15 January 2009 Volume 457 Number 7227, pp 234 - 346
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EDITORIALS
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Science is not a spectator sport p235
As Barack Obama sets a fresh agenda for the US approach to climate change
and energy, scientists must make sure that they do not merely watch from
the sidelines.
doi:10.1038/457235a
http://links.ealert.nature.com/ctt?kn=128&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
The biggest threat? pp235-236
The Obama administration must help prevent terrorists from building a
nuclear device.
doi:10.1038/457235b
http://links.ealert.nature.com/ctt?kn=57&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
A lifesaving arrangement p236
George Bush's AIDS programme needs leadership and support from the
Obama administration.
doi:10.1038/457236a
http://links.ealert.nature.com/ctt?kn=27&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Geology: Old Faithful Erebus p238
doi:10.1038/457238a
http://links.ealert.nature.com/ctt?kn=68&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Chemical biology: Fluorescent timers p238
doi:10.1038/457238b
http://links.ealert.nature.com/ctt?kn=171&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Microscopy: Inside information p238
doi:10.1038/457238c
http://links.ealert.nature.com/ctt?kn=7&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Animal behaviour: Caught red hydrocarboned p238
doi:10.1038/457238d
http://links.ealert.nature.com/ctt?kn=255&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Molecular biology: A bilingual genetic code p238
doi:10.1038/457238e
http://links.ealert.nature.com/ctt?kn=120&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Ecological acoustics: Love buzz pp238-239
doi:10.1038/457238f
http://links.ealert.nature.com/ctt?kn=44&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Chemical synthesis: Take that, flu p239
doi:10.1038/457239a
http://links.ealert.nature.com/ctt?kn=73&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Cell biology: Lost nuclei p239
doi:10.1038/457239b
http://links.ealert.nature.com/ctt?kn=94&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Evolutionary biology: Headstrong p239
doi:10.1038/457239c
http://links.ealert.nature.com/ctt?kn=241&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Chemistry: An aromatic hybrid p239
doi:10.1038/457239d
http://links.ealert.nature.com/ctt?kn=159&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
JOURNAL CLUB
----------------------
Journal club p239
Jason W. Chin
doi:10.1038/457239e
http://links.ealert.nature.com/ctt?kn=176&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
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NEWS
----------------------
Science tipped to score in Obama cash stimulus pp240-241
Researchers jockey for a piece of the US economic package.
Jeff Tollefson
doi:10.1038/457240a
http://links.ealert.nature.com/ctt?kn=225&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Steven Chu prepares for power p241
Energy agency may be in for a shake-up.
Rex Dalton
doi:10.1038/457241a
http://links.ealert.nature.com/ctt?kn=64&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
On the record pp242-243
Barack Obama's nominees for top federal positions are not speaking
to the press until their appointments are confirmed, but they have
spoken out before.
doi:10.1038/457242a
http://links.ealert.nature.com/ctt?kn=74&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Ocean study draws ire pp243
Indo-German research cruise sets sail despite criticism.
Quirin Schiermeier
doi:10.1038/457243a
http://links.ealert.nature.com/ctt?kn=118&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Brain imaging studies under fire p245
Social neuroscientists criticized for exaggerating links between
brain activity and emotions.
Alison Abbott
doi:10.1038/457245a
http://links.ealert.nature.com/ctt?kn=60&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Where the rubber meets the garden pp246-247
China's leading conservation centre is facing down an onslaught
of rubber plantations. Jane Qiu reports from Jinghong.
Jane Qiu
doi:10.1038/457246a
http://links.ealert.nature.com/ctt?kn=86&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Genome deal seeks to accelerate pore sequencing pp248
doi:10.1038/457248a
http://links.ealert.nature.com/ctt?kn=113&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Obama urged to make exports and visas a priority pp248
doi:10.1038/457248b
http://links.ealert.nature.com/ctt?kn=35&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Scheduling problems beset delayed Mars mission pp248
doi:10.1038/457248c
http://links.ealert.nature.com/ctt?kn=254&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Suspended urologist set to return to Austrian university pp249
doi:10.1038/457249a
http://links.ealert.nature.com/ctt?kn=80&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Coal conversion plant fires up in China pp249
doi:10.1038/457249b
http://links.ealert.nature.com/ctt?kn=51&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Italian universities lose freedom to appoint staff pp249
doi:10.1038/457249c
http://links.ealert.nature.com/ctt?kn=13&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Corrections pp249
doi:10.1038/457249d
http://links.ealert.nature.com/ctt?kn=203&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
NEWS FEATURES
----------------------
Bush's legacy: The wasted years pp250-251
In the first of three features on the legacy of the Bush administration,
Declan Butler looks at the United States' failure to deal with the
risks of nuclear proliferation.
