23 October 2008 Volume 455 Number 7216, pp1007-1148
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The next US president will have a vital role in
determining how the US, and the world, tackles
climate change. In Nature Reports Change Climate
this month, we take an in-depth look at how
climate policy and energy issues are playing out
in the US elections, with a special package of
features and opinion pieces.
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EDITORIALS
----------------------
Getting personal p1007
The commercialization of personal genomics is moving with dizzying
speed and scientists need to find innovative ways of discussing the
implications with consumers.
doi:10.1038/4551007a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Sr0EM
A look within pp1007-1008
A series of Essays examines what science has to say about being human.
doi:10.1038/4551007b
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ss0EN
Fair trade? p1008
Europe needs to find a responsible way out of its climate-regulation
impasse.
doi:10.1038/4551008a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8St0EO
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RESEARCH HIGHLIGHTS
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Botany: Growing flowers p1010
doi:10.1038/4551010a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Su0EP
Geosciences: Exporting ice p1010
doi:10.1038/4551010b
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Sv0EQ
Nanomedicine: Disease nanosensors p1010
doi:10.1038/4551010c
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Sw0ER
Chemistry: Selective separation p1010
doi:10.1038/4551010d
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Sx0ES
Neurology: Contextual views p1010
doi:10.1038/4551010e
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Sy0ET
Plant chemistry: Banana blues pp1010-1011
doi:10.1038/4551010f
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Sz0EU
Biochemistry: Fungal facilitation p1011
doi:10.1038/4551011a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8S10EH
Ecology: Grunter gathering p1011
doi:10.1038/4551011b
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8S20EI
Animal behaviour: Idle ants p1011
doi:10.1038/4551011c
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8S30EJ
Drug design: Hitting the hinge p1011
doi:10.1038/4551011d
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8S40EK
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JOURNAL CLUB
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Journal club p1011
Lynne B. McCusker
doi:10.1038/4551011e
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8S50EL
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NEWS
----------------------
Biosafety lab passes disaster test p1012
Texas facility cleared to analyse lethal pathogens.
Rex Dalton
doi:10.1038/4551012a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8S60EM
Cash row threatens Earth-monitoring system pp1013-1013
Europe's flagship Kopernikus mission faces potential delays.
Declan Butler
doi:10.1038/4551013a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8S70EN
Accessible genomes move closer pp1014-1014
Meeting captures human interest in genetic research.
Erika Check Hayden
doi:10.1038/4551014a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8S80EO
Eight-month delay for LHC p1015
Broken magnets put particle collider in limbo.
Geoff Brumfiel
doi:10.1038/4551015a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Lj0E6
Pharma payment probe widens its net p1017
Psychiatrists accused of flouting financial-disclosure rules.
Meredith Wadman
doi:10.1038/4551017a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TA0EY
Plumes of methane identified on Mars p1018
Finding could influence choice of landing site for Mars Science
Laboratory.
Eric Hand
doi:10.1038/4551018a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TB0EZ
Iranian paper sparks sense of déjà vu p1019
Allegations of plagiarism prompt journal to retract report.
Declan Butler
doi:10.1038/4551019a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TC0Ea
Canada bans bisphenol A in baby products pp1020-1020
doi:10.1038/4551020a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TD0Eb
US slashes acceptable limit for airborne lead pp1020-1020
doi:10.1038/4551020b
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TE0Ec
A sticky situation hits the record books pp1020-1020
doi:10.1038/4551020c
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TF0Ed
Initiative waives human life in favour of life on humans
pp1021-1021
doi:10.1038/4551021a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TG0Ee
Computer failure leaves Hubble in limbo pp1021-1021
doi:10.1038/4551021b
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TH0Ef
US agencies struggle over public relations pp1021-1021
doi:10.1038/4551021c
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TI0Eg
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NEWS FEATURE
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Language: Disputed definitions pp1023-1028
If you want to start an argument, ask the person who just said
'paradigm shift' what it really means. Or 'epigenetic'. Nature goes
in search of the terms that get scientists most worked up.
