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Nature Reviews Microbiology contents January 2009 Volume 7 Number 1 pp 1-87


January 2009 Volume 7 Number 1

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This month's FEATURED article:

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells
Ralph R. Isberg, Tamara J. O'Connor and Matthew Heidtman
p883 | doi:10.1038/nrmicro2012


In this issue
p1 | doi:10.1038/nrmicro2065

Editorial: Antibiotics get their day
p2 | doi:10.1038/nrmicro2066
The increasing problem of antibiotic resistance is regarded as a serious
threat to public health. Can education help to preserve the effectiveness
of antibiotics?

Bacterial transcription: Sigma 54 minds the gap
p3 | doi:10.1038/nrmicro2058

Environmental microbiology | Bacterial pathogenesis | Viral infection
p4 | doi:10.1038/nrmicro2059

Archaea: Viral exclusion order
p4 | doi:10.1038/nrmicro2067

Viruses and cancer: Engineering viral cancer killers
p5 | doi:10.1038/nrmicro2054

Bacterial physiology: RodZ helps E. coli stay in shape
p5 | doi:10.1038/nrmicro2061

Biofilms: A little help from a phage friend
p6 | doi:10.1038/nrmicro2063

Fungal pathogenesis: Fungal communication gets volatile
p6 | doi:10.1038/nrmicro2064

Bacterial physiology: New alarm call for spores
p7 | doi:10.1038/nrmicro2060

Fishy business
Mohammed Sebaihia
p9 | doi:10.1038/nrmicro2055

In the News
p10 | doi:10.1038/nrmicro2062

The Legionella pneumophila replication vacuole: making a cosy niche
inside host cells
Ralph R. Isberg, Tamara J. O'Connor and Matthew Heidtman
p13 | doi:10.1038/nrmicro1967
In this Review, the authors evaluate the strategies that the intracellular
pathogen Legionella pneumophila uses to establish growth inside cells and
probe why this microorganism has accumulated an unprecedented number of
translocated substrates that are targeted to host cells.

How do bacterial cells ensure that metalloproteins get the correct metal?
Kevin J. Waldron and Nigel J. Robinson
p25 | doi:10.1038/nrmicro2057
Metalloproteins constitute up to one-third of the total cellular cohort of
proteins, and cells have evolved elaborate mechanisms for scavenging and
storing metal atoms. In this Review, the authors summarize the homeostatic
mechanisms by which bacteria and archaea ensure that metalloproteins
receive and bind the correct metal.

Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium
Klas Flardh and Mark J. Buttner
p36 | doi:10.1038/nrmicro1968
In the filamentous bacteria Streptomyces, morphological differentiation is
closely integrated with fundamental growth and cell-cycle processes, as well as
with truly complex multicellular behaviour. Important progress is being made
towards understanding the intriguing processes that underlie growth and
morphogenesis in Streptomyces.

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans
Caroline Demangel, Timothy P. Stinear and Stewart T. Cole
p50 | doi:10.1038/nrmicro2016
Humans contract Buruli ulcer following infection with Mycobacterium ulcerans,
a slow-growing toxin producer that evolved from Mycobacterium marinum.
Both M. ulcerans and M. marinum are waterborne, but M. ulcerans is associated
with various insects that might serve as vectors. This Review summarizes
recent findings and explains how the toxin, a polyketide called mycolactone,
acts on immune cells.

Genome-scale analyses of health-promoting bacteria: probiogenomics
Marco Ventura, Sarah O'Flaherty, Marcus J. Claesson, Francesca Turroni, Todd R. Klaenhammer, Douwe van Sinderen and Paul W. O'Toole
p61 | doi:10.1038/nrmicro2047
The human gut microbiota contain health-promoting indigenous species
(probiotic bacteria) that are commonly consumed as live dietary supplements.
The genomics of probiotic bacteria - or probiogenomics - could shed light
on how beneficial gut bacteria adapt to the gut environment and promote
better gut health.


A dynamic view of the spread and intracellular distribution of Salmonella enterica
Pietro Mastroeni, Andrew Grant, Olivier Restif and Duncan Maskell
p73 | doi:10.1038/nrmicro2034
Using Salmonella enterica infection as a model, Mastroeni and colleagues
discuss how developing an understanding of bacterial proliferation and
dissemination in a host during infection is a prerequisite for the
development of targeted drugs and vaccines. They also highlight a new
technique for monitoring the spread of a bacterial population in vivo.

Doomsday postponed? Preventing and reversing epidemics of drug-resistant tuberculosis
Christopher Dye
p81 | doi:10.1038/nrmicro2048
Despite bleak news on the spread of drug-resistant tuberculosis (TB) strains
in Eastern Europe and southern Africa, there are signs that drug-resistant
TB can be controlled. Evidence suggests that good control programmes,
using the current suite of anti-TB drugs, can cut the number of multiply
resistant TB cases even more quickly than drug-sensitive cases.

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