16 October 2008 Volume 455 Number 7215, pp835-1006
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Direct PCR from Finnzymes
Can you amplify DNA directly from tissues such as blood, mouse ears,
or FFPE? With Finnzymes' PCR enzymes you can. PCR from a wide variety
of starting materials without prior DNA purification - that's what we
call Direct PCR.
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7um0Ep
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This Insight highlights recent progress made in our understanding of
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underlying neuropsychiatric diseases. Together, this research points
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Web Focus: Meetings that changed the world
This series covers six scientific meetings that had such
a great impact, they can be said to have changed the world.
Each piece is written by an expert who attended the conference
in question. The authors recall what it was like to live through
these momentous occasions, and reflect upon the events' broad
and lasting legacies.
Click here to access the web focus online.
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B5OF0EW
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----------------------
EDITORIALS
----------------------
More than one bad apple p835
A congressional investigation alleges that some researchers have
failed to report all the drug-company money that they have received
-- and that universities may have been too slow to police them.
doi:10.1038/455835a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7un0Eq
Cut-throat savings pp835-836
In an attempt to boost its struggling economy, Italy's government
is focusing on easy, but unwise, targets.
doi:10.1038/455835b
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7uo0Er
Meeting expectations p836
Scientists need to ask themselves if their meeting or conference
is really necessary.
doi:10.1038/455836a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7up0Es
----------------------
RESEARCH HIGHLIGHTS
----------------------
Molecular biology: Zebrafish cell zipcodes p838
doi:10.1038/455838a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7uq0Et
Chemistry: Prion progress p838
doi:10.1038/455838b
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7ur0Eu
Materials science: Iron option p838
doi:10.1038/455838c
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7us0Ev
Nanotechnology: Leveraging antibiotics p838
doi:10.1038/455838d
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7ut0Ew
Chemistry: Sugar coated p838
doi:10.1038/455838e
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7uu0Ex
Chemical biology: Double trouble pp838-839
doi:10.1038/455838f
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7uv0Ey
Molecular biology: It's all in the timing p839
doi:10.1038/455839a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7uw0Ez
Neurobiology: Empowering the middleman p839
doi:10.1038/455839b
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7ux0E1
Geosciences: Peatering out p839
doi:10.1038/455839c
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7uy0E2
Parasitology: Hopping mad p839
doi:10.1038/455839d
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7uz0E3
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JOURNAL CLUB
----------------------
Journal club p839
Andrzej Pietrzykowski
doi:10.1038/455839e
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7u10Ep
----------------------
NEWS
----------------------
Mars missions face cost crunch pp840-841
In Europe and America, future missions are in doubt.
doi:10.1038/455840a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7u20Eq
New law threatens Italian research jobs pp840-841
Scientists protest over government's cost cutting.
Emiliano Feresin and Alison Abbott
doi:10.1038/455840b
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7u30Er
No more third time lucky pp841-841
NIH clamps down on proposal resubmissions.
Heidi Ledford
doi:10.1038/455841a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7u40Es
Icelandic biotech feels the pinch p842
deCode Genetics runs risk of losing stock-market listing.
Meredith Wadman
doi:10.1038/455842a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7u50Et
Dark energy: the quest for galaxies p843
South Pole Telescope offers fresh view of Universe's expansion.
Eric Hand
doi:10.1038/455843a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7u60Eu
Outcry at scale of inheritance project p845
NIH launches multi-million-dollar epigenomics programme.
Helen Pearson
doi:10.1038/455845a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7u70Ev
The death of microarrays? pp847
High-throughput gene sequencing seems to be stealing a march on
microarrays. Heidi Ledford looks at a genome technology facing
intense competition.
doi:10.1038/455847a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7u80Ew
Snapshot: Green ham (no eggs) pp848
This year's chemistry Nobel.
doi:10.1038/455848a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vA0E7
Pakistan's education head is asked to resign pp849
doi:10.1038/455849a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vB0E8
Europe plans fewer free emissions allowances pp849
doi:10.1038/455849b
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vC0EA
Harvard gift paves way for bioengineering institute p849
doi:10.1038/455849c
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vD0EB
'Manipulated' stem-cell paper faces retraction pp849
doi:10.1038/455849d
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vE0EC
UN agency warns of biofuel production implications pp849
doi:10.1038/455849e
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vF0ED
Cassini makes successful swoop on Enceladus pp849
doi:10.1038/455849f
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vG0EE
----------------------
NEWS FEATURES
----------------------
Agriculture: Is China ready for GM rice? pp850-852
In an effort to avoid a food crisis as the population grows, China is
putting its weight behind genetically modified strains of the
country's staple food crop.
