Cancer Gene Expression Trends Indentified in Developmental Stages:
Study
Scientists from Children's Hospital Boston and Harvard University
claim to have uncovered the trends in cancer gene expression in the
early developmental stages of different human tissues.
The team led by Isaac S Kohane performed a comprehensive comparison
of genes expressed in early developmental stages of various human
tissues and those expressed in different cancers affecting these
tissues.
"Our study reveals potentially clinically relevant differences in the
gene expression of different cancer types and represents a reference
framework for interpretation of smaller-scale functional studies," he
said.
One of the three described groups of cancers has an early
developmental phenotype and expresses genes that are characteristic
of stem cells.
A second, more heterogeneous group tends to be more similar to late
development and is characterized by an inflammatory signature.
The third is a small group of cancers that present as a transition
phenotype between these two extremes and displays both
characteristics.
"This segregation of tumors into three groups with distinct
expression patterns is surprising. Clearly, the developmental
trajectory provides a meaningful background for capturing large-scale
differences in gene expression across diverse conditions," said
Kohane.
The research is published in BioMed Central's open access journal
Genome Biology.
Source-ANI
THK/L
http://www.medindia
Indentified-
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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