http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50BuK70EH
Exiqon stays ahead of the competition, so you can do the same. We are
now launching version 11.0 of our miRCURY LNA[TM] Array
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50BovG0EA ,
the most comprehensive version ever. This array covers all human,
mouse and rat microRNAs listed in miRBase 11.0, as well as 435
proprietary microRNAs available nowhere else (miRPlus[TM]).
And you only 30 ng total RNA to get started.
See also a 3-D visualization of the research benefits of LNA
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50BuK80EI
The EMBO Journal
Table of contents
Volume 27, Number 18 (17 September 2008)
In this issue...
Mutations of RNA polymerase II activate key genes of the nucleoside
triphosphate biosynthetic pathways
How ribonucleotide shortage, which impedes transcription in general,
nevertheless increases transcription of key NTP biosyntheses genes, is
an intensely investigated open question. Intriguingly, a yeast screen
by Kwapisz et al. now suggests that not only the promoters of such
genes, but also RNA polymerase II itself may act as sensors of NTP
depletion.
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5c80Ec
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of
dopaminergic neurons in Drosophila
Yuzuru Imai and colleagues report that LRRK2, which is associated with
Parkinson's disease, phosphorylates 4E-BP and show that this is
important for the in vivo pathogenic effects of mutant dLRRK in
Drosophila. The findings support a novel mechanism linking deregulated
protein translation to stress sensitivity and neurodegeneration in PD.
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dA0Em
New EMBO Member's Review
Nuclear receptor signalling in dendritic cells connects lipids, the
genome and immune function.
Istvan Szatmari and Laszlo Nagy
The EMBO Journal (2008) 27, 18, 2353-2362
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dB0En
Published online: 21 August 2008
Articles
The SpoMBe pathway drives membrane bending necessary for cytokinesis
and spore formation in yeast meiosis.
Peter Maier, Nicole Rathfelder, Celine I Maeder, Julien Colombelli,
Ernst H K Stelzer and Michael Knop
The EMBO Journal (2008) 27, 18, 2363-2374
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dC0Eo
Published online: 28 August 2008
Distinct roles of RalA and RalB in the progression of cytokinesis are
supported by distinct RalGEFs.
Ilaria Cascone, Rasim Selimoglu, Cafer Ozdemir, Elaine Del Nery,
Charles Yeaman, Michael White and Jacques Camonis
The EMBO Journal (2008) 27, 18, 2375-2387
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dD0Ep
Published online: 28 August 2008
A glial DEG/ENaC channel functions with neuronal channel DEG-1 to
mediate specific sensory functions in C. elegans.
Ying Wang, Alfonso Apicella Jr, Sun-Kyung Lee, Marina Ezcurra, Robert
D Slone, Maya Goldmit, William R Schafer, Shai Shaham, Monica
Driscoll and Laura Bianchi
The EMBO Journal (2008) 27, 18, 2388-2399
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dE0Eq
Published online: 14 August 2008
Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage
response.
Isabelle Morin, Hien-Ping Ngo, Amanda Greenall, Mikhajlo K Zubko,
Nick Morrice and David Lydall
The EMBO Journal (2008) 27, 18, 2400-2410
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dF0Er
Published online: 28 August 2008
Mutations of RNA polymerase II activate key genes of the nucleoside
triphosphate biosynthetic pathways.
Marta Kwapisz, Maxime Wery, Daphn?espr? Yad Ghavi-Helm, Julie
Soutourina, Pierre Thuriaux and Francois Lacroute
The EMBO Journal (2008) 27, 18, 2411-2421
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5c80Ec
Published online: 21 August 2008
SUMO modification of PCNA is controlled by DNA.
Joanne L Parker, Andrea Bucceri, Adelina A Davies, Katharina
Heidrich, Hanna Windecker and Helle D Ulrich
The EMBO Journal (2008) 27, 18, 2422-2431
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dG0Es
Published online: 14 August 2008
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of
dopaminergic neurons in Drosophila.
Yuzuru Imai, Stephan Gehrke, Hua-Qin Wang, Ryosuke Takahashi, Kazuko
Hasegawa, Etsuro Oota and Bingwei Lu
The EMBO Journal (2008) 27, 18, 2432-2443
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dA0Em
Published online: 14 August 2008
Structures of RabGGTase-substrate/product complexes provide insights
into the evolution of protein prenylation.
Zhong Guo, Yao-Wen Wu, Debapratim Das, Christine Delon, Janinna
Cramer, Shen Yu, Sandra Thuns, Nataliya Lupilova, Herbert Waldmann,
Luc Brunsveld, Roger S Goody, Kirill Alexandrov and Wulf Blankenfeldt
The EMBO Journal (2008) 27, 18, 2444-2456
http://ealerts.nature.com/cgi-bin24/DM/y/enaE0Xztnp0Hh50B5dH0Et
Published online: 28 August 2008
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