8 January 2009 Volume 457 Number 7226, pp 129 - 228
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EDITORIALS
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Data for the masses p129
Initiatives for digital research infrastructure should focus more on
making standardized data openly available, and less on developing new
portals.
doi:10.1038/457129a
http://links.ealert.nature.com/ctt?kn=188&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Culture clash pp129-130
Samuel Huntington will be remembered for his ideas, controversial as
they might have been.
doi:10.1038/457129b
http://links.ealert.nature.com/ctt?kn=120&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Cuba's biotech boom p130
The United States would do well to end restrictions on collaborations
with the island nation's scientists.
doi:10.1038/457130a
http://links.ealert.nature.com/ctt?kn=28&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Taxonomy: Aloha Mohoidae p132
doi:10.1038/457132a
http://links.ealert.nature.com/ctt?kn=119&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Environmental science: It's in the water p132
doi:10.1038/457132b
http://links.ealert.nature.com/ctt?kn=60&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Cancer: Interfering with cancer p132
doi:10.1038/457132c
http://links.ealert.nature.com/ctt?kn=230&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Neurobiology: Crossing the barrier p132
doi:10.1038/457132d
http://links.ealert.nature.com/ctt?kn=121&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Mathematical biology: Sensible swarming p132
doi:10.1038/457132e
http://links.ealert.nature.com/ctt?kn=225&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Biomechanics: Wobble mystery solved pp132-133
doi:10.1038/457132f
http://links.ealert.nature.com/ctt?kn=195&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Geochemistry: Oh molybdenum! p133
doi:10.1038/457133a
http://links.ealert.nature.com/ctt?kn=151&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Materials science: Hitting a nerve gas p133
doi:10.1038/457133b
http://links.ealert.nature.com/ctt?kn=22&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Genomics: 25 to life p133
doi:10.1038/457133c
http://links.ealert.nature.com/ctt?kn=215&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Zoology: Breathing deep p133
doi:10.1038/457133d
http://links.ealert.nature.com/ctt?kn=77&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
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JOURNAL CLUB
----------------------
Journal club p133
Stephen Curry
doi:10.1038/457133e
http://links.ealert.nature.com/ctt?kn=229&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
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NEWS
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China builds inland Antarctic base pp134-135
Kunlun station to open later this month atop the frozen continent's
oldest ice.
Jane Qiu
doi:10.1038/457134a
http://links.ealert.nature.com/ctt?kn=220&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Companies racing into India's nuclear market pp134-135
Deal between India and United States spurs investment rush.
K. S. Jayaraman
doi:10.1038/457134b
http://links.ealert.nature.com/ctt?kn=114&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Biotechs feel the pain pp136-137
The biotechnology industry is weathering the financial crisis
better than some. That doesn't mean it's in great shape,
reports Heidi Ledford.
doi:10.1038/457136a
http://links.ealert.nature.com/ctt?kn=55&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
European boost for particle therapy pp139-139
Treatment centres poised to use carbon-ion beams to tackle cancer.
Vicki Brower
doi:10.1038/457139a
http://links.ealert.nature.com/ctt?kn=126&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Geophysicists accused of breach of publishing ethics p140
doi:10.1038/457140a
http://links.ealert.nature.com/ctt?kn=5&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
UK revises visa rules to help visiting scientists pp140-140
doi:10.1038/457140b
http://links.ealert.nature.com/ctt?kn=122&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
US National Academies suspend visits to Iran pp140-140
doi:10.1038/457140c
http://links.ealert.nature.com/ctt?kn=112&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
California sues in bid to preserve wildlife laws pp140-140
doi:10.1038/457140d
http://links.ealert.nature.com/ctt?kn=53&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Nigeria finally appoints its health ministers pp140-140
doi:10.1038/457140e
http://links.ealert.nature.com/ctt?kn=203&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Dinosaur graveyard promises clues to extinction pp140-140
doi:10.1038/457140f
http://links.ealert.nature.com/ctt?kn=118&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Correction pp140-140
doi:10.1038/457140g
http://links.ealert.nature.com/ctt?kn=157&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
NEWS FEATURES
----------------------
Ocean research: The lab at the bottom of the sea pp141-143
The best way to study life beneath the waves is to live there.
Mark Schrope describes his experiences in the world's
longest-running undersea laboratory.
Mark Schrope
doi:10.1038/457141a
http://links.ealert.nature.com/ctt?kn=43&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Forestry: A green investment pp144-146
If growing forests in India can generate lucrative carbon credits,
then why isn't everyone planting trees? Paroma Basu reports.
