October 2008 Volume 10 Number 10, pp 1123 - 1231
Visit Nature Cell Biology online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD04qe0EB
Please note that you need to be a subscriber to enjoy full text access
to Nature Cell Biology online. To purchase a subscription, please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0aAN0Ej
Alternatively, to recommend a subscription to your library, please visit
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0BRtz0EB
=====================================================================
Superior qPCR results in half the time
Bio-Rad's new iTaq(TM) fast supermixes with ROX provide
maximum PCR efficiency, sensitivity, and specificity under
fast or standard cycling conditions. Designed for use with
any real-time detection chemistry, our new supermixes deliver
superior results on your ABI 7500 Fast Real-Time PCR System.
Learn more at:
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kY0Ez
=====================================================================
Free Access to Featured Cell Research Articles
Available for a Limited Time Only
Act now and take advantage of FREE access to some of the top Cell Research articles from the past two years. Featured articles cover topics including but not limited to: apoptosis, stem cells, cell growth and differentiation, signal transduction, immunology, neurosciences and much more!
Take advantage of this limited time special by visiting http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6iA0EZ
=====================================================================
Webinar Olink October 16th
Visualizing protein interactions in cells and tissue by Duolink(TM)
- detection of protein interactions
- localization and quantification of phosphorylations
- studying endogenous proteins
- digitally count individual proteins
Please visit our homepage for more details
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0Bv8B0Ep
=====================================================================
----------------------
EDITORIALS
----------------------
Standardizing data pp1123 - 1124
Biological research is benefiting from an explosion of data. There is
an urgent need to invest in bioinformatic infrastructure and education
to interpret this data and guarantee its archiving.
doi:10.1038/ncb1008-1123
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kZ0E1
ELSO into EMBO goes p1124
The European Life Sciences Organization is set to close shop at the
end of the year by fusing with EMBO.
doi:10.1038/ncb1008-1124
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6ka0E8
----------------------
NEWS AND VIEWS
----------------------
Pores galore for the Golgi pp1125 - 1126
Strict control of cisternal pH in the Golgi is required for posttranslational
modification and trafficking of proteins and lipids. A chloride channel to
neutralize the charge of the proton pump and to keep the Golgi membrane
potential near zero has finally been discovered.
John H. Caldwell and Kathryn E. Howell
doi:10.1038/ncb1008-1125
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kb0EA
One hit, two outcomes for VHL-mediated tumorigenesis pp1127 - 1128
The tumour suppressor VHL is known to suppress hypoxia-induced gene
expression by degrading HIF family transcription factors. Evidence that
VHL also targets the oncoprotein beta-catenin for degradation highlights
a new road to transformation by loss of VHL.
Jurgen Behrens
doi:10.1038/ncb1008-1127
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kc0EB
Stressed out? Make some modifications! pp1129 - 1130
Stress granules and processing bodies are related mRNA-containing granules
implicated in controlling mRNA translation and decay. A genomic screen
identifiesnumerous factors affecting granule formation, including proteins
involved in O-GlcNAc modifications. These results highlight the importance
of post-translational modifications in translational control and mRNP
granule formation.
Angela Hilliker and Roy Parker
doi:10.1038/ncb1008-1129
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kd0EC
Dynein branches out pp1131 - 1132
Individual neurons form specific elaborate dendritic structures that
receive presynaptic information. The pattern of dendritic branching
is regulated by the microtubule-associated motor protein dynein, which
is responsible for the transport of essential endosomes and other
organelles into the dendrites.
Guy Tear
doi:10.1038/ncb1008-1131
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6ke0ED
Research highlights p1133
doi:10.1038/ncb1008-1133
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kf0EE
----------------------
ARTICLES
----------------------
GPHR is a novel anion channel critical for acidification and functions
of the Golgi apparatus pp1135 - 1145
This study identifies a voltage-dependent anion channel involved in
Golgi acidification, thus providing insights into pH regulation in the Golgi.
Yusuke Maeda et al.
doi:10.1038/ncb1773
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kg0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kh0EG
A role for phosphatidic acid in COPI vesicle fission yields insights into
Golgi maintenance pp1146 - 1153
Two distinct steps drive COPI vesicle fission: bud-neck constriction,
which is dependent on the protein BARS and COPI constituents,
followed by bud-neck scission, which is dependent on phosphatidic acid.
Jia-Shu Yang et al.
doi:10.1038/ncb1774
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6ki0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kj0EI
Proof-by-synthesis of the transcriptional logic of mammalian circadian
clocks pp1154 - 1163
Regulatory loops between transcriptional activators and repressors
control the circadian clock. A minimal synthetic combination of these
transcription factors is sufficient to drive a robust circadian rhythm.
