February 2009 Volume 23 Number 2, pp 215 - 431
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Lymphocytes Return Home
Immunology & Cell Biology is proud to bring you Lymphocytes Return Home - a focus that brings together
a collection of articles representing our current understanding of how numerous cell types can return to
the thymus. Accompanying this focus is a special feature dealing with the nature and possible functional
consequences of cellular traffic, both lymphoid and myeloid, back to the primary lymphoid organs.
Take advantage of this limited time offer today!
Lymphocytes Return Home
http://links.ealert.nature.com/ctt?kn=72&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
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Why Publish in Leukemia?
Efficient peer-review, hassle-free submission, recognition...
Papers benefit from wide readership through hosting on nature.com and inclusion in the leading abstracting
and indexing services. Rapid publication is also assured through Advance Online Publication.
To read the full Guide to Authors for Leukemia, visit
http://links.ealert.nature.com/ctt?kn=148&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
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SPOTLIGHT REVIEW
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International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and
related disorders
A Dispenzieri, R Kyle, G Merlini, J S Miguel, H Ludwig, R Hajek, A Palumbo, S Jagannath, J Blade, S Lonial,
M Dimopoulos, R Comenzo, H Einsele, B Barlogie, K Anderson, M Gertz, J L Harousseau, M Attal, P Tosi,
P Sonneveld, M Boccadoro, G Morgan, P Richardson, O Sezer, M V Mateos, M Cavo, D Joshua, I Turesson, W Chen,
K Shimizu, R Powles, S V Rajkumar and B G M Durie
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
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REVIEW
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Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of
cytogenetics in the light of todays knowledge
E G Boerma, R Siebert, P M Kluin and M Baudis
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Molecular recognition of acute myeloid leukemia using aptamers
K Sefah, Z W Tang, D H Shangguan, H Chen, D Lopez-Colon, Y Li, P Parekh, J Martin, L Meng, J A Phillips,
Y M Kim and W H Tan
Abstract: http://links.ealert.nature.com/ctt?kn=124&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Clinical consequences of hyperglycemia during remission induction therapy for pediatric acute lymphoblastic
leukemia
J R Roberson, H L Spraker, J Shelso, Y Zhou, H Inaba, M L Metzger, J E Rubnitz, R C Ribeiro, J T Sandlund,
S Jeha, C-H Pui and S C Howard
Abstract: http://links.ealert.nature.com/ctt?kn=117&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=132&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia
B Wegiel, J Ekberg, K M Talasila, S Jalili and J L Persson
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on
cytogenetically normal AML
I H I M Hollink, C M Zwaan, M Zimmermann, T C J M Arentsen-Peters, R Pieters, J Cloos, G J L Kaspers,
S S N de Graaf, J Harbott, U Creutzig, D Reinhardt, M M van den Heuvel-Eibrink and C Thiede
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=2&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
The molecular anatomy of the FIP1L1-PDGFRA fusion gene
C Walz, J Score, J Mix, D Cilloni, C Roche-Lestienne, R-F Yeh, J L Wiemels, E Ottaviani, P Erben, A Hochhaus,
M Baccarani, D Grimwade, C Preudhomme, J Apperley, G Martinelli, G Saglio, N C P Cross and A Reiter
Abstract: http://links.ealert.nature.com/ctt?kn=159&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
BCR//ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold
J Dierov, P V Sanchez, B A Burke, H Padilla-Nash, M E Putt, T Ried and M Carroll
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Telomere length is severely and similarly reduced in JAK2V617F-positive and -negative myeloproliferative
neoplasms
L Bernard, C Belisle, L Mollica, S Provost, D-C Roy, D G Gilliland, R L Levine and L Busque
Abstract: http://links.ealert.nature.com/ctt?kn=136&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and
represses the pro-proliferative signal of CD40-ligand, in part through increased 15d[Delta]12,14,PGJ2
R E Hayden, G Pratt, N J Davies, F L Khanim, J Birtwistle, J Delgado, C Pearce, T Sant, M T Drayson
