Signaling Gateway - 8 August 2008
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0M40Eh
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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PI(3)K SIGNALING: SEPARATE BUT NOT EQUAL
The kinase activity of the PI(3)K subunit p110[beta] is linked to the
oncogenic transformation of mouse prostate epithelium, whereas a
second, kinase-independent activity regulates cellular proliferation
and signaling downstream of tyrosine-kinase receptors.
Original research paper: Nature 454, 776-779 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0vP0Eq
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Molecule Pages
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The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
G protein alpha 13
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2ir0E8
One of the first recognized functions of this G protein was the
ability of a constitutively activated G[alpha]13 mutant to transform
cultured fibroblasts when overexpressed. G[alpha]13 stimulates the
formation of actin stress fibers and the assembly of focal adhesions
in a RhoA-dependent manner. It also has an important role in the
immune system, where it regulates neutrophil polarity and motility.
Also published this week:
Glucagon-like peptide 2 receptor
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2is0EA
Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0BUuz0E3
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Selected Updates
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MEMBRANE TRAFFICKING: ALL CISTERNAE ARE NOT CREATED EQUAL
A novel 'membrane partitioning' model of membrane trafficking posits
that Golgi enzymes and transmembrane cargo are rapidly partitioned
between two distinct lipid phases of a continuous Golgi stack, with
a high rate of exchange among the cisternae.
Original research paper: Cell 133, 1055-1067 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2it0EB
LEUKAEMIA: MIXED UP
A mouse model of mixed-lineage leukemia has revealed that inhibition
of the GTPase Rac results in cell cycle arrest and apoptosis, with a
concomitant increase in BCL-XL degradation.
Original research paper: Cancer Cell 13, 483-495 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2iu0EC
IMAGING AND VISUALIZATION: A TIME STAMP FOR PROTEINS
A self-cleaving protein tag simplifies the labeling and visualization
of newly synthesized target proteins in tissue and whole animals.
Original research paper: Proc. Natl. Acad. Sci. USA 105, 7744-7749 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2iv0ED
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0vO0Ep
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Research Library
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A TRAFFIC-ACTIVATED GOLGI-BASED SIGNALLING CIRCUIT COORDINATES THE
SECRETORY PATHWAY
Nature Cell Biology 10, 912-922 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2iw0EE
SILICA CRYSTALS AND ALUMINUM SALTS ACTIVATE THE NALP3 INFLAMMASOME
THROUGH PHAGOSOMAL DESTABILIZATION
Nature Immunology 9, 847-856 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2ix0EF
DETECTION OF HETEROMERIZATION OF MORE THAN TWO PROTEINS BY SEQUENTIAL
BRET-FRET
Nature Methods 5, 727-733 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2iy0EG
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Signaling News
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NEUROSCIENCE: STANDARD MODEL
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2am0Eu
The results of drug tests in mice have never translated perfectly to
tests in humans, but researchers are coming to believe that tests in
mouse models of neurodegenerative conditions may have been performed
with less than optimal rigor. The studies included small sample sizes
and were not properly randomized, casting doubt on the statistical
and clinical significance of the findings.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0Crw0EY
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Gateway Updates
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THE CELL MIGRATION GATEWAY - AUGUST UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0uLB0Er
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles:
Local recycling: Rab goes back to Rac
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2gV0Ed
EMT: Giving senescence a TWIST
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2gW0Ee
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0BJrg0EV
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Signaling Job of the Week
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Group Leader Position
Employer: Institut Curie
Location: Orsay, France
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0B2iz0EH
Junior group leader positions are available at the Orsay campus of
Institut Curie. Successful applicants will be part of a new signaling,
neurobiology and cancer department that will focus on cellular
proliferation, apoptosis, migration and differentiation in
neurodegenerative disorders and brain tumors.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0BnjC0EN
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/emnk0Xztnp0H2W0vqs0EK
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