27 November 2008 Volume 456 Number 7221 pp421-544
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----------------------
EDITORIALS
----------------------
Course corrections p421
If the US government chooses to bail out the nation's vehicle
manufacturers, it must ensure that the industry commits to the
innovations required for future transportation.
doi:10.1038/456421a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkV0Ek
A fruitless campaign pp421-422
Another protracted fight over genetically modified crops in Africa
will be costly and wasteful.
doi:10.1038/456421b
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkW0El
Friendly rivalry p422
The spirit of collaboration in the race to define the LHC's successor
sets an example for large projects.
doi:10.1038/456422a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkX0Em
----------------------
RESEARCH HIGHLIGHTS
----------------------
Social science: Breakin' the law p424
doi:10.1038/456424a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkY0En
Space science: Colour test p424
doi:10.1038/456424b
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkZ0Eo
Biology: Mile-high strategies p424
doi:10.1038/456424c
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCka0Ev
Virology: Inside knowledge p424
doi:10.1038/456424d
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkb0Ew
Theoretical physics: Eyeing entanglement p424
doi:10.1038/456424e
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkc0Ex
Oncology: Odd ones out pp424-425
doi:10.1038/456424f
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkd0Ey
Systems biology: Radical methods p425
doi:10.1038/456425a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCke0Ez
Molecular biology: Cancer 101 p425
doi:10.1038/456425b
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkf0E1
Physical chemistry: Electrons with a twist p425
doi:10.1038/456425c
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkg0E2
Atmospheric sciences: Methane mutterings p425
doi:10.1038/456425d
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkh0E3
----------------------
JOURNAL CLUB
----------------------
Journal club p425
William B. McKinnon
doi:10.1038/456425e
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCki0E4
----------------------
NEWS
----------------------
Beamline bonanza for Japanese researchers pp426-427
A proton-accelerator complex will incorporate one of the world's most
intense pulsed neutron sources.
David Cyranoski
doi:10.1038/456426a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkj0E5
Astronomers unveil wish list p427
Roadmap sets out Europe's space priorities.
Katharine Sanderson
doi:10.1038/456427a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkk0E6
Obama's win refreshes key climate talks pp428-429
As all eyes turn to Poland for the start of the United Nations meeting
next week, Jeff Tollefson looks at what progress is likely to be made.
doi:10.1038/456428a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkl0E7
Acoustic sensors for rare porpoise pp431
Survey tracks world's most endangered marine mammal.
Rex Dalton
doi:10.1038/456431a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkm0E8
Self-publishing editor set to retire pp432
Criticism grows over high number of self-penned articles in physics
journal.
Quirin Schiermeier
doi:10.1038/456432a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkn0EA
Mice share yeast's ageing system pp433
Sirtuin proteins linked to lifespan in mammals.
Heidi Ledford
doi:10.1038/456433a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCko0EB
Social-science programme hit by murder charge pp435
doi:10.1038/456435a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkp0EC
Distant world sports gassy signature of habitability pp435
doi:10.1038/456435b
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkq0ED
European Union declares Arctic interests pp435
doi:10.1038/456435c
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkr0EE
United Kingdom auctions carbon emissions permits pp435
doi:10.1038/456435d
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCks0EF
Unique collaborations at Howard Hughes institute pp435
doi:10.1038/456435e
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkt0EG
Deep-ocean observatories take the plunge pp435
doi:10.1038/456435f
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCku0EH
----------------------
NEWS FEATURES
----------------------
Car industry: Charging up the future pp436-440
A new generation of lithium-ion batteries, coupled with rising oil
prices and the need to address climate change, has sparked a global
race to electrify transportation.
Jeff Tollefson investigates.
doi:10.1038/456436a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkv0EI
Argentina: The come back pp441-442
Argentina's government has pledged to reverse a decades-long
scientific brain drain.
Rex Dalton reports.
doi:10.1038/456441a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkw0EJ
----------------------
CORRESPONDENCE
----------------------
What other treasures could be hidden in conference papers? p443
Min-Liang Wong
doi:10.1038/456443a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkx0EK
Public opinion and the ethics of primate brain research p443
Ulrike Gross German
doi:10.1038/456443b
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCky0EL
Marker metabolites can be therapeutic targets as well p443
Adrian K. Arakaki, Jeffrey Skolnick and John F. McDonald
doi:10.1038/456443c
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCkz0EM
----------------------
BOOKS AND ARTS
----------------------
Science, dogmas and the state pp444-445
Misrepresentation of stem-cell science in Italy by political and
religious groups is damaging that nation's laws and the funding and
perceived value of biomedical research, argues Elena Cattaneo.
