Signaling Gateway - 3 October 2008
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0M40Ea
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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COLON CANCER: A BETA-CATENIN-CDK8-E2F1 MENAGE A TROIS
CDK8 and E2F1 have antagonistic roles in beta-catenin-mediated
transcription.
Original research paper: Nature 455, 547-551 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0vP0Ej
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Alpha-Parvin
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67Y0Ep
alpha-parvin is a focal adhesion and cytoskeleton-associated protein
that functions as a crucial linker between important cytoskeletal
proteins. It is involved in many cellular processes ranging from
cell adhesion, spreading and proliferation, to the deposition of
extracellular matrix proteins. Together with PINCH, alpha-parvin and
ILK form a complex that is crucial for many cell functions, including
survival.
Also published this week:
Frizzled 7;
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67Z0Eq
Beta-Parvin,
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67a0Ex
Copine II;
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67b0Ey
Copine III;
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67c0Ez
Copine IV;
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67d0E1
Copine V;
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67e0E2
Copine VI;
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67f0E3
Copine VII;
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67g0E4
Copine VIII
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W034j0Eu
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0BUuz0Ev
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Selected Updates
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POST-TRANSLATIONAL MODIFICATION: PICKING APART POLYUBIQUITIN CHAINS
Antibodies that discriminate between Lys-63-linked and Lys-48-linked
ubiquitin chains have revealed that polyubiquitin editing might be
a general mechanism for attenuating signaling.
Original research paper: Cell 134, 668-678 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67h0E5
METASTASIS: MICRO SILENCING
Hypermethylation of microRNAs could lead to their deregulated
expression, which has been implicated in the development of tumor
metastases.
Original research paper: Proc. Natl Acad. Sci. USA 105, 13556-13561
(2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67i0E6
ANTIPSYCHOTICS: TUNING MUSCARINIC RECEPTOR SIGNALLING
The small-molecule modulator LY2033298 specifically potentiates
acetylcholine binding to the M4 muscarinic acetylcholine receptor
subtype and shows promising effects in preclinical models of
schizophrenia.
Original research paper: Proc. Natl Acad. Sci. USA 105,
10978-10983 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67j0E7
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0vO0Ei
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Research Library
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MODELLING MYC INHIBITION AS A CANCER THERAPY
Nature 455, 679-683 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67k0E8
CASCADING SUPPRESSION OF TRANSCRIPTIONAL SILENCERS BY ThPOK SEALS
HELPER T CELL FATE
Nature Immunology 9, 1113-1121 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67l0EA
TRACKING THE STRUCTURAL DYNAMICS OF PROTEINS IN SOLUTION USING
TIME-RESOLVED WIDE-ANGLE X-RAY SCATTERING
Nature Methods 5, 881-886 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67m0EB
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Signaling News
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CELL THERAPY: BEING PATIENT
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B6vL0Ef
Nature talks to Christine Mummery and Viviane Tabar, two stem-cell
researchers who have veered from conventional career paths in the
hope of making stem cells more useful therapeutically. Mummery and
Tabar believe that the best way to ensure that stem-cell therapies
are 'translated' into patients is to be as close as possible to the
patients themselves.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0Crw0ER
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Gateway Updates
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NATURE PRECEDINGS: PRE-PUBLICATION RESEARCH AND PRELIMINARY FINDINGS
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0BVUp0EG
Nature Precedings is a place for researchers to share pre-publication
research and other scientific documents.
Recent presentations and pre-print manuscripts posted to
Nature Precedings include:
Yeast Features: Identifying Significant Features Shared Among Yeast
Proteins for Functional Genomics
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67n0EC
Interruption of beta-Catenin Signaling Reduces Neurogenesis in
Alzheimer's Disease Brains
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67o0ED
Just-in-time assembly of cell-cycle protein complexes
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67p0EE
Search for documents or browse recently posted manuscripts to stay
informed of the latest research in your field.
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67q0EF
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Signaling Job of the Week
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Postdoctoral Fellow
Employer: The New York Stem Cell Foundation
Location: New York, New York
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0B67r0EG
A postdoctoral fellowship is available to explore the basic biology
and therapeutic potential of human pluripotent stem cells at the
New York Stem Cell Foundation. The successful applicant will
elucidate the cell signaling mechanisms that guide the first steps of
neural cell fate choice and patterning and will aim to find novel
strategies of controlling neural differentiation of human pluripotent
cells.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0BnjC0EG
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/enwZ0Xztnp0H2W0vqs0ED
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