Signaling Gateway - 07 November 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0M40Ei
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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New! WideScreen Biomarker Assays
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To ensure gold standard quality data, and to maximize the
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http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0B8mO0Ej
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In Signaling Update this week:
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Featured Article
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SMALL MOLECULE INHIBITORS: DOUBLE TROUBLE
A rational design-based approach to developing targeted therapeutics
has generated a small-molecule inhibitor that blocks both PI(3)K and
tyrosine kinase activity.
Original research paper: Nature Chemical Biology 4, 691-699 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0vP0Er
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Ubr5
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3g0EL
UBR5 was originally identified as a progestin-induced gene in human
breast cancer cells. Altered expression of UBR5 has been observed
in numerous tumor types including breast, ovarian, colon, melanoma
and hepatocellular. Ubr5 has been shown to have E3 ubiquitin ligase
activity, and several studies have identified a role for Ubr5 in
cell-cycle control and mediation of the cellular response to
DNA damage.
Also published this week:
Rab35:
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3h0EM
CAP1:
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3i0EN
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0BUuz0E4
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Selected Updates
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MUCOSAL IMMUNOLOGY: MISMANAGED ER STRESS AND INFLAMMATION
A dysregulated response to endoplasmic reticulum (ER) stress caused
by depletion of the transcription factor XBP1 can lead to
inflammatory bowel disease.
Original research paper: Cell 134, 743–756 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3j0EO
GENETICS: ALK TAKES THE RAP
Amplification or constitutive activation of the anaplastic lymphoma
kinase (ALK) is a frequent event in familial and sporadic cases of
neuroblastoma.
Original research paper: Nature 455, 930–935 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3k0EP
GENE REGULATION: A TINY MISSING LINK FOR REGULATORY NETWORKS
Genome-wide experimentally mapped and computationally predicted
transcription factor (TF)-miRNA interaction sets have provided
important insights into the role of miRNAs in regulating gene
expression at a global level.
Original research paper: Genes Dev 22, 2535–2549 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3l0EQ
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0vO0Eq
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Research Library
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MODULATION OF THE ANTITUMOR IMMUNE RESPONSE BY COMPLEMENT
Nature Immunology 9, 1225-1235 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3m0ER
PHOSPHOLIPASE A2 REDUCTION AMELIORATES COGNITIVE DEFICITS IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
Nature Neuroscience 11, 1311-1318 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3n0ES
CORTISONE DISSOCIATES THE SHAKER FAMILY K+ CHANNELS FROM THEIR BETA SUBUNITS
Nature Chemical Biology 4, 708-714 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3o0ET
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Signaling News
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NATURE CHEMICAL BIOLOGY: FOCUS ON CHEMICAL SYSTEMS BIOLOGY
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0B8Mv0Eq
Systems-based approaches are a powerful way to understand the often
pleiotropic biological effects of small molecules. Nature Chemical
Biology presents a focus on chemical systems biology that highlights
the emerging interface of chemical biology and systems biology,
including an article on reverse engineering intracellular biochemical
networks and a review on targeting and tinkering with interaction
networks.
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3p0EU
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CAPK0EM
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0Crw0EZ
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Gateway Updates
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THE CELL MIGRATION GATEWAY – November UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0uLB0Es
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles:
Myosin-II: An extending tail
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CAwr0Ee
Adhesion dynamics: Actin and microtubules get along with ACF7
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CAws0Ef
Sign up to receive the table of contents e-alert for the Cell
Migration Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0BJrg0EW
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Signaling Job of the Week
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Postdoctoral and Graduate Student Positions
Employer: A. I. Virtanen Institute, University of Kuopio
Location: Kuopio, Finland
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0CA3q0EV
The A. I. Virtanen Institute for Molecular Sciences at the University
of Kuopio seeks postdoctoral and graduate student researchers to
study the regulation and function of small G-protein signaling
pathways in neuronal cells. Potential projects will focus on the
mechanisms regulating stress-activated MAP kinases in
neurodegenerative processes.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0BnjC0EO
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eoio0Xztnp0H2W0vqs0EL
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