18 December 2008 Volume 456 Number 7224, pp 837 - 1008
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EDITORIALS
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Machine-makers matter p837
Nature is pleased to name Lyn Evans, the project manager of the Large Hadron Collider, as its 2008
newsmaker of the year.
doi:10.1038/456837a
http://links.ealert.nature.com/ctt?kn=351&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Facilitating the future pp837-838
Europe needs a better way to plan, prioritize and fund the next generation of research infrastructure.
doi:10.1038/456837b
http://links.ealert.nature.com/ctt?kn=303&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Eyes west p838
Could the United States topple Europe as the driver of international climate-change regulations?
doi:10.1038/456838a
http://links.ealert.nature.com/ctt?kn=286&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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A healthier haul p840
As an end of the year round-up we asked Nature's editors to nominate their favourite papers published
elsewhere this year. For a pick of favourites from Nature itself, see page xii.
doi:10.1038/456840a
http://links.ealert.nature.com/ctt?kn=81&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Biophysics: Mob rule p840
doi:10.1038/456840b
http://links.ealert.nature.com/ctt?kn=139&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Neuroscience: Glia on fire p840
doi:10.1038/456840c
http://links.ealert.nature.com/ctt?kn=52&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Zoology: Queen Bee p840
doi:10.1038/456840d
http://links.ealert.nature.com/ctt?kn=220&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Nanotechnology: Super speakers p840
doi:10.1038/456840e
http://links.ealert.nature.com/ctt?kn=150&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Genetics: Many but rare p841
doi:10.1038/456841a
http://links.ealert.nature.com/ctt?kn=140&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Astrophysics: Cosmic tiara p841
doi:10.1038/456841b
http://links.ealert.nature.com/ctt?kn=250&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Evolution: Genetic bric-a-brac p841
doi:10.1038/456841c
http://links.ealert.nature.com/ctt?kn=142&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Biochemistry: Catalytic creator p841
doi:10.1038/456841d
http://links.ealert.nature.com/ctt?kn=48&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Organic chemistry: Tag-team catalysts p841
doi:10.1038/456841e
http://links.ealert.nature.com/ctt?kn=124&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Neuroscience: MRI beebop p841
doi:10.1038/456841f
http://links.ealert.nature.com/ctt?kn=208&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Human biology: Bird's eye view pp841-842
doi:10.1038/456841g
http://links.ealert.nature.com/ctt?kn=133&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Physics: Black holes on the strand p842
doi:10.1038/456842a
http://links.ealert.nature.com/ctt?kn=145&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Cell biology: Bent out of shape p842
doi:10.1038/456842b
http://links.ealert.nature.com/ctt?kn=70&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Evolution: Yeast rewired p842
doi:10.1038/456842c
http://links.ealert.nature.com/ctt?kn=287&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Geology: Magma mix-up p842
doi:10.1038/456842d
http://links.ealert.nature.com/ctt?kn=132&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Molecular biology: Shaping up p842
doi:10.1038/456842e
http://links.ealert.nature.com/ctt?kn=201&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
A breath of fresh air p843
doi:10.1038/456843a
http://links.ealert.nature.com/ctt?kn=313&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Immunology: Successful delivery p843
doi:10.1038/456843b
http://links.ealert.nature.com/ctt?kn=199&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Photonics: Telescopic TV p843
doi:10.1038/456843c
http://links.ealert.nature.com/ctt?kn=252&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Neurobiology: The motor-neuron driver p843
doi:10.1038/456843d
http://links.ealert.nature.com/ctt?kn=123&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Geoscience: The speed of ice p843
doi:10.1038/456843e
http://links.ealert.nature.com/ctt?kn=143&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
This year in Nature p843
Nature's manuscript editors made a selection of 'favourites' from
the papers we published in 2008.
doi:10.1038/456xiia
http://links.ealert.nature.com/ctt?kn=97&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Nature's newsmaker of the year: Lyn Evans
Nature is pleased to honour Lyn Evan's achievement as the 2008
newsmaker of the year. For almost 15 years, he has worked as the
project manager of the Large Hadron Collider (LHC), located at CERN,
near Geneva, Switzerland and did more than any other to build the
world's newest and most powerful particle accelerator.