Heidi Ledford
doi:10.1038/4551023a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TJ0Eh
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CORRESPONDENCE
----------------------
Does risk to humans justify high cost of fighting bovine TB? p1029
Paul Torgerson and David Torgerson
doi:10.1038/4551029a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TK0Ei
Childcare not enough to make a science career family-friendly p1029
Timothy J. Roper and Larissa Conradt
doi:10.1038/4551029b
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TL0Ej
Flags of convenience shield polluters in battle to protect seas p1029
Scott P. Wilson
doi:10.1038/4551029c
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TM0Ek
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COMMENTARY
----------------------
The charge of technology pp1030-1031
Science policies based on techno-nationalist thinking and fantasies
about the past technological revolutions will get us nowhere fast,
says David Edgerton.
doi:10.1038/4551030a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TN0El
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BOOKS AND ARTS
----------------------
Deciphering vanished scripts pp1033-1034
The origins of communication are explored in a landmark compilation
that charts the disappearance of writing systems from ancient
cuneiform to Turkish Arabic script.
Andrew Robinson reviews The Disappearance of Writing Systems:
Perspectives on Literacy and Communication
doi:10.1038/4551033a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TO0Em
New look at cancer drugs pp1034-1035
Brendan Maher reviews Durchleuchtet
doi:10.1038/4551034a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TP0En
Bioethics laid bare pp1035-1036
Sheila McLean reviews Future Bioethics: Overcoming Taboos, Myths, and
Dogmas by Ronald A. Lindsay
doi:10.1038/4551035a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TQ0Eo
Q&A: An insider's view of the body p1036
Radiologist Anders Persson of Linkoping University Hospital, Sweden,
reveals the body's hidden structures to clinicians by applying new
techniques in magnetic resonance imaging and computed tomography to
produce stunning computer-enhanced three-dimensional images. The
winner of the 2008 Lennart Nilsson Award for scientific photography,
he tells Nature how visualization can revolutionize medicine.
doi:10.1038/4551036a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TR0Ep
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ESSAYS
----------------------
Being human: Religion: Bound to believe? pp1038-1039
Atheism will always be a harder sell than religion, Pascal Boyer
explains, because a slew of cognitive traits predispose us to faith.
doi:10.1038/4551038a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TS0Eq
A question of class pp1040-1041
Fundamental misunderstandings about classification can lead
scientists down unproductive or dangerous paths, argue
Jeffrey Parsons and Yair Wand.
doi:10.1038/4551040a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TT0Er
Correction p1041
doi:10.1038/4551041a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TU0Es
----------------------
NEWS AND VIEWS
----------------------
Biochemistry: Cells enforce an ion curtain pp1043-1044
Metal cofactors are an essential part of many proteins. But how is
the right choice of metal made? For bacteria, one answer is to change
the cellular compartment where cofactor insertion occurs.
Ben C. Berks
doi:10.1038/4551043a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TV0Et
Economics: Sustainable fisheries pp1044-1045
Fishermen's aims of increasing their catch seem at odds with preserving
fish stocks by limiting catch. A study of more than 11,000 fisheries
shows that 'individual tradable quotas' can reconcile these goals.
Geoffrey Heal & Wolfram Schlenker
doi:10.1038/4551044a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TW0Eu
Inorganic chemistry: Confirmation of the improbable pp1045-1047
Certain transition-metal complexes are thought to exist only fleetingly,
perhaps as intermediates in reactions. So the discovery of one such
complex that is stable at room temperature is provocative.
Craig L. Hill
doi:10.1038/4551045a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TX0Ev
Apoptosis: Stabbed in the BAX pp1047-1049
Apoptotic cell death is an intricate and highly regulated process.
To initiate apoptosis, the protein BIM binds to a hitherto unrecognized
site on the BAX protein to trigger permeabilization of the outer
mitochondrial membrane.
Douglas R. Green & Jerry E. Chipuk
doi:10.1038/4551047a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TY0Ew
Astrophysics: How do galaxies form? pp1049-1051
A study of galaxies indicates that galaxy formation may be regulated
by a single parameter. This unexpected finding shows that prevailing
views on the process could need revision.
Sidney van den Bergh
doi:10.1038/4551049a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8TZ0Ex
Biogeochemistry: Life before the rise of oxygen pp1051-1052
The discovery of molecular fossils in 2.7-billion-year-old rocks
prompted a re-evaluation of microbial evolution, and of the advent
of photosynthesis and rise of atmospheric oxygen. That discovery
now comes into question.
Woodward W. Fischer
doi:10.1038/4551051a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ta0E5
50 & 100 years ago p1052
doi:10.1038/4551052a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tb0E6
Obituary: Anatol Zhabotinsky (1938-2008) p1053
Pioneer of oscillating chemical reactions.
