Signaling Gateway - 25 July 2008
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0M40Ek
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
AGEING: NOTCHING UP MUSCLE REGENERATION
Muscle stem cell proliferation and regeneration is inhibited by an
age-associated decrease in active Notch that permits Smad3-mediated
transcription of cyclin-dependent kinase inhibitors.
Original research paper: Nature 454, 528-532 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0vP0Et
------------------------------
Molecule Pages Automated Data
------------------------------
The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
PATHWAYS
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1WB0E4
Each of the 4000 Molecule Pages in the database features an extensive
automated data section. The Pathways section contains links to
biological signaling pathways that involve the Molecule Page protein.
The pathways are imported from the NCI-Nature Pathway Interaction Database.
-------------------
Selected Updates
-------------------
TUMORIGENESIS: SOME HIFs ARE MORE EQUAL THAN OTHERS
Loss of function of the von Hippel-Lindau (VHL) tumor suppressor
activates hypoxia-inducible factor 2[alpha] (HIF2[alpha]), which
potentiates the development of highly vascularized tumors in multiple
organs.
Original research paper: Oncogene published online 19 May 2008
(doi: 10.1038/onc.2008.160)
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1WC0E5
SYNAPTOGENESIS: WHAT MAKETH THE MAN?
Male-specific neural circuitry is established by estrogen receptor
signaling, which activates PI3K and triggers dendritic spine
formation through a MAPK-dependent mechanism.
Original research paper: Neuron 58, 584-598 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1WD0E6
CHEMICAL BIOLOGY: NEW ELECTROPHILIC PROBES SLIDE IN
Electrophilic or photoreactive probes that covalently target an
enzyme's conserved active site permit activity-based protein profiling
(ABPP) studies of a broad range of proteins.
Original research paper: Nat. Chem. Biol. 4, 405-407 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1WE0E7
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0vO0Es
------------------------
Research Library
------------------------
TAZ CONTROLS Smad NUCLEOCYTOPLASMIC SHUTTLING AND REGULATES HUMAN
EMBRYONIC STEM-CELL SELF-RENEWAL
Nature Cell Biology 10, 837-848 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1WF0E8
COMBINED TREATMENT WITH STATINS AND AMINOBISPHOSPHONATES EXTENDS
LONGEVITY IN A MOUSE MODEL OF HUMAN PREMATURE AGING
Nature Medicine 14, 767-772 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1WG0EA
AN ORALLY DELIVERED SMALL-MOLECULE FORMULATION WITH ANTIANGIOGENIC
AND ANTICANCER ACTIVITY
Nature Biotechnology 26, 799-807 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1WH0EB
------------------------
Signaling News
------------------------
NATURE INSIGHT: INFLAMMATION
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1PG0E2
Inflammation is the body's immediate response to damage to its tissues
and cells by pathogens, noxious stimuli such as chemicals, or physical
injury. This Nature Insight highlights recent advances in our knowledge
of chronic inflammation, and features reviews on cancer-related
inflammation, the coupling of endoplasmic-reticulum stress and the
inflammatory response, and the integration of metabolism and
inflammation by lipid-activated nuclear receptors.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0Crw0Eb
-------------------------
Gateway Updates
-------------------------
THE FUNCTIONAL GLYCOMICS GATEWAY - JULY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0BKHW0Eb
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Alzheimer disease and protein turnover: A GlcNAc trick
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0BzRg0Eo
Neutrophil trafficking: CXCR2's icing on the cake
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0BzRh0Ep
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0BJYw0EP
-----------------------------
Signaling Job of the Week
-----------------------------
Research Associate
Employer: Genentech
Location: South San Francisco, CA
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0B1WI0EC
A research associate position is available in the Cancer Signaling
and Translational Oncology Department at Genentech. The successful
applicant will administer test compounds and collect and analyze
data to evaluate new anti-cancer agents in xenograft models of human
cancer.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0BnjC0EQ
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0vqs0EN
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0dIO0En
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0BCGZ0EV
For further technical assistance or any other enquiries, please click here:
http://ealerts.nature.com/cgi-bin24/DM/y/emVJ0Xztnp0H2W0mg0E8
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2008 Nature Publishing Group
---------------------------------------------------------------------
