Nature Methods Contents: October 2008 Volume 10 pp 851-910

NATURE METHODS

October 2008 Volume 5 Number 10, pp 853 - 879

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----------------------
EDITORIAL
----------------------
Elective affinities p851
A feasibility study for the systematic generation of affinity
reagents to human proteins provides an opportunity to test
the merits of recombinant affinity reagents.
doi:10.1038/nmeth1008-851
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eK0E4

----------------------
CORRESPONDENCE
----------------------
Large-scale evaluation of protein reductive methylation for improving
protein crystallization pp853 - 854
Youngchang Kim et al.
doi:10.1038/nmeth1008-853
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eL0E5

A pilot project to generate affinity reagents to human
proteins pp854 - 855
Mathias Uhlen, Susanne Graslund and Michael Sundstrom
doi:10.1038/nmeth1008-854
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eM0E6

----------------------
RESEARCH HIGHLIGHTS
----------------------
Microbes right on target p857
Researchers use a targeted metagenomic approach to functionally
characterize complex microbial communities.
Michelle Pflumm
doi:10.1038/nmeth1008-857
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eN0E7

New twists on photoswitchable proteins pp858 - 859
Fluorescent proteins with new photoswitching properties allow
multilabel imaging at a single detection wavelength and dual-color
superresolution microscopy.
Natalie de Souza
doi:10.1038/nmeth1008-858a
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eO0E8

Phosphorylation and the cell cycle pp858 - 859
Two groups used quantitative mass spectrometry to look at changes
in protein phosphorylation across the cell cycle.
Allison Doerr
doi:10.1038/nmeth1008-858b
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eP0EA

News in brief p859
doi:10.1038/nmeth1008-859
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eQ0EB

Antibodypedia p860
A web portal to share antibody validation data.
Veronique Kiermer
doi:10.1038/nmeth1008-860
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eR0EC

A surrogate scaffold tested p861
Researchers tested an alternate antibody scaffold, creating so-called
Surrobodies.
Irene Kaganman
doi:10.1038/nmeth1008-861
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eS0ED

----------------------
NEWS AND VIEWS
----------------------
Classical genetics goes high-tech pp863 - 864
A combination of automated screening and next-generation sequencing
makes it possible to identify Caenorhabditis elegans mutants
at unprecedented speed and scale.
David S Fay
doi:10.1038/nmeth1008-863
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eT0EE

----------------------
BRIEF COMMUNICATIONS
----------------------
Caenorhabditis elegans mutant allele identification by
whole-genome sequencing pp865 - 867
Identifying the molecular lesions in mutants isolated in forward
genetic screens can be a laborious process. A proof-of-principle
study in Caenorhabditis elegans now shows that this can be achieved
rapidly by whole-genome deep sequencing.
Sumeet Sarin et al.
doi:10.1038/nmeth.1249
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eU0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eV0EG

Automated screening for mutants affecting dopaminergic-neuron
specification in C. elegans pp869 - 872
An automated sorting method using the COPAS Biosort machine
allows the isolation of mutant C. elegans displaying differences in
GFP expression in small numbers of cells. Compared to manual methods
this increases the efficiency of the phenotypic selection step in
cell-fate screens.
Maria Doitsidou et al.
doi:10.1038/nmeth.1250
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eW0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eX0EI

Building consensus spectral libraries for peptide identification in
proteomics pp873 - 875
Spectral searching, based on matching experimental peptide spectra
to reference spectral libraries, is gaining interest as an
alternative to traditional sequence-database searching in mass
spectrometry-based proteomics. A software tool, SpectraST, now allows
users to build their own high-quality spectral libraries from raw data.
Henry Lam et al.
doi:10.1038/nmeth.1254
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eY0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eZ0EK

Imaging individual mRNA molecules using multiple singly labeled
probes pp877 - 879
A strategy using 48 or more singly labeled fluorescent
oligonucleotide probes targeted to individual mRNA molecules allows
the simultaneous localization and quantification of three mRNA
species in fixed cells. mRNA visualization in whole animals and other
organisms is also demonstrated.
Arjun Raj et al.
doi:10.1038/nmeth.1253
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6ea0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eb0ES

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----------------------
ARTICLES
----------------------
Tracking the structural dynamics of proteins in solution using
time-resolved wide-angle X-ray scattering pp881 - 886
Time-resolved wide-angle X-ray scattering (TR-WAXS) using
synchrotron radiation can be used to observe dynamic protein
structural changes with nanosecond time resolution in solution,
complementing time-resolved optical spectroscopy and Laue
crystallography methods.
Marco Cammarata et al.
doi:10.1038/nmeth.1255
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6ec0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6ed0EU