Access selected content from the End of Year Nature News special free
online including the newsmaker of the year
http://links.ealert.nature.com/ctt?kn=102&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
find out more about the LHC by ordering your FREE print copy of
Nature's Insight on the LHC
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NEWS
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News 2008 pp844-845
The year in which...
Ashley Yeager
doi:10.1038/456844a
http://links.ealert.nature.com/ctt?kn=169&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Climate talks defer major challenges pp846-847
Minor progress in Poland on adaptation and deforestation sets the stage
for Copenhagen in 2009.
Jeff Tollefson
doi:10.1038/456846a
http://links.ealert.nature.com/ctt?kn=311&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Europe agrees emissions deal p847
Heavy industry wins key concessions in last-minute negotiations.
Quirin Schiermeier
doi:10.1038/456847a
http://links.ealert.nature.com/ctt?kn=40&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Nobel physicist to run energy agency pp849-850
Obama appointments likely to focus on renewable energy and implementing
cap and trade.
Eric Hand
doi:10.1038/456849a
http://links.ealert.nature.com/ctt?kn=310&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Imaging advances provide immune-cell breakthroughs p850
Microscopy tracks living cells as they move through the body.
Erika Check Hayden
doi:10.1038/456850a
http://links.ealert.nature.com/ctt?kn=42&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Salary for CIRM head despite deficit pp851-851
Outcry as stem-cell agency puts chairman on the payroll.
Erika Check Hayden
doi:10.1038/456851a
http://links.ealert.nature.com/ctt?kn=129&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
US bioindustry calls for government bailout pp852-852
doi:10.1038/456852a
http://links.ealert.nature.com/ctt?kn=277&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Vatican formalizes rules on human stem-cell research pp852-852
doi:10.1038/456852b
http://links.ealert.nature.com/ctt?kn=153&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Michigan State wins battle to host isotope accelerator pp852-852
doi:10.1038/456852c
http://links.ealert.nature.com/ctt?kn=160&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
US nanotechnology plan lacks risk research pp853-853
doi:10.1038/456853a
http://links.ealert.nature.com/ctt?kn=69&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Rift-valley countries set for geothermal power pp853-853
doi:10.1038/456853b
http://links.ealert.nature.com/ctt?kn=261&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Lectures gain electronic life in Egyptian library pp853-853
doi:10.1038/456853c
http://links.ealert.nature.com/ctt?kn=187&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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NEWS FEATURES
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2008 Gallery: Images of the year pp854-859
This gallery showcases some of the year's most eye-catching science,
from a close encounter with squid suckers that look like a carnivorous
cartoon choir to mathematical forms given shape in purple yarn.
It also recalls some of the biggest science news stories: the staggering
devastation wrought by Hurricane Ike; a Nobel prize for putting a glowing
protein to work; and the ongoing robotic exploration of Mars.
Emma Marris
doi:10.1038/456854a
http://links.ealert.nature.com/ctt?kn=82&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Prizewinners of the year pp860-861
Medals, cash and fame rained down on the heads of prominent scientists
in 2008. Ashley Yeager rounds up some of them.
Ashley Yeager
doi:10.1038/456860a
http://links.ealert.nature.com/ctt?kn=6&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Newsmaker of the year: The machine maker pp862-868
He did more than anyone to build the Large Hadron Collider. This year
he saw it finished ? and then break down. Geoff Brumfiel profiles the
LHC's project leader, Nature's newsmaker of the year.