Jane Qiu explores the reasons for the unprecedented push.
doi:10.1038/455850a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vH0EF
Particle physics: Sam Ting's last fling pp854-857
The International Space Station's one chance of scientific greatness
rests on a high-profile refugee from the world of the particle
accelerator -- but is it too long a shot to be worth taking?
Eric Hand reports.
doi:10.1038/455854a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vI0EG
Palaeontology: School of rock pp858-860
Native Americans want to claim fossil resources found on their lands.
Rex Dalton looks at how tribes and palaeontologists are working
together to avoid bitter ownership disputes.
doi:10.1038/455858a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vJ0EH
----------------------
CORRESPONDENCE
----------------------
Britain should not abandon curiosity-driven research p861
Andy Fabian
doi:10.1038/455861a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vK0EI
Editorial comment should accompany hot papers online p861
Vincent Detours
doi:10.1038/455861b
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vL0EJ
Last chance to save one of world's most species-rich regions p861
Max Christian, Matt Finer and Carl Ross
doi:10.1038/455861c
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vM0EK
----------------------
AUTUMN BOOKS
----------------------
Relics of the modern mind pp863-864
Our enduring search for meaning in life explains the reverence with
which the bones of seventeenth-century French philosopher Rene
Descartes were worshipped, suggests Lisa Jardine.
Lisa Jardine reviews Descartes' Bones: A Skeletal History of the
Conflict Between Faith and Reason by Russell Shorto
doi:10.1038/455863a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vN0EL
New in paperback pp863-872
doi:10.1038/455863b
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vO0EM
Psychology's pet subject pp864-865
Clive Wynne reviews Alex & Me: How a Scientist and a Parrot Discovered
a Hidden World of Animal Intelligence -- and Formed a Deep Bond in the
Process by Irene Pepperberg
doi:10.1038/455864a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vP0EN
How a hoax fooled the faithful pp866-867
David Bodanis reviews The Sun and the Moon: The Remarkable True
Account of Hoaxers, Showmen, Dueling Journalists, and Lunar Man-Bats
in Nineteenth-Century New York by Matthew Goodman
doi:10.1038/455866a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vQ0EO
Tale of a clockwork computer pp867-868
Andrew Robinson reviews Decoding the Heavens: Solving the Mystery
of the World's First Computer by Jo Marchant
doi:10.1038/455867a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vR0EP
Liver satire delivers pp868-869
Simon Ings reviews Liver: A Fictional Organ with a Surface Anatomy
of Four Lobes by Will Self
doi:10.1038/455868a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vS0EQ
Drug-fuelled counterculture p870
Arran Frood reviews Albion Dreaming: A Popular History of LSD in
Britain by Andy Roberts
doi:10.1038/455870a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vT0ER
A scientist's life for me pp871-872
Forty years after the publication of James Watson's The Double Helix,
Georgina Ferry asks why the life stories of so few scientists make it
into the bookshops.
doi:10.1038/455871a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vU0ES
----------------------
ESSAYS
----------------------
India's rise to the Moon pp874-875
Why does a developing nation have such an ambitious space programme?
Subhadra Menon traces its foundations back to the work of one
visionary physicist 60 years ago.
doi:10.1038/455874a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vV0ET
Meetings that changed the world: Santa Fe 1986: Human genome
baby-steps pp876-877
The 1980s saw plenty of discussion on sequencing the human genome.
But, according to Charles DeLisi, one conference was crucial for
converting an idea to reality.
doi:10.1038/455876a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vW0EU
----------------------
NEWS AND VIEWS
----------------------
Structural biology: Clamour for a kiss pp879-880
Precisely how proteins snake their way through channels in cell
membranes is unclear. Complexes between the SecY channel and its
motor protein, and the use of a 'molecular endoscope', provide
fascinating clues.
