13 November 2008 Volume 456 Number 7219 pp141-280
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Web Focus: Voltage Sensing
The electrical potential across cellular membranes
is sensed by specialized proteins; typically,
voltage-gated ion channels. Until recently, the
mechanism by which 'voltage sensors' respond to
potential changes has been unclear, this focus
celebrates the twists and turns of that progress
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EDITORIALS
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Danger and opportunity p141
The response to the financial crisis needs to go beyond the immediate
pressures. Policy-makers must seize this moment to solidify the
science and innovation required for sustained economic growth.
doi:10.1038/456141a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMI0ES
Situations vacant p142
Italy's universities should be free to hire who they want -- and
should be accountable for the result.
doi:10.1038/456142a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMJ0ET
Science by litigation p142
A company's lawsuit against researchers should not be allowed to
intimidate others.
doi:10.1038/456142b
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMK0EU
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RESEARCH HIGHLIGHTS
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Molecular biology: Clones of the dead p144
doi:10.1038/456144a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBML0EV
Astronomy: Star birth p144
doi:10.1038/456144b
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMM0EW
Meteorology: Prediction with plants p144
doi:10.1038/456144c
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMN0EX
Animal behaviour: Got the scent p144
doi:10.1038/456144d
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMO0EY
Molecular biology: Micro-conspirator pp144-145
doi:10.1038/456144e
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMP0EZ
Chemical biology: Clotting by quorum p145
doi:10.1038/456145a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMQ0Ea
Quantum physics: Entangled accuracy p145
doi:10.1038/456145b
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMR0Eb
Molecular biology: Chewing the fat p145
doi:10.1038/456145c
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMS0Ec
Geosciences: Submarine slippage p145
doi:10.1038/456145d
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMT0Ed
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JOURNAL CLUB
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Journal club p145
Douglas Natelson
doi:10.1038/456145e
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMU0Ee
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NEWS
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Climate first for Obama transition team pp146-147
Appointments to key energy positions should reveal the new president's
priorities.
Alexandra Witze
doi:10.1038/456146a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMV0Ef
Modified genes spread to local maize p149
Findings reignite debate over genetically modified crops.
Rex Dalton
doi:10.1038/456149a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMW0Eg
China asks world to step up on climate pp151
Beijing conference tackles how to help developing countries.
Jane Qiu
doi:10.1038/456151a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMX0Eh
WHO congress backs traditional medicine pp152
doi:10.1038/456152a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMY0Ei
Proposed reform to animal testing rules draws fire pp152
doi:10.1038/456152b
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMZ0Ej
Contaminants identified in plastic lab equipment pp152
doi:10.1038/456152c
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMa0Eq
Marine census nets wealth of unknown ocean life pp153
doi:10.1038/456153a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMb0Er
Research agency focuses on first-time applicants pp153
doi:10.1038/456153b
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMc0Es
Billion-dollar bid for stem-cell treatments pp153
doi:10.1038/456153c
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMd0Et
Science in the meltdown pp155-159
The research enterprise faces many uncertainties in the looming
global recession — but it also has many strengths that may help it
weather the storm. Nature investigates.
M. Mitchell Waldrop
doi:10.1038/456155a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMe0Eu
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NEWS FEATURE
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Neuroscience: The plaque plan pp161-164
Neuroscientists are pretty sure they know what causes Alzheimer's
disease, but their theory has not yet given rise to effective drugs.
Alison Abbott asks what's wrong.
doi:10.1038/456161a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMf0Ev
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CORRESPONDENCE
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Italy: 'draconian' new law galvanizes demonstrations p166
Rete Nazionale Ricercatori Precari
doi:10.1038/456166a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMg0Ew
Italy: restoring axed funds is not enough to cure all ills p166
Ferdinando Boero
doi:10.1038/456166b
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMh0Ex
Peer-reviewed parrot studies speak for themselves, as he did p166
Irene M. Pepperberg
doi:10.1038/456166c
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMi0Ey
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COMMENTARY
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The innovative brain pp168-169
'Hot' decision-making, involving the evaluation of reward and
punishment, is essential to the entrepreneurial process and may be
possible to teach, argue Barbara Sahakian and her coauthors.
Andrew Lawrence et al.
doi:10.1038/456168a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMj0Ez
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BOOKS AND ARTS
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Meditating on consciousness pp170-171
Two books exploring the relationship between Buddhism and science
reveal surprising synergies -- and hint that insights into the brain
may come from studying the religion's practices, finds Michael Bond.
