Signaling Gateway - 9 January 2009
http://links.ealert.nature.com/ctt?kn=37&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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G-PROTEIN SIGNALING: ERK BREAKS HEARTS
Gq signaling in hypertrophic cardiomyocytes promotes an association
between the G protein betagamma complex and Raf or Erk, stimulating Erk2
phosphorylation and nuclear localization.
Original research paper: Nature Medicine, 15, 75-83 (2009)
http://links.ealert.nature.com/ctt?kn=20&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
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Molecule Pages
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GCAP1
http://links.ealert.nature.com/ctt?kn=38&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
GCAP1 (guanylyl cyclase activating protein 1) is a soluble protein
that localizes to the outer segments of rods and cones and regulates
their recovery from photoexcitation by modulating recGC-catalyzed
cGMP synthesis. GCAP1 stimulates retGC in the light, when the
hydrolysis of cGMP is fast, and decelerates retGC activity in the
dark, when cGMP hydrolysis is slow and its rapid resynthesis is not
required. Gain-of-function mutations in GCAP1 that deregulate cGMP
synthesis in the dark have been linked to congenital retinal
dystrophies
Also published this week:
Adrenergic receptor alpha 2b:
http://links.ealert.nature.com/ctt?kn=23&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
Adrenergic receptor alpha 2c:
http://links.ealert.nature.com/ctt?kn=30&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
Search the molecule pages
http://links.ealert.nature.com/ctt?kn=31&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
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Selected Updates
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CELL DEATH: DIAP1 PUTS UBIQUITIN ON drICE
Caspase activity in Drosophila is regulated by a negative-feedback
loop in which effector caspases activate DIAP1 (Drosophila inhibitor
of apoptosis protein 1) and are in turn inhibited by DIAP1-mediated
non-degradative ubiquitylation.
Original research paper: Mol. Cell 32, 540-553 (2008)
http://links.ealert.nature.com/ctt?kn=29&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
TUMORIGENESIS: CAN YOU HAVE TOO MUCH MYC?
The ability of the proto-oncogene MYC to elicit tumor suppressor or
proliferative responses depends on its level of expression - low
expression is sufficient to induce proliferation, whereas
overexpression drives apoptosis.
Original research paper: Cancer Cell 14, 447-457 (2008)
http://links.ealert.nature.com/ctt?kn=35&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
TYPE 1 DIABETES: NEW LINK TO KINASES AS TARGETS
Pharmacologic inhibition of the platelet-derived growth factor
receptor (PDGFR) has been shown to induce remission in a mouse
model of diabetes.
Original research paper: Proc. Natl Acad. Sci. USA 105, 18895-18900
(2008)
http://links.ealert.nature.com/ctt?kn=3&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=28&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
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Research Library
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FREQUENT IN-FRAME SOMATIC DELETIONS ACTIVATE gp130 IN INFLAMMATORY
HEPATOCELLULAR TUMOURS
Nature 457, 200-204 (2009)
http://links.ealert.nature.com/ctt?kn=33&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
APOPTOTIC HISTONE MODIFICATION INHIBITS NUCLEAR TRANSPORT BY
REGULATING RCC1
Nature Cell Biology 11, 36-45 (2008)
http://links.ealert.nature.com/ctt?kn=32&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
AN EMPIRICAL FRAMEWORK FOR BINARY INTERACTOME MAPPING
Nature Methods 6, 83-90 (2008)
http://links.ealert.nature.com/ctt?kn=24&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
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Signaling News
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NATURE REVIEWS MOLECULAR CELL BIOLOGY: FOCUS ON MECHANOTRANSDUCTION
http://links.ealert.nature.com/ctt?kn=16&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
Cells sense their physical three-dimensional environment - properties
of the extracellular matrix, neighboring cells and physical
stress - by translating mechanical forces and deformations into
biochemical signals. This special Focus issue of Nature Reviews
Molecular Cell Biology presents the current understanding of
mechanotransduction in development, normal physiology and disease.
More News
http://links.ealert.nature.com/ctt?kn=34&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
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Gateway Updates
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RNAi GATEWAY
http://links.ealert.nature.com/ctt?kn=27&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
From humble beginnings as an obscure phenomenon in plants, RNA
interference (RNAi) has evolved into an area of significant impact
in numerous fields. The RNAi Gateway provides a convenient portal
into Nature Publishing Group publications relevant to every aspect
of RNAi.
The gateway features a podcast and a library of relevant reviews and
articles organized by date, subject or organism.
http://links.ealert.nature.com/ctt?kn=17&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
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Job of the Week
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Postdoctoral Endowed chairs and professorships
Employer: University of New Mexico Cancer Center
Location: Albuquerque, New Mexico, United States
http://links.ealert.nature.com/ctt?kn=9&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
The University of New Mexico Cancer Center at the UNM Health Sciences
Center and School of Medicine in Albuquerque invites applications at
the associate and full professor levels for a series of newly endowed
chairs and professorships in cancer research. These positions include
clinical and translational research in cancer and leukemia stem cell
biology, cancer molecular therapeutics, women's and
hormone-responsive cancers, and animal models of cancer.
More Jobs:
http://links.ealert.nature.com/ctt?kn=2&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=21&m=30913870&r=MTU3NjU1MzAzMQS2&b=2&j=NDQ5NjI3NzgS1&mt=1&rt=0
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