4 September 2008 Volume 455 Number 7209, pp1-136
Visit Nature online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0d4W0ER
Please note that you need to be a subscriber to enjoy full text access
to Nature online. To purchase a subscription, please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0Z4L0E5
Alternatively, to recommend a subscription to your library, please visit
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0BRQi0E1
=====================================================================
Fondation IPSEN, Nature Neuroscience and
Nature Genetics present:
An Emergence & Convergence mini-symposium-
Mitochondrial Dysfunction in Neurological Disease
December 5, 2008,
Washington Duke Inn and Golf Club
Durham, North Carolina, USA
Deadline for application: October 10, 2008
Attendance at this meeting is free on acceptance
of application.
To apply and for more information visit
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B2ga0Ei
=====================================================================
Big data special
Massive new datasets present scientists with
unprecedented opportunities to expand their
understanding of nature. But they also present
them with unprecedented challenges, as they
struggle to devise new ways to keep their data
accessible, up-to-date, well-integrated, and
safe-over the course of decades, if not centuries.
Click here and access the Nature News special
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0Paz0ER
=====================================================================
----------------------
EDITORIALS
----------------------
Community cleverness required p1
Researchers need to adapt their institutions and practices in response
to torrents of new data -- and need to complement smart science
with smart searching.
doi:10.1038/455001a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4ou0EE
Cool philosophies p2
High-energy physicists should not gloss over fundamental conundrums.
doi:10.1038/455002a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4ov0EF
The hour of diplomacy p2
Scientific collaboration between East and West must survive the crisis
in Georgia.
doi:10.1038/455002b
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4ow0EG
----------------------
RESEARCH HIGHLIGHTS
----------------------
Cell biology: Cause of death p4
doi:10.1038/455004a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4ox0EH
Geosciences: Clubmoss clues p4
doi:10.1038/455004b
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4oy0EI
Physics: A bolt from the blue p4
doi:10.1038/455004c
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4oz0EJ
Molecular biology: Precision dumping p4
doi:10.1038/455004d
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4o10E5
Chemistry: Silicon pulls it off p4
doi:10.1038/455004e
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4o20E6
Immunology: Hitting 'pause' pp4-5
doi:10.1038/455004f
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4o30E7
Geosciences: Goodbye April showers p5
doi:10.1038/455005a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4o40E8
Neuroscience: Coke heads p5
doi:10.1038/455005b
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4o50EA
Archaeology: Amazonian urbanites p5
doi:10.1038/455005c
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4o60EB
Astrophysics: Far off fly-by p5
doi:10.1038/455005d
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4o70EC
----------------------
JOURNAL CLUB
----------------------
Journal club p5
Caroline Harwood
doi:10.1038/455005e
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4o80ED
----------------------
NEWS
----------------------
Russia's international research ties under threat pp6-7
Responses to Russia's military action in Georgia have implications for
non-proliferation, space exploration, climate negotiation and the
European Union's framework programme.
doi:10.1038/455006a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pA0EN
Physicists aflutter about data photographed at conference p7
Digital cameras snap slides ahead of publication.
Geoff Brumfiel
doi:10.1038/455007a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pB0EO
Big data: The next Google pp8-9
Ten years ago this month, Google's first employee turned up at the
garage where the search engine was originally housed. What technology
at a similar early stage today will have changed our world as much by
2018? Nature asked some researchers and business people to speculate
— or lay out their wares. Their responses are wide ranging, but one
common theme emerges: the integration of the worlds of matter and
information, whether it be by the blurring of boundaries between
online and real environments, touchy-feely feedback from a phone or
chromosomes tucked away on databases.
doi:10.1038/455008a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pC0EP
Mathematical biology centre launched p11
Tennessee institute will focus on dynamics of animal disease.
John Whitfield
doi:10.1038/455011a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pD0EQ
Republicans at odds over human embryo research p12
Stem cells divide McCain's camp.
