Signaling Gateway - 17 October 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0M40Ek
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
NOW 800 ANTIBODIES... 2 SAMPLES... 1 MICROARRAY
Benefits of our new Kinex 800 antibody microarray service:
* 300 phospho-sites tracked
* Only 100 ug cell/tissue protein required
* As low as $1.10 per antibody in duplicate
* Save time, money and effort
Call 1-866-KINEXUS or email info@kinexus.ca
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78e0EF
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
RAPAMYCIN: INTERFERON WITH TLR-MEDIATED ANTIVIRAL IMMUNITY
The PI(3)K–mTOR signaling pathway regulates Toll-like
receptor-stimulated production of type I interferons in plasmacytoid
dendritic cells.
Original research paper: Nature Immunology 9, 1157-1164 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0vP0Et
------------------------
Molecule Pages
------------------------
The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
mTOR
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78f0EG
The atypical Ser/Thr kinase TOR (Target of Rapamycin) is a central
controller of cell growth that is structurally and functionally
conserved in all species. mTOR controls cell growth by the positive
and negative regulation of several anabolic and catabolic processes,
respectively, that collectively determine cell size. These cellular
processes include translation, ribosome biogenesis, nutrient
transport, autophagy, and AGC kinase activation.
Also published this week: Dyrk1b
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78g0EH
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0BUuz0E6
-------------------
Selected Updates
-------------------
DEVELOPMENT: BROWN FAT: MUSCLE UNDERCOVER?
The transcriptional regulator PRDM16 mediates the bidirectional cell
fate switch between muscle and brown fat.
Original research paper: Nature 454, 961-967 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78h0EI
ANTICANCER DRUGS: PARTNERING TO PROMOTE APOPTOSIS
Combining novel agents that target apoptotic pathways with other
approved cancer drugs can enhance tumor-cell apoptosis.
Original research paper: J. Clin. Invest 118, 3109-3122 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78i0EJ
PROTEOMICS: ANTIBODYPEDIA
The 'Antibodypedia' is a wiki-based web portal that allows users to
share information about antibodies along with raw data from western
blots, immunohistochemistry, protein array and immunofluorescence.
Original research paper: Mol. Cell Proteomics 7, 2028-2037 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78j0EK
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0vO0Es
------------------------
Research Library
------------------------
ONCOGENIC MUTATIONS OF ALK KINASE IN NEUROBLASTOMA
Nature 455, 971-974 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78k0EL
GPHR IS A NOVEL ANION CHANNEL CRITICAL FOR ACIDIFICATION AND
FUNCTIONS OF THE GOLGI APPARATUS
Nature Cell Biology 10, 1135-1145 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78l0EM
NOTCH2 INTEGRATES SIGNALING BY THE TRANSCRIPTION FACTORS RBP-J AND
CREB1 TO PROMOTE T CELL CYTOTOXICITY
Nature Immunology 9, 1140-1147 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78m0EN
------------------------
Signaling News
------------------------
NO MORE THIRD TIME LUCKY
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B7u40ER
Effective 25 January 2009, the US National Institutes of Health (NIH)
will permit biomedical researchers to amend and resubmit a failed
grant application only once. Applicants whose grants are unfunded
after the second submission may reapply only after designing a new
proposal. The new guidelines are part of an NIH overhaul of the
peer-review system for evaluating grant proposals.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0Crw0Eb
-------------------------
Gateway Updates
-------------------------
NCI-NATURE PATHWAY INTERACTION DATABASE - OCTOBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0BGyx0Et
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.
Recently added pathways include:
The Glypican 3 network
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B7nV0Es
The EphrinB-EPHB pathway
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B7nW0Et
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0BJYy0ER
-----------------------------
Signaling Job of the Week
-----------------------------
Post Doctoral Research Fellow
Employer: Medical Research Council
Location: London, UK
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0B78n0EO
A postdoctoral position is available at the MRC Clinical Sciences
Centre to study intracellular regulation of TGF-beta/Smad signaling and
characterize its impact on development and disease. A potential
project will focus on the ubiquitin-mediated regulation of this
pathway in neuronal cell contexts and cancer.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0BnjC0EQ
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0vqs0EN
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0dIO0En
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0BCGZ0EV
For further technical assistance or any other enquiries, please click here:
http://ealerts.nature.com/cgi-bin24/DM/y/eoGW0Xztnp0H2W0mg0E8
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2008 Nature Publishing Group
---------------------------------------------------------------------