Michael Bond reviews Buddhism and Science: A Guide for the Perplexed
by Donald S. LopezMind and Life: Discussions with the Dalai Lama on
the Nature of Reality by Pier Luigi Luisi and Zara Houshmand
doi:10.1038/456170a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMk0E1
Seeing is behaving pp171-172
Warren Mansell reviews Living Control Systems III: The Fact of Control
by William T. Powers
doi:10.1038/456171a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMl0E2
Change begins at home p172
Josie Glausiusz reviews Climate Change: The Threat to Life and a New
Energy Future
doi:10.1038/456172a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMm0E3
The two cultures of Wall Street pp173-174
J. Doyne Farmer reviews Physicists on Wall Street and Other Essays on
Science and Society by Jeremy Bernstein
doi:10.1038/456173a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMn0E4
Mapping the cerebral globe p174
A detailed sketch by architect Christopher Wren reveals his surprising
contribution to neuroscience, explain Martin Kemp and Nathan Flis.
Martin Kemp and Nathan Flis
doi:10.1038/456174a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMo0E5
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ESSAY
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Why do intelligent people live longer? pp175-176
We must discover why cognitive differences are related to morbidity
and mortality, argues Ian Deary, in order to help tackle health
inequalities.
doi:10.1038/456175a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMp0E6
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NEWS AND VIEWS
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Neuroscience: Light moulds plastic brains pp177-178
In tadpoles, the number of neurons expressing the neurotransmitter
dopamine increases on exposure to light. Such plasticity might allow
animals to match their brains' response to environmental stimuli.
Stefan Thor
doi:10.1038/456177a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMq0E7
Analytical chemistry: Home diagnostics to music pp178-179
Fed up with sitting in the doctor's surgery among all those sneezy
patients, waiting for the results of a health check? With the latest
technology, you could one day perform bioassays on your home
compact-disc player.
Jeffrey S. Erickson and Frances S. Ligler
doi:10.1038/456178a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMr0E8
Marine biology: Genes in the glass house pp179-181
Sequence data on a second species of diatom provide abundant insights
into the evolution and metabolic capabilities of this group, as well
as into mechanisms of gene acquisition and diversification.
Ronald P. Kiene
doi:10.1038/456179a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMs0EA
Quantum physics: Swift control of a single spin pp182-183
For now, quantum information processing systems remain a dream. Step
by step, however, progress towards that goal is being made, with one
promising route involving a novel means of manipulating electron spin.
Keiichi Edamatsu
doi:10.1038/456182a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMt0EB
Ion channels: The voltage-sensor quartet pp183-185
Decoding the workings of voltage-gated sodium channels is crucial
because their mutation leads to severe disease and their activity is
modulated by toxins and drugs. An innovative approach now allows such
investigations.
J. R. Bankston and R. S. Kass
doi:10.1038/456183a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMu0EC
Microscopy: Watching catalysts at work pp185-186
Solid catalysts speed up many industrial chemical reactions and steer
them towards making desired products. A microscopy technique could
reveal the changes in composition that catalysts undergo as they
perform.
Alexis T. Bell
doi:10.1038/456185a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMv0ED
Biochemistry: Flexible peptide assembly pp186-187
A jack of all trades is a master of none, as the saying goes. But a
protein has been discovered that shuns specialism, and that multitasks
to give flexibility to its biosynthetic repertoire.
Jan C. M. van Hest
doi:10.1038/456186a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMw0EE
Neuroscience: Cool songs pp187-188
Cooling a specific cluster of neurons in songbirds' brains slows song
tempo without changing other acoustic features. This clever technique
could be used for understanding neural control of other complex
behaviours.
Chris M. Glaze and Todd Troyer
doi:10.1038/456187a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMx0EF
----------------------
BRIEF COMMUNICATIONS ARISING
----------------------
The origin of hydrogen around HD 209458b pE1
A. Lecavelier des Etangs, A. Vidal-Madjar and J.-M. Desert
doi:10.1038/nature07402
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMy0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBMz0EH
Holmstrom et al. reply ppE1-E2
M. Holmstrom et al.
doi:10.1038/nature07403
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBM10E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBM20E4
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=====================================================================
----------------------
ARTICLES
----------------------
Using temperature to analyse temporal dynamics in the
songbird motor pathway pp189-194
Complex motor behaviours, such as human speech or bird song require
precisely timed execution at multiple time scales of an ordered set
of movements. In zebra finches, reducing the activity of premotor
area HVC by cooling slows down the overall speed of songs produced,
but leaving the acoustic structure of elements within the song intact.