Meredith Wadman
doi:10.1038/455012a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pE0ER
The energy election pp12
In the first of a special series of election podcasts starting this
week, Nature gathered an expert panel to discuss how energy and
climate issues will play out in the US presidential election.
doi:10.1038/455012b
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pF0ES
DNA databases shut after identities compromised pp13
doi:10.1038/455013a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pG0ET
Bubble-fusion researcher loses misconduct appeal pp13
doi:10.1038/455013b
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pH0EU
'No pollution effects' from Chinese chemical explosion p13
doi:10.1038/455013c
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pI0EV
Alaska's polar bears trigger lawsuit from industry pp13
doi:10.1038/455013d
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pJ0EW
'YouTube for test tubes' to be listed on PubMed pp13
doi:10.1038/455013e
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pK0EX
Mars rover climbs out of crater to focus on plains pp13
doi:10.1038/455013f
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pL0EY
----------------------
COLUMN
----------------------
Big data: Data wrangling pp15
Collecting and releasing environmental data have stirred up
controversy in Washington, says David Goldston, and will continue
to do so.
doi:10.1038/455015a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pM0EZ
----------------------
NEWS FEATURES
----------------------
Big data: Welcome to the petacentre pp16-21
What does it take to store bytes by the tens of thousands of trillions?
Cory Doctorow meets the people and machines for which it's all in a
day's work.
doi:10.1038/455016a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pN0Ea
Big data: Wikiomics pp22-25
Pioneering biologists are trying to use wiki-type web pages to manage
and interpret data, reports Mitch Waldrop. But will the wider research
community go along with the experiment?
doi:10.1038/455022a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pO0Eb
----------------------
CORRESPONDENCE
----------------------
Better writing and more space needed online p26
Linda Cooper
doi:10.1038/455026a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pP0Ec
Languages: Catalan speakers learn a wider range p26
Antoni Rosell-Mele
doi:10.1038/455026b
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pQ0Ed
Languages: Spain's minority-language speakers are bilingual p26
Jesus Purroy
doi:10.1038/455026c
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pR0Ee
Religion: science is partially based on faith pp26-27
Jonathan Cowie
doi:10.1038/455026d
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pS0Ef
Vavilov's vision for genetics was among Stalin's many victims p27
Victor Fet and Michael D. Golubovsky
doi:10.1038/455027a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pT0Eg
Message from the heavens may be that there is no message p27
Bernardo A. Huberman
doi:10.1038/455027b
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pU0Eh
Senior staff of Mexican institute speak up p27
Carlos Barajas-Lopez and senior staff members
doi:10.1038/455027c
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pV0Ei
----------------------
COMMENTARY
----------------------
Big data: How do your data grow? pp28-29
Scientists need to ensure that their results will be managed for the
long haul. Maintaining data takes big organization,
says Clifford Lynch.
doi:10.1038/455028a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pW0Ej
----------------------
BOOKS AND ARTS
----------------------
Big data: Distilling meaning from data p30
Buried in vast streams of data are clues to new science. But we may
need to craft new lenses to see them, explain Felice Frankel
and Rosalind Reid.
doi:10.1038/455030a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pX0Ek
A shared digital future? pp31-32
Will the possibilities for mass creativity on the Internet be realized
or squandered, asks Tony Hey.
Tony Hey reviews The Future of the Internet: And How to Stop It by
Jonathan Zittrain, Here Comes Everybody: The Power of Organizing
Without Organizations by Clay Shirky and We-think: The Power of
Mass Creativity by Charles Leadbeater
doi:10.1038/455031a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pY0El
Virtual similarities pp32-33
David Robson reviews Coming of Age in Second Life: An Anthropologist
Explores the Virtually Human by Tom Boellstorff
doi:10.1038/455032a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pZ0Em
Q&A: Museum's metamorphosis is nearly complete p34
On the unveiling of the second phase of the Darwin Centre at London's
Natural History Museum, Anna Maria Indrio, partner at the Scandinavian
architectural firm C. F. Moller, explains how the new £78 million
(US$145 million) wing will reveal 20 million of the museum's insect
and plant specimens to the public when it opens in September 2009.
Joanne Baker
doi:10.1038/455034a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pa0Et
In Retrospect: Leibniz's Protogaea p35
The first English translation of Gottfried Leibniz's earth science
treatise records the difficulties of understanding our planet before
geologists appreciated deep time, Richard Fortey discovers.
Richard Fortey reviews Protogaea by Gottfreid Wilhelm Leibniz
doi:10.1038/455035a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pb0Eu
----------------------
ESSAY
----------------------
Big data: The Harvard computers pp36-37
The first mass data crunchers were people, not machines. Sue Nelson
looks at the discoveries and legacy of the remarkable women of
Harvard's Observatory.
doi:10.1038/455036a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pc0Ev
----------------------
NEWS AND VIEWS
----------------------
Astrophysics: Bringing black holes into focus pp39-40
Do black holes exist? Observations at the finest resolution so far
indicate that only gross deviations in the behaviour of gravity from
that predicted by general relativity can invalidate the case that
they do.