Identification of genetic variants using bar-coded multiplexed
sequencing pp887 - 893
Targeted regions of the human genome are resequenced in multiplex
with Illumina technology, and the pipeline is evaluated for
polymorphism discovery and genotyping.
David W Craig et al.
doi:10.1038/nmeth.1251
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6ee0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6ef0EW

Optogenetic analysis of synaptic function pp895 - 902
Using both behavioral and electrophysiological readouts,
Channelrhodopsin-2, a light-gated cation channel, is applied
to the study of synaptic function in Caenorhabditis elegans.
Jana F Liewald et al.
doi:10.1038/nmeth.1252
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eg0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6eh0EY

----------------------
TECHNOLOGY FEATURE
----------------------
Scientific software: seeing the SNPs between us pp903 - 908
The results of large genome-wide association studies (GWASs) are
being deposited in public databases with increasing frequency. But
the software to analyze and interpret GWAS datasets can be difficult
to use. Could a new generation of user-friendly programs fill
the gap?
Steven David Buckingham
doi:10.1038/nmeth1008-903
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6ei0EZ

----------------------
ERRATUM
----------------------
Erratum: Mass spectrometry and proteomics: hitting the mark p910
Nathan Blow
doi:10.1038/nmeth1008-910
http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6ej0Ea

----------------------
APPLICATION NOTES
----------------------
Development of an Eg5 assay using the HTRFreg Transcreenerreg ADP kit
Laurence Jacquemart, Marion De Decker and Bastien Caumes
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6ek0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6el0Ec

Rapid, on-demand protein stabilization and destabilization using the ProteoTunertrade systems
Michael Haugwitz et al.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6em0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enp70Xztnp0Hi80B6en0Ee

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Nature Clinical Practice Rheumatology - Table of Contents alert Volume 4 Issue 10

NATURE CLINICAL PRACTICE RHEUMATOLOGY

October 2008 Volume 4 Number 10

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----------------------
EDITORIAL
----------------------
The cardiovascular threat of lupus
Joan M Von Feldt
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RG0EC

----------------------
RESEARCH HIGHLIGHTS
----------------------
Abatacept therapy in patients with JIA refractory to standard treatment
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RH0ED

Rivaroxaban prevents blood clots after major orthopedic surgery
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RI0EE

Daily alendronate sodium is better tolerated than once-weekly treatment
for Paget disease
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RJ0EF

Multitarget therapy for lupus nephritis with diffuse proliferative and
membranous lesions
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RK0EG

Etanercept is suitable for children with JIA under the age of 4 years
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RL0EH

Anti-osteopontin monoclonal antibody improves and prevents arthritis in
a mouse model
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RM0EI

Bortezomib eliminates antibody-producing plasma cells in mice with
lupus-like disease
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RN0EJ

In briefs
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RO0EK

----------------------
PRACTICE POINTS
----------------------
Adalimumab, etanercept and infliximab are equally effective treatments
for patients with psoriatic arthritis
Dafna D Gladman
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RP0EL

Strengthening resilience capacity might light the way to a brighter future
for patients with fibromyalgia
Alex J Zautra
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RQ0EM

Is pregabalin a safe and effective treatment for patients with fibromyalgia?
Michael Spaeth
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RR0EN

----------------------
CLINICAL ADVANCE
----------------------
MRI-detected bone marrow edema in early rheumatoid arthritis
Peter C Taylor
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RS0EO

Glucosamine sulfate might have no effect on pain or structural changes
associated with osteoarthritis
David T Felson
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RT0EP

----------------------
VIEWPOINTS
----------------------
International guidelines on access to biologic therapy: why the differences
and which is best?
Chris Deighton and Kimme Hyrich
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RU0EQ

Hypermobility: an important but often neglected area within rheumatology
Rodney Grahame
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RV0ER

----------------------
REVIEWS
----------------------
Genomic and nongenomic effects of glucocorticoids
Cindy Stahn and Frank Buttgereit
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RW0ES

MicroRNAs, the immune system and rheumatic disease
Esmerina Tili, Jean-Jacques Michaille, Stefan Costinean and Carlo M Croce
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RX0ET

Growing pains: a noninflammatory pain syndrome of early childhood
Robert M Lowe and Philip J Hashkes
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RY0EU

Wnt-[beta]-catenin signaling in the pathogenesis of osteoarthritis
Maripat Corr
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6RZ0EV

----------------------
CASE STUDY
----------------------
Progressive arm and leg stiffness in a patient with chronic renal impairment
Kichul Shin, Scott R Granter, Jonathan S Coblyn and Samardeep Gupta
http://ealerts.nature.com/cgi-bin24/DM/y/enmA0Xztnp0HjN0B6Ra0Ec

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Mol. Biol. Cell Table of Contents for 1 October 2008; Vol. 19, No. 10

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A new issue of Molecular Biology of the Cell is available online:

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The below Table of Contents is available online at: http://www.molbiolcell.org/content/vol19/issue10/?etoc

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InCytes from MBC

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InCytes from MBC, Octomber 2008 http://www.molbiolcell.org/cgi/reprint/19/10/4019

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Articles

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Phosphatidylinositol (4,5)-bisphosphate Modulates Nox5 Localization via an N-Terminal Polybasic Region

Tsukasa Kawahara and J. David Lambeth

Glucocorticoid Signaling Defines a Novel Commitment State during Adipogenesis In Vitro

Carlos Pantoja, Jason T. Huff, and Keith R. Yamamoto

p120-Catenin Is a Key Component of the Cadherin–-Secretase Supercomplex

Alexi Kiss, Regina B. Troyanovsky, and Sergey M. Troyanovsky

An RNA Interference Screen Identifies a Novel Regulator of Target of Rapamycin That Mediates Hypoxia Suppression of Translation in Drosophila S2 Cells

Soo-Jung Lee, Renny Feldman, and Patrick H. O'Farrell

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

Andrew J. Wilson, Do-Sun Byun, Shannon Nasser, Lucas B. Murray, Kanyalakshmi Ayyanar, Diego Arango, Maria Figueroa, Ari Melnick, Gary D. Kao, Leonard H. Augenlicht, and John M. Mariadason

Interaction between Tumor Suppressor Adenomatous Polyposis Coli and Topoisomerase II: Implication for the G2/M Transition

Yang Wang, Yoshiaki Azuma, David Moore, Neil Osheroff, and Kristi L. Neufeld

Consequences of Individual N-glycan Deletions and of Proteasomal Inhibition on Secretion of Active BACE

Omar Vanoni, Paolo Paganetti, and Maurizio Molinari

Nse1 RING-like Domain Supports Functions of the Smc5-Smc6 Holocomplex in Genome Stability

Stephanie Pebernard, J. Jefferson P. Perry, John A. Tainer, and Michael N. Boddy

p120 and Kaiso Regulate Helicobacter pylori-induced Expression of Matrix Metalloproteinase-7

Seth R. Ogden, Lydia E. Wroblewski, Christiane Weydig, Judith Romero-Gallo, Daniel P. O'Brien, Dawn A. Israel, Uma S. Krishna, Barbara Fingleton, Albert B. Reynolds, Silja Wessler, and Richard M. Peek, Jr

Microtubules Have Opposite Orientation in Axons and Dendrites of Drosophila Neurons

Michelle C. Stone, Fabrice Roegiers, and Melissa M. Rolls

A Mitotic GlcNAcylation/Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein Vimentin   InCytes from MBC Chad Slawson, T. Lakshmanan, Spencer Knapp, and Gerald W. Hart

YY1 Protects Cardiac Myocytes from Pathologic Hypertrophy by Interacting with HDAC5

Carmen C. Sucharov, Karen Dockstader, and Timothy A. McKinsey

The Dynamics of Mammalian P Body Transport, Assembly, and Disassembly In Vivo

Adva Aizer, Yehuda Brody, Lian Wee Ler, Nahum Sonenberg, Robert H. Singer, and Yaron Shav-Tal

Regulation of Early Endosomal Entry by the Drosophila Tumor Suppressors Rabenosyn and Vps45

Holly A. Morrison, Heather Dionne, Tor Erik Rusten, Andreas Brech, William W. Fisher, Barret D. Pfeiffer, Susan E. Celniker, Harald Stenmark, and David Bilder

Direct Interaction between a Myosin V Motor and the Rab GTPases Ypt31/32 Is Required for Polarized Secretion

Zhanna Lipatova, Andrei A. Tokarev, Yui Jin, Jon Mulholland, Lois S. Weisman, and Nava Segev

G Protein-coupled Receptor-promoted Trafficking of Gβ₁₂ Leads to AKT Activation at Endosomes via a Mechanism Mediated by Gβ₁₂-Rab11a Interaction

Alejandro García-Regalado, María Luisa Guzmán-Hernández, Iliana Ramírez-Rangel, Evelyn Robles-Molina, Tamas Balla, José Vázquez-Prado, and Guadalupe Reyes-Cruz

Tumor Necrosis Factor-–elicited Stimulation of -Secretase Is Mediated by c-Jun N-terminal Kinase-dependent Phosphorylation of Presenilin and Nicastrin

Lan-Hsin Kuo, Ming-Kuan Hu, Wen-Ming Hsu, Ying-Tsen Tung, Bo-Jeng Wang, Wang-Wei Tsai, Chen-Tung Yen, and Yung-Feng Liao