Irving R. Epstein
doi:10.1038/4551053a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tc0E7
----------------------
NEWS AND VIEWS Q&A
----------------------
Systems biology: Metabonomics pp1054-1056
Organisms often respond in complex and unpredictable ways to stimuli
that cause disease or injury. By measuring and mathematically modelling
changes in the levels of products of metabolism found in biological
fluids and tissues, metabonomics offers fresh insight into the effects
of diet, drugs and disease.
Jeremy K. Nicholson & John C. Lindon
doi:10.1038/4551054a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Td0E8
----------------------
FEATURE
----------------------
The mental wealth of nations pp1057-1060
Countries must learn how to capitalize on their citizens' cognitive
resources if they are to prosper, both economically and socially.
Early interventions will be key.
John Beddington et al.
doi:10.1038/4551057a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8QQ0El
----------------------
BRIEF COMMUNICATIONS ARISING
----------------------
MicroRNA-10b and breast cancer metastasis ppE8-E9
Harriet E. Gee et al.
doi:10.1038/nature07362
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Te0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tf0EB
Ma et al. reply pE9
Li Ma, Julie Teruya-Feldstein and Robert A. Weinberg
doi:10.1038/nature07363
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tg0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Th0ED
Can light be stopped in realistic metamaterials? ppE10-E11
A. Reza, M. M. Dignam and S. Hughes
doi:10.1038/nature07359
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ti0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tj0EF
Tsakmakidis et al. reply ppE11-E12
Kosmas L. Tsakmakidis, Alan D. Boardman and Ortwin Hess
doi:10.1038/nature07360
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tk0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tl0EH
=====================================================================
Direct PCR from Finnzymes
Can you amplify DNA directly from tissues such as blood, mouse ears,
or FFPE samples? With Finnzymes' PCR enzymes you can. PCR from a wide
variety of starting materials without prior DNA purification -
that's what we call Direct PCR.
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tm0EI
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----------------------
ARTICLES
----------------------
Comprehensive genomic characterization defines human glioblastoma genes
and core pathways p1061
With a comprehensive analysis of sequencing data, DNA copy number,
gene expression and DNA methylation in a large number of human
glioblastomas, The Cancer Genome Atlas project initiative provides
a broad overview of the genes and pathways that are altered in this
cancer type.
The Cancer Genome Atlas Research Network
doi:10.1038/nature07385
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tn0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8To0EK
Somatic mutations affect key pathways in lung adenocarcinoma
pp1069-1075
Sequencing of over 600 genes in a large collection of lung
adenocarcinoma samples provides an overview of somatic mutations
and signalling pathways altered in cancer genes in this tumour type.
Li Ding et al.
doi:10.1038/nature07423
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tp0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tq0EM
BAX activation is initiated at a novel interaction site pp1076-1081
A structural analysis of the apoptosis-inducing protein BAX in complex
with a peptide derived from its activator BIM reveals an unforeseen
interaction site that does not involve the classic hydrophobic groove
reported for inhibitors of apoptosis. This identification of BAX's
activation site provides mechanistic insights into a cell's demise.
Evripidis Gavathiotis et al.
doi:10.1038/nature07396
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tr0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ts0EO
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=====================================================================
----------------------
LETTERS
----------------------
Galaxies appear simpler than expected pp1082-1084
This paper reports that a sample of galaxies (first detected from
neutral hydrogen emission) shows five independent correlations amongst
six independent observables. This implies that the structure of such
galaxies must be controlled by a single parameter, which cannot yet be
identified. Such a degree of organization is at odds with hierarchical
galaxy formation.
M. J. Disney et al.
doi:10.1038/nature07366
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tu0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tv0ER
Solid-state quantum memory using the 31P nuclear spin pp1085-1088
The transfer of information between processing entities and memory is
crucial for quantum computation; it is challenging because the process
must remain coherent at all times to preserve the quantum nature of the
information. This paper demonstrates coherent storage and readout of
information between electron spin processing elements and memory
elements based on a nuclear spin.
John J. L. Morton et al.
doi:10.1038/nature07295
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tw0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tx0ET
Correlation between nanosecond X-ray flashes and stick-slip friction in
peeling tape pp1089-1092
Relative motion between two contacting surfaces can produce visible
light, a process known as triboluminescence. Scientists now fully
characterize the energy emissions from peeling sticky tape in a vacuum
and show the generation of X-rays with sufficient intensity that they
were used for X-ray imaging.
