August 2008 Volume 10 Number 8, pp 875 - 1012
Visit Nature Cell Biology online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD04qe0Et
Please note that you need to be a subscriber to enjoy full text access
to Nature Cell Biology online. To purchase a subscription, please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0aAN0ET
Alternatively, to recommend a subscription to your library, please visit
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0BRtz0Et
=====================================================================
THE SOURCE EVENT -- London, 26/09/2008
The Source Event is a dedicated science career fair from Naturejobs. Meet 1-1 with employers from across Europe looking to fill hundreds of vacancies. REGISTER NOW for the conference and workshop sessions: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0BwBw0Ed
Post your career questions for The Source Event speakers before the event in the online discussion forum: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0BYIT0Ef
=====================================================================
Cell Signaling Review Series and Web Focus -
brought to you by Cell Research
Since March 2008, Cell Research has featured many articles about the recent advances in cell signaling. This review series and accompanying web focus highlights articles from Cell Research as well as Nature and explores the context of stem cell self-renewal and differentiation, cancer and other human diseases.
Access the Cell Signaling Review Series and Web Focus today to view select articles FREE of charge.
=====================================================================
----------------------
EDITORIAL
----------------------
CNRS evolution sparks revolution p875
At a time when change is necessary, French researchers are on the
barricades resisting efforts to reform CNRS, the country's well respected
basic research agency.
doi:10.1038/ncb0808-875
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1px0EG
----------------------
BOOK REVIEW
----------------------
Bringing models to life p876
Pierre-Francois Lenne reviews Modeling Biology Edited by Manfred D.
Laublicher and Gerd B. Muller
doi:10.1038/ncb0808-876
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1py0EH
----------------------
MEETING REPORT
----------------------
Twenty years of cell-cycle conferences in Roscoff pp877 - 880
Isabelle Vernos and Jan-Michael Peters
doi:10.1038/ncb0808-877
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1pz0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1p10E4
----------------------
NEWS AND VIEWS
----------------------
Nutrient sensing: TOR's Ragtime pp881 - 883
The mammalian target of rapamycin (mTOR) controls cell growth and size.
Amino acids are known to activate TOR, and Rag (Ras-related GTP-
binding protein) GTPases have now been found to act as their effectors.
Alfred J. Meijer and Patrice Codogno
doi:10.1038/ncb0808-881
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1p20E5
VE-cadherin and claudin-5: it takes two to tango pp883 - 885
Endothelial barrier function requires the adhesive activity of VE-cadherin
and claudin-5, which are key components of adherens and tight
endothelial junctions, respectively. Emerging evidence suggests that
VE-cadherin controls claudin-5 expression by preventing the nuclear
accumulation of FoxO1 and beta-catenin, which repress the claudin-5
promoter. This indicates that a crosstalk mechanism operates between
these junctional structures.
Julie Gavard and J. Silvio Gutkind
doi:10.1038/ncb0808-883
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1p30E6
Golgi gets wired up pp885 - 887
In endocrine cells, secretion can be rapidly upregulated in response
to stimuli without the need for additional synthesis of transport components.
A new and unexpected function of KDEL-R as a signalling receptor that
senses cargo protein load in the early secretory pathway has been identified.
Lennart Asp and Tommy Nilsson
doi:10.1038/ncb0808-885
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1p40E7
Cytokine loops driving senescence pp887 - 889
Cellular senescence, the permanent state of cell-cycle arrest, is
emerging as an intrinsic barrier against tumorigenesis and a mechanism
contributing to organismal ageing. Unexpected findings now identify
multiple secreted inflammatory cytokines, their cognate receptors and
positive-feedback loops with corresponding transcription factors, as key
mediators of both oncogene-induced and replicative senescence.
Jiri Bartek, Zdenek Hodny and Jiri Lukas
doi:10.1038/ncb0808-887
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1p50E8
----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights p890
doi:10.1038/ncb0808-890
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1p60EA
----------------------
ARTICLES
----------------------
The regulated assembly of a PKCepsiv complex controls the completion
of cytokinesis pp891 - 901
Adrian T. Saurin et al.
doi:10.1038/ncb1749
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1p70EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1p80EC
EGFR signalling as a negative regulator of Notch1 gene transcription
and function in proliferating keratinocytes and cancer pp902 - 911
Vihren Kolev et al.
doi:10.1038/ncb1750
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qA0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qB0EN
A traffic-activated Golgi-based signalling circuit coordinates the secretory
pathway pp912 - 922
Teodoro Pulvirenti et al.
doi:10.1038/ncb1751
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qC0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qD0EP
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated
upregulation of claudin-5 pp923 - 934
Andrea Taddei et al.
doi:10.1038/ncb1752
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qE0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qF0ER
Regulation of TORC1 by Rag GTPases in nutrient response pp935 - 945
Eunjung Kim et al.
doi:10.1038/ncb1753
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qG0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qH0ET
The auxin influx carrier LAX3 promotes lateral root emergence
pp946 - 954
Kamal Swarup et al.
doi:10.1038/ncb1754
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qI0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qJ0EV
Actin restricts FcepsivRI diffusion and facilitates antigen-induced
receptor immobilization pp955 - 963
Nicholas L. Andrews et al.
doi:10.1038/ncb1755
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qK0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qL0EX
----------------------
LETTERS
----------------------
Modulation of intracellular trafficking regulates cell intercalation in the
Drosophila trachea pp964 - 970
Daniel D. Shaye, Jordi Casanova and Marta Llimargas
doi:10.1038/ncb1756
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qM0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qN0EZ
IQGAP3 regulates cell proliferation through the Ras/ERK signalling
cascade pp971 - 978
Hisashi Nojima et al.
doi:10.1038/ncb1757
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qO0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qP0Eb
EphrinB1 controls cell-cell junctions through the Par polarity complex
pp979 - 986
Hyun-Shik Lee et al.
doi:10.1038/ncb1758
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qQ0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qR0Ed
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation
during neural stem-cell commitment pp987 - 993
Agnieszka Rybak et al.
doi:10.1038/ncb1759
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qS0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qT0Ef
Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1
for activation by CKIP-1 pp994 - 1002
Kefeng Lu et al.
doi:10.1038/ncb1760
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qU0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qV0Eh
Epidermal JunB represses G-CSF transcription and affects haematopoiesis
and bone formation pp1003 - 1011
Arabella Meixner et al.
doi:10.1038/ncb1761
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qW0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qX0Ej
----------------------
ERRATUM
----------------------
Erratum p1012
doi:10.1038/ncb0808-1012
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0B1qY0Ek
=====================================================================
Molecular Therapy focus on RNAi as a Therapeutic Strategy
www.nature.com/mt/webfocus/rnai
FREE access to various articles from the world's leading journals.
Presented by Molecular Therapy, this special web-focus gathers together top articles on RNAi originally published in Molecular Therapy, Nature, Nature Medicine, and British Journal of Cancer, and offers several of them to you FREE for a limited time!
Visit www.nature.com/mt/webfocus/rnai to access this special web focus today.
=====================================================================
You have been sent this Table of Contents Alert because you have opted
in to receive it. You can change or discontinue your e-mail alerts at any
time, by modifying your preferences on your nature.com account at:
http://ealerts.nature.com/cgi-bin24/DM/y/embM0Xztnp0HjD0Zzu0Ew
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration
department: registration@nature.com
For print subscription enquiries, please contact our subscription
department: subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
