Signaling Gateway - 12 December 2008
http://links.ealert.nature.com/ctt?kn=34&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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P53: ARGININE METHYLATION PROMOTES CELL-CYCLE ARREST
Following DNA damage, PRMT5-stimulated arginine methylation of p53
elicits cell-cycle arrest in favor of apoptosis.
Original research paper: Nature Cell Biology, 10, 1431-1439 (2008)
http://links.ealert.nature.com/ctt?kn=18&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
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Selected Updates
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SIGNALLING: MAKING MORE OF A MARK
Notch 1 is required for Akt-dependent oncogenic transformation and
melanocyte growth.
Original research paper: J. Clin. Invest. 118, 3660?3670 (2008)
http://links.ealert.nature.com/ctt?kn=24&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
GENE NETWORKS: NETWORK ANALYSIS GETS DYNAMIC
Expression analyses of the Saccharomyces cerevisiae metabolic network
illuminate the timing of mRNA transcription and degradation.
Original research paper: Nature Biotechnol. 26, 1251-1259 (2008)
http://links.ealert.nature.com/ctt?kn=29&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
ION CHANNELS: SMALL CONDUCTANCE, BIG EFFECTS
Stress hormones activate beta-adrenoceptor G-protein-coupled
receptors to enhance long-term potentiation (LTP), providing an
explanation for why emotionally salient memories are better
remembered than neutral ones.
Original research paper: J. Neurosci. 28, 10803-10813 (2008)
http://links.ealert.nature.com/ctt?kn=3&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
More Updates:
http://links.ealert.nature.com/ctt?kn=22&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
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Research Library
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TRANSFORMING GROWTH FACTOR-BETA 'REPROGRAMS' THE DIFFERENTIATION OF
T HELPER 2 CELLS AND PROMOTES AN INTERLEUKIN 9-PRODUCING SUBSET
Nature Immunology 9, 1341-1346 (2008)
http://links.ealert.nature.com/ctt?kn=27&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
META-ANALYSIS OF GENOME-WIDE ASSOCIATION DATA IDENTIFIES FOUR NEW
SUSCEPTIBILITY LOCI FOR COLORECTAL CANCER
Nature Genetics 40, 1426-1435 (2008)
http://links.ealert.nature.com/ctt?kn=26&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
BACH1 INHIBITS OXIDATIVE STRESS-INDUCED CELLULAR SENESCENCE BY
IMPEDING P53 FUNCTION ON CHROMATIN
Nature Structural & Molecular Biology 15, 1246-1254 (2008)
http://links.ealert.nature.com/ctt?kn=20&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
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Signaling News
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NATURE INSIGHT: QUANTITATIVE GENETICS
http://links.ealert.nature.com/ctt?kn=11&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
Recent advances in genomic technologies have led to a renewed
interest in quantitative genetics. One approach for examining complex
traits in humans is the genome-wide association (GWA) study, which
compares variation across the genomes of two groups of individuals
and looks for markers that are associated with one group more than
the other. This Nature Insight highlights progress in teasing apart
the basis for complex traits using GWA studies, and includes a FREE
review on reverse-engineering the 'genotype?phenotype map'.
http://links.ealert.nature.com/ctt?kn=12&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
More News
http://links.ealert.nature.com/ctt?kn=28&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
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Gateway Updates
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PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - DECEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=35&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
The Structural Genomics Knowledgebase is a free portal to research
data and other resources from the Protein Structure Initiative and
is designed to keep structural biologists informed of the latest
developments in their field. This month's update features the
following articles:
This month's update features articles on:
The structure of the adenosine A2A G protein-coupled receptor
http://links.ealert.nature.com/ctt?kn=33&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
The pro-apoptotic protein BAX
http://links.ealert.nature.com/ctt?kn=13&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
The Human Cancer Pathway Protein Interaction Network
http://links.ealert.nature.com/ctt?kn=36&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
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Job of the Week
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Scientist II
Employer: SAIC Frederick, Inc.
Location: Frederick, Maryland
http://links.ealert.nature.com/ctt?kn=9&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
SAIC Frederick, Inc., the operations and technical support contractor
for the National Cancer Institute-Frederick, has a new opportunity
for a Scientist II in the Center for Advanced Preclinical Research.
The successful applicant will evaluate a variety of experimental
anticancer agents in genetically engineered mouse models of cancer.
More Jobs:
http://links.ealert.nature.com/ctt?kn=2&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
To advertise a job in this spot, please contact Naturejobs.
http://links.ealert.nature.com/ctt?kn=19&m=30659830&r=MTQyMzYwODk0MgS2&b=2&j=NDM4NDAxMDAS1&mt=1&rt=0
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