Geoff Brumfiel
doi:10.1038/456862a
http://links.ealert.nature.com/ctt?kn=272&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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CORRESPONDENCE
----------------------
You're the best man for this job, son. What a coincidence! p870
Albert Ruggi
doi:10.1038/456870a
http://links.ealert.nature.com/ctt?kn=103&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Online archives are revealing uncensored history of science p870
William Burns
doi:10.1038/456870b
http://links.ealert.nature.com/ctt?kn=146&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Finding of unusual soil on Mars could stem from tools used p870
Alberto G. Fairen
doi:10.1038/456870c
http://links.ealert.nature.com/ctt?kn=203&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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COMMENTARIES
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Three rules for technological fixes pp871-872
Not all problems will yield to technology. Deciding which will and which
won't should be central to setting innovation policy, say Daniel Sarewitz
and Richard Nelson.
Daniel Sarewitz and Richard Nelson
doi:10.1038/456871a
http://links.ealert.nature.com/ctt?kn=157&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Correction pp871-872
doi:10.1038/456872a
http://links.ealert.nature.com/ctt?kn=87&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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BOOKS AND ARTS
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A wonderful life by leaps and bounds pp873-874
Stephen Jay Gould's idea of evolution by bursts was controversial.
But it gave the field of palaeontology a long-overdue boost, explains
Steve Jones. Steve Jones reviews Stephen Jay Gould: Reflections on
His View of Life
doi:10.1038/456873a
http://links.ealert.nature.com/ctt?kn=71&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Does genius breed success? p874
Michael Bond reviews Outliers: The Story of Success by Malcolm Gladwell
doi:10.1038/456874a
http://links.ealert.nature.com/ctt?kn=217&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
The science communicator p875
Zaheer Baber reviews Science and Controversy: A Biography of Sir Norman
Lockyer, Founder Editor of Nature by A. J. Meadows
doi:10.1038/456875a
http://links.ealert.nature.com/ctt?kn=79&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Looking at the face of the Earth p876
A sixteenth-century Dutch master's carefully orchestrated winter
landscape may have benefited from his knowledge of geographers'
techniques of the time, explains Martin Kemp.
doi:10.1038/456876a
http://links.ealert.nature.com/ctt?kn=49&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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ESSAY
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Being human: Migration: An engine for social change p877
The movement of people into societies that offer a better way of life
is a more powerful driver of cultural evolution than conflict and
conquest, say Peter J. Richerson
and Robert Boyd.
doi:10.1038/456877a
http://links.ealert.nature.com/ctt?kn=84&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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NEWS AND VIEWS
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Molecular biology: Spliceosome meets telomerase pp879-880
The spliceosome is best known for shepherding primary messenger RNA
transcripts to maturity. This enzyme complex also contributes to the
synthesis of an enzyme that maintains chromosome ends.
Sophie Bonnal and Juan Valcarcel
doi:10.1038/456879a
http://links.ealert.nature.com/ctt?kn=283&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Quantum physics: Don't look now pp880-881
Before picking up the phone and calling a technician to fix a faulty
microwave oven, there are always a few simple things one should check.
So far, "stop looking at it" has not been part of the checklist.
Alexei Ourjoumtsev
doi:10.1038/456880a
http://links.ealert.nature.com/ctt?kn=128&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Circadian clocks: Tips from the tip of the iceberg pp881-883
Daily remodelling of histone proteins underlies interactions between
circadian clock genes and metabolic genes. This regulatory mechanism
could be widespread, affecting other physiological processes.
Fred W. Turek
doi:10.1038/456881a
http://links.ealert.nature.com/ctt?kn=258&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Organometallic chemistry: Catalyst takes control to heart
pp883-885
Some transition-metal catalysts control organic reactions so that,
given a choice of two mirror-image products, only one forms. The metal
atom in these catalysts has been ignored as a source of control -
until now.