These findings suggest a potential model by which the brain controls
song production and timing.
Michael A. Long and Michale S. Fee
doi:10.1038/nature07448
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBM40E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBM50E7
Illumination controls differentiation of dopamine neurons regulating
behaviour pp195-201
The balance between neurons expressing various neurotransmitters is
thought to be set under genetic control during brain development.
This study shows that exposing tadpoles to natural light results
in higher number of central neurons expressing dopamine. These in
turn regulate changes in the animal skin coloration in response
to illumination. The results may be relevant to light therapy of
some types of depression in humans, which also implicates aminergic
neurons.
Davide Dulcis and Nicholas C. Spitzer
doi:10.1038/nature07569
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBM60E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBM70EA
Deconstructing voltage sensor function and pharmacology in
sodium channels pp202-208
Unlike voltage gated Kv channels, which comprise four subunits
containing potentially identical voltage sensing domains, voltage
gated Nav channels are derived from one gene and contain four non
identical voltage sensing domains. The symmetry of Kv channels is
utilized to report the properties of different Nav channel voltage
sensors transplanted into a Kv channel core. It is found that the
paddle domain is important for Nav channel function and that
toxin–paddle interactions are highly specific.
Frank Bosmans, Marie-France Martin-Eauclaire and Kenton J. Swartz
doi:10.1038/nature07473
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBM80EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNA0EL
Structure of the guide-strand-containing argonaute silencing complex
p209
This study describes the crystal structure of an Argonaute protein
with a single stranded, 21 nucleotide DNA that mimics the strand
which is used to silence gene expression. The structure illustrates
how the DNA is anchored in the protein, how the nucleotides that are
most critical in sequence recognition are available for binding the
target mRNA, and how the nucleotides opposite the site of cleavage
are positioned.
Yanli Wang, Gang Sheng, Stefan Juranek, Thomas Tuschl
& Dinshaw J. Patel
doi:10.1038/nature07315
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNB0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNC0EN
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=====================================================================
----------------------
LETTERS
----------------------
Complex structure within Saturn's infrared aurora pp214-217
The majority of planetary aurorae are produced by currents flowing
between the planet's ionosphere and magnetosphere, which accelerate
energetic charged particles that subsequently hit the upper atmosphere.
Recent models of Saturn's aurorae predict only weak emission away from
the main auroral oval. This paper reports images that show emission
both poleward and equatorward of the main oval. The extensive polar
emission is highly variable with time, and appears not to be directly
linked with strong magnetospheric compressions.
Tom Stallard et al.
doi:10.1038/nature07440
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBND0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNE0EP
Complete quantum control of a single quantum dot spin using ultrafast
optical pulses pp218-221
Full quantum control involving initialization, spin rotation and
detection, has been demonstrated with electrically controlled radio
frequency pulses, but this method will eventually be too slow for
construction of quantum computing circuits operating at useful clock
speeds. Optical manipulation of electron spin allows much faster
operations. This study achieves ultrafast optical control of electron
spin in a quantum dot and demonstrates, in combination with optical
initialization and detection, a single qubit logic gate operation,
involving a sequence involving two optical pulses.
David Press, Thaddeus D. Ladd, Bingyang Zhang and Yoshihisa Yamamoto
doi:10.1038/nature07530
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNF0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNG0ER
Nanoscale chemical imaging of a working catalyst by scanning
transmission X-ray microscopy pp222-225
Most industrial processes make use of heterogeneous catalysts, which
typically consist of nanometre sized particles of metal or metal oxide
dispersed on a solid support material. Any attempt to unravel how such
complex systems function requires detailed information on the morphology
and chemical composition of the catalysts during operation.
Microspectroscopy methods have advanced to a stage where this challenge
can be tackled and enables the direct imaging of an iron based
Fisher–Tropsch catalyst with nanometre resolution to reveal how
changes in the catalyst correlate with its activity.