and C M Bunce
Abstract: http://links.ealert.nature.com/ctt?kn=125&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=138&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Stem cell factor and high-dose twice daily filgrastim is an effective strategy for peripheral blood stem
cell mobilization in patients with indolent lymphoproliferative disorders previously treated with fludarabine:
results of a Phase II study with an historical comparator
K E Herbert, S Morgan, H M Prince, D A Westerman, M M Wolf, D A Carney, K Yuen, J di Iulio and J F Seymour
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
D Schotte, J C K Chau, G Sylvester, G Liu, C Chen, V H J van der Velden, M J C Broekhuis, T C J M Peters,
R Pieters and M L den Boer
Abstract: http://links.ealert.nature.com/ctt?kn=135&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=144&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and
adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB//LMB 96 international study
H A Poirel, M S Cairo, N A Heerema, J Swansbury, A Auperin, E Launay, W G Sanger, P Talley, S L Perkins,
M Raphael, K McCarthy, R Sposto, M Gerrard, A Bernheim and C Patte
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Detection and molecular monitoring of FIP1L1-PDGFRA-positive disease by analysis of patient-specific genomic
DNA fusion junctions
J Score, C Walz, J V Jovanovic, A V Jones, K Waghorn, C Hidalgo-Curtis, F Lin, D Grimwade, F Grand, A Reiter
and N C P Cross
Abstract: http://links.ealert.nature.com/ctt?kn=111&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=114&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Allogeneic bone marrow transplantation and donor lymphocyte infusion in a mouse model of irradiation-induced myelodysplastic//myeloproliferation syndrome (MD//MPS): evidence for a graft-versus-MD//MPS effect
B Sprangers, B Van Wijmeersch, A Luyckx, X Sagaert, L De Somer, O Rutgeerts, C Lenaerts, W Landuyt, N Boeckx,
B Dubois, C De Wolf-Peeters, M Waer and A D Billiau
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=107&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Early clearance of peripheral blasts measured by flow cytometry during the first week of AML induction
therapy as a new independent prognostic factor: a GOELAMS study
F Lacombe, C Arnoulet, M Maynadie, E Lippert, I Luquet, A Pigneux, N Vey, O Casasnovas, F Witz and M C Bene
Abstract: http://links.ealert.nature.com/ctt?kn=147&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1//CSF1R signaling abnormalities in
the cell line GDM1
A Chase, B Schultheis, S Kreil, J Baxter, C Hidalgo-Curtis, A Jones, L Zhang, F H Grand, J V Melo and
N C P Cross
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=156&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
C//EBP[alpha] or C//EBP[alpha] oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct
interaction with NF-[kappa]B p50 bound to the bcl-2 and FLIP gene promoters
I Paz-Priel, A K Ghosal, J Kowalski and A D Friedman
Abstract: http://links.ealert.nature.com/ctt?kn=152&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=129&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
PD-1//PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia//lymphoma
patients
T Kozako, M Yoshimitsu, H Fujiwara, I Masamoto, S Horai, Y White, M Akimoto, S Suzuki, K Matsushita, K Uozumi,
C Tei and N Arima
Abstract: http://links.ealert.nature.com/ctt?kn=130&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway
V Ullmannova-Benson, M Guan, X Zhou, V Tripathi, X-Y Yang, D B Zimonjic and N C Popescu
Abstract: http://links.ealert.nature.com/ctt?kn=149&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=48&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
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LETTERS TO THE EDITOR
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Decreased IRF8 expression found in aging hematopoietic progenitor//stem cells
D L Stirewalt, Y E Choi, N E Sharpless, E L Pogosova-Agadjanyan, M R Cronk, M Yukawa, E B Larson, B L Wood,
F R Appelbaum, J P Radich and S Heimfeld
http://links.ealert.nature.com/ctt?kn=163&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Combining SDF-1//CXCR4 antagonism and chemotherapy in relapsed acute myeloid leukemia