Steven T. Diver
doi:10.1038/456883a
http://links.ealert.nature.com/ctt?kn=15&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Epigenetics: How to lose a tail pp885-886
Everyone carries some baggage they would like to lose. For the histone
protein H3, that baggage is a chunk of its tail, which when clipped off
affects the expression of genes with which the histone is associated.
Mary Ann Osley
doi:10.1038/456885a
http://links.ealert.nature.com/ctt?kn=59&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Condensed-matter physics: The eternal triangle pp886-887
The frustration that atomic interactions can undergo is not unlike
that occurring when human aims are thwarted. An elegant study offers
a way of visualizing the hitherto mysterious dynamics of 'frustrated'
systems.
Mark Harris
doi:10.1038/456886a
http://links.ealert.nature.com/ctt?kn=83&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Neuroscience: Greasy proteins of the neuron pp887-888
An analysis of neuronal proteins reveals that many are regulated through
covalent attachment of the lipid palmitate. This reversible modification
seems to affect the form and function of synaptic junctions.
Maurine E. Linder
doi:10.1038/456887a
http://links.ealert.nature.com/ctt?kn=10&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Biogeochemistry: Nitrous oxide in flux pp888-889
In drought conditions, forest soils can serve as a small but surprisingly
persistent sink for the greenhouse gas nitrous oxide. The effect highlights
a research avenue necessary for predicting Earth's climate.
Sharon A. Billings
doi:10.1038/456888a
http://links.ealert.nature.com/ctt?kn=241&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Ralph Lewin (1921-2008) pp888-889
doi:10.1038/456888b
http://links.ealert.nature.com/ctt?kn=238&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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BRIEF COMMUNICATIONS ARISING
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Snowball prevention questioned pE7
Paul F. Hoffman et al.
doi:10.1038/nature07655
Abstract: http://links.ealert.nature.com/ctt?kn=316&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=137&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Carbon cycling and snowball Earth pE8
Yves Godderis and Yannick Donnadieu
doi:10.1038/nature07653
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=182&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Peltier & Liu reply ppE9-E10
W. R. Peltier and Yonggang Liu
doi:10.1038/nature07656
Abstract: http://links.ealert.nature.com/ctt?kn=175&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=326&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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REVIEW
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Sensing voltage across lipid membranes pp891-897
Kenton J. Swartz
doi:10.1038/nature07620
Abstract: http://links.ealert.nature.com/ctt?kn=334&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=215&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
----------------------
ARTICLES
----------------------
Geometric frustration in buckled colloidal monolayers pp898-903
Geometric frustration arises when lattice structure prevents energetic
interactions between neighbouring particles to be minimized, leading to
complex phases of matter. This paper reports a simple geometrically
frustrated system composed of closely packed colloidal spheres confined
between parallel walls. Because the diameter of the spheres is tunable,
the system provides a unique means to directly visualize the dynamics
of frustration, thermal excitations and defects.
Yilong Han et al.
doi:10.1038/nature07595
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=284&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation
pp904-909
A proteomics study unveils a large collection of proteins that get
reversibly palmitoylated in response to neuronal activity - the neuronal
palmitoyl-proteome. In particular, this study focuses on the discovery
of a brain-specific isoform of the small GTPase Cdc42, whose unexpected
palmitoylation specifically affects dendritic spine morphogenesis in
response to neuronal activity. These findings identify palmitoylation
as a key modifiable signal on many synapse-enriched proteins that
contribute to activity-driven changes in synapse morphology and function.
Rujun Kang et al.
doi:10.1038/nature07605
Abstract: http://links.ealert.nature.com/ctt?kn=246&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Spliceosomal cleavage generates the 3' end of telomerase RNA
pp910-914
This work identifies the spliceosome, which normally excises introns
from mRNAs, as being responsible for generating the 3' end of TER. It
does so by performing a site-specific cleavage reaction that previously
had not been observed for the spliceosome.