Christopher S. Reynolds
doi:10.1038/455039a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pd0Ew
Immunology: Oxysterols hold T cells in check pp40-41
The oxysterol-dependent gene transcription factor LXRbeta restricts
premature expansion of T cells by limiting cellular cholesterol
levels. This pathway might be a pharmacological target for regulating
immune responses.
Christopher K. Glass and Kaoru Saijo
doi:10.1038/455040a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pe0Ex
Experimental physics: A shift in spectroscopy pp41-43
Spectroscopic measurement of the energy absorbed or emitted by an
object is an invaluable experimental technique. An innovative approach
opens the door to the acquisition of previously inaccessible data.
Frank K. Wilhelm
doi:10.1038/455041a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pf0Ey
Medical imaging: Less is more pp43-44
The magnetic resonance imagers used in medicine fill rooms with their
large-field magnets. But developments in ultra-low-field devices may
give the doctor of tomorrow a more portable version.
Klaas P. Pruessmann
doi:10.1038/455043a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pg0Ez
Small RNAs: The seeds of silence pp44-45
Individual microRNA sequences can suppress the production of hundreds
of proteins. Reduction of protein levels in this way is often modest,
however, and many such RNAs probably collectively fine-tune gene
expression.
Zissimos Mourelatos
doi:10.1038/455044a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4ph0E1
Obituary: Victor Almon McKusick (1921-2008) p46
Quiet revolutionary in genetic medicine.
Aravinda Chakravarti
doi:10.1038/455046a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pi0E2
----------------------
FEATURE
----------------------
Big data: The future of biocuration pp47-50
To thrive, the field that links biologists and their data urgently
needs structure, recognition and support.
Doug Howe et al.
doi:10.1038/455047a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pj0E3
----------------------
ARTICLE
----------------------
Amplitude spectroscopy of a solid-state artificial atom pp51-57
Artificial atoms, quantum systems with atom like energy structure,
have been studied with frequency spectroscopic techniques. However,
much information about the energy level spectrum has been hidden, as
the technique is impractical for high frequencies. A complementary
technique has been developed where the energy level of an artificial
atom is not scanned by tuning frequency, but amplitude of the
radiation, while the frequency is tuned to a specific feature in the
spectrum.
David M. Berns et al.
doi:10.1038/nature07262
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pk0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pl0E5
Widespread changes in protein synthesis induced by microRNAs p58-63
In one of two studies, a technique known as SILAC is used to measure,
on a large scale, changes in protein level as a function of expression
of endogenous and exogenous miRNAs. It is found that although miRNAs
directly repress the translation of hundreds of genes, additional
indirect effects result in changes in expression of thousands of genes.
Matthias Selbach, Björn Schwanhäusser, Nadine Thierfelder, Zhuo Fang,
Raya Khanin & Nikolaus Rajewsky
doi:10.1038/nature07228
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pm0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pn0E7
The impact of microRNAs on protein output p64-71
In one of two studies, a technique known as SILAC is used to measure,
on a large scale, changes in protein level as a function of expression
of endogenous and exogenous miRNAs. It is found that although miRNAs
directly repress the translation of hundreds of genes, additional
indirect effects result in changes in expression of thousands of genes.
Daehyun Baek, Judit Villén, Chanseok Shin, Fernando D. Camargo,
Steven P. Gygi & David P. Bartel
doi:10.1038/nature07242
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4po0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pp0EA
Type IV collagens regulate BMP signalling in Drosophila p72-77
This paper establishes a role of the extracellular matrix for
regulating the BMP morphogen gradient responsible for dorsal–ventral
patterning of vertebrate and invertebrate embryos. Type IV collagen
binds to the Dpp ligand (the Drosophila form of BMP) and regulates
its signalling in the Drosophila embryo and ovary by sequestering Dpp.
Human type IV collagen binds the analogous protein in humans.
Xiaomeng Wang, Robin E. Harris, Laura J. Bayston & Hilary L. Ashe
doi:10.1038/nature07214
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pq0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pr0EC
----------------------
LETTERS
----------------------
Event-horizon-scale structure in the supermassive black hole candidate
at the Galactic Centre pp78-80
The cores of most large galaxies are thought to harbour super massive
black holes. Sagittarius A*, the compact source of radio, infrared and
x ray emission at the centre of the Milky Way, is the closest example
of this phenomenon. This paper reports observations that set a limit
less than the expected apparent size of the event horizon of the
presumed black hole, suggesting that the bulk of Sgr A* emission may
not be centred on the black hole, but arises in the surrounding
accretion flow.