Elena Cattaneo reviews Staminalia: Le Cellule Etiche e i Nemici Della
Ricerca by Armando Massarenti
doi:10.1038/456444a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCk10E8
A blogging professor in print p445
Peggy Kolm reviews Academeology: Random Musings, Strong Opinions and
Somewhat Bizarre Anecdotes from an Academic Life by
Female Science Professor
doi:10.1038/456445a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCk20EA
Imprisoned by intelligence pp446-447
Jennifer Rohn reviews Anathem by Neal Stephenson
doi:10.1038/456446a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCk30EB
In Retrospect: Fernel's Physiologia pp446-447
The seeds of systems biology were sown 450 years ago by a classic
medical text, explains G. Rickey Welch.
G. Rickey Welch reviews The Physiologia of Jean Fernel
doi:10.1038/456446b
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCk40EC
Rothko's methods revealed p447
Jane Qiu reviews Rothko: the Late Series
doi:10.1038/456447a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCk50ED
----------------------
NEWS AND VIEWS
----------------------
Particle physics: Mass by numbers pp449-450
A highly precise calculation of the masses of strongly interacting
particles, based on fundamental theory, is testament to the age-old
verity that physical reality embodies simple mathematical laws.
Frank Wilczek
doi:10.1038/456449a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCk60EE
Palaeontology: Turtle origins out to sea pp450-451
Various aspects of turtle evolution are the subject of vigorous debate
among vertebrate palaeontologists. A newly described fossil species,
the oldest yet discovered, adds grist to the mill.
Robert R. Reisz and Jason J. Head
doi:10.1038/456450a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCk70EF
Organic chemistry: Short cuts to complexity pp451-453
The credit crunch is forcing people to tighten their belts, but
chemists have long known the benefits of being economical with atoms.
The latest synthesis of an anticancer agent shows how effective
parsimony can be.
Andre B. Charette
doi:10.1038/456451a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCk80EG
50 & 100 years ago p452
doi:10.1038/456452a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClA0EQ
Molecular Biology: The Bloom's complex mousetrap pp453-454
Genomic instability often underlies cancer. Analyses of proteins
implicated in a cancer-predisposing condition called Bloom's syndrome
illustrate the intricacies of protein interactions that ensure
genomic stabili
Robert M. Brosh, Jr
doi:10.1038/456453a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClB0ER
Microscopy: A terahertz nanoscope pp454-455
Replacing the 'micro' in microscope with 'nano', and using invisible
light instead of visible, won't give scientists an instrument that can
image nanostructures -- unless they first beat the system's
diffraction limit.
Paul Planken
doi:10.1038/456454a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClC0ES
Plant Biology: Gibberellins close the lid pp455-456
Gibberellins regulate many aspects of plant growth and development.
Crystal structures of their receptors provide a view in unprecedented
detail of how these hormones operate at the molecular level.
Peter Hedden
doi:10.1038/456455a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClD0ET
Earth science: On the evolution of minerals pp456-458
The variety of mineral species has increased since the birth of the
Solar System and the development of terrestrial planets. A refreshing
view likens the steady rise in mineral diversity to biological
evolution.
Minik T. Rosing
doi:10.1038/456456a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClE0EU
Photonics: Nanomechanics gets the shakes p458
Photonic circuits can allow light to be tightly confined on a chip.
A clever experiment reveals how this process can be exploited to
create optical forces that drive a nanoscale mechanical oscillator.
Tobias J. Kippenberg
doi:10.1038/456458a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClF0EV
----------------------
ARTICLE
----------------------
Gibberellin-induced DELLA recognition by the gibberellin receptor
GID1 pp459-463
Gibberellin is an important plant hormone that regulates several
development processes. This paper presents a ternary complex of
gibberellin bound to its receptor and a fragment of a DELLA protein.
The structures reveal the mechanistic basis of gibberellin
recognition, which is distinct from auxin perception.
