Signaling Gateway - 26 September 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0M40Ej
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
MEMBRANE RAFTS: A LIFE BOAT FOR AKT
Akt membrane localization and activation is dependent on the presence
of cholesterol- and sphingolipid-rich nanodomains.
Original research paper: Nature Chemical Biology 4, 538-547 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0vP0Es
------------------------
Molecule Pages
------------------------
The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Pea15
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V30Er
Phosphoprotein enriched in astrocytes of 15 kilodaltons (PEA-15) is a
death-effector domain-containing protein that is reported to regulate
apoptosis, proliferation, glucose transport, adhesion and migration.
PEA-15 binds a diverse set of signal transduction proteins that are
responsible for these functions. PEA-15 expression is upregulated in
some breast cancers and gliomas as well as in type 2 diabetes.
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0BUuz0E5
-------------------
Selected Updates
-------------------
PROTEIN DEGRADATION: EXAMINING E1
The crystal structure of ubiquitin bound to Uba1, the Saccharomyces
cerevisiae E1 ubiquitin ligase, has been solved.
Original research paper: Cell 134, 268-278 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V40Es
TRANSLATION: INTERPRETING p53
Mutations in ribosomal proteins (RPs) alter p53 function to promote
human disease and tumorigenesis.
Original research paper: Proc. Natl Acad. Sci. USA 105, 10408-10413
(2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V50Et
NETWORK BIOLOGY: WHY DO WE NEED HUBS?
A study of the yeast interaction network suggests that essential
proteins tend to be network hubs because they belong to biological
processes that are densely interconnected.
Original research paper: PLoS Comput. Biol. 4, e1000140 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V60Eu
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0vO0Er
------------------------
Research Library
------------------------
FCRN-MEDIATED ANTIBODY TRANSPORT ACROSS EPITHELIAL CELLS REVEALED BY
ELECTRON TOMOGRAPHY
Nature 455, 542-546 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V70Ev
THE KINASE P38a SERVES CELL TYPE-SPECIFIC INFLAMMATORY FUNCTIONS IN
SKIN INJURY AND COORDINATES PRO- AND ANTI-INFLAMMATORY GENE
EXPRESSION
Nature Immunology 9, 1019-1027 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V80Ew
PREDICTING PDZ DOMAIN-PEPTIDE INTERACTIONS FROM PRIMARY SEQUENCES
Nature Biotechnology 26, 1041-1045 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6WA0E7
------------------------
Signaling News
------------------------
MACARTHUR FOUNDATION ANNOUNCES ANNUAL GRANTS
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6Ah0EP
The MacArthur Foundation has announced the winners of the US$500,000
so-called 'genius grant'. The MacArthur Fellowship is awarded to
creative people from the arts, sciences and humanities with a track
record of achievement and potential for further success. This year's
recipients include plant evolutionary geneticist Kirsten Bomblies,
developmental biologist Susan Mango, neuroscientist Sally Temple and
experimental neurobiologist Rachel Wilson.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0Crw0Ea
-------------------------
Gateway Updates
-------------------------
THE FUNCTIONAL GLYCOMICS GATEWAY - SEPTEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0BKHW0Ea
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Proteoglycan editing: Sulfatases change a frog's fate
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B5Rs0Eq
Golgi protein glycosylation: Keeping transferases safe and sound
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B5Rt0Er
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0BJYw0EO
-----------------------------
Signaling Job of the Week
-----------------------------
Faculty Position
Employer: Princeton University
Location: Princeton, New Jersey
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6WB0E8
The Department of Molecular Biology at Princeton University invites
applications for a tenure-track faculty position at the Assistant
Professor level. The successful applicant will use vertebrate or
invertebrate model systems to address fundamental questions in cell
signaling, pattern formation, morphogenesis and/or gene expression.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0BnjC0EP
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0vqs0EM
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0dIO0Em
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0BCGZ0EU
For further technical assistance or any other enquiries, please click here:
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0mg0E7
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2008 Nature Publishing Group
---------------------------------------------------------------------