Rapid Turnover Rate of Phosphoinositides at the Front of Migrating MDCK Cells   InCytes from MBC Teruko Nishioka, Kazuhiro Aoki, Kazuhiro Hikake, Hisayoshi Yoshizaki, Etsuko Kiyokawa, and Michiyuki Matsuda

Arf GTPase-activating Protein ASAP1 Interacts with Rab11 Effector FIP3 and Regulates Pericentrosomal Localization of Transferrin Receptor–positive Recycling Endosome

Hiroki Inoue, Vi Luan Ha, Rytis Prekeris, and Paul A. Randazzo

Nuclear Cathepsin F Regulates Activation Markers in Rat Hepatic Stellate Cells

Gunter Maubach, Michelle Chin Chia Lim, and Lang Zhuo

Epidermal Growth Factor–induced Enhancement of Glioblastoma Cell Migration in 3D Arises from an Intrinsic Increase in Speed But an Extrinsic Matrix- and Proteolysis-dependent Increase in Persistence

Hyung-Do Kim, Tiffany W. Guo, Angela P. Wu, Alan Wells, Frank B. Gertler, and Douglas A. Lauffenburger

Efg1-mediated Recruitment of NuA4 to Promoters Is Required for Hypha-specific Swi/Snf Binding and Activation in Candida albicans

Yang Lu, Chang Su, Xuming Mao, Prashna Pala Raniga, Haoping Liu, and Jiangye Chen

Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase

Roberto J. Botelho, Jem A. Efe, David Teis, and Scott D. Emr

Prominent Actin Fiber Arrays in Drosophila Tendon Cells Represent Architectural Elements Different from Stress Fibers

Juliana Alves-Silva, Ines Hahn, Olga Huber, Michael Mende, Andre Reissaus, and Andreas Prokop

Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein

Eelco van Anken, Rogier W. Sanders, I. Marije Liscaljet, Aafke Land, Ilja Bontjer, Sonja Tillemans, Alexey A. Nabatov, William A. Paxton, Ben Berkhout, and Ineke Braakman

The THP1-SAC3-SUS1-CDC31 Complex Works in Transcription Elongation-mRNA Export Preventing RNA-mediated Genome Instability

Cristina González-Aguilera, Cristina Tous, Belén Gómez-González, Pablo Huertas, Rosa Luna, and Andrés Aguilera

A Protein Methylation Pathway in Chlamydomonas Flagella Is Active during Flagellar Resorption   InCytes from MBC Mark J. Schneider, Megan Ulland, and Roger D. Sloboda

Different Levels of Bfa1/Bub2 GAP Activity Are Required to Prevent Mitotic Exit of Budding Yeast Depending on the Type of Perturbations

Junwon Kim, Selma Sun Jang, and Kiwon Song

Exon Loss Accounts for Differential Sorting of Na-K-Cl Cotransporters in Polarized Epithelial Cells

Monica Carmosino, Ignacio Giménez, Michael Caplan, and Biff Forbush

Drosophila Sec16 Mediates the Biogenesis of tER Sites Upstream of Sar1 through an Arginine-Rich Motif

Viorica Ivan, Gert de Voer, Despina Xanthakis, Kirsten M. Spoorendonk, Vangelis Kondylis, and Catherine Rabouille

Spatiotemporal Analysis of Differential Akt Regulation in Plasma Membrane Microdomains

Xinxin Gao and Jin Zhang

Activation of the DNA Damage Checkpoint in Mutants Defective in DNA Replication Initiation

Ling Yin, Alexandra Monica Locovei, and Gennaro D'Urso

Maternal Argonaute 2 Is Essential for Early Mouse Development at the Maternal-Zygotic Transition

Karin Lykke-Andersen, Michael J. Gilchrist, Joanna B. Grabarek, Partha Das, Eric Miska, and Magdalena Zernicka-Goetz

MNL1 Regulates Weak Acid–induced Stress Responses of the Fungal Pathogen Candida albicans

Mark Ramsdale, Laura Selway, David Stead, Jan Walker, Zhikang Yin, Susan M. Nicholls, Jonathan Crowe, Emma M. Sheils, and Alistair J.P. Brown

Calnexin Is Involved in Apoptosis Induced by Endoplasmic Reticulum Stress in the Fission Yeast

Renée Guérin, Geneviève Arseneault, Stéphane Dumont, and Luis A. Rokeach

DNA Topoisomerase II Is a Determinant of the Tensile Properties of Yeast Centromeric Chromatin and the Tension Checkpoint   InCytes from MBC Tariq H. Warsi, Michelle S. Navarro, and Jeff Bachant

Cyclic Guanosine Monophosphate-dependent Protein Kinase I Promotes Adhesion of Primary Vascular Smooth Muscle Cells

Pascal Weinmeister, Robert Lukowski, Stefan Linder, Claudia Traidl-Hoffmann, Ludger Hengst, Franz Hofmann, and Robert Feil