Jessica A. Box, Jeremy T. Bunch, Wen Tang and Peter Baumann
doi:10.1038/nature07584
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=112&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
SUMOylation regulates Rad18-mediated template switch pp915-920
When damaged DNA is replicated, gaps can be left behind in the
replicated DNA. Two processes, recombinational repair or
post-replication repair (PRR), were thought to act independently in
gap filling. This study defines how the error-free branch of PRR
is involved in lesion bypass and finds that when the replicative
clamp PCNA is SUMO modified, Rad18 and Rad5 are able to promote
polyubiquitination of PCNA.
Dana Branzei, Fabio Vanoli and Marco Foiani
doi:10.1038/nature07587
Abstract: http://links.ealert.nature.com/ctt?kn=225&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Structure of an argonaute silencing complex with a seed-containing
guide DNA and target RNA duplex pp921-926
The structure of a thermophilic Ago protein bound to a duplex nucleic
acid that mimics the interaction of the single-strand of the small RNA
and the target mRNA has been solved. This structure reveals the
conformational changes that are necessary to accommodate the target,
and the changes that occur in the vicinity of the site of cleavage.
Yanli Wang et al.
doi:10.1038/nature07666
Abstract: http://links.ealert.nature.com/ctt?kn=198&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
----------------------
LETTERS
----------------------
A gravitationally lensed water maser in the early Universe
pp927-929
This paper reports the discovery of a water maser at redshift 2.64 in
the dust- and gas-rich gravitationally lensed type-1 quasar
MG J0414+0534. Using the locally determined luminosity function, the
probability of finding a maser this luminous associated with any single
active galaxy is 10-6, leading to the conclusion that the volume
densities and luminosities of masers are higher at that epoch.
C. M. Violette Impellizzeri et al.
doi:10.1038/nature07544
Abstract: http://links.ealert.nature.com/ctt?kn=159&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Unconventional superconductivity in Ba0.6K0.4Fe2As2 from inelastic
neutron scattering pp930-932
A new family of superconductors containing layers of iron arsenide
has attracted considerable interest because of their high transition
temperatures and similarities with the high-Tc copper oxide
superconductors. This paper reports inelastic neutron scattering
observations of a magnetic resonance below Tc in Ba0.6K0.4Fe2As2,
demonstrating that the superconducting energy gap has unconventional
symmetry.
A. D. Christianson et al.
doi:10.1038/nature07625
Abstract: http://links.ealert.nature.com/ctt?kn=247&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=155&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Highly efficient molybdenum-based catalysts for enantioselective alkene
metathesis pp933-937
This paper discloses a new class of chiral catalysts that initiate
olefin metathesis with exceptional efficiency and enantioselectivity.
These new catalysts bear a stereogenic metal centre and carry only
monodentate ligands; the molybdenum-based complexes are rendered
non-racemic by a stereoselective ligand exchange process involving an
enantiomerically pure aryloxide, a class of ligands rarely used in
asymmetric catalysis.
Steven J. Malcolmson et al.
doi:10.1038/nature07594
Abstract: http://links.ealert.nature.com/ctt?kn=51&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=210&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
How supercontinents and superoceans affect seafloor roughness
pp938-941
This study presents a global analysis of seafloor roughness derived
from marine gravity data and finds that residual roughness anomalies
remain over large swaths of ocean floor. The Atlantic ocean floor that
formed over mantle previously overlain by the Pangaea supercontinent
displays anomalously low roughness, and attribute this observation to
a sub-Pangaean supercontinental mantle temperature anomaly leading to
slightly thicker than normal Atlantic crust. In contrast, ocean crust
formed above Pacific superswells is not associated with basement
roughness anomalies.
Joanne M. Whittaker et al.
doi:10.1038/nature07573
Abstract: http://links.ealert.nature.com/ctt?kn=309&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Parallel adaptations to high temperatures in the Archaean eon pp942-945
Phylogeny-driven reconstructions of ancestral protein sequences have
predicted that the last universal common ancestor (LUCA) was a
thermophile, but analyses of ribosomal RNA sequences suggested that
LUCA preferred a cooler environment. rRNA and protein sequences are
used to show that thermotolerance initially increased from a mesophilic
LUCA to thermophilic ancestors of Bacteria and Archaea-Eukaryota, and
then subsequently decreased.
