October 2008 Volume 8 Number 10
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This month's FEATURED article:
Cancer stem cells in solid tumours: accumulating evidence and unresolved
questions
Jane E. Visvader and Geoffrey J. Lindeman
p755 | doi:10.1038/nrc2499
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6EY0Eu
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From the editors
p733 | doi:10.1038/nrc2520
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6EZ0Ev
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RESEARCH HIGHLIGHTS
----------------------
Therapy: Developmental parallels
p735 | doi:10.1038/nrc2517
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ea0E3
Tumorigenesis: Understanding one's origins
p736 | doi:10.1038/nrc2506
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Eb0E4
Therapy: Combine and conquer
p736 | doi:10.1038/nrc2519
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ec0E5
RNA biology: There's nothing abnormal about chimeric RNA
p737 | doi:10.1038/nrc2511
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ed0E6
Tumorigenesis: Taking the MYC
p738 | doi:10.1038/nrc2508
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ee0E7
Evolution: Deep down
p738 | doi:10.1038/nrc2509
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ef0E8
IN THE NEWS
All clear for now
p738 | doi:10.1038/nrc2518
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Eg0EA
IN BRIEF
Metastasis | Oncogenes | Signalling
p739 | doi:10.1038/nrc2515
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Eh0EB
Cell division: Back and forth
p740 | doi:10.1038/nrc2514
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ei0EC
TRIAL WATCH
Skin Deep | Global risk and incidence
p740 | doi:10.1038/nrc2516
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ej0ED
Epigenetics: Rewriting the ending
p741 | doi:10.1038/nrc2512
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ek0EE
Metastasis: Micro silencing
p741 | doi:10.1038/nrc2513
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6El0EF
Genetics: More than one way....
p742 | doi:10.1038/nrc2510
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Em0EG
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REVIEWS
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Basal cell carcinomas: attack of the hedgehog
Ervin H. Epstein
p743 | doi:10.1038/nrc2503
The discovery that aberrant Hedgehog signalling can lead to the development
of basal cell carcinoma (BCC) has facilitated a remarkable increase in our
understanding of BCC. How is this information being used to refine the
treatment of this disease?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6En0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Eo0EI
Cancer stem cells in solid tumours: accumulating evidence and unresolved
questions
Jane E. Visvader and Geoffrey J. Lindeman
p755 | doi:10.1038/nrc2499
In this Review article, the authors discuss the evidence supporting the
existence of CSCs in solid tumours.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ep0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6EY0Eu
The role of the RB tumour suppressor pathway in oxidative stress responses
in the haematopoietic system
Kay F. Macleod
p769 | doi:10.1038/nrc2504
This Review assesses emerging data that indicate a specific role for the RB
tumour suppressor pathway in the response of the haematopoietic system to
oxidative stress, and discusses the relevance of these findings to future
cancer therapies.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Eq0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Er0EL
The TRAIL apoptotic pathway in cancer onset, progression and therapy
Ricky W. Johnstone, Ailsa J. Frew and Mark J. Smyth
p782 | doi:10.1038/nrc2465
Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)
receptors (TRAILR1 and TRAILR2) are promising targets for cancer therapy:
both recombinant TRAIL and monoclonal antibodies that target these receptors
have entered clinical trials. How are these agents faring? What are the
current stumbling blocks?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Es0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Et0EN
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PERSPECTIVES
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OPINION
Replication licensing and cancer - a fatal entanglement?
J. Julian Blow and Peter J. Gillespie
p799 | doi:10.1038/nrc2500
Replication licensing proteins are inappropriately expressed and misregulated
in a wide variety of cancers. What are the consequences for DNA replication
and genomic stability?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Eu0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ev0EP
OPINION
Bone morphogenetic protein signalling in colorectal cancer
James C. Hardwick, Liudmila L. Kodach, G. Johan Offerhaus and
Gijs R. van den Brink
p806 | doi:10.1038/nrc2467
Mutations in the bone morphogenetic protein pathway have been found in
juvenile polyposis, an inherited polyposis syndrome that predisposes to
colorectal cancer. What relevance do these findings have to sporadic cases
of colorectal cancer?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ew0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ex0ER
OPINION
Can genes for mammographic density inform cancer aetiology?
Linda E. Kelemen, Thomas A. Sellers and Celine M. Vachon
p812 | doi:10.1038/nrc2466
High mammographic density (MD) is an established risk factor for breast
cancer. In theory, the number of genes that regulate MD should be smaller
than that influencing breast cancer risk. How informative have the initial
studies of the genetics of MD proved to be?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ey0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6Ez0ET
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CORRESPONDENCE
----------------------
Correspondence: Opinions regarding cord blood use need an update
J. J. Nietfeld
p823 | doi:10.1038/nrc2418-c1
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6E10EG
Correspondence: Cord blood stem cells: worth the investment
David T. Harris
p823 | doi:10.1038/nrc2418-c2
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6E20EH
Correspondence: Banking on cord blood stem cells
Michael J. Sullivan
p823 | doi:10.1038/nrc2418-c3
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6E30EI
Correspondence: Towards a hybrid model for the cryopreservation of
umbilical cord blood stem cells
Zafiris Polymenidis and George P. Patrinos
p823 | doi:10.1038/nrc2418-c4
http://ealerts.nature.com/cgi-bin24/DM/y/enkW0Xztnp0Hja0B6E40EJ
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