September 2008 Volume 26 Number 9, pp 953 - 1050
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EDITORIALS
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Calling all patients p953
Disease-orientated consumer online communities radically change the way in which individuals monitor their health, but they could also create new ways of testing treatments and speed patient recruitment into clinical trials.
doi:10.1038/nbt0908-953
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DL0Ee
This means war p954
Does a role-playing game reveal any new insights into the factors holding back the UK biotech sector?
doi:10.1038/nbt0908-954
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DM0Ef
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NEWS
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Big pharma swallows biotech's pride pp955 - 956
Brady Huggett
doi:10.1038/nbt0908-955
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DN0Eg
GSK's Harvard cash injection p956
Victor Alamo-Bethencourt
doi:10.1038/nbt0908-956
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DO0Eh
Actemra poised to launch IL-6 inhibitors pp957 - 959
Lisa Melton and Amy Coombs
doi:10.1038/nbt0908-957
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HAE market heats up p958
Jodi Hyer
doi:10.1038/nbt0908-958a
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mAb quality by design p958
Susan Aldridge
doi:10.1038/nbt0908-958b
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Pharmas partner in venture seeking drug discovery tools pp960 - 961
George S Mack
doi:10.1038/nbt0908-960
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EU clone green light p961
Peter Vermij
doi:10.1038/nbt0908-961a
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Return to sender p961
Jeffrey L Fox
doi:10.1038/nbt0908-961b
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Western biotechs ponder follow-on possibilities pp962 - 963
Emily Waltz
doi:10.1038/nbt0908-962
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DV0Eo
SBIR boost p963
Catherine Shaffer
doi:10.1038/nbt0908-963a
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DW0Ep
Startups lure oil giants p963
Emily Waltz
doi:10.1038/nbt0908-963b
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DX0Eq
Profile: Vera Sharav p965
Personal tragedy motivates Vera Sharav in her campaign to protect the human rights of research subjects in clinical trials.
Charlie Schmidt
doi:10.1038/nbt0908-965
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DY0Er
NEWS FEATURE
Trouble at the office pp967 - 969
The FDA's Office of Oncology Products has come in for stinging criticism from drug developers, advocates and even a US legislator over the use of surrogate endpoints. Has the agency struck the right balance between speed and caution? Malorye Allison investigates.
Malorye Allison
doi:10.1038/nbt0908-967
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5DZ0Es
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BIOENTREPRENEUR
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BUILDING A BUSINESS
Building for an exit (or not) pp971 - 973
A young biotech firm can grow in several ways. The key to success is preparing for them all.
Thomas G Gunning
doi:10.1038/bioe.2008.8
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Da0Ez
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OPINION AND COMMENT
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CORRESPONDENCE
Auf Wiedersehen, agbiotech pp974 - 975
Henry I Miller
doi:10.1038/nbt0908-974
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Db0E1
Trace and traceability - a call for regulatory harmony pp975 - 978
Koreen Ramessar et al.
doi:10.1038/nbt0908-975
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dc0E2
Do-it-yourself (DIY) pathology pp978 - 979
Tan A Ince et al.
doi:10.1038/nbt0908-978
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dd0E3
Reply to Do-it-yourself (DIY) pathology p979
doi:10.1038/nbt0908-979a
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5De0E4
Bypassing consent for research on biological material pp979 - 980
Bjorn M Hofmann
doi:10.1038/nbt0908-979b
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Reply to Bypassing consent for research on biological material pp980 - 981
doi:10.1038/nbt0908-980
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Cost/success projections for US biodefense countermeasure development pp981 - 983
Jason Matheny, Michael Mair and Bradley Smith
doi:10.1038/nbt0908-981
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dh0E7
Data completeness - the Achilles heel of drug-target networks pp983 - 984
Jordi Mestres, Elisabet Gregori-Puigjane, Sergi Valverde and Ricard V Sole
doi:10.1038/nbt0908-983
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Di0E8
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COMMENTARY
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Toward biosimilar monoclonal antibodies pp985 - 990
To what extent is the existing framework for biosimilars in Europe likely to be applicable to monoclonal antibodies?
Christian K Schneider and Ulrich Kalinke
doi:10.1038/nbt0908-985
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dj0EA
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BOOK REVIEW
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Context, context, context! A delicate empiricism for biotechnology pp991 - 992
Lenny Moss reviews Beyond Biotechnology: The Barren Promise of Genetic Engineering by Craig Holdrege and Steve Talbott
doi:10.1038/nbt0908-991
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dk0EB
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FEATURES
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PATENTS
DNA-based patents: an empirical analysis pp993 - 995
The perception of rising litigation rates is driving the push for patent reform.