Paracingulin Regulates the Activity of Rac1 and RhoA GTPases by Recruiting Tiam1 and GEF-H1 to Epithelial Junctions

Laurent Guillemot, Serge Paschoud, Lionel Jond, Andrea Foglia, and Sandra Citi

Swf1p, a Member of the DHHC-CRD Family of Palmitoyltransferases, Regulates the Actin Cytoskeleton and Polarized Secretion Independently of Its DHHC Motif

Shubha A. Dighe and Keith G. Kozminski

Translationally Repressed mRNA Transiently Cycles through Stress Granules during Stress

Stephanie Mollet, Nicolas Cougot, Ania Wilczynska, François Dautry, Michel Kress, Edouard Bertrand, and Dominique Weil

Structural and Functional Dissection of Mif2p, a Conserved DNA-binding Kinetochore Protein

R. L. Cohen, C. W. Espelin, P. De Wulf, P. K. Sorger, S. C. Harrison, and K. T. Simons

Piecemeal Microautophagy of the Nucleus Requires the Core Macroautophagy Genes

R. Krick, Y. Muehe, T. Prick, S. Bremer, P. Schlotterhose, E.-L. Eskelinen, J. Millen, D. S. Goldfarb, and M. Thumm

Genetic and Structural Analysis of Hmg2p-induced Endoplasmic Reticulum Remodeling in Saccharomyces cerevisiae

Christine M. Federovitch, Ying Z. Jones, Amy H. Tong, Charles Boone, William A. Prinz, and Randolph Y. Hampton

Glial Fibrillary Acidic Protein Filaments Can Tolerate the Incorporation of Assembly-compromised GFAP-, but with Consequences for Filament Organization and B-Crystallin Association

Ming-Der Perng, Shu-Fang Wen, Terry Gibbon, Jinte Middeldorp, Jacqueline Sluijs, Elly M. Hol, and Roy A. Quinlan

Two Microtubule-associated Proteins of Arabidopsis MAP65s Promote Antiparallel Microtubule Bundling

Jérémie Gaillard, Emmanuelle Neumann, Daniel Van Damme, Virginie Stoppin-Mellet, Christine Ebel, Elodie Barbier, Danny Geelen, and Marylin Vantard

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Signaling Update contents for 26 September 2008

*********************************************************************
Signaling Gateway - 26 September 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0M40Ej
*********************************************************************

Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.

*********************************************************************
In Signaling Update this week:

------------------------
Featured Article
------------------------
MEMBRANE RAFTS: A LIFE BOAT FOR AKT

Akt membrane localization and activation is dependent on the presence
of cholesterol- and sphingolipid-rich nanodomains.

Original research paper: Nature Chemical Biology 4, 538-547 (2008)

http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0vP0Es

------------------------
Molecule Pages
------------------------
The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.

Pea15
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V30Er

Phosphoprotein enriched in astrocytes of 15 kilodaltons (PEA-15) is a
death-effector domain-containing protein that is reported to regulate
apoptosis, proliferation, glucose transport, adhesion and migration.
PEA-15 binds a diverse set of signal transduction proteins that are
responsible for these functions. PEA-15 expression is upregulated in
some breast cancers and gliomas as well as in type 2 diabetes.

Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0BUuz0E5

-------------------
Selected Updates
-------------------
PROTEIN DEGRADATION: EXAMINING E1
The crystal structure of ubiquitin bound to Uba1, the Saccharomyces
cerevisiae E1 ubiquitin ligase, has been solved.
Original research paper: Cell 134, 268-278 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V40Es

TRANSLATION: INTERPRETING p53
Mutations in ribosomal proteins (RPs) alter p53 function to promote
human disease and tumorigenesis.
Original research paper: Proc. Natl Acad. Sci. USA 105, 10408-10413
(2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V50Et

NETWORK BIOLOGY: WHY DO WE NEED HUBS?
A study of the yeast interaction network suggests that essential
proteins tend to be network hubs because they belong to biological
processes that are densely interconnected.
Original research paper: PLoS Comput. Biol. 4, e1000140 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V60Eu

More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0vO0Er

------------------------
Research Library
------------------------
FCRN-MEDIATED ANTIBODY TRANSPORT ACROSS EPITHELIAL CELLS REVEALED BY
ELECTRON TOMOGRAPHY
Nature 455, 542-546 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V70Ev

THE KINASE P38a SERVES CELL TYPE-SPECIFIC INFLAMMATORY FUNCTIONS IN
SKIN INJURY AND COORDINATES PRO- AND ANTI-INFLAMMATORY GENE
EXPRESSION
Nature Immunology 9, 1019-1027 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6V80Ew

PREDICTING PDZ DOMAIN-PEPTIDE INTERACTIONS FROM PRIMARY SEQUENCES
Nature Biotechnology 26, 1041-1045 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6WA0E7

------------------------
Signaling News
------------------------
MACARTHUR FOUNDATION ANNOUNCES ANNUAL GRANTS
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B6Ah0EP

The MacArthur Foundation has announced the winners of the US$500,000
so-called 'genius grant'. The MacArthur Fellowship is awarded to
creative people from the arts, sciences and humanities with a track
record of achievement and potential for further success. This year's
recipients include plant evolutionary geneticist Kirsten Bomblies,
developmental biologist Susan Mango, neuroscientist Sally Temple and
experimental neurobiologist Rachel Wilson.

