Signaling Gateway - 15 August 2008
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0M40Ep
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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POLYCYSTIC KIDNEY DISEASE: THE TNF-[alpha] CONNECTION
TNF-[alpha]-mediated induction of FIP2 causes mislocalization of
polycystin-2 and potentiates the development of autosomal dominant
polycystic kidney disease.
Original research paper: Nature Medicine 14, 863-868 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0vP0Ey
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Selected Updates
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T-CELL ACTIVATION: ADAPTIVE CHOLESTEROL
Liver X receptor (LXR), a nuclear receptor that has a key role in
lipid metabolism, represses T-cell activation, thus linking
cholesterol biosynthesis with the aquired immune response.
Original research paper: Cell 134, 97-111 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B3HM0E7
ANGIOGENESIS: TGF[beta] MAKES A NEW FRIEND
Prostaglandin E2 (PGE2) signals through metalloproteinases and SMAD3
to enhance transforming growth factor beta (TGF[beta]) activation.
Original research paper: Blood 112, 1120-1128 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B3HN0E8
STEM CELLS: INDUCED PLURIPOTENCY: IS THERE A SILVER BULLET?
Small molecules can replace some of the genetic factors required for
the generation of induced pluripotent stem (iPS) cells.
Original research paper: Nat. Biotechnol. 26, 795-797 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B3HO0EA
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0vO0Ex
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Research Library
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EGFR SIGNALLING AS A NEGATIVE REGULATOR OF NOTCH1 GENE TRANSCRIPTION
AND FUNCTION IN PROLIFERATING KERATINOCYTES AND CANCER
Nature Cell Biology 10, 902-911 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B3HP0EB
NONMUSCLE MYOSIN LIGHT-CHAIN KINASE MEDIATES NEUTROPHIL TRANSMIGRATION
IN SEPSIS-INDUCED LUNG INFLAMMATION BY ACTIVATING [beta]2 INTEGRINS
Nature Immunology 9, 880-886 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B3HQ0EC
SITE-SPECIFIC CONJUGATION OF A CYTOTOXIC DRUG TO AN ANTIBODY IMPROVES
THE THERAPEUTIC INDEX
Nature Biotechnology 26, 925-932 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B3HR0ED
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Signaling News
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CRIME AND PUNISHMENT IN THE LAB
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B2w30ES
Is science too soft on its miscreants? A study published in Science
shows that 43% of a small sample of scientists found guilty of
misconduct remained employed in academia, and half of them continued
to turn out a paper a year.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0Crw0Eg
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - AUGUST UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0BGyx0Ey
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and bioinformaticians
to explore, visualize and mine signaling events.
Recently added pathways include:
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0Buvt0Ed
FOXA1 transcription factor network
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B3HS0EE
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0BJYy0EW
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Signaling Job of the Week
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Senior Research Cell Molecular Biologist
Employer: Abbott Labs
Location: Chicago, IL
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0B3HT0EF
A cancer biologist is sought to initiate and lead research projects in
cancer biomarker discovery at Abbott Labs. The successful candidate
will analyze intracellular signaling in cancer cells with an aim to
discover genomic correlates of cancer initiation, progression and
response to drugs.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0BnjC0EV
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0vqs0ES
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http://ealerts.nature.com/cgi-bin24/DM/y/emvk0Xztnp0H2W0dIO0Es
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