doi:10.1038/457250a
http://links.ealert.nature.com/ctt?kn=138&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Bush's legacy: 43 by the numbers pp252-253
A look at George W. Bush's legacy in science.
Mark Schrope
doi:10.1038/457252a
http://links.ealert.nature.com/ctt?kn=257&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Bush legacy: An unlikely champion pp254-256
Was setting up PEPFAR � a massive HIV treatment programme � the best thing
that President Bush ever did? Erika Check Hayden investigates.
Erika Check Hayden
doi:10.1038/457254a
http://links.ealert.nature.com/ctt?kn=246&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
OPINION
Choosing between batteries or biomass to stay on the road p257
Lucien F. Trueb
doi:10.1038/457257a
http://links.ealert.nature.com/ctt?kn=123&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Genetic records threaten patients' privacy p257
Tom Goffman
doi:10.1038/457257b
http://links.ealert.nature.com/ctt?kn=221&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Japan should intensify embryonic stem-cell investigations p257
Hisashi Moriguchi and Chifumi Sato
doi:10.1038/457257c
http://links.ealert.nature.com/ctt?kn=234&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Research on primate brains is scrutinized and must be justified p257
Kevan A. C. Martin
doi:10.1038/457257d
http://links.ealert.nature.com/ctt?kn=38&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
COMMENTARY
----------------------
OPINION
Your inbox, Mr President pp258-261
Rejuvenate the Environmental Protection Agency. End the stem-cell ban.
Re-engage with the UN on climate change. Six leading voices tell
Nature what the new US president needs to do to move beyond the
Bush legacy.
doi:10.1038/457258a
http://links.ealert.nature.com/ctt?kn=29&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
ESSAY
----------------------
OPINION
Fifty years of pheromones pp262-263
Powerful chemical signals have been identified in moths, elephants
and fish, recounts Tristram D. Wyatt. But, contrary to stories in
the popular press, the race is still on to capture human scents.
Tristram D. Wyatt
doi:10.1038/457262a
http://links.ealert.nature.com/ctt?kn=95&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
BOOKS AND ARTS
----------------------
OPINION
How to end the copyright wars pp264-265
A high-profile copyright activist is fighting for traditional publishers
to stop criminalizing their own readers, explains Jonathan Zittrain.
Jonathan Zittrain reviews Remix: Making Art and Commerce Thrive in
the Hybrid Economy by Lawrence Lessig
doi:10.1038/457264a
http://links.ealert.nature.com/ctt?kn=186&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Fusion history beyond the fiascos pp265-266
Jean Jacquinot reviews Sun in a Bottle: The Strange History of Fusion
and the Science of Wishful Thinking by Charles Seife
doi:10.1038/457265a
http://links.ealert.nature.com/ctt?kn=102&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Our culture of obsession pp266-267
Ian Brooks reviews Obsession: A History by Lennard J. Davis
doi:10.1038/457266a
http://links.ealert.nature.com/ctt?kn=59&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Q&A: Chemistry in the kitchen p267
Voted the world's best restaurant, Spain's elBulli near Barcelona offers
an unusual culinary experience, from hot velvet-crab aspic with mini-corncob
couscous to ice-cold liquorice nitro-dragon dessert. Innovative head chef
Ferran Adria explains how science and haute cuisine can work together.
Jascha Hoffman reviews A Day At elBulli by Ferran Adria, Albert Adria and Juli Soler
doi:10.1038/457267a
http://links.ealert.nature.com/ctt?kn=226&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Stem cells: Tailor-made diseased neurons pp269-270
How can we investigate a disease affecting neurons, which cannot be isolated
from patients for analysis? As the study of one neurological disorder shows,
a first step might be to make patient-specific neurons.