Kohji Murase, Yoshinori Hirano, Tai-ping Sun and Toshio Hakoshima
doi:10.1038/nature07519
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClG0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClH0EX
HITS-CLIP yields genome-wide insights into brain alternative RNA
processing p464-469
Recent studies have indicated that a cell's proteome is significantly
larger than the number of protein coding genes due to extensive
alternative splicing. This study describes an unbiased, genome wide
method to characterize RNA protein binding interactions in vivo. The
binding sites of the neuron-specific splicing factor Nova are
characterized with the unexpected result that Nova may have an
additional function in regulating alternative polyadenylation as well.
Donny D. Licatalosi et al.
doi:10.1038/nature07488
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClI0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClJ0EZ
Alternative isoform regulation in human tissue transcriptomes p470-476
This paper reports on an intensive bioinformatic analysis of human
alternative splicing in various tissues and cancers. The analysis
offers insight into tissue specificity, coordinated regulation and
sequence conservation of alternative splicing. Evidence is also
obtained that alternative splicing is mechanistically linked to a
modification of mRNAs known as polyadenylation.
Eric T. Wang et al.
doi:10.1038/nature07509
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClK0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClL0Eb
----------------------
LETTERS
----------------------
Water vapour jets inside the plume of gas leaving Enceladus pp477-479
A plume of water vapour escapes from fissures crossing the south polar
region of Saturn's moon, Enceladus. This study reports observations of
an occultation of a star by the plume on 24 October 2007, which
revealed four high density gas jets at positions that coincide with
those of the previously seen dust jets. The amount of water seen does
not agree with earlier predictions.
C. J. Hansen et al.
doi:10.1038/nature07542
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClM0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClN0Ed
Harnessing optical forces in integrated photonic circuits pp480-484
The direct detection and exploitation of optical forces in an
integrated silicon photonic circuit that contains a nanomechanical
resonator is reported. This nanomechanical device, which is a
freestanding, vibrating waveguide, is driven by a laser diode and its
motion can be read out through evanescent coupling of the light
through the waveguide to the dielectric substrate. This demonstration
uncovers a new optical force that enables all optical operation of
nanomechanical systems on a CMOS compatible platform.
Mo Li et al.
doi:10.1038/nature07545
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClO0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClP0Ef
Total synthesis of bryostatin 16 using atom-economical and
chemoselective approaches pp485-488
The ideal in organic synthesis is to prepare complex molecules using
the smallest possible number of steps. Also important is atom economy,
limiting waste by ensuring that most of atoms present in the reactants
end up in the product. This paper demonstrates both of these
principles to great effect in the synthesis of bryostatin 16, a
biologically active, naturally occurring compound. The synthesis uses
nearly half the number of steps of previously reported routes to
bryostatins.
Barry M. Trost and Guangbin Dong
doi:10.1038/nature07543
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClQ0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClR0Eh
Agulhas leakage dynamics affects decadal variability in Atlantic
overturning circulation pp489-492
The Meridional Overturning Circulation (MOC) mixes heat and salinity
among ocean basins and between deep and shallow waters. Global climate
effects, including moderation of the climate of western Europe, are
extensive. Changes in the strength of the MOC could thus have dramatic
impacts for local to regional climate change, but evidence for
systematic changes is, to date, equivocal. Analysis of the residuals
between a coarse resolution ocean model and a model with a localized
fine resolution grid shows that the input of warm and salty water
transferred around the southern tip of Africa (termed the Agulhas
leakage) contributes strongly to the strength of the MOC.
A. Biastoch, C. W. Boning and J. R. E. Lutjeharms
doi:10.1038/nature07426
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClS0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClT0Ej
Low heat flow inferred from >4 Gyr zircons suggests Hadean plate
boundary interactions pp493-496
An examination of inclusion assemblages in Hadean zircons from Jack
Hills (Western Australia) is presented, which constrain the magmatic
formation conditions to about 700 degreesC and 7 kbars. This result
implies a near surface heat flow about 3–5 times lower than estimates
of global Hadean heat flow. As the only site of magmatism on modern
Earth that is characterized by heat flow of about one-quarter of the
global average is above subduction zones, it is suggested that the
magmas from which the Jack Hills Hadean zircons crystallized were
formed largely in an underthrust environment, perhaps similar to
modern convergent margins.