More News
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0Crw0Ea

-------------------------
Gateway Updates
-------------------------
THE FUNCTIONAL GLYCOMICS GATEWAY - SEPTEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0BKHW0Ea

The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.

This month's update features:
Proteoglycan editing: Sulfatases change a frog's fate
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B5Rs0Eq

Golgi protein glycosylation: Keeping transferases safe and sound
http://ealerts.nature.com/cgi-bin24/DM/y/ennl0Xztnp0H2W0B5Rt0Er

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-----------------------------
Signaling Job of the Week
-----------------------------
Faculty Position
Employer: Princeton University
Location: Princeton, New Jersey
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The Department of Molecular Biology at Princeton University invites
applications for a tenure-track faculty position at the Assistant
Professor level. The successful applicant will use vertebrate or
invertebrate model systems to address fundamental questions in cell
signaling, pattern formation, morphogenesis and/or gene expression.

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Nature Clinical Practice Oncology - Table of Contents alert Volume 5 Issue 10

NATURE CLINICAL PRACTICE ONCOLOGY

October 2008 Volume 5 Number 10

Visit Nature Clinical Practice Oncology online to browse the journal.

Now available at http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0UgF0EI

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Announcing the NEW British Journal of Cancer website with enhanced
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Visit http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0f8c0EH
and benefit from new features, including RSS Web Feeds, Article Links
and Top Ten downloaded articles.

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----------------------
EDITORIAL
----------------------
Radiation oncology health technology assessment-the best is the enemy
of the good
Soren M Bentzen
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6F80E5

----------------------
RESEARCH HIGHLIGHTS
----------------------
Nonmyeloablative stem-cell transplantation can induce long-term remission
in relapsed FL
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GA0EG

Salvage radiotherapy improves survival in men with recurrence after
radical prostatectomy
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GB0EH

Chromosomal instability confers poor prognosis in patients with colorectal
cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GC0EI

Small molecule JAK2 inhibitor is effective in murine model of polycythemia
vera
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GD0EJ

High-dose conformal RT improves tumor control in patients with prostate
cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GE0EK

Preoperative chemoradiation in addition to preoperative chemotherapy
in stage III NSCLC
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GF0EL

Vitamin D concentration does not affect the risk of prostate cancer
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GG0EM

Liver resection with salvage transplantation for hepatocellular carcinoma
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GH0EN

----------------------
PRACTICE POINTS
----------------------
The ROC 'n' role of the multiplex assay for early detection of ovarian
cancer
Alpa M Nick and Anil K Sood
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GI0EO

Choosing a taxane for adjuvant treatment of breast cancer: more than a
flip of the coin?
Linda Vahdat
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GJ0EP

Should surgery followed by whole-brain radiation therapy be the standard
treatment for single brain metastasis?
David W Andrews
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GK0EQ

----------------------
VIEWPOINT
----------------------
Intermittent androgen blockade should be regarded as standard therapy
in prostate cancer
Bostjan Seruga and Ian F Tannock
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GL0ER

----------------------
REVIEWS
----------------------
Gene-expression profiling in epithelial ovarian cancer
Panagiotis A Konstantinopoulos, Dimitrios Spentzos and Stephen A Cannistra
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GM0ES

Strategies for discovering novel cancer biomarkers through utilization
of emerging technologies
Vathany Kulasingam and Eleftherios P Diamandis
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GN0ET

Mechanisms of Disease: survival benefit of temsirolimus validates a role
for mTOR in the management of advanced RCC
Robert A Figlin
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GO0EU

Mechanisms of Disease: signal transduction in lung carcinogenesis-a
comparison of smokers and never-smokers
Giannis Mountzios, Pierre Fouret and Jean-Charles Soria
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GP0EV

----------------------
CASE STUDY
----------------------
The impact of histopathologic diagnosis on the proper management of
testis neoplasms
Giovanni Ponti, Maurilio Ponzoni, Andres JM Ferreri, Marco Foppoli,
Luca Mazzucchelli and Emanuele Zucca
http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0B6GQ0EW

=====================================================================

Leukemia - Celebrating 20 years of distinguished research

Leukemia covers all aspects of research and treatment of leukemia and
allied diseases. It brings the science community the latest advances
in Oncogenes, Growth factors, Stem cells, Leukemia genomics, Cell
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Visit http://ealerts.nature.com/cgi-bin24/DM/y/enkY0Xztnp0HjM0U6k0E5
for a variety of free featured articles and special promotions throughout
the year.