Michael Sendtner
doi:10.1038/457269a
http://links.ealert.nature.com/ctt?kn=258&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Fluid dynamics: Rotating convection on the edge pp270-271
Turbulent convection in a rotating body is a common but poorly understood
phenomenon in astrophysical and geophysical settings. Consideration of
boundary effects offers a fresh angle on this thorny problem.
Peter L. Read
doi:10.1038/457270a
http://links.ealert.nature.com/ctt?kn=45&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Synthetic biology: The yin and yang of nature pp271-272
Oscillations in gene expression regulate various cellular processes and
so must be robust and tunable. Interactions between both negative and
positive feedback loops seem to ensure these features.
Jeff Gore and Alexander van Oudenaarden
doi:10.1038/457271a
http://links.ealert.nature.com/ctt?kn=55&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Condensed-matter physics: Going with the flow pp273-274
Observations of superfluid behaviour - flow without friction -
of unusual character in a condensed-matter system pave the way to
investigations of superfluidity in systems that are out of thermal
equilibrium.
Jonathan Keeling and Natalia G. Berloff
doi:10.1038/457273a
http://links.ealert.nature.com/ctt?kn=180&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
50 & 100 years ago p273
doi:10.1038/457273b
http://links.ealert.nature.com/ctt?kn=24&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Materials science: Bend, fold and stretch p274
Liesbeth Venema
doi:10.1038/457274a
http://links.ealert.nature.com/ctt?kn=235&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Obituary: Edwin Salpeter (1924-2008) p275
Multi-talented astrophysicist and public servant.
Saul A. Teukolsky and Ira Wasserman
doi:10.1038/457275a
http://links.ealert.nature.com/ctt?kn=11&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
ARTICLES
----------------------
Induced pluripotent stem cells from a spinal muscular atrophy patient pp277-280
This paper generates an iPS cell line from patients with spinal muscular atrophy,
an autosomal recessive genetic disorder that is one of the most common inherited
forms of neurological disease in children.
Allison D. Ebert et al.
doi:10.1038/nature07677
Abstract: http://links.ealert.nature.com/ctt?kn=252&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=136&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Photon capture and signalling by melanopsin retinal ganglion cells pp281-287
Intrinsically photosensitive retinal ganglion cells sense and transmit light
information to brain centres that control non-image-forming visual functions,
such as the pupillary light reflex and circadian photoentrainment. This paper
describes the biophysical properties of these melanopsin-containing cells.
It is found that single-photons of light are sufficient to elicit large and
prolonged responses.
Michael Tri H. Do et al.
doi:10.1038/nature07682
Abstract: http://links.ealert.nature.com/ctt?kn=154&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=270&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
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LETTERS
----------------------
A binary origin for `blue stragglers' in globular clusters pp288-290
Blue stragglers in globular clusters are abnormally massive stars that
should have evolved off the stellar main sequence long ago. There are
two processes that can create these objects: direct stellar collisions
or binary evolution. This study reports that there is a clear, but
sublinear, correlation between the number of blue stragglers found in
a cluster core and the total stellar mass contained within it, and it
is concluded that most blue stragglers come from binary systems.
Christian Knigge, Nathan Leigh and Alison Sills
doi:10.1038/nature07635
Abstract: http://links.ealert.nature.com/ctt?kn=140&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=260&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Collective fluid dynamics of a polariton condensate in a semiconductor
microcavity pp291-295
Recently, evidence has been reported of a Bose–Einstein condensation in a
semiconductor microcavity formed by exciton polaritons. It has been anticipated
that superfluid-like behaviour may be observed in such polariton condensates,
although it would be of an unusual character, as microcavity polaritons are
short-lived and the condensates are therefore not in thermal equilibrium. This
work has developed a pulsed optical excitation technique to set a microcavity
polariton condensate in motion and observes clear manifestations of collective
dynamics with superfluid characteristics, such as flow without resistance when
crossing a defect.
