Nature Reviews Molecular Cell Biology contents February 2009 Volume 10 Number 2 pp 83-155

TABLE OF CONTENTS
February 2009 Volume 10 Number 2
Impact Factor 31.921 * Subscribe to Nature Reviews Molecular Cell Biology Recommend to your library	In this issue Research Highlights Reviews Perspectives Also this month Article series: Stem cells Article series: Post-transcriptional control  Featured article: Biogenesis of small RNAs in animals V. Narry Kim, Jinju Han & Mikiko C. Siomi	IT'S NOW FREE TO POST YOUR VACANCY ON It's the breakthrough you've been waiting for. Naturejobs.com - the scientific jobs board from Nature now lets you advertise your vacancy completely FREE OF CHARGE Go to www.naturejobs.com /postmyjob or telephone: Europe: +44 (0) 20 78434961 US: + 1 800 9897718
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Nature Review Molecular Cell Biology Poster on Production and Actions of Small RNAs Recent progress in cloning, deep sequencing and bioinformatics have revealed an astounding landscape of small RNAs in eukaryotic cells. This Poster by V. Narry Kim and Mikiko C. Siomi depicts our current understanding of the processing pathways of eukaryotic small RNAs and their possible mechanisms of action. Access the Poster FREE online! www.nature.com/nrm/posters/smallrnas Produced with support from: Abcam
From the editors p83 | doi:10.1038/nrm2629 PDF
RESEARCH HIGHLIGHTS Top Cell signalling: An efficient and timely getting together p85 | doi:10.1038/nrm2622 PDF Cell migration: Calcium flickers at the front p86 | doi:10.1038/nrm2625 PDF Telomeres: Splicing uncoupled p86 | doi:10.1038/nrm2626 PDF Gene expression: Common sense and antisense p87 | doi:10.1038/nrm2624 PDF STRUCTURE WATCH Ternary Argonaute complex | Recognizing UV damage p88 | doi:10.1038/nrm2627 PDF Membrane trafficking: Squeezing and releasing p88 | doi:10.1038/nrm2631 PDF JOURNAL CLUB Where's Waldo for autophagosomes p89 | doi:10.1038/nrm2603 PDF Mechanisms of disease: How stress affects fat p89 | doi:10.1038/nrm2620 PDF mRNA decay: Cutting in the middle p90 | doi:10.1038/nrm2623 PDF IN BRIEF Cytoskeleton | Lipids | Nuclear organization p90 | doi:10.1038/nrm2628 PDF Molecular Cell Biology JOBS of the week Post Doctorate Population Geneticists Rivers and Fisheries Trusts of Scotland (RAFTS) Edinburgh, Scotland Research Assistant / Associate (Reference 14521) University of Bristol Bristol, UK Tenure-Track Faculty Positions - Keck School of Medicine University of Southern California Los Angeles, CA Researchers INRA Paris Cedex France Assistant / Associate / Project Scientist UCSD La Jolla, CA 92039-0739 United States More Science jobs from Molecular Cell Biology EVENT Cellular Protein Homeostasis in Disease and Ageing 23.-28.05.09 More science events from
REVIEWS		Top
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo Sebastian J. Arnold & Elizabeth J. Robertson p91 | doi:10.1038/nrm2618 Genetic studies combined with in vivo imaging analysis have identified signalling pathways and developmentally regulated transcription factors that govern cell lineage allocation and axis patterning in the early mammalian embryo. These mechanisms are also conserved in lower vertebrates. Abstract | Full Text | PDF
Molecular mechanisms of proteasome assembly Shigeo Murata, Hideki Yashiroda & Keiji Tanaka p104 | doi:10.1038/nrm2630 The 26S proteasome is a large protein complex that consists of a catalytic 20S core and a 19S regulatory particle, each of which contains numerous subunits. Proteasome-dedicated chaperones guarantee the efficient and correct assembly of this degradation machine, which is essential for its function. Abstract | Full Text | PDF | Supplementary information
Article series: Stem cells MicroRNAs: key regulators of stem cells Vamsi K. Gangaraju & Haifan Lin p116 | doi:10.1038/nrm2621 MicroRNAs (miRNAs) are non-coding RNAs that bind to the 3? untranslated region of target mRNAs to repress their translation and stability. Recently, miRNAs have been shown to regulate stem cell fate and behaviour by fine-tuning the protein levels of factors that are required for their function. Abstract | Full Text | PDF
Article series: Post-transcriptional control Biogenesis of small RNAs in animals V. Narry Kim, Jinju Han & Mikiko C. Siomi p126 | doi:10.1038/nrm2632 Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Post-transcriptional control Revisiting the principles of microRNA target recognition and mode of action Peter Brodersen & Olivier Voinnet p141 | doi:10.1038/nrm2619 General principles that govern how microRNAs select their targets and determine their mode of action are being challenged by recent findings in plant and animal systems. A common shortcoming of studies to date has been to address these questions under true in vivo conditions. Abstract | Full Text | PDF
OPINION Mechanisms of regulated unconventional protein secretion Walter Nickel & Catherine Rabouille p148 | doi:10.1038/nrm2617 Although most eukaryotic proteins are secreted through the conventional endoplasmic reticulum-Golgi secretory pathway, both cytoplasmic and nuclear proteins have been shown to reach the cell surface by non-conventional transport pathways. The mechanisms and molecular components of unconventional protein secretion are beginning to emerge. Abstract | Full Text | PDF
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