Carlos G. Camara, Juan V. Escobar, Jonathan R. Hird and Seth J. Putterman
doi:10.1038/nature07378
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ty0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Tz0EV
Evidence for a terminal Pt(iv)-oxo complex exhibiting diverse reactivity
pp1093-1096
Terminal oxo complexes of transition metals are important in biological
and chemical processes, for example, the catalytic oxidation of organic
molecules and the activation of dioxygen on metal surfaces are thought
to involve oxo complexes. This paper explored the reactivity of a d6
Pt(IV) complex, a dn (n > 5) terminal oxo complex that is not stabilized
by an electron withdrawing ligand framework. The complex exhibits
reactivity as an inter and intra molecular oxygen donor and as an
electrophile.
Elena Poverenov et al.
doi:10.1038/nature07356
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8T10EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8T20EJ
Fault-induced seismic anisotropy by hydration in subducting oceanic plates
pp1097-1100
It is shown that the amount and geometry of seismic anisotropy measured
in the forearc regions of subduction zones strongly depend on the
preferred orientation of hydrated faults in the subducting oceanic
plate. The anisotropy originates from the crystallographic preferred
orientation of highly anisotropic hydrous minerals formed along steeply
dipping faults and from the larger-scale vertical layering consisting
of dry and hydrated crust–mantle sections, the spacing of which is
several times smaller than teleseismic wavelengths.
Manuele Faccenda, Luigi Burlini, Taras V. Gerya and David Mainprice
doi:10.1038/nature07376
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8T30EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8T40EL
Reassessing the first appearance of eukaryotes and cyanobacteria
pp1101-1104
The oldest widely accepted evidence for oxygenic photosynthesis comes
from hydrocarbon biomarkers extracted from 2.7 billion year old shales
in the Pilbara Craton, Australia, thought to be evidence of eukaryotes
and photosynthetic cyanobacteria. But evidence now shows that the
organic biomarkers were not indigenous to the rocks containing them,
and must have entered the rocks after ~ 2.2 Gyr ago. The earliest
unambiguous fossil evidence for eukaryotes and cyanobacteria thus
reverts to 1.78–1.68 and 2.15 Gyr, respectively.
Birger Rasmussen, Ian R. Fletcher, Jochen J. Brocks and Matt R. Kilburn
doi:10.1038/nature07381
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8T50EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8T60EN
A bizarre Jurassic maniraptoran from China with elongate
ribbon-like feathers pp1105-1108
This paper presents another chapter in the earliest history of birds,
with the discovery of a feathered dinosaur from the Mid to Late Jurassic
of China. Living a little earlier than the famous fossil bird
Archaeopteryx, the newly discovered creature is birdlike in many ways
including the presence of four very long tail feathers, but otherwise
no sign of flight feathers of the kind seen in birdlike dinosaurs such
as Microraptor.
Fucheng Zhang et al.
doi:10.1038/nature07447
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8T70EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8T80EP
Innate immunity and intestinal microbiota in the development of Type 1
diabetes p1109
The effect of deficiency of MyD88 on the generation of type 1 diabetes
(T1D) has been investigated through the generation of congenic strains
in the non obese diabetic (NOD) mouse model. It is found that in
specific pathogen-free conditions, MyD88 deficiency attenuates T1D,
indicating that the interaction of intestinal microbes with the innate
immune system is a critical factor in modifying susceptibility to
type 1 diabetes.
Li Wen et al.
doi:10.1038/nature07336
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UA0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UB0Ea
Conjugated action of two species-specific invasion proteins for
fetoplacental listeriosis p1114
Listeria monocytogenes can cross the placental barrier and may result
in fetal or neonatal mortality. Using two complementary animal models,
it is now shown that virulence factors InlA and InlB are both required
for this process in vivo.
Olivier Disson et al.
doi:10.1038/nature07303
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UC0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UD0Ec
Paracrine Wingless signalling controls self-renewal of Drosophila
intestinal stem cells p1119
In the Drosophila midgut, multipotent intestinal stem cells (ISCs)
produce daughters that differentiate into either enterocytes or
enteroendocrine cells. It is shown that canonical Wnt signalling
pathway controls ISC self renewal, and that Notch acts downstream
of the Wg pathway and a hierarchy of Wg/Notch signalling pathway
controls the balance between self renewal and differentiation of ISCs.