Bastien Boussau et al.
doi:10.1038/nature07393
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=131&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Successful range-expanding plants experience less above-ground and
below-ground enemy impact pp946-948
Several species are observed to expand their habitat range towards
cooler, higher latitude environments as a result of climate warming.
It is shown that plant migrations can lead to successful invasions
due to their relatively low susceptibility to native soil pathogens
and herbivores.
Tim Engelkes et al.
doi:10.1038/nature07474
Abstract: http://links.ealert.nature.com/ctt?kn=285&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=230&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Low conservation of gene content in the Drosophila Y chromosome pp949-951
In Drosophila more than 95% of the genes have remained on the same
chromosome arm in 12 species that diverged 63 Myr ago.This study finds
that only a quarter of D. melanogaster Y linked genes are also Y-linked
in these 12 species. Gene losses are known to play a major role in the
evolution of Y chromosomes, but this study shows that in contrast with
the mammalian Y, gene gains play an important role in the evolution of
the Drosophila Y chromosome.
Leonardo B. Koerich, Xiaoyun Wang, Andrew G. Clark and
Antonio Bernardo Carvalho
doi:10.1038/nature07463
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=200&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Experience with moving visual stimuli drives the early development of
cortical direction selectivity pp952-956
Neural circuits in the visual cortex are immature at birth, and require
exposure to visual stimuli to form the connections and selectivity of
the mature visual system. It has been unclear how stimulus-driven neural
activity guides the emergence of properties such as direction
selectivity. This paper tracks this process with a combination of
intrinsic and two-photon calcium imaging in visually naive ferrets.
After exposing the animals to stimuli moving along one single axis of
motion, it is found that selectivity for those directions emerges
rapidly as well as the local organization of direction preference
between neighbouring cells.
Ye Li et al.
doi:10.1038/nature07417
Abstract: http://links.ealert.nature.com/ctt?kn=101&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=314&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Contact inhibition of locomotion in vivo controls neural crest
directional migration pp957-961
This paper studies a phenomenon called contact inhibition of locomotion,
whereby fibroblast cells grown in cell culture retract their protrusions
and change their direction on contact. It is shown that this occurs in
vivo, and the molecular basis is revealed. Neural crest cells, highly
migratory cells of embryonic origin, exhibit contact inhibition of
locomotion both in vivo and in vitro, which accounts for their
directional migration. However, when a neural crest cell meets another
cell type, it fails to display contact inhibition of locomotion,
allowing it to invade the tissue.
Carlos Carmona-Fontaine et al.
doi:10.1038/nature07441
Abstract: http://links.ealert.nature.com/ctt?kn=352&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=166&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Generation of cell polarity in plants links endocytosis, auxin
distribution and cell fate decisions pp962-966
The polar transport of the plant hormone auxin is dependent on the
localization of its efflux carriers called PINs, but the mechanism
mediating polarity of PIN proteins within cells remains unclear. This
study suggests a two-step mechanism generating PIN polarity. PINs are
first targeted to the plasma membrane in a non-polar manner, and
polarity is established in subsequent step involving internalization
and recycling. Interference with endocytosis results in the loss of PIN
polarity leading to a perturbation in auxin gradients.
Pankaj Dhonukshe et al.
doi:10.1038/nature07409
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=295&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
G protein G[alpha]i functions immediately downstream of Smoothened in
Hedgehog signalling
Whether G proteins have a role in hedgehog (Hh) signal transduction
has been controversial. In this study, Smoothened (Smo) is shown to
activate a G protein, G[alpha]i, to modulate intracellular cyclic
AMP levels in response to Hh.
