|  | 
 Letter Describes Human Parthenogenetic Stem Cell Company's        Distinct Science and Business Model        International Stem Cell Corporation (OTCBB:ISCO),  the first company to        perfect a method of creating human stem cells from unfertilized eggs,         has issued a letter to its shareholders.  To view the shareholder letter        in its entirety,  please follow the link to the company's        website: www.internationalstemcell.com/shareholderletter.htm.             In the letter,  International Stem Cell CEO,  Ken Aldrich,  updates        shareholders on the company's continued        efforts to increase shareholder value related to its key initiatives,         which include:               Providing the company's proprietary cells to          leading worldwide academic and scientific research institutions,  while          retaining the rights to develop and commercialize products that are          derived from these joint ventures                Driving awareness to the potential that human parthenogenetic stem          cells have for curing disease while avoiding certain ethical problems          that surround the use of embryonic stem cells       
          Human parthenogenic stem cell advantages over those of newly          discovered induced pluripotent cells                Rapid revenue growth through its Lifeline Cell Tech subsidiary                Recent hiring of the Investor Relations Group to build public awareness       
 About International Stem Cell Corporation        International Stem Cell Corporation (ISCO) is a California biotechnology        company focused on developing therapeutic and research products.  ISCO's        technology,  parthenogenesis,  results in the creation of pluripotent        human stem cell lines from unfertilized human eggs.  ISCO scientists also        have created the first parthenogenetic homozygous stem cell line        (phSC-Hhom-4) that can be a source of therapeutic cells that will not be        immune rejected after transplantation into millions of individuals of        differing sexes,  ages and racial groups.  These advancements offer the        potential to create the first true "stem cell        bank" and address ethical issues by        eliminating the need to use or destroy fertilized embryos.  ISCO also        produces and markets specialized cells and growth media worldwide for        therapeutic research through its subsidiary Lifeline Cell Technology.         For more information,  visit the ISCO website at: www.internationalstemcell.com.             To subscribe to receive ongoing corporate communications please click on        the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.      Forward-Looking Statements Statements pertaining to future financial and/or operating results,         future growth in research,  technology,  clinical development and        potential opportunities for the company and its subsidiary,  along with        other statements about the future expectations,  beliefs,  goals,  plans,         or prospects expressed by management constitute forward-looking        statements.  Any statements that are not historical fact (including,  but        not limited to statements that contain words such as "will,""believes,""plans,""anticipates,""expects,""estimates,")        should also be considered to be forward-looking statements.         Forward-looking statements involve risks and uncertainties,  including,         without limitation,  risks inherent in the development and/or        commercialization of potential products,  uncertainty in the results of        clinical trials or regulatory approvals,  need and ability to obtain        future capital,  and maintenance of intellectual property rights.  Actual        results may differ materially from the results anticipated in these        forward-looking statements and as such should be evaluated together with        the many uncertainties that affect the company's business,  particularly        those mentioned in the cautionary statements found in the company's        Securities and Exchange Commission filings.  The company disclaims any        intent or obligation to update these forward-looking statements.        The Investor Relations Group212-825-3210
 Investor Relations:
 Adam        Holdsworth
 aholdsworth@investorrelationsgroup.com
 or
 Erica        Ruderman
 eruderman@investorrelationsgroup.com
 or
 Brett        Foley
 bfoley@investorrelationsgroup.com
 or
 Media        Relations:
 Laura Colontrelle
 lcolontrelle@investorrelationsgroup.com
 |