Nature Reviews Cancer contents February 2009 Volume 9 Number 2 pp 73-144

TABLE OF CONTENTS
February 2009 Volume 9 Number 2
Impact Factor 29.19 * Subscribe to Nature Reviews Cancer Recommend to your library	In this issue Research Highlights Reviews Perspectives Correspondence Also this month Article series: Senescence Also this month  Featured article: Senescence–messaging secretome: SMS–ing cellular stress Thomas Kuilman & Daniel S. Peeper	IT'S NOW FREE TO POST YOUR VACANCY ON It's the breakthrough you've been waiting for. Naturejobs.com - the scientific jobs board from Nature now lets you advertise your vacancy completely FREE OF CHARGE Go to www.naturejobs.com /postmyjob or telephone: Europe: +44 (0) 20 78434961 US: + 1 800 9897718
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From the editors p73 | doi:10.1038/nrc2601 PDF
RESEARCH HIGHLIGHTS Top Cancer stem cells: Can mutated stem cells produce tumours? p74 | doi:10.1038/nrc2593 PDF Technology: Indirect activation p75 | doi:10.1038/nrc2592 PDF Melanoma: Digging around moles p75 | doi:10.1038/nrc2596 PDF Therapeutics: Akt: a double-edged sword p76 | doi:10.1038/nrc2586 PDF IN THE NEWS Selecting for susceptibility p76 | doi:10.1038/nrc2597 PDF Inflammation: Orchestrating metastasis p76 | doi:10.1038/nrc2598 PDF Mouse models: Role reversal p77 | doi:10.1038/nrc2585 PDF Kinase inhibitors: Thinking outside the box p78 | doi:10.1038/nrc2588 PDF Tumorigenesis: MYCN and aurora A: a stable relationship p79 | doi:10.1038/nrc2599 PDF TRIAL WATCH Predicting chemotherapy resistance p79 | doi:10.1038/nrc2600 PDF Oncogene repression: CDYL and REST — a silent team p80 | doi:10.1038/nrc2582 PDF IN BRIEF Genetics | Tumorigenesis | Angiogenesis | Stem cells p80 | doi:10.1038/nrc2595 PDF Cancer JOBS of the week Tenure-Track Faculty Positions - Keck School of Medicine University of Southern California Los Angeles, CA Tenured or Tenure Track Researcher National Cancer Institute Bethesda, MD 20892-1374 United States Research Fellow in Cancer Metabolomics University of Birmingham Birmingham, UK Biopharmaceutical Development Manager ALIZE PHARMA II SAS Ecully (Lyon area), France Post-Doctoral Research Fellow University of Oxford Oxford OX3 9DU United Kingdom More Science jobs from Cancer EVENT Stem Cells and Cancer 23.-25.02.09 Madrid, Spain More science events from
REVIEWS		Top
Article series: Senescence Senescence-messaging secretome: SMS-ing cellular stress Thomas Kuilman & Daniel S. Peeper p81 | doi:10.1038/nrc2560 Emerging evidence points to a crucial role for secreted factors in oncogene-induced cellular senescence and indicates possible cross-talk between senescent cells and their microenvironment. How are such signals integrated and what are the implications of this unexpected finding? Abstract | Full Text | PDF
p53 polymorphisms: cancer implications Catherine Whibley, Paul D. P. Pharoah & Monica Hollstein p95 | doi:10.1038/nrc2584 There are >200 naturally occurring single nucleotide polymorphisms (SNPs) of TP53 in human populations and only a fraction, if any, are expected to perturb p53 function. This Review discusses the evidence linking p53 SNPs with cancer risk and prognosis. Abstract | Full Text | PDF | Supplementary information
A tense situation: forcing tumour progression Darci T. Butcher, Tamara Alliston & Valerie M. Weaver p108 | doi:10.1038/nrc2544 It is often forgotten that cells within tissues are continuously exposed to physical forces to which they respond by exerting reciprocal cell-generated force. This Review examines why the changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION How does SIRT1 affect metabolism, senescence and cancer? Christopher L. Brooks & Wei Gu p123 | doi:10.1038/nrc2562 The function of protein deacetylase SIRT1 in cancer is controversial: it has been shown to have oncogenic properties as well as tumour suppressor activity. How might these opposing functions be explained? Abstract | Full Text | PDF
OPINION Do 'basal-like' breast cancers really exist? Barry Gusterson p128 | doi:10.1038/nrc2571 Which breast tumours does the term 'basal-like' best describe? In this Perspective the author argues that this term is misleading and explains why by use of current understanding of breast cancer pathology. Abstract | Full Text | PDF
OPINION Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype Gillian C. Barnett, Catherine M. L. West, Alison M. Dunning, Rebecca M. Elliott, Charlotte E. Coles, Paul D. P. Pharoah & Neil G. Burnet p134 | doi:10.1038/nrc2587 Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to characterize genetic profiles that predict patient response to radiotherapy. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
Correspondence: On the abundance of EpCAM on cancer stem cells Olivier Gires, Christoph A. Klein & Patrick A. Baeuerle p143 | doi:10.1038/nrc2499-c1 Full Text | PDF
Correspondence: EpCAM and solid tumour fractionation Jane E. Visvader & Geoffrey J. Lindeman p143 | doi:10.1038/nrc2499-c2 Full Text | PDF
Correspondence: Mechanism of E-cadherin lysosomal degradation Wen Jin Wu & Dianne S. Hirsch p143 | doi:10.1038/nrc2521-c1 Full Text | PDF
Correspondence: Cadherin endocytosis Yaron Mosesson, Gordon B. Mills & Yosef Yarden p143 | doi:10.1038/nrc2521-c2 Full Text | PDF
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