November 2008 Volume 26 Number 11, pp 1199 - 1312
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EDITORIAL
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Aligning interests p1199
As sources of funding dwindle, could the health insurance sector do more to support biotech innovation and help itself at the same time?
doi:10.1038/nbt1108-1199
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzp0EY
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NEWS
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Gunvalson decision sends shockwaves through industry pp1201 - 1202
Malorye Allison
doi:10.1038/nbt1108-1201
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzq0EZ
India partners to fast track biotech p1202
Killugudi Jayaraman
doi:10.1038/nbt1108-1202
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzr0Ea
FDA cracks down on labeling, initiates trial result reporting pp1203 - 1204
Randy Osborne and Emily Waltz
doi:10.1038/nbt1108-1203
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzs0Eb
Polar biotech p1204
Hannah Hoag
doi:10.1038/nbt1108-1204a
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzt0Ec
Deaths stalk GLP-1 agonist p1204
Jodi Hyer
doi:10.1038/nbt1108-1204b
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzu0Ed
FDA transgenic animal guidance finally surfaces pp1205 - 1207
Jeffrey L Fox
doi:10.1038/nbt1108-1205
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzv0Ee
Amgen's bone blockbuster p1206
Hayley Birch
doi:10.1038/nbt1108-1206a
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzw0Ef
Enbrel patent feud p1206
Asher Mullard
doi:10.1038/nbt1108-1206b
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzx0Eg
Agency rushes to redraw plant biotech rules p1206
Jeffrey L Fox
doi:10.1038/nbt1108-1206c
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzy0Eh
Investors temper interest in grain biofuels, focus on alternatives pp1208 - 1209
Brady Huggett
doi:10.1038/nbt1108-1208
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAzz0Ei
Europe imports GM soy p1209
Susan Aldridge
doi:10.1038/nbt1108-1209a
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAz10EV
East Africa pushes GM law p1209
Daniel Kamanga
doi:10.1038/nbt1108-1209b
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAz20EW
PROFILE
Deborah Dunsire p1211
In under three years, Deborah Dunsire transformed Millennium Pharmaceuticals from an unprofitable company to Takeda's oncology centerpiece. What's next?
Crispin Littlehales
doi:10.1038/nbt1108-1211
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAz30EX
DATA PAGE
Biotech resilient in Q3 p1212
Stacy Lawrence
doi:10.1038/nbt1108-1212
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAz40EY
NEWS FEATURE
Breaching the barrier pp1213 - 1215
The blood-brain barrier has confounded the development of many neurological treatments over the years. Now, several companies are claiming they can tackle the problem. Alan Dove reports.
Alan Dove
doi:10.1038/nbt1108-1213
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAz50EZ
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BIOENTREPRENEUR
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BUILDING A BUSINESS
Five IP tips to spread your business wings pp1217 - 1219
Intellectual property (IP) is a critical asset at most life science start-up companies. Savvy organizational management of IP strategies and assets is essential in optimizing IP value as a sustainable business is built.
James G. Cullem
doi:10.1038/bioe.2008.9
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAz60Ea
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OPINION AND COMMENT
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CORRESPONDENCE
Most gene test sales are misleading p1221
Helen Wallace
doi:10.1038/nbt1108-1221
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAz70Eb
Pharming in crop commodities pp1222 - 1223
C Neal Stewart, Jr
doi:10.1038/nbt1108-1222
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CAz80Ec
Coexistence in the EU[mdash]return of the moratorium on GM crops? pp1223 - 1225
Yann Devos, Matty Demont and Olivier Sanvido
doi:10.1038/nbt1108-1223
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1A0EY
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BOOK REVIEW
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The fear factor p1226
Alan McHughen reviews The Science of Fear: Why We Fear the Things We Shouldn't[mdash]and Put Ourselves in Greater DangerDaniel Gardner
doi:10.1038/nbt1108-1226
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1B0EZ
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FEATURES
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What's fueling the biotech engine - 2007 pp1227 - 1233
Despite losses in revenue from erythropoietins, historically the highest earner of all biologics, more than 100 biotech drugs continued their upward trend in sales begun in 2006, with antibodies and insulin analogs fueling growth at double-digit rates.
Saurabh Aggarwal
doi:10.1038/nbt1108-1227
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1C0Ea
PATENTS
Enforcing pharmaceutical and biotech patent rights in China pp1235 - 1240
Companies with a significant intellectual property stake in China should put in place an effective protection and enforcement strategy against local and overseas competitors.
