September 2008 Volume 14 Number 9, pp 985 - 921
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MULTIPLEX CYTOKINE BIOCHIPS
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Molecular Targets for Cancer Therapy: Regulatory Myeloid
Suppressor Cells in Health & Disease, March 12 -15, 2009,
Clearwater Beach, FL.
Focuses on origin, mechanisms of action and role of immune
suppressive myeloid cells in different diseases and their
therapeutic correction.
Deadline for Abstracts 12/15/08.
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yd0EQ
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Nature Insight Inflammation
Inflammation is our body's immediate response to damage to its tissues and cells by pathogens or noxious stimuli such as chemicals or physical injury. While initiation and the process of acute inflammation are reasonably well defined, much less is known about the causes and pathways associated with chronic inflammation. This Insight highlights recent advances in our knowledge of the exogenous and endogenous inducers of chronic inflammation, the inflammatory mediators and the cells that carry out the response.
Read the Insight in the 24th July issue of Nature or access it online.
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0BuvF0Ew
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EDITORIAL
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Playing it safe p891
Dual-use research - research that could be misused to pose a threat to public safety[mdash]needs to be regulated, but the best way to do so is not straightforward at all.
doi:10.1038/nm0908-891
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4y10EZ
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NEWS
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Bioterror experts split on recommendations for 'dual use' research p893
Charlotte Schubert
doi:10.1038/nm0908-893
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4y20Ea
Hope in Alzheimer's fight emerges from unexpected places p894
Trisha Gura
doi:10.1038/nm0908-894
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4y30Eb
Circumcision strategy against HIV continues to prove divisive p895
Cassandra Willyard
doi:10.1038/nm0908-895a
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4y40Ec
Stem cells promise to dish on diseases p895
Coco Ballantyne
doi:10.1038/nm0908-895b
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4y50Ed
Math and semen analyses cast doubt on Swiss HIV stance p896
Coco Ballantyne
doi:10.1038/nm0908-896a
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4y60Ee
Bigger returns sought on health initiatives p896
Coco Ballantyne
doi:10.1038/nm0908-896b
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4y70Ef
10 ways to transform your lab pp897 - 899
A tremendous amount of investment went into the construction of science facilities during the 1950s through the 1970s. And, because huge sums of money went into building up many of these laboratories, which still stand today, they can't just be bulldozed and rebuilt[mdash]it would be terribly wasteful. Yet these labs often seem ill suited for modern research. Researchers' complaints range from cluttered countertops to distracting noise to overcrowded work spaces, just to name a few. These problems create stress and drag on productivity. Others say they have simply outgrown their space, or their work has developed beyond their lab's current technical capabilities.
What happens when a scientist would like to take her research in a certain direction, but her assigned space doesn't allow it? Remodeling could be the answer. There's a growing industry in rehabilitating and modernizing research facilities. Architectural experts say a few strategic changes can bring much needed relief while boosting productivity.
James Hudspeth, director of the F.M. Kirby Center for Sensory Neuroscience at the Rockefeller University in New York, knows firsthand the challenges and rewards of remodeling a lab. As his interdisciplinary research into the biophysical aspects of hearing has expanded over the years, Hudspeth has had to undertake major lab renovations three times during his career.
The most recent remodeling of his lab, completed last year, involved revamping a workspace in an entirely different building. Hudspeth's move is a good example of creative problem-solving that employed a team of architects, engineers, his lab manager and an unflappable project manager. On the following pages leading architects offer suggestions on how you, too, can update your lab space.
Genevive Bjorn
doi:10.1038/nm0908-897
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4y80Eg
News in brief pp900 - 901
doi:10.1038/nm0908-900
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zA0Eq
Straight talk with...Fotis Kafatos pp902 - 903
Biologist Fotis Kafatos has spent a career balancing his own research endeavors with efforts to create opportunities for other scientists. Born and raised in Crete, Greece, Kafatos moved to the US to study zoology at Cornell University and, later in the 1960s, biology at Harvard University, where he went on to become the university's youngest full professor at age 29. During his three decades at Harvard, Kafatos maintained close ties with Europe, teaching part-time at Greek universities and founding Crete's Institute of Molecular Biology and Biotechnology. In 1993, he returned to Europe to direct the continent's premiere molecular biology center, the Heidelberg-based European Molecular Biology Laboratory (EMBL), where he strived to create an equal-opportunity environment for scientists from all corners of Europe.
More recently, in late 2005, Kafatos was elected chairman of the policy-setting body for the European Research Council (ERC). Kafatos now divides his time between studying malaria-causing mosquitoes at Imperial College London and leading an organization charged with doling out some [euro]7.5 billion ([dollar]11 billion) to Europe's most promising scientists from 2007 to 2013[mdash]an infusion of money intended to revitalize the continent's research community. Kafatos talks about his research and his stewardship of the ERC with Coco Ballantyne.
doi:10.1038/nm0908-902
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zB0Er
An evolving threat pp904 - 907
Epidemiologists at the University of Stellenbosch, near Cape Town, South Africa, have assembled a vast collection of tuberculosis strains. With it, they're revealing how drug-resistant strains evolve and spread through human populations. Charlie Schmidt reports.
