenomena have emerged from the deep sea.
Rory Howlett
doi:10.1038/457973a
http://links.ealert.nature.com/ctt?kn=157&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Materials science: Let assemblies bloom p974
Stefano Tonzani
doi:10.1038/457974a
http://links.ealert.nature.com/ctt?kn=191&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Molecular biology: The long and short of RNAs pp974-975
The known world of RNA is expanding faster than that of any other
cellular building block. The latest additions are types of long
and short non-coding RNAs formed by bidirectional transcription
and unusual processing.
Piero Carninci
doi:10.1038/457974b
http://links.ealert.nature.com/ctt?kn=259&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Obituary: Frederic Richards (1925-2009) p976
Pioneer in studies of protein structure and function.
Robert O. Fox
doi:10.1038/457976a
http://links.ealert.nature.com/ctt?kn=68&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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HYPOTHESIS
----------------------
A hierarchical model for evolution of 23S ribosomal RNA pp977-980
Konstantin Bokov and Sergey V. Steinberg
doi:10.1038/nature07749
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=167&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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ARTICLE
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APP binds DR6 to trigger axon pruning and neuron death via distinct
caspases pp981-989
Anatoly Nikolaev, Todd McLaughlin, Dennis D. M. O'Leary and
Marc Tessier-Lavigne
doi:10.1038/nature07767
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=125&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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LETTERS
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Massive star formation within the Leo `primordial' ring pp990-993
The Leo ring is a massive, 200-kpc-wide structure orbiting the galaxies
M105 and NGC3384 with a 4-Gyr period. This paper reports ultraviolet
light originating from gaseous substructures, which is attributed to
recent massive star formation. If structures like the Leo ring were
common in the early Universe, they may have produced a large, yet
undetected population of faint, metal-poor, halo-lacking dwarf galaxies.
David A. Thilker et al.
doi:10.1038/nature07780
Abstract: http://links.ealert.nature.com/ctt?kn=224&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=79&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Travelling-wave nuclear magnetic resonance pp994-998
Magnetic resonance imaging is widely used in the sciences and medicine,
with the same basic underlying detection principle: the need for intimate
coupling between nuclear magnetization in the sample under investigation
and the detector. This study now shows a new detection principle, where
the nuclear magnetization signal can be excited (and detected) via a
long-range interaction utilizing travelling radiofrequency waves in a
suitably modified MRI system. This approach offers more uniform coverage
of larger samples.
David O. Brunner et al.
doi:10.1038/nature07752
Abstract: http://links.ealert.nature.com/ctt?kn=117&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Magnetic assembly of colloidal superstructures with multipole symmetry
pp999-1002
Assembling complex structures out of simple colloidal building blocks
can produce materials with important practical properties and enables
enhanced understanding of the self-assembly processes on several length
scales. This paper shows self-assembly of a multi-component colloidal
mixture of magnetic and nonmagnetic particles driven by magnetic
interactions.
Randall M. Erb et al.
doi:10.1038/nature07766
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Increasing carbon storage in intact African tropical forests pp1003-1006
This study reports data from a network of long-term monitoring plots across
African tropical forests, which finds that above-ground carbon storage in
live trees increased by 0.63 Mg C ha-1 yr-1 between 1968 and 2007. The
data is extrapolated to unmeasured forest components, and by scaling to
the continent, a total increase in carbon storage in African tropical
forest trees of 0.34 Pg C yr-1 is estimated. These results provide evidence
that increasing carbon storage in old-growth forests is a pan-tropical
phenomenon.
Simon L. Lewis et al.
doi:10.1038/nature07771
Abstract: http://links.ealert.nature.com/ctt?kn=93&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=217&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Nodal signalling is involved in left-right asymmetry in snails pp1007-1011
In vertebrates and other deuterostomes, the molecular pathway that leads
to asymmetry utilizes the signalling molecule Nodal, a member of the
TGF-[beta] superfamily. But no orthologues of Nodal have been found in
the other two great groups of bilaterians. This paper finds orthologues
of nodal and one of its targets, Pitx, in two species of snail, and show
that loss of nodal disrupts shell coiling.
Cristina Grande and Nipam H. Patel
doi:10.1038/nature07603
Abstract: http://links.ealert.nature.com/ctt?kn=99&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=201&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Detecting influenza epidemics using search engine query data pp1012-p1014
This report introduces a computational model based on internet search
queries for real-time surveillance of influenza-like illness (ILI),
which reproduces the patterns observed in ILI data from the Centers
for Disease Control and Prevention.
Jeremy Ginsberg et al.
doi:10.1038/nature07634
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=215&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Synaptic depression enables neuronal gain control pp1015-1018
Neurons can perform mathematical operations such as additions, with their
firing rate (the output) representing the sum of their synaptic
conductances (the input). Multiplication, in turn, can result from changes
in the slope (or gain) of such input-output relationship. Such changes
in a neuron's sensitivity result from neuromodulation and are key to
numerous higher brain computations. A study using rat cerebellum
demonstrates that short-term synaptic plasticity brings the fundamental
non-linearity, allowing neuromodulatory inhibition to act multiplicatively
instead of additively.