Stacey K. Ogden et al.
doi:10.1038/nature07459
Abstract: http://links.ealert.nature.com/ctt?kn=349&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Suppression of Myc oncogenic activity by ribosomal protein
haploinsufficiency pp971-975
This study shows that Myc-driven tumourigenesis is dependent on its
ability to increase protein synthesis, as haploinsufficiency in
ribosomal proteins decreases Myc-induced tumour formation. However,
tumours caused by the loss of p53, were not affected. Myc stimulates
cap-dependent protein translation at the expense of IRES-dependent
translation, leading to the synthesis of a different set of proteins,
and this effect is reversed by ribosomal protein haploinsufficiency.
Maria Barna et al.
doi:10.1038/nature07449
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=191&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
A structural explanation for the binding of endocytic dileucine motifs
by the AP2 complex
During clathrin-mediated endocytosis, cargo proteins are recognized by
clathrin adaptors. The clathrin adaptor AP2 recognizes two major classes
of endocytic motifs, including an acidic dileucine motif. This study
presents the crystal structure of AP2 in complex with the diceucine
motif of a cargo protein,
thereby revealing the mechanism of cargo-adaptor recognition.
Bernard T. Kelly et al.
doi:10.1038/nature07422
Abstract: http://links.ealert.nature.com/ctt?kn=204&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=232&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase
signalling in fibroblasts pp980-984
MicroRNAs are expressed in a type of heart cell known as cardiomyocytes
and their aberrant regulation was correlated with heart disease. This
study looks at how miRNAs in other heart cells may contribute to disease.
It is found that in cardiac fibroblasts, miR-21 is upregulated in
diseased heart. This activates a signalling pathway that exacerbates
cardiac disease. By using an RNA molecule directed against miR-21, it
was possible to reverse these effects, demonstrating that therapeutic
treatment to downregulate a microRNA can be effective in vivo.
Thomas Thum et al.
doi:10.1038/nature07511
Abstract: http://links.ealert.nature.com/ctt?kn=248&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus
pp985-988
The NS1 protein of the influenza virus is a critical virulence factor
that antagonizes the host antiviral response by multiple mechanisms,
including the binding and sequestration of double-stranded RNA. This
paper describes the structure of full-length NS1 protein and shows that
individual domains interact in such a way as to form tubules, which may
sequester dsRNA, allowing the virus to evade the innate immune response.
Zachary A. Bornholdt and B. V. Venkataram Prasad
doi:10.1038/nature07444
Abstract: http://links.ealert.nature.com/ctt?kn=341&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=185&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Structural recognition and functional activation of Fc[gamma]R by innate
pentraxins pp989-992
The classical pentraxins, serum amyloid P component (SAP) and C-reactive
protein (CRP), are major acute phase reactants in mouse and man. It is
shown that pentraxins recognize various Fc[gamma]Rs and SAP opsonization
activates Fc[gamma]R-mediated phagocytosis and cytokine secretion. The
receptor binding sites for SAP and IgG overlap, resulting in competition
of IgG binding to Fc[gamma]R as well as inhibition of immune
complex-mediated phagocytosis by soluble pentraxins.
Jinghua Lu et al.
doi:10.1038/nature07468
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=275&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Endonucleolytic RNA cleavage by a eukaryotic exosome pp993-996
The exosome is a multisubunit exonuclease complex that degrades many
types of RNAs, in many different contexts, in a 3' to 5' manner. The
catalytic component of the exosome is the Dis3 subunit. Dis3 contains
a PIN domain, which is sometimes associated with nuclease activity.
This work shows that the Dis3 PIN domain also possesses endonuclease
activity (that is, it can cleave RNA internally, rather than from an end).
Mutations in either this domain or in the exonuclease domain exhibit a
growth phenotype, suggesting that both activities are physiologically
important.