A. Amo et al.
doi:10.1038/nature07640
Abstract: http://links.ealert.nature.com/ctt?kn=192&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Competition between the pseudogap and superconductivity in the high-Tc copper
oxides pp296-300
In a classical Bardeen-Cooper-Schrieffer superconductor, pairing and coherence
are established simultaneously below the critical transition temperature (Tc).
But in the copper oxide high- Tc superconductors, a pseudogap extends above Tc.
Spectral gaps arising from pairing precursors are qualitatively similar to those
caused by competing states, rendering a standard approach to their analysis
inconclusive. This paper reports that the spectral weight of the superconducting
coherent peak increases away from the node following the trend of the superconducting
gap, but then starts to decrease in the antinodal region.
Takeshi Kondo et al.
doi:10.1038/nature07644
Abstract: http://links.ealert.nature.com/ctt?kn=266&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Boundary layer control of rotating convection systems pp301-304
Turbulent rotating convection controls many observed features in stars and planets,
such as magnetic fields. It has been argued that the influence of rotation on
turbulent convection dynamics is governed by the ratio of the relevant global-scale
forces: the Coriolis force and the buoyancy force. This paper presents results
from laboratory and numerical experiments which exhibit transitions between
rotationally dominated and non-rotating behaviour that are not determined by this
global force balance. Instead, the transition is controlled by the relative
thicknesses of the thermal (non-rotating) and Ekman (rotating) boundary layers.
Eric M. King et al.
doi:10.1038/nature07647
Abstract: http://links.ealert.nature.com/ctt?kn=222&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=223&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
The braincase and jaws of a Devonian `acanthodian' and modern gnathostome
origins pp305-308
This paper presents the first detailed description of the braincase of Ptomacanthus,
an acanthodian that lived in the Early Devonian. The results show that acanthodians
were probably not a natural group: Ptomacanthus was either a very early relative of
sharks, or close to the common ancestry of all modern jawed vertebrates.
Martin D. Brazeau
doi:10.1038/nature07436
Abstract: http://links.ealert.nature.com/ctt?kn=251&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
A tunable synthetic mammalian oscillator pp309-312
A synthetic sense-antisense circuit has now been developed in mammalian cells, which
produces autonomous, self-sustained and tunable cyclic gene expression. This synthetic
mammalian clock will be used to improve our understanding of natural circadian clocks
and associated diseases.
Marcel Tigges, Tatiana T. Marquez-Lago, Jorg Stelling and Martin Fussenegger
doi:10.1038/nature07616
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=88&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Experience leaves a lasting structural trace in cortical circuits pp313-317
Dendritic spine morphogenesis is sensitive to experience-dependent plasticity, but
whether or not experience-induced structural changes outlast the experience itself
is unknown. This paper reveals that long-lived spine density increases in response
to monocular deprivation that persist beyond the duration of time the eye was closed.
Subsequent deprivation fails to induce further spine density increases, suggesting
initial experience may provide a structural experience 'trace' that could be utilized
in response to further functional shifts.
Sonja B. Hofer, Thomas D. Mrsic-Flogel, Tobias Bonhoeffer and Mark Hubener
doi:10.1038/nature07487
Abstract: http://links.ealert.nature.com/ctt?kn=161&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Role for Spi-C in the development of red pulp macrophages and splenic iron
homeostasis pp318-321
The PU.1-related transcription factor Spi-C controls the development of a tissue
macrophage subset in the spleen involved in the removal of red blood cells. Spi-C
deficient mice fail to phagocytose trapped red blood cells.
Masako Kohyama et al.
doi:10.1038/nature07472
Abstract: http://links.ealert.nature.com/ctt?kn=99&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=199&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
The insect nephrocyte is a podocyte-like cell with a filtration slit
diaphragm pp322-326
This paper shows that insects possess a structure very similar, both anatomically and
functionally, to the blood-filtering tissue of the vertebrate kidney, and raises the
possibility that components of the vertebrate excretory system were inherited from
their invertebrate ancestors. It is also shown that fly orthologues of the major
constituents of the slit diaphragm of the kidney form a complex of interacting
proteins similar to the vertebrate slit diaphragm complex.