Michelle Hopkins, T. Mark Harrison and Craig E. Manning
doi:10.1038/nature07465
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClU0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClV0El
An ancestral turtle from the Late Triassic of southwestern China pp497-501
220 million year old fossils from southwestern China represent the
most primitive turtle known, and shed light on intermediate steps in
the acquisition of the unique and highly specialized turtle body plan.
Chun Li et al.
doi:10.1038/nature07533
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClW0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClX0En
Self-renewal and expansion of single transplanted muscle stem
cells p502-506
Clonal analysis is used to show that muscle satellite cells are in
fact stem cells and are capable of self renewal. A single luciferase
expressing muscle stem cell is transplanted into the muscle of mice,
and it is shown that it is capable of extensive proliferation,
contributes to muscle fibres and can be transplanted. Imaging is also
used to show that the muscle stem cells are highly proliferative
following muscle damage in the course of repair.
Alessandra Sacco, Regis Doyonnas, Peggy Kraft, Stefan Vitorovic
& Helen M. Blau
doi:10.1038/nature07384
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClY0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClZ0Ep
Lymphoid tissue genesis induced by commensals through NOD1 regulates
intestinal homeostasis p507-510
The generation of isolated lymphoid follicles is shown to depend on
NOD1-induced responses to bacterial components. Isolated lymphoid
follicles are in turn are shown to affect the composition of the host
microbiota.
Djahida Bouskra et al.
doi:10.1038/nature07450
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCla0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClb0Ex
Sarcolemma-localized nNOS is required to maintain activity after mild
exercise p511-515
Many neuromuscular conditions are characterized by an exaggerated
exercise induced fatigue response. This form of inactivity is a major
determinant of disability. The mechanism underlying this type of
fatigue remains unknown. It is shown in mice that such exaggerated
fatigue is due to a lack of contraction induced signalling from
sarcolemma localized nNOS. In addition, in patient biopsies from a
large number of distinct myopathies, sarcolemmal nNOS is
reduced—pointing towards a common mechanism of fatigue.
Yvonne M. Kobayashi et al.
doi:10.1038/nature07414
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClc0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCld0Ez
A fast, robust and tunable synthetic gene oscillator p516-519
Synthetic biologists aim to apply well known principles of gene
regulation to build living systems with desired properties. This study
has combined microfluidics, single cell microscopy and computational
modelling to develop a bacterial gene oscillator that is fast, robust,
persistent and whose frequency can be tuned externally. The combination
of experimental and theoretical work reveals a simplified oscillator
design without the need for positive feedback.
Jesse Stricker, Scott Cookson, Matthew R. Bennett, William H. Mather,
Lev S. Tsimring & Jeff Hasty
doi:10.1038/nature07389
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCle0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClf0E2
Structural basis for gibberellin recognition by its receptor
GID1 pp520-523
Gibberellin is an important plant hormone that regulates several
development processes. This paper presents the structure of
gibberellin bound to its receptor.
Asako Shimada et al.
doi:10.1038/nature07546
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClg0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClh0E4
53BP1 promotes non-homologous end joining of telomeres by increasing
chromatin mobility p524-528
53BP1 is required for V(D)J recombination and for joining of DNA
breaks in telomeres. In V(D)J recombination, the ends of the programmed
double strand break are degraded when 53BP1 is absent, and joining
between distal V and DJ segments is affected. At broken telomeres,
53BP1 increases the mobility of the DNA ends in the nucleus so that
they are more likely to encounter a partner to which they can be
ligated. Thus, 53BP1 facilitates repair by changing the dynamics of
movement of broken ends, making long range interactions more frequent.
Nadya Dimitrova, Yi-Chun M. Chen, David L. Spector & Titia de Lange
doi:10.1038/nature07433
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCli0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClj0E6
53BP1 facilitates long-range DNA end-joining during V(D)J
recombination p529-533
A previously unrecognized defect in the joining phase of V(D)J
recombination in 53BP1-deficient lymphocytes that is distinct from
that found in classical non-homologous-end-joining-, H2ax-, Mdc1- and
Atm-deficient mice, is reported.