Charlie Schmidt
doi:10.1038/nm0908-904
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zC0Es
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BOOK REVIEW
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Science of addiction: lost in a labyrinth p908
Antonello Bonci reviews The Science of Addiction: From Neurobiology to TreatmentCarlton K. Erickson
doi:10.1038/nm0908-908
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zD0Et
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NEWS AND VIEWS
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Live longer with LAMP-2 pp909 - 910
Upregulation of a protein involved in lysosomal degradation of proteins helps stave off some of the cellular decline observed with aging. The findings could lead to new approaches to fend off age-related disease or even extend lifespan (pages 959-965).
Paul Saftig and Eeva-Liisa Eskelinen
doi:10.1038/nm0908-909
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zE0Eu
Mitochondrial missile defense pp910 - 912
A relatively obscure immune cell, the eosinophil, has a dramatic way of defending against pathogens. It rapidly ejects mitochondrial DNA, ensnaring bacteria and hastening their demise (pages 949-953).
Victor Nizet and Marc E Rothenberg
doi:10.1038/nm0908-910
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zF0Ev
Disarming the malaria parasite pp912 - 913
Investigation of a genetically attenuated malaria parasite[mdash]which infects but does not kill its host[mdash]provides insight into how to develop a malaria vaccine (pages 954-958).
Christian R Engwerda and Michael F Good
doi:10.1038/nm0908-912
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zG0Ew
Cell-free DNA resuscitated for tumor testing pp914 - 915
Extracellular DNA floating around in blood plasma provides an accessible template for detecting mutations associated with tumors. A new technique is able to quantify such mutated DNA and predict relapse in individuals with colorectal cancer. The technique complements other approaches, such as the analysis of tumor cells in the plasma(pages 985-990).
Michael Fleischhacker and Bernd Schmidt
doi:10.1038/nm0908-914
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zH0Ex
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COMMUNITY CORNER
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Community corner p916
doi:10.1038/nm0908-916
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zI0Ey
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BETWEEN BEDSIDE AND BENCH
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Boosting platelet production pp917 - 918
Andrew Wei and Shaun P Jackson
doi:10.1038/nm0908-917
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zJ0Ez
Counteracting clotting in sepsis pp918 - 919
The complexity of factors that regulate bleeding and coagulation has long confounded researchers. Andrew Wei and Shaun Jackson help clear the air by examining clinical findings pointing to a mechanistic basis for a common bleeding disorder, immune thrombocytopenic purpura. Mark Kahn tackles two research studies that could lead to improved therapies for a coagulation syndrome that hits people with severe sepsis.
Mark L. Kahn
doi:10.1038/nm0908-918
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zK0E1
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RESEARCH HIGHLIGHTS
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Research highlights pp920 - 921
doi:10.1038/nm0908-920
http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4zL0E2
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REVIEW
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Endocannabinoid signaling as a synaptic circuit breaker in neurological disease pp923 - 930
Istvan Katona and Tamas F Freund
doi:10.1038/nm.f.1869
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yy0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yz0Em
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ARTICLES
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The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A pp931 - 938
Christian Faul et al.
doi:10.1038/nm.1857
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yo0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yp0Ec
RPN2 gene confers docetaxel resistance in breast cancer pp939 - 948
Kimi Honma et al.
doi:10.1038/nm.1858
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yq0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yr0Ee
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LETTERS
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Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense pp949 - 953
Shida Yousefi et al.
doi:10.1038/nm.1855
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4ym0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yn0Ea
Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity pp954 - 958
Li-Min Ting et al.
doi:10.1038/nm.1867
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yw0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yx0Ek
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function pp959 - 965
Cong Zhang and Ana Maria Cuervo
doi:10.1038/nm.1851
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yi0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yj0EW
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption pp966 - 972
Eun-Ju Chang et al.
doi:10.1038/nm.1860
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4ys0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yt0Eg
PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle pp973 - 978
Cesare Gargioli et al.
doi:10.1038/nm.1852
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yk0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yl0EY
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TECHNICAL REPORTS
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An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice pp979 - 984
Milena Traykova-Brauch et al.
doi:10.1038/nm.1865
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yu0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yv0Ei
Circulating mutant DNA to assess tumor dynamics pp985 - 990
Frank Diehl et al.
doi:10.1038/nm.1789
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4ye0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enNb0Xztnp0HjT0B4yf0ES
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Fondation IPSEN, Nature Neuroscience and Nature Genetics present:
An Emergence & Convergence mini-symposium-
Mitochondrial Dysfunction in Neurological Disease
December 5, 2008
Washington Duke Inn and Golf Club
Durham, North Carolina, USA
Deadline for application: October 10, 2008
Attendance at this meeting is free on acceptance of application.
To apply and for more information visit:
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anatureconference
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