Helen Weavers et al.
doi:10.1038/nature07526
Abstract: http://links.ealert.nature.com/ctt?kn=212&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=213&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids
pp327-331
Polploidy is a common feature of many plants, and in addition some plants exist as
intra- and interspecific hybrinds. Such plants display growth vigour, and genes
involved in metabolism and energy, photosynthesis and starch accumulation are
upregulated compared to the parents. This study examines the mechanistic basis of
increased growth, and reports that epigenetic modifications of circadian clock
regulators mediates the expression of genes in photosynthetic and metabolic pathways.
Zhongfu Ni et al.
doi:10.1038/nature07523
Abstract: http://links.ealert.nature.com/ctt?kn=183&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Transcription inactivation through local refolding of the RNA polymerase structure
pp332-335
A crystal structure of the antibiotic myxopyronin bound to bacterial RNA polymerase
(RNAP) reveals insights into how the antibiotic binds to the transcription
initiation complex and the mechanism of open complex formation.
Georgiy A. Belogurov et al.
doi:10.1038/nature07510
Abstract: http://links.ealert.nature.com/ctt?kn=210&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=189&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Dynamics of DNA replication loops reveal temporal control of lagging-strand
synthesis pp336-339
Both strands of DNA are replicated simultaneously, but they have opposite
polarities. A trombone model has been proposed to explain how replication
machinery that moves in one direction can accomplish this feat. In this model,
the lagging strand forms a loop that allows it to enter the replication machinery
in the same direction as the leading strand. This study uses single molecule
techniques to examine this process in real time, and it finds that this loop is
reinitiated with the priming of every Okazaki fragment, and released when the
previous fragment is encountered by the replisome.
Samir M. Hamdan et al.
doi:10.1038/nature07512
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
CORRIGENDUM
----------------------
Microfibre-nanowire hybrid structure for energy scavenging p340
Yong Qin, Xudong Wang and Zhong Lin Wang
doi:10.1038/nature07628
http://links.ealert.nature.com/ctt?kn=108&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
Naturejobs
----------------------
Prospects
A question of rank p341
Finding a job that satisfies.
Gene Russo
doi:10.1038/nj7227-341a
http://links.ealert.nature.com/ctt?kn=224&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Postdocs and Students
Fear factor p342
Job prospects are looking gloomy as the economic downturn runs its course, but
there are bright spots for some. Genevive Bjorn reports on ways to shelter from
the storm.
Genevive Bjorn
doi:10.1038/nj7227-342a
http://links.ealert.nature.com/ctt?kn=47&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Making memories p346
You must remember this ...
John Frizell
doi:10.1038/457346a
http://links.ealert.nature.com/ctt?kn=245&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
14 January 2009
Synaptic depression enables neuronal gain control
Jason S. Rothman, Laurence Cathala, Volker Steuber and R. Angus Silver
doi:10.1038/nature07604
Abstract: http://links.ealert.nature.com/ctt?kn=248&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=133&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic
transfer RNA
Sebastian Leidel et al.
doi:10.1038/nature07643
Abstract: http://links.ealert.nature.com/ctt?kn=263&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=178&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Large-scale pattern growth of graphene films for stretchable transparent electrodes
Keun Soo Kim et al.
doi:10.1038/nature07719
Abstract: http://links.ealert.nature.com/ctt?kn=134&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=227&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
11 January 2009
Transcriptome sequencing to detect gene fusions in cancer
Christopher A. Maher et al.
doi:10.1038/nature07638
Abstract: http://links.ealert.nature.com/ctt?kn=105&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=147&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Adaptive immune features of natural killer cells
Joseph C. Sun, Joshua N. Beilke and Lewis L. Lanier
doi:10.1038/nature07665
Abstract: http://links.ealert.nature.com/ctt?kn=233&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Genetic architecture of mouse skin inflammation and tumour susceptibility
David A. Quigley et al.
doi:10.1038/nature07683
Abstract: http://links.ealert.nature.com/ctt?kn=205&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=264&m=30970037&r=MTUyNzA1NDkwOQS2&b=2&j=NDUxMzEwNTUS1&mt=1&rt=0
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