November 13 2008
Visit Nature Reports Stem Cells online.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0BU280El
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Regenerative medicine heads to the army
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OUR TOP STORIES
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Thomas Graf: Cellular identity and transdifferentiation
In the quest to switch one cell type to another, how far can tweaking transcription factors go?
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGV0EK
Stem cells drafted for war on wounds
A new programme at the US Department of Defense funds regenerative medicine for wounded vets, but a surprising level of detail seems top secret
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGW0EL
In search of a viable business model
Stem cell companies evolve to meet the demands of investors, partners and customers
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGX0EM
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RESEARCH HIGHLIGHTS AND NEWS STORIES KEYING OFF RECENT PUBLICATIONS
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Human cortical neuron cell balls
Cells cultured in embryoid bodies self-organize into specific neural subtypes
Eiraku, M. et al. Cell Stem Cell 3, 519-532 (2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGY0EN
Embryoid bodies get organized
Wnt signaling stimulate the beginnings of gastrulation
Ten Berge, D. et al. Cell Stem Cell 3, 508-518 (2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGZ0EO
MicroRNAs control help embryonic stem cells grow fast
A new screening technique identifies molecules that control the cell cycle
Wang, Y. Nature Genet. advanced online publication, doi:10.1038/ng.250 (2 November 2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGa0EV
Multitasking methyltransferase
G9a silences gene expression two ways
Epsztejn-Litman, S. et al. Nature Struct. Mol. Biol. advance online publication, doi:10.1038/nsmb.1476 (26 October 2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGb0EW
Exogenous aids to reprogramming and self-renewal
Small molecules replace pluripotency gene; Wnt boosts self-renewal, reprogramming
Shi, Y. et al. Cell Stem Cell 3, 568-574 (2008).
Kalani, M. & Yashar, S. Proc. Natl Acad. Sci. USA 105, 16970-16975 (2008).
Lluis, F., Pedone, E., Pepe, S. & Cosma, M.P. Cell Stem Cell 3, 493-507 (2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0Bkui0E4
Embryonic-like stem cells from a single human hair
Compared to fibroblasts, keratinocytes generate a hundred times more iPS cells in half the time
Huangfu, D. et al. Nature Biotechnol. advance online publication, doi:10.1038/nbt.1502 (12 October 2008).
Aasen, T. et al. Nature Biotechnol. advance online publication, doi:10.1038/nbt.1503 (17 October 2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGc0EX
Grow your own prostate
Researchers generate new prostates from single stem cells
Leong, K. G. et al. Nature advance online publication, doi:10.1038/nature07427 (22 October 2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGd0EY
Stem cells cycle in the hair follicle
An intestinal marker of cycling cells, Lgr5, helps identify surprising activity in the hair follicle niche
Jaks, V. et al. Nature Genet. advance online publication, doi:10.1038/ng.239 (12 October 2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0Bkuq0ED
Mis-oriented stem cells don't divide
An apparent checkpoint against unwanted proliferation lowers sperm production in aging flies
Cheng, J. et al. Nature advance online publication, doi:10.1038/nature07386 (15 October 2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0CBGe0EZ
Neural stem cells, young and old
How ageing stem cells trade regeneration for tumour suppression
Nishino, J., Kim, I., Chada, K. & Morrison, S. Cell 135, 227-239 (2008).
http://ealerts.nature.com/cgi-bin24/DM/y/eolu0Xztnp0JEp0Bkuo0EB
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Nature Reports Stem Cells is an interactive forum for stem cell scientists and other stakeholders to communicate about the research, policy, ethics, business and medicine of stem cell science. And it's all free!
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