F A Fierro, S Brenner, U Oelschlaegel, A Jacobi, H Knoth, G Ehninger, T Illmer and M Bornhauser
http://links.ealert.nature.com/ctt?kn=162&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia
using a novel nanofluidic platform and mutation-specific PCR
V G Oehler, J Qin, R Ramakrishnan, G Facer, S Ananthnarayan, C Cummings, M Deininger, N Shah, F McCormick,
S Willis, A Daridon, M Unger and J P Radich
http://links.ealert.nature.com/ctt?kn=68&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Kinetics of humoral response to ALK and its relationship with minimal residual disease in pediatric ALCL
L Mussolin, P Bonvini, K Ait-Tahar, M Pillon, G Tridello, S Buffardi, A Lombardi, K Pulford and A Rosolen
http://links.ealert.nature.com/ctt?kn=19&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Coding polymorphisms in CD33 and response to gemtuzumab ozogamicin in pediatric patients with AML: a pilot study
J K Lamba, S Pounds, X Cao, J R Downing, D Campana, R C Ribeiro, C-H Pui and J E Rubnitz
http://links.ealert.nature.com/ctt?kn=9&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Acetylation of FOXO3a transcription factor in response to imatinib of chronic myeloid leukemia
P Corrado, M Mancini, G Brusa, S Petta, G Martinelli, E Barbieri and M A Santucci
http://links.ealert.nature.com/ctt?kn=102&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia
J W Tyner, M M Loriaux, H Erickson, C A Eide, J Deininger, M MacPartlin, S G Willis, T Lange, B J Druker,
T Kovacsovics, R Maziarz, N Gattermann and M W Deininger
http://links.ealert.nature.com/ctt?kn=64&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation
M Honda, M Takagi, L Chessa, T Morio and S Mizuatni
http://links.ealert.nature.com/ctt?kn=41&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Expression of cyclin A in childhood acute lymphoblastic leukemia cells reveals undisturbed G1-S phase transition
and passage through the S phase
A Hirt, A M Schmid, F Julmy, N M R Schmitz and K Leibundgut
http://links.ealert.nature.com/ctt?kn=51&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Redundant function of retinoic acid receptor isoforms in leukemogenesis unravels a prominent function of genome
topology and architecture in the selection of mutagenic events in cancer
A Marinelli, D Bossi, P G Pelicci and S Minucci
http://links.ealert.nature.com/ctt?kn=113&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes
E Cornet, J F Lesesve, H Mossafa, G Sebahoun, V Levy, F Davi and X Troussard
http://links.ealert.nature.com/ctt?kn=160&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
The research mission in myeloma
P G Richardson, J San-Miguel, S Lonial, D Reece, A Jakubowiak, M Hussein, S Jagannath, C S Mitsiades,
N Raje, J Kaufman, D Avigan, I Ghobrial, R L Schlossman, N Munshi, W Dalton and K C Anderson
http://links.ealert.nature.com/ctt?kn=4&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Reply to the research mission in myeloma by Richardson et al.
P L Bergsagel
http://links.ealert.nature.com/ctt?kn=140&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
Molecular detection of AML1-MTG8-positive cells in peripheral blood from a patient with isolated
extramedullary relapse of t(8;21) acute myeloid leukemia
H Tamaki, S Yoshihara, T Fujioka, M Kawakami, Y Oka and H Ogawa
http://links.ealert.nature.com/ctt?kn=92&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
The B-cell calcium sensor predicts progression of chronic lymphocytic leukemia
C M Hammond, Y Shi, D White, D Cervi, J Tomic and D E Spaner
http://links.ealert.nature.com/ctt?kn=22&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
----------------------
CORRIGENDA
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Decreased IRF8 expression found in aging hematopoietic progenitor//stem cells
D L Stirewalt, Y E Choi, N E Sharpless, E L Pogosova-Agadjanyan, M R Cronk, M Yukawa, E B Larson,
B L Wood, F R Appelbaum, J P Radich and S Heimfeld
http://links.ealert.nature.com/ctt?kn=118&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
A novel arsenical has antitumor activity toward As2O3-resistant and MRP1//ABCC1-overexpressing
cell lines
Z Diaz, K K Mann, S Marcoux, M Kourelis, M Colombo, P B Komarnitsky and W H Miller
http://links.ealert.nature.com/ctt?kn=1&m=31352331&r=MTc2MzIyNTA1NQS2&b=2&j=NDU3MDE5NTUS1&mt=1&rt=0
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