Paroma Basu
doi:10.1038/457144a
http://links.ealert.nature.com/ctt?kn=52&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
Replacement of animals in research will never be possible p147
Roberto Caminiti
doi:10.1038/457147a
http://links.ealert.nature.com/ctt?kn=87&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Western prosperity is based on resources that are running out p147
Herve Philippe
doi:10.1038/457147b
http://links.ealert.nature.com/ctt?kn=98&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
'Subspecies' and 'race' should not be used as synonyms p147
Michael A. Patten
doi:10.1038/457147c
http://links.ealert.nature.com/ctt?kn=47&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
ESSAY
----------------------
Being Human: Love: Neuroscience reveals all p148
Poetry it is not. Nor is it particularly romantic. But reducing love
to its component parts helps us to understand human sexuality, and
may lead to drugs that enhance or diminish our love for another,
says Larry J. Young.
Larry J Young
doi:10.1038/457148a
http://links.ealert.nature.com/ctt?kn=192&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
BOOKS AND ARTS
----------------------
Future tigers of innovation pp149-150
Manufacturing in China and India has seen huge expansion, but
California's Silicon Valley can breathe easy [mdash] the countries
are still some way from becoming world innovation leaders, explains
Ming-Wei Wang.
Ming-Wei Wang reviews The Venturesome Economy: How Innovation Sustains
Prosperity in a More Connected World by Amar Bhide
doi:10.1038/457149a
http://links.ealert.nature.com/ctt?kn=219&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Innovative reading p150
Jenny Meyer
doi:10.1038/457150a
http://links.ealert.nature.com/ctt?kn=113&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
India's scientific legacy pp150-151
Jayant V. Narlikar reviews Technology at the Core: Science and
Technology with Indira Gandhi by Ashok Parthasarathi
doi:10.1038/457150b
http://links.ealert.nature.com/ctt?kn=108&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
The learning revolution pp151-152
Jean-Claude Bradley reviews Opening Up Education: The Collective
Advancement of Education Through Open Technology, Open Content,
and Open Knowledge
doi:10.1038/457151a
http://links.ealert.nature.com/ctt?kn=170&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Rare books in the flesh p152
Jay M. Pasachoff reviews Beautiful Science: Ideas that Changed
the World
doi:10.1038/457152a
http://links.ealert.nature.com/ctt?kn=82&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Organic chemistry: Molecular diversity by design pp153-154
Many organic syntheses are target-oriented [mdash] each multi-step
route is designed to make just one compound. But now a diversity-oriented
synthesis can make 80 different molecular skeletons in just a few steps.
Stuart L. Schreiber
doi:10.1038/457153a
http://links.ealert.nature.com/ctt?kn=97&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
50 & 100 years ago p154
doi:10.1038/457154a
http://links.ealert.nature.com/ctt?kn=67&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Immunology: Barrier to electrical storms pp155-156
Epilepsy is characterized by repetitive seizures due to abnormal
electrical activity in the brain. Immune cells promote development
of this disorder by mediating the breakdown of the blood-brain barrier.
Richard M. Ransohoff
doi:10.1038/457155a
http://links.ealert.nature.com/ctt?kn=69&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Quantum physics: Quantum force turns repulsive pp156-157
The experimental verification that a bizarre quantum effect [mdash]
the Casimir force [mdash] can manifest itself in its repulsive form
is pivotal not only for fundamental physics but also for nanotechnology.
Steve K. Lamoreaux
doi:10.1038/457156a
http://links.ealert.nature.com/ctt?kn=19&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Protein synthesis: Errors rectified in retrospect pp157-158
During protein synthesis, mistakes in adding amino acids to the growing
polypeptide chain are usually prevented. If they are not, a quality-control
mechanism ensures premature termination of erroneous sequences.
Kurt Fredrick and Michael Ibba
doi:10.1038/457157a
http://links.ealert.nature.com/ctt?kn=105&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Astrophysics: Magnetic bond pp158-159
How low-mass stars produce their ubiquitous magnetic fields has long
puzzled astronomers. Models of how Earth accomplishes this task could
hold the key to understanding the phenomenon on such stars.
Christopher M. Johns-Krull
doi:10.1038/457158a
http://links.ealert.nature.com/ctt?kn=61&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Structural biology: Anticancer drug target pictured pp159-160
Not only is the aromatase enzyme implicated in a common form of breast
cancer, but it also catalyses an unusual biochemical reaction. Its crystal
structure therefore offers both practical and fundamental insights.
Michael R. Waterman
doi:10.1038/457159a
http://links.ealert.nature.com/ctt?kn=224&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Molecular biology: A taste of umami p160
Sadaf Shadan
doi:10.1038/457160a
http://links.ealert.nature.com/ctt?kn=54&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
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----------------------
ARTICLE
----------------------
Quality control by the ribosome following peptide bond formation pp161-166
The DNA and RNA polymerases encode proofreading activities that help to
ensure the fidelity of the readout. The ribosome, which synthesizes
protein, was believed to lack a similar activity that would recognize
errors after a peptide bond had been formed. This study provides
evidence that the ribosome does have such a quality control mechanism.
