Signaling Gateway - 10 October 2008
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0M40Ec
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TGF-BETA SIGNALING: A NEW ROUTE TO P38 AND JNK
TGF-beta activates p38/JNK through TRAF6-mediated polyubiquitylation
of TAK1.
Original research paper: Nature Cell Biology 10, 1199-1207 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0vP0El
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
CUX1
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7X20Em
CUX1 (Cut homeobox 1) designates a group of protein isoforms that
bind to DNA and function as regulators of RNA polymerase II
transcription. CUX1 can function in either transcriptional repression
or activation, depending on the isoform and the promoter.
Cux1-/- mice display phenotypes in various organs including curly
whiskers, growth retardation, delayed differentiation of lung
epithelia, altered hair follicle morphogenesis, male infertility,
and are deficient in T and B cells.
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0BUuz0Ex
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Selected Updates
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CELL DIVISION: BACK AND FORTH
The transcriptional repressor hairy and enhancer of split-1 (HES1)
enables quiescent cells to resume proliferation following prolonged
cell-cycle arrest.
Original research paper: Science 321, 1095-1100 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7X30En
THERAPY: COMBINE AND CONQUER
Choosing the best combination of therapies for patients with
progressive or non-responsive forms of cancer is enhanced by
understanding the PTEN-Akt-mTOR and MAPK signaling feedback loops
that lead to the evasion of therapeutic responses in cancer.
Original research paper: J. Clin. Invest 118, 3065-3074
(2008)
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7X40Eo
IMAGING AND VISUALIZATION: NEW TWISTS ON PHOTOSWITCHABLE PROTEINS
Fluorescent proteins with novel photoswitching properties allow
multilabel imaging at a single detection wavelength and dual-color
super-resolution microscopy.
Original research paper: Nat. Biotechnol. 26, 1035-1040 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7X50Ep
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0vO0Ek
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Research Library
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THE DEUBIQUITINYLATION AND LOCALIZATION OF PTEN ARE REGULATED BY A
HAUSP-PML NETWORK
Nature 455, 813-817 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7X60Eq
SPATIAL CONTROL OF BRANCHING WITHIN DENDRITIC ARBORS BY
DYNEIN-DEPENDENT TRANSPORT OF RAB5-ENDOSOMES
Nature Cell Biology 10, 1164-1171 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7X70Er
SYSTEMS-LEVEL METABOLIC FLUX PROFILING IDENTIFIES FATTY ACID
SYNTHESIS AS A TARGET FOR ANTIVIRAL THERAPY
Nature Biotechnology 26, 1179-1186 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7AX0E2
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Signaling News
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AND THE WINNER IS…
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7LQ0E6
The 2008 Nobel Prizes in chemistry and physiology or medicine have
been announced. Osamu Shimomura, Martin Chalfie and Roger Tsien share
the Nobel prize in chemistry for their discovery and development of
green fluorescent protein (GFP). The prize in physiology or medicine
was awarded to Harald zur Hausen his work on the human papilloma
virus (HPV) and its role in cervical cancer, and
Francoise Barre-Sinoussi and Luc Montagnier for their discovery of
the human immunodeficiency virus (HIV-1), which causes AIDS.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0Crw0ET
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Gateway Updates
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THE CELL MIGRATION GATEWAY - OCTOBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0uLB0Em
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles:
Actin branching: Coronin 1B vs. cortactin
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7BF0Ek
Actin bundling: Where shall we start?
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7X80Es
PKA: Activity at the leading edge
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7YA0E3
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0BJrg0EQ
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Signaling Job of the Week
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Postdoctoral Position
Employer: German Cancer Research Center
Location: Heidelberg, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0B7YB0E4
A postdoctoral position is available at the German Cancer Research
Center in the Systems Biology of Signal Transduction Division.
The successful applicant will establish a mathematical model of
PI3-kinase and MAP kinase signaling in primary hepatocytes.
This model will then be used to predict strategies that will correct
oncogenic alterations in Ras and MAP kinase signaling.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0BnjC0EI
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/en6a0Xztnp0H2W0vqs0EF
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