Anastassios Economou
doi:10.1038/455879a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vX0EV
Condensed-matter physics: Surviving the transition pp880-881
Observations of the birth of a superfluid have uncovered details of
the microphysics of phase transitions. Whether these results can be
used to model such transitions in the early Universe is an open
question.
Kristian Helmerson
doi:10.1038/455880a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vY0EW
Earth science: Deducing a reducing mantle pp881-883
Increasingly sophisticated techniques are being used to persuade
ancient rocks to yield information about conditions on and in the
early Earth -- for instance, about the oxidation state of the mantle.
William F. McDonough
doi:10.1038/455881a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vZ0EX
Cancer: A ringleader identified pp883-884
The childhood cancer neuroblastoma can either run in families or
occur sporadically. Several studies find that the gene ALK is a
chief offender in this disease, because its germline mutations mediate
both forms.
Charis Eng
doi:10.1038/455883a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7va0Ee
Philosophy of science: Theories of almost everything pp884-885
A provocative contribution to the logic of science extends the
theorems of Kurt Godel and Alan Turing, and bears on thinking about
prediction, the standard model of particles, and quantum gravity.
P.-M. Binder
doi:10.1038/455884a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vb0Ef
Molecular biology: Bound to splice pp885-886
Messenger RNAs don't usually correspond exactly to DNA -- portions of
the primary transcript, known as introns, are removed by splicing. A
study reveals new ways in which splicing can be regulated.
Bruce Futcher and Janet K. Leatherwood
doi:10.1038/455885a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vc0Eg
50 & 100 years ago p886
doi:10.1038/455886a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vd0Eh
Nano-optics: Optical antennas tuned to pitch p887
Mapping out the resonant modes of optical antennas is part of a
largely unexplored terrain -- but not any more, as a study that
applies a luminescence technique to gold antennas demonstrates.
Lukas Novotny
doi:10.1038/455887a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7ve0Ei
Oceanography: Ripples run deep p888
Tiny, wind-generated ripples on the sea surface can interact and
produce pressure changes felt on the ocean floor. The same line of
study points to a basic distinction between two types of surface wave.
Steve Elgar
doi:10.1038/455888a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vf0Ej
----------------------
INSIGHT
----------------------
EDITORIAL
Neuropsychiatric disease p889
I-han Chou and Tanguy Chouard
doi:10.1038/455889a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vg0Ek
INTRODUCTION
A glimmer of light for neuropsychiatric disorders pp890-893
Steven E. Hyman
doi:10.1038/nature07454
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vh0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vi0Em
REVIEW ARTICLE
The molecular neurobiology of depression pp894-902
Vaishnav Krishnan and Eric J. Nestler
doi:10.1038/nature07455
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vj0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vk0Eo
Neuroligins and neurexins link synaptic function to cognitive disease pp903-911
Thomas C. Sudhof
doi:10.1038/nature07456
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vl0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vm0Eq
Failure of neuronal homeostasis results in common neuropsychiatric phenotypes pp912-918
Melissa B. Ramocki and Huda Y. Zoghbi
doi:10.1038/nature07457
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vn0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vo0Es
Copy-number variations associated with neuropsychiatric conditions pp919-923
Edwin H. Cook Jr and Stephen W. Scherer
doi:10.1038/nature07458
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vp0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vq0Eu
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=====================================================================
----------------------
ARTICLES
----------------------
The cranial endoskeleton of Tiktaalik roseae pp925-929
The Devonian fossil Tiktaalik roseae represents a transitional form
between fishes and tetrapods. This paper presents a detailed
examination of the braincase of this creature. Although primitive in
many respects, some features nod to the tetrapod state.
Jason P. Downs, Edward B. Daeschler, Farish A. Jenkins and Neil H. Shubin
doi:10.1038/nature07189
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vr0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vs0Ew
Identification of ALK as a major familial neuroblastoma predisposition
gene p930-935
ALK is identified as a neuroblastoma predisposition gene. Germline
mutations were found in ALK, a tryrosine kinase receptor, in affected
families. In addition, somatic point mutations in ALK were found in
sporadic cases of neuroblastomas. ALK mutations seem to lead to
constitutive activation of its kinase activity and promote cell
proliferation.