Emiel de Smit et al.
doi:10.1038/nature07516
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNH0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNI0ET
Transient nature of late Pleistocene climate variability
pp226-230
The past three million years has been a period of dramatic climate
fluctuations. The usual framework within which such changes are
interpreted is to invoke large nonlinear responses of the climate
system to subtle cyclical changes in Earth's orbit or gradual
reduction in the Earth's background CO2 level. This study offers
a different perspective, proposing that these increasingly pronounced
fluctuations (while still driven by orbital variations) are indicative
of the transient behaviour of a system approaching a bifurcation point,
that is, a point at which the system will undergo a transition to a
new stable climate state of permanent midlatitude northern hemisphere
glaciation.
Thomas J. Crowley and William T. Hyde
doi:10.1038/nature07365
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNJ0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNK0EV
Radiative conductivity in the Earth's lower mantle pp231-234
The radiative component of thermal conductivity in the dominant
silicate perovskite material of Earth's lower mantle is controlled
by the amount of ferric iron. The estimated pressure dependent radiative
conductivity from these data is 2–5 times lower than that previously
inferred from model extrapolations, with implications for the evolution
of the mantle, such as generation and stability of thermo chemical
plumes in the lower mantle.
Alexander F. Goncharov et al.
doi:10.1038/nature07412
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNL0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNM0EX
The interaction between predation and competition pp235-238
Understanding how interactions between species contributes to the
maintenance of species diversity is one of the most fundamental and
long-standing questions in ecology. New theoretical results highlight
the mutually interdependent roles of predation and competition in
governing coexistence.
Peter Chesson and Jessica J. Kuang
doi:10.1038/nature07248
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNN0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNO0EZ
The Phaeodactylum genome reveals the evolutionary history of
diatom genomes p239
Phaeodactylum tricornutum is the first pennate diatom to have its
genome sequenced. Comparative genome analysis suggests high rates
of genome diversification during evolution, high occurrence of
bacterial genes acquired through horizontal gene transfer and provides
insight into the metabolic capabilities of these important marine
primary producers.
Chris Bowler et al.
doi:10.1038/nature07410
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNP0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNQ0Eb
Associative learning of social value pp245-249
It was previously thought that social learning competed with simpler
paradigms, such as reward based associative learning. This study
reveals that the same neural mechanisms may underlie the acquisition
of social information and reward based feedback, but with each
operating in parallel processing streams within the anterior cingulate
cortex. Information was then integrated and combined in ventromedial
prefrontal cortex to guide behavioural decisions.
Timothy E. J. Behrens, Laurence T. Hunt, Mark W. Woolrich &
Matthew F. S. Rushworth
doi:10.1038/nature07538
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNR0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNS0Ed
Oligopotent stem cells are distributed throughout the mammalian
ocular surface p250
It was believed that the limbus is the niche for the stem cells
responsible for the long term renewal of the cornea. This paper shows
that instead, the renewal of the corneal epithelium is not different
from other squamous epithelia, and is self maintained without limbal
contribution. It is also shown that the entire ocular surface of the
pig, including the central cornea, contains stem cells that are
oligopotent and can generate individual colonies of corneal and
conjunctival cells.
Francois Majo, Ariane Rochat, Michael Nicolas, Georges Abou Jaoude
& Yann Barrandon
doi:10.1038/nature07406
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNT0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNU0Ef
Stereocilin-deficient mice reveal the origin of cochlear waveform
distortions p255
The mammalian cochlea possesses two types of hair cells, inner and
outer hair cells, the latter of which are responsible for non linear
distortion products such as otoacoustic emissions. This paper provides
evidence that that the origin of this non linearity is in the connections
between outer hair cell sterocilia, known as top connectors, and more
specifically, in a protein called stereocilin.
Elisabeth Verpy et al.
doi:10.1038/nature07380
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNV0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNW0Eh
A key role for autophagy and the autophagy gene Atg16l1 in mouse and
human intestinal Paneth cells p259
The chronic inflammation of the gut associated with Chron's disease
has been linked to alleic polymorphisms in the human gene ATG16L1.
This paper applies mouse genetics to demonstrate that Atg16l1 function
is critical to Paneth cell development and function. Paneth cells are
critically important for maintenance of the intestinal barrier.
Ken Cadwell et al.
doi:10.1038/nature07416
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNX0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNY0Ej
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced
IL-1beta production p264
Autophagy is a bulk degradation system that controls the clearance of
intracellular protein debris and invading microbes. This paper shows
that Atg16L1 is an essential component of the autophagic machinery
and that autophagy is a critical negative regulator of inflammation
in isolated macrophages and mouse intestine.