Alice Lebreton, Rafal Tomecki, Andrzej Dziembowski and Bertrand Seraphin
doi:10.1038/nature07480
Abstract: http://links.ealert.nature.com/ctt?kn=114&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=293&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Nuclear receptor corepressor and histone deacetylase 3 govern circadian
metabolic physiology pp997-1000
This paper shows that specific genetic disruption of the Ncor-HdaC3
interaction in mice causes aberrant regulation of clock genes and
results in abnormal circadian behaviour. These mice are also leaner
and more insulin sensitive due to increased energy expenditure. Loss
of a functional Ncor-HdaC3 complex in vivo changes the oscillatory
patterns of several metabolic genes, demonstrating that circadian
regulation of metabolism is critical for normal energy balance.
Theresa Alenghat et al.
doi:10.1038/nature07541
Abstract: http://links.ealert.nature.com/ctt?kn=188&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Conformational changes in an ultrafast light-driven enzyme determine
catalytic activity pp1001-1004
The chlorophyll biosynthetic enzyme NADPH:protochlorophyllide
oxidoreductase, which catalyses a light-driven reaction involving
hydride and proton transfers is examined. It is determined that
prior excitation of the enzyme-substrate complex with a laser pulse
induces a more favourable conformation of the active site and increases
the catalytic efficiency of the coupled hydride and proton transfer
reactions. Spectral changes in the mid-infrared after the absorption
of one photon reveal significant conformational changes in the enzyme.
Olga A. Sytina et al.
doi:10.1038/nature07354
Abstract: http://links.ealert.nature.com/ctt?kn=324&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=172&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
----------------------
FUTURES
----------------------
Harnessing the brane-deer pp1007-1008
It's a constant worry.
Robert Billing
doi:10.1038/4561007a
http://links.ealert.nature.com/ctt?kn=89&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
17 December 2008
Peptide neurotransmitters activate a cation channel complex of NALCN
and UNC-80
Boxun Lu et al.
doi:10.1038/nature07579
Abstract: http://links.ealert.nature.com/ctt?kn=321&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=135&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Quality control by the ribosome following peptide bond formation
Hani S. Zaher and Rachel Green
doi:10.1038/nature07582
Abstract: http://links.ealert.nature.com/ctt?kn=259&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Prominin 1 marks intestinal stem cells that are susceptible to
neoplastic transformation
Liqin Zhu et al.
doi:10.1038/nature07589
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Crypt stem cells as the cells-of-origin of intestinal cancer
Nick Barker et al.
doi:10.1038/nature07602
Abstract: http://links.ealert.nature.com/ctt?kn=325&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=2&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
The DNA-encoded nucleosome organization of a eukaryotic genome
Noam Kaplan et al.
doi:10.1038/nature07667
Abstract: http://links.ealert.nature.com/ctt?kn=121&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=271&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
WSTF regulates the H2A.X DNA damage response via a novel tyrosine
kinase activity
Andrew Xiao et al.
doi:10.1038/nature07668
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Article: http://links.ealert.nature.com/ctt?kn=100&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
14 December 2008
RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose
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Article: http://links.ealert.nature.com/ctt?kn=94&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Signalling through RHEB-1 mediates intermittent fasting-induced
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doi:10.1038/nature07583
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Article: http://links.ealert.nature.com/ctt?kn=196&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Sleep and sensorimotor integration during early vocal learning
in a songbird
Sylvan S. Shank and Daniel Margoliash
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Article: http://links.ealert.nature.com/ctt?kn=332&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Messenger RNA targeting to endoplasmic reticulum stress
signalling sites
Tomas Aragon et al.
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Abstract: http://links.ealert.nature.com/ctt?kn=242&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
The unfolded protein response signals through high-order assembly
of Ire1
Alexei V. Korennykh et al.
doi:10.1038/nature07661
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=255&m=30714246&r=MTQxMDI1NjIxMwS2&b=2&j=NDQwNjQ1MTES1&mt=1&rt=0
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