Signaling Gateway - 12 September 2008
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0M40Es
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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KINEX: AN ARRAY OF POSSIBILITIES...
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5Q60Ex
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In Signaling Update this week:
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Featured Article
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NEURONAL MIGRATION: A DIRECT ROAD FROM Neurog2 TO Rnd2
The transcription factor Neurogenin 2 promotes the radial migration of
newly born neurons by directly activating the small Rho GTPase Rnd2.
Original research paper: Nature 455, 114-118 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0vP0E2
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
LIMK1
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5Q70Ey
The LIM kinase (LIMK) proteins regulate actin polymerization via
phosphorylation and inactivation of the actin depolymerizing factors
ADF and cofilin, resulting in accumulation of actin filaments
(F-actin). LIMK1 is activated by the Rho GTPase effector kinases
ROCK, PAK1 and PAK4, which phosphorylate LIMK1 in the activation loop
of its kinase domain. Active LIMK1 influences actin-dependent
physiological functions such as morphology, motility, neurite
extension, neurite pathfinding and cytokinesis.
Also published this week:
LIMK2
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5Q80Ez
Mapkap kinase 5
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RA0EB
Nkd2
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RB0EC
Adenylyl cyclase type 8
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5R10Et
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0BUuz0EF
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Selected Updates
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TUMORIGENESIS: TWO-FACED
Menin links the MLL (mixed-lineage leukemia) histone methyltransferase
to the LEDGF (lens epithelium-derived growth factor) transcriptional
coactivator to promote oncogenic transformation of myeloid progenitor
cells.
Original research paper: Cancer Cell 14, 36-46 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RC0ED
TUMOUR SUPPRESSION: SHARING THE LIMELIGHT
The tumor suppressor p53 represses expression of CD44 - a stem-cell
marker that inhibits cell death and induces chemotherapy resistance.
Original research paper: Cell 134, 62-73 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RD0EE
ANIMAL MODELS: PROTEOMICS GOES LIVE IN THE MOUSE
An in vivo SILAC (stable isotope labeling with amino acids in cell
culture) technique permits comprehensive, quantitative proteomic
analysis of whole tissues.
Original research paper: Cell 134, 353-364 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RE0EF
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0vO0E1
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Research Library
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p53 mRNA CONTROLS p53 ACTIVITY BY MANAGING MDM2 FUNCTIONS
Nature Cell Biology 10, 1098-1105 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RF0EG
PATHOLOGICAL RESPONSES TO ONCOGENIC HEDGEHOG SIGNALING IN SKIN ARE
DEPENDENT ON CANONICAL WNT/[beta]-CATENIN SIGNALING
Nature Genetics 40, 1130-1135 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RG0EH
PHOTOSWITCHABLE FLUORESCENT PROTEINS ENABLE MONOCHROMATIC MULTILABEL
IMAGING AND DUAL COLOR FLUORESCENCE NANOSCOPY
Nature Biotechnology 26, 1035-1040 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RH0EI
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Signaling News
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NATURE REVIEWS MOLECULAR CELL BIOLOGY POSTER: PLURIPOTENT CELL
ISOLATION FOR REGENERATIVE MEDICINE
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B3jb0E5
Pluripotent cells offer great promise for the future of regenerative
medicine and tissue engineering. This FREE poster compares and
contrasts the properties of pluripotent embryonic stem cells with
those of laboratory-generated pluripotent cells.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0Crw0Ej
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - SEPTEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0BGyx0E2
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and bioinformaticians
to explore, visualize and mine signaling events.
Recently added pathways include:
FOXA2 and FOXA3 transcription factor networks
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RI0EJ
TRAIL signaling pathway
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5Ew0Eq
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0BJYy0EZ
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Signaling Job of the Week
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Faculty Positions
Employer: The Mount Sinai School of Medicine
Location: New York City, New York
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0B5RJ0EK
The Mount Sinai Cancer Institute invites applications for tenure
track/tenured positions at all faculty levels in the area of Cancer
Pharmacology. Successful applicants will build an interdisciplinary
research program in target identification and drug development for
breast, liver and hematological cancer therapeutics.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0BnjC0EY
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/enVQ0Xztnp0H2W0vqs0EV
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