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Nature Reviews Immunology Table of Contents Volume 8 Issue 10 October 2008, pp 745-822

NATURE REVIEWS IMMUNOLOGY

October 2008 Volume 8 Number 10

Visit Nature Reviews Immunology online to browse the journal.

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Nature Reviews Microbiology
October 2008 - Focus on Symbiosis

Microbial symbioses include beneficial, harmful and neutral
relationships and are important in animal and plant health, immunity
and disease, and in ecology and the environment. This special Focus
issue highlights exciting advances in our understanding of
partnerships between organisms and their environments.

This FREE focus can be accessed online at:
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=====================================================================

This month's FEATURED article:
A signal–switch hypothesis for cross–regulation of cytokine and TLR
signalling pathways
Lionel B. Ivashkiv
p816 | doi:10.1038/nri2396

http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6Rz0EQ

=====================================================================

From the editors
p745 | doi:10.1038/nri2429
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6R10ED

----------------------
RESEARCH HIGHLIGHTS
----------------------
Innate immunity: Swarms defend against parasites
p746 | doi:10.1038/nri2420
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6R20EE

T cells: Selection and tolerance involve autophagy
p747 | doi:10.1038/nri2418
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6R30EF

IN BRIEF
Inflammation | Vaccines | HIV
p747 | doi:10.1038/nri2428
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6R40EG

Autoimmunity: The threat within
p748 | doi:10.1038/nri2419
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6R50EH

Inflammation: Dealing with excessive cell death
p748 | doi:10.1038/nri2425
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6R60EI

IN BRIEF
Inflammation | Viral immunity | Natural killer T cells
p749 | doi:10.1038/nri2430
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6R70EJ

T-cell activation: Variation is the spice of life
p750 | doi:10.1038/nri2421
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6R80EK

Innate immunity: STING: adding to the antiviral arsenal
p750 | doi:10.1038/nri2424
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SA0EU

Innate immunity: PIMS knows friends and foes
p751 | doi:10.1038/nri2422
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SB0EV

Regulatory T cells: MicroRNAs maintain identity
p752 | doi:10.1038/nri2426
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SC0EW

WEB WATCH
A systems approach to immunology
p752 | doi:10.1038/nri2427
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SD0EX

=====================================================================

----------------------
REVIEWS
----------------------
The alliance of sphingosine-1-phosphate and its receptors in immunity
Juan Rivera, Richard L. Proia and Ana Olivera
p753 | doi:10.1038/nri2400
Recent research has shown that the interaction of sphingosine-1-phosphate with its receptors (S1PR1–S1PR5) has an essential role in regulating immune responses, not only through the control of immune-cell trafficking but also through effects on immune-cell function. Understanding these effects holds promise for the use of S1PR ligands as immunomodulatory therapeutics.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SE0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SF0EZ

Article series: Tissue-specific immune responses
http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6VA0EX
Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence
Tobias Junt, Elke Scandella and Burkhard Ludewig
p764 | doi:10.1038/nri2414
The anatomy of secondary lymphoid organs defines the ability of an organism to respond to pathogens. In this Review, the authors describe how the functional microarchitecture of these structures is both a determinant and a result of antimicrobial immunity.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SH0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SI0Ec

Harmful molecular mechanisms in sepsis
Daniel Rittirsch, Michael A. Flierl and Peter A. Ward
p776 | doi:10.1038/nri2402
Sepsis is an overwhelming systemic inflammatory response to severe microbial infection or extensive tissue damage. In this Review, the authors highlight recent molecular data that help to unravel the mechanisms that underlie dysregulation of immune responses in this syndrome.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SJ0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SK0Ee

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
Alfred Singer, Stanley Adoro and Jung-Hyun Park
p788 | doi:10.1038/nri2416
What determines whether a developing thymocyte becomes a CD4+ or CD8+ T cell has been an issue of longstanding debate. Here, the authors review the models that have been proposed to explain CD4/CD8-lineage choice and update us on the environmental and transcription factors that might mediate this decision.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SL0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SM0Eg

The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
Christian Weber, Alma Zernecke and Peter Libby
p802 | doi:10.1038/nri2415
Atherosclerosis is now widely considered to be a chronic inflammatory disease that is driven by the activities of many leukocyte subpopulations. Here, the authors describe the contribution of different immune-cell subsets to each stage of the disease, revealing complex and dynamic interactions.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SN0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SO0Ei

=====================================================================

----------------------
PERSPECTIVE
----------------------
OPINION
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways
Lionel B. Ivashkiv
p816 | doi:10.1038/nri2396
The activation of immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors influences signalling pathways downstream of other receptor types. In this Opinion, Lionel Ivashkiv describes how ITAM-dependent signalling can differentially influence cellular responses to Toll-like-receptor ligands and cytokines.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6Rz0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SP0Ej

=====================================================================

Nature Methods Editors are seeking your input in helping us select
the Method of the Year 2008.