Simone Difilippantonio et al.
doi:10.1038/nature07476
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClk0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCll0E8
The role of HLA-DQ8 beta57 polymorphism in the anti-gluten T-cell
response in coeliac disease pp534-538
The association of particular major histocompatibility complex (MHC)
polymorphisms with susceptibility to a number of autoimmune disease
has been a puzzling phenomenon. This paper proposes a mechanism that
might account in part for the onset of coeliac disease.
Transaminase-mediated deamination of glutamine residues in gluten
peptides may cause them to bind more tightly to disease-associated MHC
alleles, activating heteroclitic gluten peptide specific T-cell
autoreactivity in the gut.
Zaruhi Hovhannisyan et al.
doi:10.1038/nature07524
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClm0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCln0EB
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NATUREJOBS
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Prospect
Prospects p539
Computer game offers academics a chance to play role of graduate
student
Paul Smaglik
doi:10.1038/nj7221-539a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClo0EC
Special Report
Sea of Dreams p540
They may have first been lured by the romance of underwater discovery,
but oceanographers are now riding a wave of career growth and
recognition, says Quirin Schiermeier.
doi:10.1038/nj7221-540a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClp0ED
Career View
Erich Nigg, director of the Biozentrum, University of Basel, Basel,
Switzerland p542
Swiss cell biology leader returns home
Virginia Gewin
doi:10.1038/nj7221-542a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClq0EE
Toyota motors ahead p542
Despite economic downturn, Toyota opens Michigan R&D center
Karen Kaplan
doi:10.1038/nj7221-542b
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClr0EF
Calm before the storm p542
Postdoc-turned-lecturer enjoys calm before the storm
Jon Yearsley
doi:10.1038/nj7221-542c
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCls0EG
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FUTURES
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From Mars with love p544
He who dares ...
Julian Tang
doi:10.1038/456544a
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClt0EH
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ADVANCE ONLINE PUBLICATION
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26 November 2008
Letters
Major gradients in putatively nitrifying and non-nitrifying Archaea in
the deep North Atlantic
Hélène Agogué, Maaike Brink, Julie Dinasquet & Gerhard J. Herndl
doi:10.1038/nature07535
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClu0EI
Nuclear receptor corepressor and histone deacetylase 3 govern
circadian metabolic physiology
Theresa Alenghat et al.
doi:10.1038/nature07541
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClv0EJ
Parallel adaptations to high temperatures in the Archaean eon
Bastien Boussau, Samuel Blanquart, Anamaria Necsulea,
Nicolas Lartillot & Manolo Gouy
doi:10.1038/nature07393
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClw0EK
Role for Spi-C in the development of red pulp macrophages and splenic
iron homeostasis
Masako Kohyama et al.
doi:10.1038/nature07472
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClx0EL
Ferritin is used for iron storage in bloom-forming marine pennate
diatoms
Adrian Marchetti et al.
doi:10.1038/nature07539
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCly0EM
23 November 2008
Letters
Analysis of combinatorial cis-regulation in synthetic and genomic
promoters
Jason Gertz, Eric D. Siggia & Barak A. Cohen
doi:10.1038/nature07521
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CClz0EN
Dynamics of DNA replication loops reveal temporal control of
lagging-strand synthesis
Samir M. Hamdan, Joseph J. Loparo, Masateru Takahashi,
Charles C. Richardson & Antoine M. van Oijen
doi:10.1038/nature07512
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCl10EA
Pulsed contractions of an actin–myosin network drive apical
constriction
Adam C. Martin, Matthias Kaschube & Eric F. Wieschaus
doi:10.1038/nature07522
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCl20EB
Altered circadian rhythms regulate growth vigour in hybrids and
allopolyploids
Zhongfu Ni et al.
doi:10.1038/nature07523
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0CCl30EC
=====================================================================
Nature Reviews Genetics and Nature Genetics
A Look at Next-Generation Sequencing Technologies
DNA sequencing is undergoing a revolution. Sanger
sequencing has reached its limits and is being
replaced by a new generation of technologies that
promise faster and cheaper delivery of sequencing
information. Nature Genetics and Nature Reviews
Genetics present a Poster and Podcast that explore
the conceptual basis of these next-generation sequencing
technologies, their myriad applications and challenges
for the future.
Access the FREE Poster and Podcast online!
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0B77i0Ey
Produced with support from:
Applied Biosystems
http://ealerts.nature.com/cgi-bin24/DM/y/eo630Xztnp0HjB0B77j0Ez
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