Yaël P. Mossé et al.
doi:10.1038/nature07261
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vt0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vu0Ey
Structure of a complex of the ATPase SecA and the protein-translocation
channel pp936-943
This study reports the structure of the SecA-SecY complex from
bacteria. The structure reveals major conformational changes between
both partners and provides novel insights into the path taken by a
translocating protein.
Jochen Zimmer, Yunsun Nam and Tom A. Rapoport
doi:10.1038/nature07335
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vv0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vw0E1
----------------------
LETTERS
----------------------
A low-frequency radio halo associated with a cluster of galaxies pp944-947
Clusters of galaxies are the largest gravitationally bound objects in
the Universe. Magnetic fields and relativistic particles are mixed
with the gas as revealed by giant 'radio haloes'. A radio halo at low
frequencies associated with the merging cluster Abell 521 is reported.
This halo has an extremely steep radio spectrum that makes it
difficult to detect with observations at 1.4 GHz. The spectrum
supports a turbulent acceleration mechanism, which predicts that many
radio haloes in the Universe should emit mainly at low frequencies.
G. Brunetti et al.
doi:10.1038/nature07379
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vx0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vy0E3
Spontaneous vortices in the formation of Bose-Einstein condensates pp948-951
This paper presents an experimental and theoretical study of the
Bose-Einstein condensation phase transition of a trapped atomic gas.
The vortices formed spontaneously during condensation are observed and
characterized, and the results provide further understanding of the
development of coherence in superfluids.
Chad N. Weiler et al.
doi:10.1038/nature07334
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7vz0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7v10Eq
Quantum oscillations in an overdoped high-Tc superconductor pp952-955
This paper reports the observation of quantum oscillations in the
overdoped superconductor Tl2Ba2CuO6+[delta] that show the existence
of a large Fermi surface of well-defined quasiparticles covering
two-thirds of the Brillouin zone. These measurements firmly establish
the applicability of a generalized Fermi-liquid picture on the
overdoped side of the superconducting dome.
B. Vignolle et al.
doi:10.1038/nature07323
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7v20Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7v30Es
Bottom-up organic integrated circuits pp956-959
An ambition in the field of organic electronics has been to harness
the self-organizing properties of certain classes of molecules to
assemble key device structures without human intervention. Single,
self-assembled layers of such molecules have been successfully
implemented in transistors, but the devices' properties have not been
promising, largely due to defects in the monolayers and poor
electronic coupling between the molecules within the layers. It is
now shown how such limitations can be overcome, by carefully tuning
the properties of the molecules through chemical design to ensure
dense, highly ordered packing in the self-assembled monolayer. The
good electrical performance and high reproducibility of the resulting
devices is demonstrated by combining over 300 of them into a
functional integrted circuit.
Edsger C. P. Smits et al.
doi:10.1038/nature07320
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7v40Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7v50Eu
Oxidation state of iron in komatiitic melt inclusions indicates hot
Archaean mantle pp960-963
The original iron isotope ratios of a 2.7 billion-year-old komatiitic
magma from Belingwe, Zimbabwe have been determined. These measurements
are consistent with near-anhydrous melting of a source with similar
oxidation state to that of present-day ocean-floor basalt. The results
support the identification of the Belingwe komatiite as a product of
high mantle temperatures of ~1,700 degC, rather than melting under
hydrous conditions, confirming the existence of anomalously hot mantle
in the Archean.
Andrew J. Berry et al.
doi:10.1038/nature07377
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7v60Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7v70Ew
Pairs of cooperating cleaner fish provide better service quality than
singletons pp964-966
The evolution of cooperation between unrelated individuals is a puzzle
that attracts interest both in the social and in the natural sciences.
Theoretical concepts may fail to capture essential features of real
life cooperation. This paper focuses on the cleaning mutualism between
cleaner wrasse and their client fish. A game theoretical model predicts
that two providers should offer a higher service quality to clients
than single providers, as long as they cooperate among each other.