Sheperd S. Doeleman et al.
doi:10.1038/nature07245
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4ps0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pt0EE
Electronic structure of the iron-based superconductor LaOFeP pp81-84
Angle resolved photoemission spectroscopy (ARPES) of LaOFeP
(Tc = 5.9 K) is reported. These results favour the itinerant ground
state, albeit with band renormalization. In addition, the data reveal
important differences between these and copper based superconductors.
D. H. Lu et al.
doi:10.1038/nature07263
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pu0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pv0EG
Nanoscale double emulsions stabilized by single-component block
copolypeptides pp85-88
Small water droplets within larger oil droplets, which are themselves
distributed in an aqueous phase, are a type of double emulsion. This
paper details that double emulsions can prepared and stabilized over
several months using amphiphilic diblock copolypeptides, and can even
generate robust double nanoemulsions.
Jarrod A. Hanson et al.
doi:10.1038/nature07197
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pw0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4px0EI
Interaction between liquid water and hydroxide revealed by core-hole
de-excitation pp89-91
Core level photoelectron emission and intermolecular Coulombic decay
for an aqueous hydroxide solution is measured. The results show that
in contrast to hydrated protons, hydrated hydroxide ions can
transiently donate a hydrogen bond to surrounding water molecules.
This capability can explain the unusual and fast transport of
hydroxide ions in water.
Emad F. Aziz et al.
doi:10.1038/nature07252
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4py0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4pz0EK
The increasing intensity of the strongest tropical cyclones pp92-95
Although cyclones in the tropical Atlantic seem to be getting stronger
in response to increasing ocean temperatures, no clear trends of this
sort have been discerned in other tropical regions. A new analysis of
cyclone intensity using satellite data suggests that there is a global
trend, but that it is quite subtle. The main changes appear not in an
upward trend of average cyclone intensity, but rather in the maximum
speeds attained by cyclones during their lifetimes, the stronger the
cyclone, the greater the change.
James B. Elsner, James P. Kossin and Thomas H. Jagger
doi:10.1038/nature07234
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4p10E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4p20E7
Multimodal warning signals for a multiple predator world pp96-99
Tiger moth multimodal warning signals vary according to the activity
patterns of predators with divergent sensory capacities. It is
suggested that selective pressures from multiple predator classes play
distinct roles in the evolution of multimodal warning displays.
John M. Ratcliffe and Marie L. Nydam
doi:10.1038/nature07087
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4p30E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4p40EA
The virophage as a unique parasite of the giant mimivirus p100-104
The satellite virus Sputnik is a parasite that infects the giant
Mamavirus and replicates in the virus factory built by Mamavirus,
interfering with Mamavirus reproduction.
Bernard La Scola et al.
doi:10.1038/nature07218
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4p50EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4p60EC
Single-nucleotide mutation rate increases close to
insertions/deletions in eukaryotes p105-108
Recent genomic efforts have demonstrated that large chunks of DNA
differ between individuals in many species. Insertions or deletions
of larger blocks cause single nucleotide changes to their immediate
vicinity, and population genetic models should take into account the
'mutator' effect of these insertions or deletions.
Dacheng Tian et al.
doi:10.1038/nature07175
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4p70ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4p80EE
Molecular architecture of native HIV-1 gp120 trimers p109-113
This paper investigates the structure of the HIV glycoprotein gp120 by
cryo-electron tomography and molecular modelling. gp120 is analysed in
an unliganded state, complexed with a neutralizing antibody and in a
CD4 liganded state. The analysis provides insight into the
conformational changes that occur with ligand binding.
Jun Liu, Alberto Bartesaghi, Mario J. Borgnia, Guillermo Sapiro
& Sriram Subramaniam
doi:10.1038/nature07159
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qA0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qB0EP
Neurogenin 2 controls cortical neuron migration through regulation of
Rnd2 p114-118
A study reveals that overexpression of a single target of neurogenin
2, Rnd2, can restore the neuronal migration defects of neurogenin 2
depleted neurons. Rnd2 is thus an atypical member of the Rho family of
small GTP ases, which regulate actin cytoskeleton dynamics, with its
activity regulated at the gene transcription level, rather than by the
usual post translational GTP/GDP cycle.
Julian Ik-Tsen Heng et al.
doi:10.1038/nature07198
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qC0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qD0ER
Polo-like kinase-1 is activated by aurora A to promote checkpoint
recovery p119-123
Polo like kinase 1 (PLK1) is an essential mitotic kinase regulating
multiple aspects of the cell division process. Activation of PLK1 is
shown to occur before mitosis and to depend on phosphorylation by
aurora A kinase, facilitated by a cofactor Bora. The initial
activation of PLK1 seems to be a primary function of aurora A.