It is shown that after an incorrect amino acid has been incorporated
into the growing polypeptide chain, there is a general loss of specificity
in the ribosome's active site, leading to an accumulation of errors that
triggers premature termination of peptide synthesis.
Hani S. Zaher and Rachel Green
doi:10.1038/nature07582
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=163&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Web Focus: International Year of Astronomy
To mark in 2009 the International Year of
Astronomy and 400 years since Galileo made
his first telescope observations, Nature has
commissioned a series of special articles and
reviews. Take a peak into the science article
of the future as Nature publishes the first ever
PDF with interactive figures*.
Access selected content free online for a month
including the interactive PDF*
http://links.ealert.nature.com/ctt?kn=180&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
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=====================================================================
----------------------
LETTERS
----------------------
Energy flux determines magnetic field strength of planets and stars pp167-169
The magnetic fields of Earth and Jupiter, along with those of rapidly rotating,
low-mass stars, are generated by convection-driven dynamos that may operate
similarly, although the field strengths vary. The critical factor unifying
field generation in such different objects, while still causing a large
variation, has been unclear. This paper reports an extension of a scaling law
derived from geodynamo models to rapidly rotating stars. The unifying principle
is that the energy flux available for generating the magnetic field sets the
field strength.
Ulrich R. Christensen, Volkmar Holzwarth and Ansgar Reiners
doi:10.1038/nature07626
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=117&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Measured long-range repulsive Casimir-Lifshitz forces pp170-173
In a vacuum, the Casimir-Lifshitz force causes friction effects that either
hinder or may be exploited in nanomechanical device applications. So far, only
attractive interactions have been measured, but theory predicts that when vacuum
is replaced with certain media, the Casimir-Lifshitz force can also be repulsive.
This effect is now experimentally confirmed in this study, which carefully chooses
a system of interacting materials immersed in a fluid. The measured repulsive
interaction is found to be weaker than the attractive force whereas in both cases
the magnitude of the force increases with decreasing surface separation.
J. N. Munday, Federico Capasso and V. Adrian Parsegian
doi:10.1038/nature07610
Abstract: http://links.ealert.nature.com/ctt?kn=189&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Electrically pumped photonic-crystal terahertz lasers controlled by boundary
conditions pp174-178
The spectral location of terahertz radiation, between optical and microwave
frequencies, has hindered the development of compact semiconductor terahertz
sources. One approach is to make use of photonic-crystal structures, which allows
surface emission of radiation so that the spectral and spatial modes can be
simultaneously engineered. To fabricate electrically-driven devices, it is
necessary to define boundary structures around the active, pumped area and this
paper now demonstrates a general technique to implement such boundaries.
Y. Chassagneux et al.
doi:10.1038/nature07636
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=207&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Early formation of evolved asteroidal crust pp179-182
Age and compositional data for the newly discovered, paired and differentiated meteorites
Graves Nunatak (GRA) 06128 and GRA 06129 are reported. These meteorites are feldspar-rich,
with andesite bulk compositions. Their age of 4.52 Gyr demonstrates formation early in
Solar System history, and their composition is most consistent with an origin as partial
melts from a volatile-rich, oxidized asteroid.
James M. D. Day et al.
doi:10.1038/nature07651
Abstract: http://links.ealert.nature.com/ctt?kn=156&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Diversity dynamics of marine planktonic diatoms across the Cenozoic pp183-186
Diatoms constitute a vital part of the oceanic ecosystem. As they are dependent on
silica, they are thought to have risen to prominence alongside grasslands in the
Miocene epoch, when the first large-scale weathering of grassland-derived silica
took place. A new analysis of an ocean-bed database contradicts that scenario; it
is shown that diatom diversity peaked at the Eocene-Oligocene boundary, long before
grasslands became prominent.
Daniel L. Rabosky and Ulf Sorhannus
doi:10.1038/nature07435
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Neural processing of auditory feedback during vocal practice in a songbird pp187-190
Living in noisy colonies, songbird vocal learning requires individuals to differentiate
self-generated vocalizations from other sound sources to accurately match the learned
song template. However, neurons responding to vocal output have not been identified.
This study identifies neurons in the auditory forebrain of zebra finch that specifically
responded to either song or playback perturbations, suggesting the existence of a
computational error-checking function in the forebrain auditory areas.
Georg B. Keller and Richard H. R. Hahnloser
doi:10.1038/nature07467
Abstract: http://links.ealert.nature.com/ctt?kn=166&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute
viral meningitis pp191-195
CD8+ T cells are shown to induce vascular leakage in acute viral meningitis not by
killing specific target cells, but by recruiting neutrophils and monocytes to
the blood-brain barrier.
