Signaling Gateway - 5 September 2008
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0M40Ec
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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MicroRNAs: mRNAs ARE LOST IN TRANSLATION
A single microRNA molecule can regulate the translation of hundreds
of proteins by inducing degradation and inhibiting translation of
mRNA targets.
Original research paper: Nature 455, 58-63 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0vP0El
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Rin1
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4yU0Er
Rin1 is a Ras effector protein with multiple biochemical functions.
The Ras-association (RA) domain of Rin1 shows high affinity and
specificity for active, GTP-bound HRas. Ras binding stimulates Rin1
and triggers two downstream signaling pathways: actin remodeling via
activation of Abl1 and Abl2, and clathrin-mediated endocytosis of
cell surface receptors via activation of Rab5.
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0BUuz0Ex
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Selected Updates
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IMMUNE RESPONSES: MICROMANAGING STRESS
In normal cells, microRNA molecules repress translation of
stress-induced ligands for the activating receptor NKG2D, thereby
protecting healthy cells from inappropriate natural killer (NK)
cell-mediated lysis.
Original research paper: Nature Immunology 9, 1065-1073 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4yV0Es
ANGIOGENESIS: VEGFR3 JOINS THE CREW
Inhibition of vascular endothelial growth factor receptor 3 (VEGFR3)
might help block tumor growth and circumvent drug resistance when
combined with anti-VEGF/VEGFR2 therapies.
Original research paper: Nature 454, 656-660 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4yW0Et
AFFECTIVE DISORDERS: BABY BLUES
Two studies addressing different aspects of maternal depression during
pregnancy and the post-partum period show that that exposure to
antidepressants in utero can have long-lasting effects on the
offspring's serotonin system, and that altered sensitivity of GABA
([gamma]-aminobutyric acid) type-A receptors might predispose women to
post-partum depression.
Original research paper: Neuron 59, 207-213 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4yX0Eu
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0vO0Ek
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Research Library
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STRUCTURE OF EPAC2 IN COMPLEX WITH A CYCLIC AMP ANALOGUE AND RAP1B
Nature 455, 124-127 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4yY0Ev
THE KINASES MSK1 AND MSK2 ACT AS NEGATIVE REGULATORS OF TOLL-LIKE
RECEPTOR SIGNALING
Nature Immunology 9, 1028-1036 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4yZ0Ew
CIRCADIAN OSCILLATION OF HIPPOCAMPAL MAPK ACTIVITY AND cAMP:
IMPLICATIONS FOR MEMORY PERSISTENCE
Nature Neuroscience 11, 1074-1082 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4ya0E4
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Signaling News
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SIGNALING GATEWAY SURVEY: THANKS FOR YOUR SUPPORT
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0J40EZ
The Signaling Gateway team would like to extend our
sincere appreciation to everyone who completed the on-line survey
last month. Your feedback will ensure that we continue to provide
content that you find relevant and interesting. The survey is now
closed and we have drawn a name at random to select our prizewinner.
Congratulations to Benjamin Y. Jin at Brigham and Women's Hospital
in Boston for winning the Apple iPod touch!
More News
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0Crw0ET
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Gateway Updates
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THE CELL MIGRATION GATEWAY - SEPTEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0uLB0Em
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles:
Neuronal migration: A direct road from Neurog2 to Rnd2
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4wM0Eh
siRNA screen: Showing migration-related genes
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4wN0Ei
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0BJrg0EQ
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Signaling Job of the Week
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Postdoctoral Position
Employer: Genentech
Location: South San Francisco, California
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0B4yb0E5
A postdoctoral position is available at Genentech in the laboratory of
Dr. Vishva Dixit. Candidates should possess a doctoral degree and
should have a strong background in biochemistry and molecular biology.
The successful applicant will study the role of ubiquitin in cellular
signaling.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0BnjC0EI
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0vqs0EF
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http://ealerts.nature.com/cgi-bin24/DM/y/enMJ0Xztnp0H2W0dIO0Ef
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