Maki Ukai-Tadenuma, Takeya Kasukawa and Hiroki R. Ueda
doi:10.1038/ncb1775
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kk0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kl0EK
=====================================================================
Cut out the waste!
Improve results by getting the right filter-bottomed microplate for your clean up needs from Porvair Sciences. Click to download our new selection guide and choose from over 40 applications and 30 different plates. DNA clean-up, cell lysate and protein crash are all catered for.
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6km0EL
=====================================================================
----------------------
LETTERS
----------------------
Spatial control of branching within dendritic arbors by dynein-dependent
transport of Rab5-endosomes pp1164 - 1171
Dendritic morphogenesis is important for neuronal function. In Drosophila
melanogaster dendritic arborization neurons, microtubule motors control
dendritic branching in a manner that involves trafficking of Rab5-containing
early endosomes.
Daisuke Satoh et al.
doi:10.1038/ncb1776
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kn0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6ko0EN
Dynein is required for polarized dendritic transport and uniform microtubule
orientation in axons pp1172 - 1180
Dendrites and axons differ in microtubule orientation and in composition of
organelles and protein. In Drosophila melanogaster dendritic arborization
neurons, dynein is required for axonal microtubule polarization and for
dendrite-specific targeting of Golgi outposts.
Yi Zheng et al.
doi:10.1038/ncb1777
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kp0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kq0EP
Targeting of the F-actin-binding protein drebrin by the microtubule
plus-tip protein EB3 is required for neuritogenesis pp1181 - 1189
Plus-tip (+TIP) proteins, such as EB1 and EB3, bind to growing microtubules
ends. Interaction of EB3 with drebrin is important to couple filamentous actin
to microtubules during neuronal growth-cone formation.
Sara Geraldo et al.
doi:10.1038/ncb1778
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kr0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6ks0ER
d-Asb11 is an essential mediator of canonical Delta-Notch signalling
pp1190 - 1198
The process of lateral inhibition in the canonical Delta-Notch pathway
is crucial for cell-fate determination. d-Asb11, a regulator of neural
progenitors in zebrafish, is an essential mediator of lateral inhibition
through ubiquitylation of Delta A.
Sander H. Diks et al.
doi:10.1038/ncb1779
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kt0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6ku0ET
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor
kinase-independent manner pp1199 - 1207
In response to TGFbeta, and in contrast to canonical SMAD activation,
TGFbeta receptor kinase activity is dispensable for activating the TAK1
kinase, whereas the TRAF6 ubiquitin ligase is neccessary.
Alessandro Sorrentino et al.
doi:10.1038/ncb1780
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kv0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kw0EV
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates
Wnt pathway inhibition by pVHL pp1208 - 1216
The tumour suppressor VHL is known to stabilize the ubiquitin ligase Jade-1.
Jade-1 targets both phosphorylated and unphosphorylated -catenin, thereby
linking VHL function directly to inhibition of Wnt signalling.
Vipul C. Chitalia et al.
doi:10.1038/ncb1781
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kx0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6ky0EX
The ABC transporter AtABCB14 is a malate importer and modulates
stomatal response to CO2 pp1217 - 1223
Malate is involved in mediating plant stomatal responses to high CO2.
By acting as a malate importer, the ABC transporter AtABCB14 controls
stomatal movements by increasing their osmotic pressure.
Miyoung Lee et al.
doi:10.1038/ncb1782
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6kz0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6k10EL
A functional RNAi screen links O-GlcNAc modification of ribosomal
proteins to stress granule and processing body assembly pp1224 - 1231
An RNAi sreen shows that assembly of stress granules, which are involved
in mRNA translation and decay regulation, requires glycocyslation of
translation machinery components.
Takbum Ohn et al.
doi:10.1038/ncb1783
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6k20EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6k30EN
=====================================================================
NEW PSI-Nature Structural Genomics Knowledgebase
A new gateway to protein structure is now open!
A new window onto the world of protein structure has opened with the launch of the PSI-Nature Structural Genomics Knowledgebase. The PSI-SGKB is a free site designed to let users explore the PSI's rich research findings, tools and resources, and to stay informed about advances in structural biology and structural genomics.
Visit the PSI-SGKB at http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0B6Bn0Ef
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://ealerts.nature.com/cgi-bin24/DM/y/enrL0Xztnp0HjD0Zzu0EE
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