Libor Macu ringrek et al.
doi:10.1038/nature07185
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qE0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qF0ET
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B p124-127
Epac proteins are activated by binding of cyclic AMP (cAMP) and act as
guanine nucleotide exchange factors for Rap GTPases. The structure of
Epac2 in complex with cAMP and Rap1B is determined and comparison of
this activated state of the complex with the inactive one reveals the
conformational changes in Epac2 induced by cAMP binding.
Holger Rehmann, Ernesto Arias-Palomo, Michael A. Hadders,
Frank Schwede, Oscar Llorca & Johannes L. Bos
doi:10.1038/nature07187
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qG0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qH0EV
Direct observation of the mechanochemical coupling in myosin Va during
processive movement p128-132
Myosin Va is a two headed molecular motor that transports cargo inside
cells by moving along actin filaments. The trailing head detaches and
swings 72 nm forward to bind to a new leading position. During the
processive movement at least one of the heads remain bound to actin.
This report visualizes the movement of a fluorescently labelled myosin
Va molecule while simultaneously observing the binding and
dissociation of a fluorescent ATP analogue. This is the first direct
demonstration of nucleotide binding to and movement of myosin V motors
during stepping.
Takeshi Sakamoto, Martin R. Webb, Eva Forgacs, Howard D. White
& James R. Sellers
doi:10.1038/nature07188
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qI0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qJ0EX
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p133
Online professor ratings provoke outrage but garner some support.
Gene Russo
doi:10.1038/nj7209-133a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qK0EY
Career View
Edward Seidel, director, Office of Cyberinfrastructure, National
Science Foundation, Arlington, Virginia p134
From dreams of space to designs on cyberinfrastructure.
Maria Rossbauer
doi:10.1038/nj7209-134a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qL0EZ
Boosting Brazilian bioenergy p134
Brazil strives to remain among the world's biofuels leaders.
Virginia Gewin
doi:10.1038/nj7209-134b
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qM0Ea
Diagnosing mysteries p134
A trip to the hospital made me forget my research - and then realize
its limitations.
Zachary Lippman
doi:10.1038/nj7209-134c
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qN0Eb
----------------------
FUTURES
----------------------
Gigatech p136
Testing, testing ...
David Langford
doi:10.1038/455136a
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qO0Ec
----------------------
ADVANCE ONLINE PUBLICATION
----------------------
Letters
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a
base-flipping mechanism
Kyohei Arita, Mariko Ariyoshi, Hidehito Tochio, Yusuke Nakamura
& Masahiro Shirakawa
doi:10.1038/nature07249
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qP0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qQ0Ee
Structural basis for recognition of hemi-methylated DNA by the SRA
domain of human UHRF1
George V. Avvakumov et al.
doi:10.1038/nature07273
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qR0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qS0Eg
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
Hideharu Hashimoto, John R. Horton, Xing Zhang, Magnolia Bostick,
Steven E. Jacobsen & Xiaodong Cheng
doi:10.1038/nature07280
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qT0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qU0Ei
31 August 2008
Articles
Structure of the Tribolium castaneum telomerase catalytic subunit TERT
Andrew J. Gillis, Anthony P. Schuller & Emmanuel Skordalakes
doi:10.1038/nature07283
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qV0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qW0Ek
Structural basis for specific cleavage of Lys 63-linked polyubiquitin
chains
Yusuke Sato et al.
doi:10.1038/nature07254
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qX0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qY0Em
Letters
Genes mirror geography within Europe
John Novembre et al.
doi:10.1038/nature07331
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qZ0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qa0Eu
Structure of the 30S translation initiation complex
Angelita Simonetti et al.
doi:10.1038/nature07192
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qb0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B4qc0Ew
=====================================================================
Nature Review Molecular Cell Biology
Poster on Pluripotent cell isolation for
regenerative medicine
Pluripotent cells offer great promise for
the future of regenerative medicine. In this
Poster, Christopher Lengner and Rudolf Jaenisch
compare and contrast the properties of pluripotent
embryonic stem cells with those of laboratory-generated
pluripotent cells.
Access the Poster FREE online!
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0B3i80E5
Produced with support from: STEMCELL Technologies
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0jCm0EA
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://ealerts.nature.com/cgi-bin24/DM/y/enKd0Xztnp0HjB0Zzu0Ev
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