Guonan Lin, Na Xu & Rongwen Xi
doi:10.1038/nature07329
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UE0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UF0Ee
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem
cell differentiation p1124
The coding regions of several genes that encode transcription factors
involved in maintenance of stem cell identity, such as Nanog, Oct4,
and Sox2, have miRNA target sites. Three miRNAs that are upregulated
when embryonic stem cells are induced to differentiate bind these sites
in various combinations, and thereby confer specific phenotypes.
Yvonne Tay, Jinqiu Zhang, Andrew M. Thomson, Bing Lim & Isidore Rigoutsos
doi:10.1038/nature07299
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UG0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UH0Eg
p53 and Pten control neural and glioma stem/progenitor cell renewal
and differentiation pp1129-1133
In a mouse model, it is found that the loss of the tumour suppressors
p53 and Pten leads to the development of tumours resembling human
primary glioblastomas, and both p53 and PTEN are frequently lost in
the human cancer. Loss of these tumour suppressors impairs the
differentiation of neural stem cells, due to upregulation of Myc
by the concerted action of p53 and PTEN loss.
Hongwu Zheng et al.
doi:10.1038/nature07443
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UI0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UJ0Ei
Control of plant germline proliferation by SCFFBL17 degradation of
cell cycle inhibitors pp1134-1137
Hyo Jung Kim et al.
A newly discovered F box protein of Arabidopsis thaliana that promotes
twin sperm cell production is identified. The protein, FBL17, targets
KRP7, an Arabidopsis inhibitor of CDKA1, for proteasome dependent
degradation, allowing germ cell division and twin sperm cell production.
doi:10.1038/nature07289
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UK0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UL0Ek
Protein-folding location can regulate manganese-binding versus copper-
or zinc-binding pp1138-1142
This study identifies the most abundant Cu2+- and Mn2+- containing
proteins in the periplasm of a cyanobacterium and determines that
the cellular compartment in which each of those proteins fold is
responsible for the insertion of the correct metal ion into the metalloprotein.
Steve Tottey et al.
doi:10.1038/nature07340
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UM0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UN0Em
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p1143
Is this Singapore's golden era?
Paul Smaglik
doi:10.1038/nj7216-1143a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UO0En
Region
Singapore surges upwards p1144
The Fusionopolis towers are the latest signs of Singapore's
determination to build its future on science. But can the city-state
meet the expectations it has raised?
David Cyranoski
doi:10.1038/nj7216-1144a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UP0Eo
----------------------
FUTURES
----------------------
Dewey Smith and the meaning of All p1148
Physics in action.
Robert Reed
doi:10.1038/4551148a
http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UQ0Ep
----------------------
Advance Online Publication
----------------------
22 October 2008
Transcription inactivation through local refolding of the RNA
polymerase structure
Georgiy A. Belogurov et al.
doi:10.1038/nature07510
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UR0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8US0Er
Generation of a prostate from a single adult stem cell
Kevin G. Leong, Bu-Er Wang, Leisa Johnson & Wei-Qiang Gao
doi:10.1038/nature07427
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UT0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UU0Et
Experience with moving visual stimuli drives the early development of
cortical direction selectivity
Ye Li et al.
doi:10.1038/nature07417
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UV0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UW0Ev
19 October 2008
53BP1 facilitates long-range DNA end-joining during V(D)J recombination
Simone Difilippantonio et al.
doi:10.1038/nature07476
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UX0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UY0Ex
53BP1 promotes non-homologous end joining of telomeres by increasing
chromatin mobility
Nadya Dimitrova, Yi-Chun M. Chen, David L. Spector & Titia de Lange
doi:10.1038/nature07433
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8UZ0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ua0E6
Sox18 induces development of the lymphatic vasculature in mice
Mathias François et al.
doi:10.1038/nature07391
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ub0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Uc0E8
Strong effect of dispersal network structure on ecological dynamics
Matthew D. Holland & Alan Hastings
doi:10.1038/nature07395
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ud0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ue0EB
The zinc-finger protein Zelda is a key activator of the early zygotic
genome in Drosophila
Hsiao-Lan Liang, Chung-Yi Nien, Hsiao-Yun Liu, Mark M. Metzstein,
Nikolai Kirov & Christine Rushlow
doi:10.1038/nature07388
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Uf0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoNG0Xztnp0HjB0B8Ug0ED
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