Participate in the selection of the Method of the Year 2008!

Visit http://ealerts.nature.com/cgi-bin24/DM/y/enmB0Xztnp0Hjd0B6SQ0Ek
to cast your vote or nominate a candidate method.

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(for the period 18 Sep 2008 to 25 Sep 2008):

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TISSUE-SPECIFIC STEM CELLS

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IFATS Series: Adipose Stromal/Stem Cells: Basic and Translational Advances

Susan Rainey Daher, Brian H. Johnstone, Donald G. Phinney, Keith L. March

Stem Cells published 25 September 2008, 10.1634/stemcells.2008-0927
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0927v1

Analysis of ERK2 Function in Neural Stem/Progenitor Cells Via Nervous System-Specific Gene Disruption

Osamu Imamura, Yasushi Satoh, Shogo Endo, Kunio Takishima

Stem Cells published 25 September 2008, 10.1634/stemcells.2008-0578
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0578v1

IFATS Series: Human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model

Andrew M. Altman, Yasheng Yan, Nadine Matthias, Xiaowen Bai, Carmen Rios, Anshu B. Mathur, Yao-Hua Song, Eckhard U. Alt

Stem Cells published 25 September 2008, 10.1634/stemcells.2008-0178
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0178v1

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CANCER STEM CELLS

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HTLV-1 Infection of CD34+ Hematopoietic Progenitor Cells Induces Cell Cycle Arrest by Modulation of p21^cip1/waf1 and Survivin

Prabal Banerjee, Michelle Sieburg, Elizabeth Samuelson, Gerold Feuer

Stem Cells published 25 September 2008, 10.1634/stemcells.2008-0353
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0353v1

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THE STEM CELL NICHE

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Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 Promote the Differentiation and Migration of Adult Neural Progenitor Cells in Response to Chemokines

Basam Z. Barkho, Ari E. Munoz, Xuekun Li, Lu Li, Lee Anna Cunningham, Xinyu Zhao

Stem Cells published 25 September 2008, 10.1634/stemcells.2008-0519
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0519v1

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EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS

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1,4,5-Inositol Trisphosphate Operated [Ca²⁺]_i Stores And Angiotensin-II/Endothelin-1 Signaling Pathway Are Functional In Human Embryonic Stem Cell-Derived Cardiomyocytes

Oshra Sedan, Katya Dolnikov, Naama Zeevi-Levine, Noa Fleishmann, Michal Amit, Joseph Itskovitz-Eldor, Ofer Binah

Stem Cells published 25 September 2008, 10.1634/stemcells.2008-0777
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0777v1

A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells

David M , Diderik Tirefort, Stephanie Julien, Karl Heinz Krause

Stem Cells published 25 September 2008, 10.1634/stemcells.2008-0319
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0319v1

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Solid-state physics: New order for magnetism
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Very fast optical flaring from a possible new Galactic magnetar
A. Stefanescu, G. Kanbach, A. Sl strokeowikowska, J. Greiner, S. McBreen & G. Sala
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Flares from a candidate Galactic magnetar suggest a missing link to dim isolated neutron stars
A. J. Castro-Tirado et al.
http://ealerts.nature.com/cgi-bin24/DM/y/enl10Xztnp0Hjm0B6Lf0Ep

Reconstruction of non-classical cavity field states with snapshots of their decoherence
Samuel Deléglise et al.
http://ealerts.nature.com/cgi-bin24/DM/y/enl10Xztnp0Hjm0B6Lh0Er

Magnetization vector manipulation by electric fields
D. Chiba, M. Sawicki, Y. Nishitani, Y. Nakatani, F. Matsukura & H. Ohno
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Optical nanotomography of anisotropic fluids
Antonio De Luca, Valentin Barna, Timothy J. Atherton, Giovanni Carbone, Matthew E. Sousa & Charles Rosenblatt
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Coherent generation of non-classical light on a chip via photon-induced tunnelling and blockade
Andrei Faraon et al.
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The role of magnetic anisotropy in the Kondo effect
Alexander F. Otte et al.
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Current saturation in zero-bandgap, top-gated graphene field-effect transistors
Inanc Meric et al.
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Fast focusing using a pinned-contact oscillating liquid lens
Carlos A. López & Amir H. Hirsa
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