Tatsuya Saitoh et al.
doi:10.1038/nature07383
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNZ0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNa0Er
A fasting inducible switch modulates gluconeogenesis via
activator/coactivator exchange p269
A fasting inducible switch, consisting of the histone acetyl transferase
p300 and the nutrient sensing deacetylase sirtuin 1 (SIRT1), is shown to
maintain energy balance during fasting by promoting the sequential
induction of the transcription factors TORC2 and FOXO1.
Yi Liu et al.
doi:10.1038/nature07349
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNb0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNc0Et
----------------------
CORRIGENDA
----------------------
The delayed rise of present-day mammals p274
Olaf R. P. Bininda-Emonds et al.
doi:10.1038/nature07347
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNd0Eu
STING is an endoplasmic reticulum adaptor that facilitates innate
immune signalling p274
Hiroki Ishikawa and Glen N. Barber
doi:10.1038/nature07432
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNe0Ev
A role for clonal inactivation in T cell tolerance to Mls-1a p274
Marcia A. Blackman et al.
doi:10.1038/nature07514
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNf0Ew
Structural basis for specific cleavage of Lys-63-linked
polyubiquitin chains p274
Yusuke Sato et al.
doi:10.1038/nature07515
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNg0Ex
----------------------
ADDENDUM
----------------------
Genes mirror geography within Europe p274
John Novembre et al.
doi:10.1038/nature07566
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNh0Ey
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p275
Government funds are increasingly scarce. But investing in research
could not only generate jobs but help reverse the economic downturn.
Gene Russo
doi:10.1038/nj7219-275a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNi0Ez
Careers and Recruitment
Brain work p276
Industry's urge to build on breakthroughs in neurotechnology could be
a boon for business-minded scientists, says Virginia Gewin.
Virginia Gewin
doi:10.1038/nj7219-276a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNj0E1
----------------------
FUTURES
----------------------
Quantum erat demonstrandum p280
Surfing the treacherous data wave.
C. N. Simms
doi:10.1038/456280a
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNk0E2
----------------------
Advance Online Publication
----------------------
12 November 2008
Experience leaves a lasting structural trace in cortical circuits
Sonja B. Hofer, Thomas D. Mrsic-Flogel, Tobias Bonhoeffer & Mark Hübener
doi:10.1038/nature07487
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNl0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNm0E4
Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to
tamoxifen
Antoni Hurtado et al.
doi:10.1038/nature07483
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNn0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNo0E6
Neural processing of auditory feedback during vocal practice in a
songbird
Georg B. Keller & Richard H. R. Hahnloser
doi:10.1038/nature07467
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNp0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNq0E8
Memory CD8 T-cell compartment grows in size with immunological
experience
Vaiva Vezys et al.
doi:10.1038/nature07486
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNr0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNs0EB
09 November 2008
A role for VEGF as a negative regulator of pericyte function and vessel
maturation
Joshua I. Greenberg et al.
doi:10.1038/nature07424
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNt0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNu0ED
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus
monkeys
Jinyan Liu et al.
doi:10.1038/nature07469
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNv0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNw0EF
Role for perinuclear chromosome tethering in maintenance of genome
stability
Karim Mekhail, Jan Seebacher, Steven P. Gygi & Danesh Moazed
doi:10.1038/nature07460
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNx0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNy0EH
Deletion of vascular endothelial growth factor in myeloid cells
accelerates tumorigenesis
Christian Stockmann et al.
doi:10.1038/nature07445
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBNz0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB0CBN10E4
=====================================================================
Nature Reviews Microbiology
Evaluating Diagnostics: the CD4 guide
Accurate CD4 counts are crucial laboratory
markers for assessing immunodeficiency and
the risk of disease progression in HIV-1
infection. HIV-1 causes a huge burden of
morbidity and mortality, particularly in
developing countries. This fourth supplement
in the series on evaluating diagnostics
focuses on CD4 immunodiagnostics, which can
be used to monitor CD4 counts, decide when
to treat individuals with antivirals and
whether treatments are effective.
Access the CD4 Guide online at
http://ealerts.nature.com/cgi-bin24/DM/y/eooP0Xztnp0HjB071U0Es
Produced in collaboration with TDR
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