Y Philip Zhang and Michelle M Deng
doi:10.1038/nbt1108-1235
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1D0Eb
Recent patent applications in sequencing p1241
doi:10.1038/nbt1108-1241
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1E0Ec
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NEWS AND VIEWS
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Epidermal cells rev up reprogramming pp1243 - 1244
Induced pluripotent stem cells have been generated from single human hairs, providing an easily accessible source of cells amenable to efficient reprogramming.
Paul Gadue and George Cotsarelis
doi:10.1038/nbt1108-1243
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1F0Ed
Nanotubes light up protein arrays pp1244 - 1246
Antibody-tagged carbon nanotubes permit sensitive detection on protein microarrays by surface-enhanced Raman scattering.
Sanjeeva Srivastava and Joshua LaBaer
doi:10.1038/nbt1108-1244
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1G0Ee
The many ways to make an iPS cell pp1246 - 1248
Several new approaches for generating induced pluripotent stem cells reduce the risk of insertional mutagenesis.
William E Lowry and Kathrin Plath
doi:10.1038/nbt1108-1246
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1H0Ef
Fast forward genetics pp1248 - 1249
High-throughput sequencing rapidly connects microbial phenotypes and genotypes to guide metabolic engineering.
Alistair C Darby and Neil Hall
doi:10.1038/nbt1108-1248
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1I0Eg
Research Highlights p1250
doi:10.1038/nbt1108-1250
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1J0Eh
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COMPUTATIONAL BIOLOGY
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ANALYSIS
Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network pp1251 - 1259
Gal Chechik et al.
doi:10.1038/nbt.1499
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1K0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1L0Ej
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RESEARCH
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REVIEW
Transdermal drug delivery pp1261 - 1268
Mark R Prausnitz and Robert Langer
doi:10.1038/nbt.1504
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1M0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1N0El
ARTICLES
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 pp1269 - 1275
One strategy for advancing induced pluripotent stem (iPS) cell technology toward the clinic is to replace the reprogramming genes with small molecules. Huangfu et al. show that the HDAC inhibitor valproic acid can substitute for the reprogramming gene Klf4, allowing human iPS cells to be generated with only two transgenes, Oct4 and Sox2.
Danwei Huangfu et al.
doi:10.1038/nbt.1502
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1O0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1P0En
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes pp1276 - 1284
Aasen et al. boost the efficiency of human induced pluripotent stem (iPS) cell generation 100-fold by starting with keratinocytes rather than fibroblasts. They also produce iPS cells from plucked adult hair, an easily accessible source of cells that avoids the need for a biopsy.
Trond Aasen et al.
doi:10.1038/nbt.1503
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1Q0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1R0Ep
Protein microarrays with carbon nanotubes as multicolor Raman labels pp1285 - 1292
The picomolar sensitivity of fluorescence-based protein detection limits the use of protein arrays in research and clinical diagnosis. Chen et al. use antibody-tagged single-walled carbon nanotubes as multicolor Raman labels to detect femtomolar levels of serum analytes over a wide dynamic range.
Zhuo Chen et al.
doi:10.1038/nbt.1501
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1S0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1T0Er
An integrated software system for analyzing ChIP-chip and ChIP-seq data pp1293 - 1300
Analyzing the massive and heterogenous datasets from genome-wide chromatin immunoprecipitation (ChIP) datasets presents several computational and statistical challenges. Ji et al. present a software suite that integrates all steps in ChIP-chip and ChIP-seq data analyses and illustrate the use of these tools by comparing the ability of the two platforms to identify transcription factor binding sites.
Hongkai Ji et al.
doi:10.1038/nbt.1505
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1U0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1V0Et
LETTER
Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors pp1301 - 1308
Fruit-specific overexpression of a pair of snapdragon transcription factors produces tomatoes that uniformly accumulate anthocyanins at levels unprecedented for metabolic engineering. When included as a dietary supplement, the purple tomatoes increase the life spans of tumorigenic p53 knockout mice.
Eugenio Butelli et al.
doi:10.1038/nbt.1506
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1W0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1X0Ev
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NATUREJOBS
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CAREERS AND RECRUITMENT
A case for consulting pp1309 - 1310
Today's demographics call for biotech companies to be more flexible with their workforce.
Mari Paul
doi:10.1038/nbt1108-1309
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1Y0Ew
PEOPLE
People p1312
doi:10.1038/nbt1108-1312
http://ealerts.nature.com/cgi-bin24/DM/y/eoiD0Xztnp0HjC0CA1Z0Ex
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