World Stem Cell Summit 2010

Thursday, December 18, 2008

Nature Reports Stem Cells Contents: December 18 2008

December 18 2008

Top stories

Cancer stem cells

Cancer stem cells, becoming common
Tumour cells that can initiate a new tumour are not so rare as previously thought, putting the concept of the 'cancer stem cell' under the spotlight again

The cancer stem cell concept is controversial and contentious, and that's even more true with Sean Morrison's Nature article finding that melanoma cancer stem cells are common and the standard assays flawed. Correspondence sent to Nature and Nature Reports arising from that publication can be found on the Niche.

Also: a web focus featuring NPG research articles, including a news and views by Connie Eaves; a review by Irving Weissman discussing the cancer stem cell hypothesis in experimental design and therapies; and a compilation of research highlights, meeting reports and features on cancer stem cells from Nature Reports Stem Cells.

Stem cell tourism and clinical trials

Offshore stem cell treatments require sensitive regulation
A commentary by Sorapop Kiatpongsan and Douglas Sipp analyses the costs, risks and benefits of unregulated stem cell procedures for patients, practitioners, scientists and governments

Stick to the guidelines and fewer get hurt
The ISSCR hopes its handbook will prompt regulators and governments to shut shady clinics.

Short articles keying off recent publications:

How to make a stem cell home
Making blood stem cell niches in vivo and in vitro
Chan, C. K. F. et al. Nature advance online publication, doi:10.1038/nature07547 (10 December 2008).
Lutolf, M. P. et al. Integr. Biol. doi:10.1039/b815718a (published online 21 November 2008).

Human mammary glands in mice
A new technique identifies regenerative cells
Eirew, P. et al. Nature Med. Published online, doi:10.1038/nm.1791

Stem cell lines accrue cancer mutations
Chromosome instability is a problem for long-term culture of human embryonic stem cells
Lefort, N., et al. Nat Biotechnol. Published online: 23 November 2008 doi: 10.1038/nbt.1509
Spits, C., et al. Nat Biotechnol. Published online: 23 November 2008 doi:10.1038/nbt.1510

From one, many genetically different embryonic stem cells
Copy number variants crop up in routine ES cell culture
Liang, Q., Conte, N., Skarnes, W.C. & Bradley, A. Proc. Natl. Acad. Sci. USA. 105, 17453-17456 (2008)

A neuron's molecular MapQuest
CDK5 plays a critical role in integrating new neurons into the adult brain
Jessberger, S. et al. PLoS Biol. 6, e272 (2008); doi:10.1371/journal.pbio.0060272.

Adult monkey cells reprogrammed
Mouse, human and monkey cells can be induced to pluripotency
Liu, H. et al. Cell Stem Cells 3, 587-590 (2008).

Poising ES cells for differentiation
The histone variant H2AZ cooperates with Polycomb proteins
Creyghton, M.P. et al. Cell 135, 649-661 (2008).

Other stem cell content on NPG

Nature Reviews Molecular Cell Biology has articles on human embryo and embryonic stem cell research in the United Kingdom (by Robin Lovell-Badge) and in the United States (by Richard Hynes).

See also our feature comparing policy trajectories in Germany, the UK, and the US.

In an article in Nature Methods, Nathan Blow describes how better cell lines along with improved differentiation and culture technologies are pulling more researchers into stem cell research.

Got an opinion to share? Let us know at

Nature Reports Stem Cells is an interactive forum for stem cell scientists and other stakeholders to communicate about the research, policy, ethics, business and medicine of stem cell science. And it's all free!

Visit Nature Reports Stem Cells

You have been sent this table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your account at:
(You will need to log in to be recognised as a registrant).

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our feedback department

Nature Publishing Group | 345 Park Ave South | New York | NY 10010-1707 | USA Nature Publishing Group's worldwide offices: .London - Paris - Munich - New Delhi - Tokyo - Melbourne - .San Diego - San Francisco - Washington - New York - Boston


Any Comments ?.......


World Time