Jason S. Rothman, Laurence Cathala, Volker Steuber and R. Angus Silver
doi:10.1038/nature07604
Abstract: http://links.ealert.nature.com/ctt?kn=187&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
The Fas-FADD death domain complex structure unravels signalling by receptor
clustering pp1019-1022
This study presents the crystal structure of a Fas-FADD complex, a central
feature of the so-called death inducing signalling complex. The structure
reveals a new mode of death domain interactions that allows four FADD and
four Fas proteins in one complex.
Fiona L. Scott et al.
doi:10.1038/nature07606
Abstract: http://links.ealert.nature.com/ctt?kn=212&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=193&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Artificial nanopores that mimic the transport selectivity of the nuclear pore
complex pp1023-1027
Nuclear pore complexes (NPCs) serve as gateways between the nucleus and
cytoplasm and allow only the transport of selected macromolecules across
the nuclear envelope. NPCs are comprised of a scaffold that anchors proteins
called FG-nucleoporins, which contain disordered regions that line the inner
surface of the pore and extend into the lumen. This study reports the design
of an artificial membrane that functions as a selective filter in allowing
efficient passage of transport factors and transport factor carrying cargo
that specifically bind to FG-nucleoporins.
Tijana Jovanovic-Talisman et al.
doi:10.1038/nature07600
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Post-transcriptional processing generates a diversity of 5'-modified long
and short RNAs pp1028-1032
The transcriptomes of eukaryotic cells are unexpectedly complex, with
virtually the entire non-repeat portions of many genomes being transcribed.
Using deep sequencing, this study reveals that a remarkable breadth of
RNA species that come from both within annotated genes and from unannotated
intergenic regions in human cells. Many of these small RNAs possess cap
structures and seem to be processed from mature mRNAs resulting in
populations of long and short RNAs with capped 5' ends that coincide.
doi:10.1038/nature07759
Abstract: http://links.ealert.nature.com/ctt?kn=107&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Bidirectional promoters generate pervasive transcription in yeast pp1033-1037
One of two papers in this issue that reveal the prevalence of cryptic
or hidden transcription in the yeast genome. Cryptic unstable transcripts
(CUTs) are a major class of RNA polymerase II transcripts in budding yeast
and are degraded immediately after being synthesized. In these papers,
high-resolution genome analyses reveal that CUTs arise predominantly from
promoter regions and in an antisense direction. There is therefore a
widespread occurrence of inherently bidirectional promoters in yeast.
Zhenyu Xu et al.
doi:10.1038/nature07728
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=136&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Widespread bidirectional promoters are the major source of cryptic
transcripts in yeast pp1038-1042
One of two papers in this issue that reveal the prevalence of cryptic
or hidden transcription in the yeast genome. Cryptic unstable transcripts
(CUTs) are a major class of RNA polymerase II transcripts in budding yeast
and are degraded immediately after being synthesized. In these papers,
high-resolution genome analyses reveal that CUTs arise predominantly from
promoter regions and in an antisense direction. There is therefore a
widespread occurrence of inherently bidirectional promoters in yeast.
Helen Neil et al.
doi:10.1038/nature07747
Abstract: http://links.ealert.nature.com/ctt?kn=182&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=41&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Prospects
Life through a lens p1043
Tackling corporate culture with the help of YouTube.
Gene Russo
doi:10.1038/nj7232-1043a
http://links.ealert.nature.com/ctt?kn=226&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Career View
Walter Rosenthal, scientific director, Max Delbruck Center for
Molecular Medicine, Berlin, Germany p1044
Researcher aims to turn basic science into clinical solutions as
head of Berlin institute.
Virginia Gewin
doi:10.1038/nj7232-1044a
http://links.ealert.nature.com/ctt?kn=49&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
New centres plan for healthy ageing p1044
US institutes are recruiting scientists and postdocs for ageing
research.
Virginia Gewin
doi:10.1038/nj7232-1044b
http://links.ealert.nature.com/ctt?kn=100&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
It takes a lab to raise a child p1044
Getting back to work hasn't been too much of a struggle - yet.
Julia Boughner
doi:10.1038/nj7232-1044c
http://links.ealert.nature.com/ctt?kn=181&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Penance p1046
An act of faith.
T. F. Davenport
doi:10.1038/4571046a
http://links.ealert.nature.com/ctt?kn=228&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
18 February 2009
Neisseria meningitidis recruits factor H using protein mimicry of
host carbohydrates
Muriel C. Schneider et al.
doi:10.1038/nature07769
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=150&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Decoding reveals the contents of visual working memory in early visual
areas
Stephenie A. Harrison and Frank Tong
doi:10.1038/nature07832
Abstract: http://links.ealert.nature.com/ctt?kn=131&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
15 February 2009
Identification of a dendritic cell receptor that couples sensing of
necrosis to immunity
David Sancho et al.
doi:10.1038/nature07750
Abstract: http://links.ealert.nature.com/ctt?kn=126&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=265&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Phylogenetic biome conservatism on a global scale
Michael D. Crisp et al.
doi:10.1038/nature07764
Abstract: http://links.ealert.nature.com/ctt?kn=267&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=263&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase
expression and glutamine metabolism
Ping Gao et al.
doi:10.1038/nature07823
Abstract: http://links.ealert.nature.com/ctt?kn=139&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=233&m=31506956&r=MTc2MTc4Mzk0MQS2&b=2&j=NDU5MTcyMDQS1&mt=1&rt=0
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