Field observations and an experimental test confirm the model
prediction.
Redouan Bshary, Alexandra S. Grutter, Astrid S. T. Willener
and Olof Leimar
doi:10.1038/nature07184
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7v80Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wA0E8
Somatic and germline activating mutations of the ALK kinase receptor
in neuroblastoma pp967-970
This is one of four papers in this issue that identifies mutations in
the tyrosine kinase receptor ALK in neuroblastoma, the most frequent
childhood cancer. ALK is found to be a neuroblastoma predisposition
gene and somatic points mutations were found in sporadic cases of
neuroblastoma. These mutations lead the ALK kinase activation and are
able to transform cells and display tumourigenic activity in vivo. ALK
inhibitors decrease neuroblastoma cell proliferating and are potential
anti-cancer drugs for the treatment of neuroblastoma.
Isabelle Janoueix-Lerosey et al.
doi:10.1038/nature07398
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wB0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wC0EB
Oncogenic mutations of ALK kinase in neuroblastoma pp971-974
This is one of four papers in this issue that identifies mutations in
the tyrosine kinase receptor ALK in neuroblastoma, the most frequent
childhood cancer. ALK is found to be a neuroblastoma predisposition
gene and somatic points mutations were found in sporadic cases of
neuroblastoma. These mutations lead the ALK kinase activation and are
able to transform cells and display tumourigenic activity in vivo.
ALK inhibitors decrease neuroblastoma cell proliferating and are
potential anti-cancer drugs for the treatment of neuroblastoma.
Yuyan Chen et al.
doi:10.1038/nature07399
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wD0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wE0ED
Activating mutations in ALK provide a therapeutic target in
neuroblastoma pp975-978
This is one of four papers in this issue that identifies mutations in
the tyrosine kinase receptor ALK in neuroblastoma, the most frequent
childhood cancer. ALK is found to be a neuroblastoma predisposition
gene and somatic points mutations were found in sporadic cases of
neuroblastoma. These mutations lead the ALK kinase activation and
are able to transform cells and display tumourigenic activity in
vivo. ALK inhibitors decrease neuroblastoma cell proliferating and
are potential anti-cancer drugs for the treatment of neuroblastoma.
Rani E. George et al.
doi:10.1038/nature07397
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wF0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wG0EF
The mode of Hedgehog binding to Ihog homologues is not conserved
across different phyla p979
A crystal structure of the human Hedgehog protein Shh complexed with
the cell surface protein CDO reveals that the interaction involves a
previously unrecognized calcium binding site in Shh. The binding mode
is quite different from the interaction between the Drosophila
homologues of these proteins. Mutations in Shh causing congenital
malformations map to the calcium binding site and disrupt interactions
with binding partners.
Jason S. McLellan, Xiaoyan Zheng, Glenn Hauk, Rodolfo Ghirlando,
Philip A. Beachy & Daniel J. Leahy
doi:10.1038/nature07358
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wH0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wI0EH
A role for the two-helix finger of the SecA ATPase in protein
translocation pp984-987
This is one of two papers that report the long-awaited structure of
the SecA-SecY complex from bacteria. The structure reveals major
conformational changes between both partners and suggests that SecA
uses a two-helix finger to push translocating proteins inside the
cytoplasmic funnel of SecY. Cross-linking studies provide further
experimental support for this mechanism.
Karl J. Erlandson et al.
doi:10.1038/nature07439
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wJ0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wK0EJ
Conformational transition of Sec machinery inferred from bacterial
SecYE structures pp988-991
A crystal structure of SecY bound to an anti SecY Fab fragment
revealing a pre-open state of the channel is presented.
Tomoya Tsukazaki et al.
doi:10.1038/nature07421
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wL0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wM0EL
The type IV mucolipidosis-associated protein TRPML1 is an
endolysosomal iron release channel p992
TRPML1 is a member of the Transient Receptor Potential (TRP)
superfamily of ion channels, and mutation in the human TRPML1 gene
causes mucolipidosis, symptoms of which include anaemia. It is shown
that TRPML1 functions as a Fe2+-permeable channel in lysosomes, and
that disease associated mutations impair Fe2+transport, suggesting
that impaired iron transport may underlie symptoms of mucolipidosis.
