December 2008 Volume 8 Number 12
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This month's FEATURED article:
Viral evasion and subversion of pattern-recognition receptor signalling
Andrew G. Bowie and Leonie Unterholzner
p911 | doi:10.1038/nri2436
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSY0Ew
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From the editors
p903 | doi:10.1038/nri2464
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSZ0Ex
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RESEARCH HIGHLIGHTS
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Innate immunity: Seeing mTOR in a new light
p904 | doi:10.1038/nri2457
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSa0E5
T-cell memory: Growing with experience
p905 | doi:10.1038/nri2463
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSb0E6
IN BRIEF
Signalling | Immunotherapy | Regulatory T cells
p905 | doi:10.1038/nri2468
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSc0E7
T cells: The flexibility of T-cell fates
p906 | doi:10.1038/nri2453
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSd0E8
IN THE NEWS
Pimp my ride
p906 | doi:10.1038/nri2462
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSe0EA
Immunotherapy: Designer siRNA
p906 | doi:10.1038/nri2465
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSf0EB
Thymocyte development: New roles for TRPM7
p907 | doi:10.1038/nri2467
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSg0EC
Viral immunity: Persistent viruses help opportunists
p908 | doi:10.1038/nri2452
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSh0ED
Thymocyte development: Negative selection in the cortex
p908 | doi:10.1038/nri2459
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSi0EE
Mucosal immunology: It starts with a NOD
p909 | doi:10.1038/nri2461
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSj0EF
Allergy: Bee-keepers hold clues for T-cell tolerance
p910 | doi:10.1038/nri2466
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSk0EG
IN BRIEF
Asthma and allergy | B cells | Inflammation
p910 | doi:10.1038/nri2469
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSl0EH
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REVIEWS
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Viral evasion and subversion of pattern-recognition receptor signalling
Andrew G. Bowie and Leonie Unterholzner
p911 | doi:10.1038/nri2436
This Review highlights how understanding the mechanisms by which
viruses evade and subvert host signalling by pattern-recognition
receptors has provided insights into the function of these signalling
pathways, the host proteins that are involved and ways in which the
pathways might be manipulated therapeutically.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSm0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSn0EJ
Nutrient sensing and inflammation in metabolic diseases
Gökhan S. Hotamisligil and Ebru Erbay
p923 | doi:10.1038/nri2449
This Review discusses how immune and inflammatory pathways are
integrated with those that sense and manage nutrients, dysfunction of
which underlies many chronic metabolic diseases, such as type 2
diabetes and atherosclerosis.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSo0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSp0EL
Article series: Tissue-specific immune responses
http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0B6VA0EN
Origin, homeostasis and function of Langerhans cells and other
langerin-expressing dendritic cells
Miriam Merad, Florent Ginhoux and Matthew Collin
p935 | doi:10.1038/nri2455
Our understanding of the origin, phenotype and function of epidermal
Langerhans cells and langerin-expressing dendritic cells has expanded
in recent years, details of which, as well as the challenges that
remain, are discussed in this Review.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSq0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSr0EN
Transcriptional regulation by AIRE: molecular mechanisms of central
tolerance
Pärt Peterson, Tõnis Org and Ana Rebane
p948 | doi:10.1038/nri2450
This Review focuses on the structural domains of the autoimmune
regulator (AIRE) protein, its nuclear localization, and its role in
histone binding and transcriptional elongation, which help to explain
the crucial involvement of AIRE in the negative selection of T cells
in the thymus.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSs0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSt0EP
Exploring the full spectrum of macrophage activation
David M. Mosser and Justin P. Edwards
p958 | doi:10.1038/nri2448
By proposing new criteria by which macrophage populations can be
classified based on functions that are involved in maintaining
homeostasis, this Review provides a framework to further elucidate
the functions of these cells and their role in disease.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSu0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSv0ER
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PERSPECTIVE
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SCIENCE AND SOCIETY
Immunotherapy of autoimmunity and cancer: the penalty for success
Rachel R. Caspi
p970 | doi:10.1038/nri2438
Immunotherapy for cancer sometimes has autoimmune complications, and
immunotherapy for autoimmunity can compromise microbial defence and
immunosurveillance. In this article, Rachel Caspi explores the
potential penalties of successful immunotherapeutic approaches and
highlights the need for more specific modalities.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSw0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eom70Xztnp0Hjd0CCSx0ET
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