Jiyun V. Kim, Silvia S. Kang, Michael L. Dustin and Dorian B. McGavern
doi:10.1038/nature07591
Abstract: http://links.ealert.nature.com/ctt?kn=159&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Memory CD8 T-cell compartment grows in size with immunological experience pp196-199
Repeated exposure to pathogens and generation of T-cell memory is thought to result in
attrition of the pre-existing memory T cell pool to maintain the overall size of the
memory compartment constant. This work shows that new effector memory cells can be
generated in large numbers without greatly impacting pre-existing memory.
Vaiva Vezys et al.
doi:10.1038/nature07486
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=210&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular
tumours pp200-204
Inflammatory heptocellular adenomas (IHCAs) show activation of an acute-phase
inflammatory response signalling pathways, and it is found that this is due to
gain-of function mutations in the IL6ST gene encoding gp130, a coreceptor for
IL-6 and other cytokines that activate inflammatory signalling pathways. These
mutations lead to constitutive activation of STAT3 signalling, contributing to
the inflammatory phenotype of IHACs.
Sandra Rebouissou et al.
doi:10.1038/nature07475
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=123&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
The dynein regulatory complex is required for ciliary motility and otolith
biogenesis in the inner ear pp205-209
In teleosts, proper balance and hearing depend on mechanical sensors in the inner
ear. These sensors include actin-based microvilli and microtubule-based cilia that
extend from the surface of sensory hair cells and attach to biomineralized 'ear stones',
orotoliths. This paper show that in zebra fish, fluid flow generated by cilia influences
the number, growth and localization of otoliths, as well as their mineralization during
development.
Jessica R. Colantonio et al.
doi:10.1038/nature07520
Abstract: http://links.ealert.nature.com/ctt?kn=216&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=111&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure
long-term survival pp210-214
To survive in an harsh environment, Caenorhabditis elegans larvae enter a state
called dauer, during which the worms do not eat, remain active, but become
stress-resistant and extremely long-lived. A typical dauer has reduced insulin-like
signalling, full nutrient stores and changes in its metabolism. It is shown that
without AMPK (LKB1) signalling dauers rapidly consume their stored energy and expire
prematurely, due to vital organ failure.
Patrick Narbonne and Richard Roy
doi:10.1038/nature07536
Abstract: http://links.ealert.nature.com/ctt?kn=124&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Analysis of combinatorial cis-regulation in synthetic and genomic promoters pp215-218
This paper presents a general thermodynamic model that accurately captures the
relationship between a gene promoter sequence, including weak, stastically
undetectable regulatory sites, and its expression output. The work implies a
relatively minor role of chromatin and will facilitate rational genetic design
in biotechnology and synthetic biology.
Jason Gertz, Eric D. Siggia and Barak A. Cohen
doi:10.1038/nature07521
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=164&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Structural basis for androgen specificity and oestrogen synthesis in human
aromatase pp219-223
Aromatase cytochrome P450 is the only enzyme in vertebrates known to catalyse
the biosynthesis of all oestrogens from androgens. This paper solves the X-ray
crystal structure of the first natural mammalian, full-length P450, human
placental aromatase.
Debashis Ghosh, Jennifer Griswold, Mary Erman and Walter Pangborn
doi:10.1038/nature07614
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
Naturejobs
----------------------
Prospects
Website gets a new look p225
Welcome to the improved Naturejobs website.
Gene Russo
doi:10.1038/nj7226-225a
http://links.ealert.nature.com/ctt?kn=206&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
FUTURES
----------------------
Survival p228
A life-changing experience.
Graeme Wistow
doi:10.1038/457228a
http://links.ealert.nature.com/ctt?kn=148&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
07 January 2009
Runx1 is required for the endothelial to haematopoietic cell transition but
not thereafter
Michael J. Chen et al.
doi:10.1038/nature07619
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=4&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Intersubunit coordination in a homomeric ring ATPase
Jeffrey R. Moffitt et al.
doi:10.1038/nature07637
Abstract: http://links.ealert.nature.com/ctt?kn=168&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=138&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
04 January 2009
Ca2+/calmodulin regulates salicylic-acid-mediated plant immunity
Liqun Du et al.
doi:10.1038/nature07612
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Deficiency of a [bgr]-arrestin-2 signal complex contributes to insulin resistance
Bing Luan et al.
doi:10.1038/nature07617
Abstract: http://links.ealert.nature.com/ctt?kn=135&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=165&m=30901229&r=MTUyNzA1NDkwOQS2&b=2&j=NDQ5MjU1OTES1&mt=1&rt=0
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