Xian-Ping Dong, Xiping Cheng, Eric Mills, Markus Delling, Fudi Wang,
Tino Kurz & Haoxing Xu
doi:10.1038/nature07311
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wN0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wO0EN
Promoter-driven splicing regulation in fission yeast p997
Rem1 expression is controlled not only at the level of transcription,
but also by splicing. In mitotic cells, binding of the Fkh2
transcription factor to the rem1 promoter yields a transcript that
retains its introns so that only a short protein is produced; this
protein affects recombination levels. In meiotic cells, the binding
of the meiosis specific trancription factor Mei4 to the rem1 promoter
results in splicing of rem1, yielding the cyclin isoform. Thus, this
work demonstrates that two transcription factors can differentially
affecting splicing of the same gene.
Alberto Moldón et al.
doi:10.1038/nature07325
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wP0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wQ0EP
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p1001
Financial pressures are forcing institutions to rethink their
investments.
Gene Russo
doi:10.1038/nj7215-1001a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wR0EQ
Special Report
Making a difference p1002
The demand for science skills in non-governmental organizations is
rising. Paroma Basu, Jane Qiu and Kendall Powell report.
doi:10.1038/nj7215-1002a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wS0ER
Career View
Maria Betti, director, Marine Environment Laboratories, International
Atomic Energy Agency, Monaco p1004
Passion to eradicate pollution brings marine scientist to Monaco.
Virginia Gewin
doi:10.1038/nj7215-1004a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wT0ES
Counting fish p1004
Government looking for mix of talents to help assess fisheries.
Karen Kaplan
doi:10.1038/nj7215-1004b
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wU0ET
One-man team p1004
Trying to team-up while working alone.
Jon Yearsley
doi:10.1038/nj7215-1004c
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wV0EU
----------------------
FUTURES
----------------------
The cheap crusade p1006
Fight the system.
Rahul Kanakia
doi:10.1038/4551006a
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wW0EV
----------------------
Advance Online Publication
----------------------
15 October 2008
Article
Centrosome misorientation reduces stem cell division during ageing
Jun Cheng, Nezaket Türkel, Nahid Hemati, Margaret T. Fuller,
Alan J. Hunt & Yukiko M. Yamashita
doi:10.1038/nature07386
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wX0EW
Letters
The Phaeodactylum genome reveals the evolutionary history of diatom genomes
Chris Bowler et al.
doi:10.1038/nature07410
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wY0EX
Direct control of paralysed muscles by cortical neurons
Chet T. Moritz, Steve I. Perlmutter & Eberhard E. Fetz
doi:10.1038/nature07418
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wZ0EY
Entrained rhythmic activities of neuronal ensembles as perceptual
memory of time interval
Germán Sumbre, Akira Muto, Herwig Baier & Mu-ming Poo
doi:10.1038/nature07351
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wa0Ef
Crystal structure of a stable dimer reveals the molecular basis of
serpin polymerization
Masayuki Yamasaki, Wei Li, Daniel J. D. Johnson & James A. Huntington
doi:10.1038/nature07394
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wb0Eg
12 October 2008
Letters
DNA double-strand breaks activate a multi-functional genetic program
in developing lymphocytes
Andrea L. Bredemeyer et al.
doi:10.1038/nature07392
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wc0Eh
Crystal structure of the anti-viral APOBEC3G catalytic domain and
functional implications
Lauren G. Holden et al.
doi:10.1038/nature07357
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B7wd0Ei
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Fondation IPSEN, Nature Neuroscience and
Nature Genetics present:
An Emergence & Convergence mini-symposium-
Mitochondrial Dysfunction in Neurological Disease
December 5, 2008,
Washington Duke Inn and Golf Club
Durham, North Carolina, USA
Deadline for application: October 17, 2008
Attendance at this meeting is free on acceptance
of application.
To apply and for more information visit
http://ealerts.nature.com/cgi-bin24/DM/y/eoEQ0Xztnp0HjB0B2ga0EK
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