Ann E Mills and Patti Tereskerz
doi:10.1038/nbt0908-993
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Recent patent applications in tissue culture p996
doi:10.1038/nbt0908-996
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NEWS AND VIEWS
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Dissecting microbial employment pp997 - 998
A targeted metagenomics approach profiles the methylotrophic microbes in lake sediments.
Elizabeth A Dinsdale and Forest Rohwer
doi:10.1038/nbt0908-997
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dn0EE
Agrobacterium-mediated DNA transfer, and then some pp998 - 1000
In addition to its plasmid DNA, Agrobacterium tumefaciens can transfer its chromosomal DNA to plant genomes.
Stanton B Gelvin
doi:10.1038/nbt0908-998
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Do0EF
Viral attenuation by design pp1000 - 1001
A less-virulent poliovirus generated by altering codon usage suggests a new strategy for vaccine development.
Harriet L Robinson
doi:10.1038/nbt0908-1000
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Research Highlights p1002
doi:10.1038/nbt0908-1002
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dq0EH
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COMPUTATIONAL BIOLOGY
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ANALYSIS
Network-based prediction of human tissue-specific metabolism pp1003 - 1010
Tomer Shlomi et al.
doi:10.1038/nbt.1487
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dr0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Ds0EJ
PRIMER
What are decision trees? pp1011 - 1013
Decision trees have been applied to problems such as assigning protein function and predicting splice sites. How do these classifiers work, what types of problems can they solve and what are their advantages over alternatives?
Carl Kingsford and Steven L Salzberg
doi:10.1038/nbt0908-1011
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dt0EK
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RESEARCH
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BRIEF COMMUNICATIONS
T-DNA-mediated transfer of Agrobacterium tumefaciens chromosomal DNA into plants pp1015 - 1017
Backbone fragments of the Agrobacterium tumor-inducing (Ti) plasmid that bears transgenes of interest have occasionally been reported to be transferred to plant genomes. Now, Ulker et al. show that Agrobacterium chromosomal DNA can also be integrated into transgenic plants at a low frequency. Gene-bearing chromosomal fragments as large as 18 kb are found in T-DNA-tagged populations of Arabidopsis thaliana.
Bekir Ulker et al.
doi:10.1038/nbt.1491
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Du0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dv0EM
ARTICLE
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis pp1019 - 1027
New hepatitis C treatments are urgently needed. Working with a high-throughput microfluidic affinity assay for RNA-protein interactions, Quake and colleagues identify a small molecule that negatively affects HCV replication in cell culture by inhibiting the binding between the nonstructural protein 4B and the viral RNA genome.
Shirit Einav et al.
doi:10.1038/nbt.1490
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dw0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dx0EO
LETTERS
High-resolution metagenomics targets specific functional types in complex microbial communities pp1029 - 1034
Metagenomics, or shotgun sequencing of environmental DNA, is used to study complex microbial communities. Kalyuzhnaya et al. describe a method for targeting specific microbial subpopulations in environmental samples and use it to analyze microbes that metabolize C1 compounds.
Marina G Kalyuzhnaya et al.
doi:10.1038/nbt.1488
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dy0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5Dz0EQ
Photoswitchable fluorescent proteins enable monochromatic multilabel imaging and dual color fluorescence nanoscopy pp1035 - 1040
The current reversibly switchable fluorescent proteins (RSFPs) can not be multiplexed. Jakobs and colleagues create two RSFPs with novel switching characteristics that can be used simultaneously in fluorescence microscopy experiments using only one detection color.
Martin Andresen et al.
doi:10.1038/nbt.1493
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5D10ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5D20EE
Predicting PDZ domain-peptide interactions from primary sequences pp1041 - 1045
PDZ domains represent one of the largest families of interaction domains. Chen et al. develop a scoring matrix that enables prediction of peptide-PDZ domain interactions. Unlike previous methods, the model works to some extent for PDZ domains that were not part of the training set.
Jiunn R Chen et al.
doi:10.1038/nbt.1489
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5D30EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5D40EG
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NATUREJOBS
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CAREERS AND RECRUITMENT
Growing the bioscience career pipeline pp1047 - 1048
A new program connects local science teachers with the bioscience industry.
Christine Shapard
doi:10.1038/nbt0908-1047
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5D50EH
PEOPLE
People p1050
doi:10.1038/nbt0908-1050
http://ealerts.nature.com/cgi-bin24/DM/y/enSP0Xztnp0HjC0B5D60EI
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