Signaling Gateway - 19 September 2008
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0M40Eh
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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NEW KINASE-SUBSTRATE PROFILING SERVICE
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* Identify novel substrates, their phosphosites and detection phospho-
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* Choose from >360 active kinases
* Use your cell/tissue lysates or those from Kinexus
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In Signaling Update this week:
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Featured Article
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CELL ADHESION: TALIN SHIFTS CELL SPREADING INTO HIGH GEAR
The cytoskeletal protein talin functions as a molecular clutch that
links the contracting actin cytoskeleton to extracellular
matrix-bound integrins.
Original research paper: Nature Cell Biology 10, 1062-1068 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0vP0Eq
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
Ndrg1
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yf0EG
N-myc downregulated gene 1 (NDRG1) is one of 4 members of the NDRG
alpha/beta-hydrolase family. NDRG1 mRNA and protein expression is
downregulated in advanced and poorly differentiated tumors of the
breast, prostate, pancreas and colon. NDRG1 is intensely investigated
as a biomarker for cancer progression and prognosis, and might hold
promise as a potential therapeutic target.
Also published this week:
Ndrg2
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yg0EH
RhoC
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yh0EI
DLC-1
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yi0EJ
Inositol 1,4,5-triphosphate-associated cGMP kinase substrate
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yj0EK
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0BUuz0E3
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Selected Updates
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TUMORIGENESIS: MARCHING TO A DIFFERENT DRUM
The oncogenic NUP214-ABL1 fusion protein is activated by
incorporation into the nuclear pore complex.
Original research paper: Mol. Cell 31, 134-142 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yk0EL
ANTICANCER DRUGS: PROTEASOME INHIBITOR UNLEASHES THREE-PRONGED ATTACK
The myxobacterium peptide argyrin A is a promising novel anti-cancer
compound that mediates stabilization of the p27KIP1 tumor suppressor
through proteasomal inhibition.
Original research paper: Cancer Cell 14, 23-35 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yl0EM
IMAGING AND VISUALIZATION: NEW SENSORS FROM OLD
A serendipitous discovery reveals that an existing fluorescent -
protein circularly permuted yellow fluorescent protein (cpYFP) - is
also a specific sensor for superoxide.
Original research paper: Cell 134, 279-290 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5ym0EN
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0vO0Ep
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Research Library
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A PARACRINE REQUIREMENT FOR HEDGEHOG SIGNALLING IN CANCER
Nature 455, 406-410 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yn0EO
HUMAN MICRORNAS REGULATE STRESS-INDUCED IMMUNE RESPONSES MEDIATED BY
THE RECEPTOR NKG2D
Nature Immunology 9, 1065-1073 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yo0EP
IMAGING DYNAMIC CELL-CELL JUNCTIONAL COUPLING IN VIVO USING
TROJAN-LAMP
Nature Methods 5, 835-841 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yp0EQ
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Signaling News
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BISPHENOL A LINKED TO DISEASE IN HUMANS
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5gO0EZ
High levels of bisphenol A (BPA) - a chemical used in some containers
for food and drink - may be associated with an increased risk or a
wide range of conditions, including low sperm count, altered fetal
development, behavioral disorders in children and prostate cancer.
Work in animals has suggested that BPA has the potential to disrupt
normal hormone signaling by mimicking the natural hormone, estrogen.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0Crw0EY
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Gateway Updates
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PSI-NATURE STRUCTURAL GENOMICS KNOWLEDGEBASE - SEPTEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yq0ER
Nature Publishing Group is pleased to announce the launch of the
Structural Genomics Knowledgebase, a free, comprehensive resource
produced in collaboration with the Protein Structure Initiative
(PSI). This continually updated portal to research data and other
resources from the PSI offers an easy way of keeping abreast of
developments in structural genomics and structural biology.
This month's featured molecule is the repressor protein T-Rex.
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yr0ES
Sign up to receive monthly updates from the PSI-Nature Structural
Genomics Knowledgebase.
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5ys0ET
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Signaling Job of the Week
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Research Fellow in Bioinformatics of Transcriptional Regulation
Employer: University of Warwick
Location: Coventry, United Kingdom
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0B5yt0EU
A Research Fellow position is available at the University of Warwick
in an interdisciplinary systems biology research project. The
successful applicant will work on the identification of
cis-regulatory regions in the vicinity of NF-kappaB, the
classification of different sets of target genes, the prediction of
likely NF-kappaB and co-factor binding sites, and the prediction of
likely regulatory protein complexes.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0BnjC0EN
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/enes0Xztnp0H2W0vqs0EK
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