September 2008 Volume 9 Number 9, pp 947 - 1083
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EDITORIAL
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On the move p947
Leukocytes express an array of chemoattractant and adhesion
receptors that govern their migration, behavior and survival.
doi:10.1038/ni0908-947
http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NG0EM
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OVERVIEW
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Chemokines and leukocyte traffic pp949 - 952
Federica Sallusto and Marco Baggiolini
doi:10.1038/ni.f.214
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NH0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NI0EO
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REVIEWS
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How chemokines invite leukocytes to dance pp953 - 959
Marcus Thelen and Jens V Stein
doi:10.1038/ni.f.207
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NK0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NL0ER
Interstitial leukocyte migration and immune function pp960 - 969
Peter Friedl and Bettina Weigelin
doi:10.1038/ni.f.212
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NM0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NN0ET
Orchestrating the orchestrators: chemokines in control of T cell
traffic pp970 - 980
Shannon K Bromley, Thorsten R Mempel and Andrew D Luster
doi:10.1038/ni.f.213
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NO0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NP0EV
Environmental cues, dendritic cells and the programming of
tissue-selective lymphocyte trafficking pp981 - 987
Hekla Sigmundsdottir and Eugene C Butcher
doi:10.1038/ni.f.208
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NQ0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NR0EX
Moving targets: cell migration inhibitors as new anti-inflammatory
therapies pp988 - 998
Charles R Mackay
doi:10.1038/ni.f.210
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NS0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NT0EZ
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RESEARCH HIGHLIGHTS
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Research Highlights p999
doi:10.1038/ni0908-999
http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NU0Ea
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ESSAY
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Tolerance can be infectious pp1001 - 1003
Herman Waldmann
doi:10.1038/ni0908-1001
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NV0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NW0Ec
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COMMENTARY
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Building networks for immunodeficiency diseases and immunology
training pp1005 - 1007
Peter D Burrows and Alain Fischer
doi:10.1038/ni0908-1005
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NX0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NY0Ee
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NEWS AND VIEWS
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The making of NKT cells pp1009 - 1011
Natural killer T cells acquire their unique phenotype and
characteristics during development in the thymus. Evidence suggests
that the transcription factor PLZF has a unique function in the
development of these cells and their acquisition of 'innate-like'
characteristics.
Laurent Gapin
doi:10.1038/ni0908-1009
http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3NZ0Ef
The CD200-CD200R axis in local control of lung inflammation
pp1011 - 1013
Excessive lung inflammation in response to infection or allergens
can lead to tissue damage and potentially loss of organ function.
The CD200-CD200R interaction acts to limit such destructive immune
responses in the lung.
Patrick G Holt and Deborah H Strickland
doi:10.1038/ni0908-1011
http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Na0Em
Regulation of NKG2D ligands: a purposeful but delicate affair
pp1013 - 1015
New findings show that cellular microRNAs 'calibrate' the baseline
expression of mRNAs encoding stress-inducible ligands of the
activating NKG2D receptor. This regulation serves to protect
innocent cells but may be exploited by tumors and viruses to thwart
immune attack.
Thomas Spies
doi:10.1038/ni0908-1013
http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nb0En
A birthday gift for TRADD pp1015 - 1016
Definitive new data solidify and clarify the function of the adaptor
TRADD in tumor necrosis factor receptor 1 signaling and show that in
some situations, TRADD is also required for the transmission of
Toll-like receptor signals.
Gioacchino Natoli and Liv M I Austenaa
doi:10.1038/ni0908-1015
http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nc0Eo
Research Highlights p1017
doi:10.1038/ni0908-1017
http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nd0Ep
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ARTICLES
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The kinase p38alpha serves cell type-specific inflammatory
functions in skin injury and coordinates pro- and anti-inflammatory
gene expression pp1019 - 1027
The function of the kinase p38alpha in inflammation is unclear.
Park and colleagues show that p38[alpha] exerts pro- or
anti-inflammatory effects depending on the cell type in which it
is expressed and the stimulus eliciting its activation.
Chun Kim et al.
doi:10.1038/ni.1640
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Ne0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nf0Er
The kinases MSK1 and MSK2 act as negative regulators of Toll-like
receptor signaling pp1028 - 1036
Uncontrolled TLR signaling results in excessive inflammation. Arthur
and colleagues show that the kinases MSK1 and MSK2 orchestrate a
feedback loop involving interleukin 10 and the phosphatase DUSP1 to
control TLR4 signaling.
Olga Ananieva et al.
doi:10.1038/ni.1644
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Ng0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nh0Et
Function of TRADD in tumor necrosis factor receptor 1 signaling and
in TRIF-dependent inflammatory responses pp1037 - 1046
The function of the adaptor protein TRADD is uncertain. Teams led by
Pasparakis and Liu solidify TRADD's function in TNF receptor
signaling and extend its influence to TRIF-dependent Toll-like
receptor pathways.
Maria A Ermolaeva et al.
doi:10.1038/ni.1638
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Ni0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nj0Ev
The function of TRADD in signaling through tumor necrosis factor
receptor 1 and TRIF-dependent Toll-like receptors pp1047 - 1054
The function of the adaptor protein TRADD is uncertain. Teams led
by Pasparakis and Liu solidify TRADD's function in TNF receptor
signaling and extend its influence to TRIF-dependent Toll-like
receptor pathways.
Yelena L Pobezinskaya et al.
doi:10.1038/ni.1639
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nk0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nl0Ex
The BTB-zinc finger transcriptional regulator PLZF controls the
development of invariant natural killer T cell effector functions
pp1055 - 1064
Invariant natural killer cells recognize glycolipids presented by
CD1d molecules and can mediate rapid innate responses. Sant'Angelo
and colleagues show that these cells express the transcription
factor PLZF, which is required for their innate effector function.
Damian Kovalovsky et al.
doi:10.1038/ni.1641
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nm0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nn0Ez
Human microRNAs regulate stress-induced immune responses mediated
by the receptor NKG2D pp1065 - 1073
The mechanisms controlling expression of the stress-induced NKG2D
ligands MICA and MICB are not fully understood. Mandelboim and
colleagues suggest that microRNAs maintain low MICA and MICB
expression in the absence of cell stress.
Noam Stern-Ginossar et al.
doi:10.1038/ni.1642
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3No0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Np0E2
A critical function for CD200 in lung immune homeostasis and
the severity of influenza infection pp1074 - 1083
Lungs are continually challenged by exposure to airborne
particles and microbes, yet they resist overt inflammatory
responses. Hussell and colleagues show that this 'quiescent'
state requires CD200-CD200R interactions between alveolar
macrophages and lung tissues.
Robert J Snelgrove et al.
doi:10.1038/ni.1637
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nq0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emyC0Xztnp0HjR0B3Nr0E4
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